Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

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Ecdysteroid hormones link the juvenile environment to alternative adult life histories in a seasonal insect
Oostra, V. ; Mateus, A.R.A. ; Burg, K.R.L. van den; Piessens, T. ; Eijk, M. van; Brakefield, P.M. ; Beldade, P. ; Zwaan, B.J. - \ 2014
American Naturalist 184 (2014)3. - ISSN 0003-0147 - p. E79 - E92.
butterfly bicyclus-anynana - drosophila-melanogaster - phenotypic plasticity - developmental temperature - adaptive responses - thermal plasticity - wing pattern - lepidoptera - diapause - nymphalidae
The conditional expression of alternative life strategies is a widespread feature of animal life and a pivotal adaptation to life in seasonal environments. To optimally match suites of traits to seasonally changing ecological opportunities, animals living in seasonal environments need mechanisms linking information on environmental quality to resource allocation decisions. The butterfly Bicyclus anynana expresses alternative adult life histories in the alternating wet and dry seasons of its habitat as endpoints of divergent developmental pathways triggered by seasonal variation in preadult temperature. Pupal ecdysteroid hormone titers are correlated with the seasonal environment, but whether they play a functional role in coordinating the coupling of adult traits in the alternative life histories is unknown. Here, we show that manipulating pupal ecdysteroid levels is sufficient to mimic in direction and magnitude the shifts in adult reproductive resource allocation normally induced by seasonal temperature. Crucially, this allocation shift is accompanied by changes in ecologically relevant traits, including timing of reproduction, life span, and starvation resistance. Together, our results support a functional role for ecdysteroids during development in mediating strategic reproductive investment decisions in response to predictive indicators of environmental quality. This study provides a physiological mechanism for adaptive developmental plasticity, allowing organisms to cope with variable environments
Mitochondrial DNA signature for range-wide populations of Bicyclus anynana suggests a rapid expansion from recent refugia
Jong, M.A. de; Wahlberg, N. ; Eijk, M. van; Brakefield, P.M. ; Zwaan, B.J. - \ 2011
PLoS ONE 6 (2011)6. - ISSN 1932-6203 - 5 p.
lepidoptera - butterflies - plasticity - biology - systematics - haplotypes - neutrality - evolution - selection - markers
This study investigates the genetic diversity, population structure and demographic history of the afrotropical butterfly Bicyclus anynana using mitochondrial DNA (mtDNA). Samples from six wild populations covering most of the species range from Uganda to South Africa were compared for the cytochrome c oxidase subunit gene (COI). Molecular diversity indices show overall high mtDNA diversity for the populations, but low nucleotide divergence between haplotypes. Our results indicate relatively little geographic population structure among the southern populations, especially given the extensive distributional range and an expectation of limited gene flow between populations. We implemented neutrality tests to assess signatures of recent historical demographic events. Tajima's D test and Fu's FS test both suggested recent population growth for the populations. The results were only significant for the southernmost populations when applying Tajima's D, but Fu's FS indicated significant deviations from neutrality for all populations except the one closest to the equator. Based on our own findings and those from pollen and vegetation studies, we hypothesize that the species range of B. anynana was reduced to equatorial refugia during the last glacial period, and that the species expanded southwards during the past 10.000 years. These results provide crucial background information for studies of phenotypic and molecular adaptation in wild populations of B. anynana
Glycosphingolipids and insulin resistance
Aerts, J.M. ; Boot, R.G. ; Eijk, M. van; Groener, J. ; Bijl, N. ; Lombardo, E. ; Bietrix, F.M. ; Dekker, N. ; Groen, A.K. ; Ottenhof, M. ; Roomen, C. ; Aten, J. ; Serlie, M. ; Langeveld, M. ; Wennekes, T. ; Overkleeft, H.S. - \ 2011
In: Sphingolipids and Metabolic Disease Landes Bioscience and Springer Science+Business Media - p. 99 - 119.
Rational design of a classical swine fever C-strain vaccine virus that enables the differentiation between infected and vaccinated animals
Kortekaas, J.A. ; Vloet, R.P.M. ; Weerdmeester, K. ; Ketelaar, J.H.E. ; Eijk, M. van; Loeffen, W.L.A. - \ 2010
Journal of Virological Methods 163 (2010)2. - ISSN 0166-0934 - p. 175 - 185.
hog-cholera virus - csf marker vaccine - e-rns - envelope glycoprotein-e1 - structural glycoprotein - monoclonal-antibodies - protects swine - e2 - pestivirus - challenge
The C-strain of the classical swine fever virus (CSFV) is considered the gold standard vaccine for the control of CSF. This vaccine, however, does not enable the serological differentiation between infected and vaccinated animals (DIVA). Consequently, its use can impose severe trade restrictions. The immunodominant and evolutionarily conserved A-domain of the E2 structural glycoprotein is an important target in CSFV-specific ELISAs. With the ultimate aim to render the C-strain suitable as a DIVA vaccine, mutations were introduced that were expected to dampen the immunogenicity of the A-domain. In the first of two approaches, the feasibility of shielding the A-domain by N-linked glycans was evaluated, whereas in the second approach C-strain mutants were created with targeted deletions in the A-domain. Analysis of the antibody responses elicited in rabbits suggested that shielding of the A-domain by an N-linked glycan had a minor effect on the immune response against the A-domain, whereas a targeted deletion of only a single amino acid severely dampened this response. C-strain mutants with larger deletions were highly debilitated and incapable of sustained growth in vitro. By providing the viruses with the opportunity to increase their fitness by mutation, a mutant was rescued that found a way to compensate for the imposed fitness cost. Most of the identified mutations occurred in several independently evolved viruses, demonstrating parallel evolution. By virtue of this compensatory evolution, a well replicating and genetically stable C-strain mutant was produced that can be serologically differentiated from wildtype CSFV. The findings provide the molecular basis for the development of a novel, genetically stable, live attenuated CSF DIVA vaccine.
QTL analysis of carbohydrates and growth-related traits in a new recombinant inbred polulation derived from the Ler x Kond cross
El-Lithy, M.E.M. ; Bentsink, L. ; Broekhof, J.L.M. ; Poel, H. ; Eijk, M. van; Koornneef, M. ; Vreugdenhil, D. - \ 2004
In: Book of Abstracts, Arabidopsis Conference Berlin, Germany : - p. TO7062 - TO7062.
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