Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

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    Natural killer T cells in adipose tissue prevent insulin resistance
    Schipper, H.S. ; Rakhshandehroo, M. ; Graaf, S.F.J. van de; Venken, K. ; Koppen, A. ; Stienstra, R. ; Prop, S. ; Meerding, J. ; Hamers, N. ; Besra, G.S. ; Boon, L. den; Nieuwenhuis, E.E.S. ; Elewaut, D. ; Prakken, B. ; Kersten, A.H. ; Boes, M. ; Kalkhoven, E. - \ 2012
    The Journal of Clinical Investigation 122 (2012)9. - ISSN 0021-9738 - p. 3343 - 3354.
    invariant nkt cells - alternatively activated macrophages - nonobese diabetic mice - hepatic steatosis - metabolic syndrome - innate immunity - obese mice - inflammation - fat - disease
    Lipid overload and adipocyte dysfunction are key to the development of insulin resistance and can be induced by a high-fat diet. CD1d-restricted invariant natural killer T (iNKT) cells have been proposed as mediators between lipid overload and insulin resistance, but recent studies found decreased iNKT cell numbers and marginal effects of iNKT cell depletion on insulin resistance under high-fat diet conditions. Here, we focused on the role of iNKT cells under normal conditions. We showed that iNKT cell-deficient mice on a low-fat diet, considered a normal diet for mice, displayed a distinctive insulin resistance phenotype without overt adipose tissue inflammation. Insulin resistance was characterized by adipocyte dysfunction, including adipocyte hypertrophy, increased leptin, and decreased adiponectin levels. The lack of liver abnormalities in CD1d-null mice together with the enrichment of CD1d-restricted iNKT cells in both mouse and human adipose tissue indicated a specific role for adipose tissue-resident iNKT cells in the development of insulin resistance. Strikingly, iNKT cell function was directly modulated by adipocytes, which acted as lipid antigen-presenting cells in a CD1d-mediated fashion. Based on these findings, we propose that, especially under low-fat diet conditions, adipose tissue-resident iNKT cells maintain healthy adipose tissue through direct interplay with adipocytes and prevent insulin resistance
    Zuur bestrijden met ultrasoon geluid onderzocht
    Duyvesteijn, R.G.E. ; Boon, L. den; Vermeulen, P. - \ 2010
    BloembollenVisie 2010 (2010)209. - ISSN 1571-5558 - p. 28 - 28.
    fusarium - ultrasoon sporen - geluid - ziektebestrijding - fysische gewasbeschermingsmethoden - gewasbescherming - fusarium - ultrasonic tracking - noise - disease control - physical control - plant protection
    De Bulbsweep werkt met ultrasone geluidsgolven en zou op die manier kunnen werken tegen een aantal ziekten en plagen in de bloembollenteelt. PPO Bloembollen heeft onderzocht of de Bulbsweep tegen zuur kan worden ingezet. De resultaten zijn wisselend. Nader onderzoek is nodig.
    De Natuurschoonwet: Borger van Nederlands natuurschoon?
    Boon, L. den; Schuurman, S. - \ 2008
    Vakblad Natuur Bos Landschap 5 (2008)10. - ISSN 1572-7610 - p. 18 - 19.
    landgoederen - landschapsbescherming - natuurbescherming - recht - Nederland - estates - landscape conservation - nature conservation - law - Netherlands
    De Natuurschoonwet (NSW) biedt voor landgoederen in Nederland diverse fiscale voordelen. De NSW stelt geen eisen aan de kwaliteit van het natuurschoon, wel aan de omvang van het landgoed (namelijk minstens 5 ha groot). Wat is de invloed van deze wet op landgoederen. Dat is nagegaan in een studentenonderzoek (Schuurman) door drie landgoederen onder de loep te nemen en tevens bij 23 landgoederen de toekomstmogelijkheden na te gaan, en wel in Overijssel en Gelderland
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