Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
Boess, F.G. ; Hendrix, M. ; Staay, F.J. van der; Erb, C. ; Schreiber, R. ; Staveren, W.C.G. ; Vente, J. de; Prikaerts, J. ; Blokland, A. ; Koenig, G. - \ 2004
Neuropharmacology 47 (2004)7. - ISSN 0028-3908 - p. 1081 - 1092.
long-term potentiation - dependent protein-kinase - soluble guanylyl cyclase - cyclic-nucleotide phosphodiesterase - messenger nitric-oxide - rat-brain - retrograde messenger - adenosine-deaminase - serotonin receptor - nmda receptors
An essential element of the signalling cascade leading to synaptic plasticity is the intracellular second messenger molecule guanosine 3¿,5¿-cyclic monophosphate (cGMP). Using the novel, potent, and selective inhibitor Bay 60-7550, we show that the enzyme 3¿,5¿-cyclic nucleotide phosphodiesterase type 2 (PDE2) is responsible for the degradation of newly synthesized cGMP in cultured neurons and hippocampal slices. Inhibition of PDE2 enhanced long-term potentiation of synaptic transmission without altering basal synaptic transmission. Inhibition of PDE2 also improved the performance of rats in social and object recognition memory tasks, and reversed MK801-induced deficits in spontaneous alternation in mice in a T-maze. Our data provide strong evidence that inhibition of PDE2 can improve memory functions by enhancing neuronal plasticity
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