Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Effect of daily antenatal iron supplementation on plasmodium infection in Kenyan women. A randomized clinical trial
    Mwangi, M.N. ; Roth, J.M. ; Smit, M.R. ; Trijsburg, Laura ; Mwangi, A.M. ; Demir, A.Y. ; Wielders, J.P.M. ; Mens, P.F. ; Verweij, J.J. ; Cox, S.E. ; Prentice, A.M. ; Brouwer, I.D. ; Savelkoul, H.F.J. ; Andang'o, P.E.A. ; Verhoef, J.C.M. - \ 2015
    JAMA: The Journal of the American Medical Association 314 (2015)10. - ISSN 0098-7484 - p. 1009 - 1020.
    Importance Anemia affects most pregnant African women and is predominantly due to iron deficiency, but antenatal iron supplementation has uncertain health benefits and can increase the malaria burden. Objective To measure the effect of antenatal iron supplementation on maternal Plasmodium infection risk, maternal iron status, and neonatal outcomes. Design, Setting, and Participants Randomized placebo-controlled trial conducted October 2011 through April 2013 in a malaria endemic area among 470 rural Kenyan women aged 15 to 45 years with singleton pregnancies, gestational age of 13 to 23 weeks, and hemoglobin concentration of 9 g/dL or greater. All women received 5.7 mg iron/day through flour fortification during intervention, and usual intermittent preventive treatment against malaria was given. Interventions Supervised daily supplementation with 60 mg of elemental iron (as ferrous fumarate, n¿=¿237 women) or placebo (n¿=¿233) from randomization until 1 month postpartum. Main Outcomes and Measures Primary outcome was maternal Plasmodium infection at birth. Predefined secondary outcomes were birth weight and gestational age at delivery, intrauterine growth, and maternal and infant iron status at 1 month after birth. Results Among the 470 participating women, 40 women (22 iron, 18 placebo) were lost to follow-up or excluded at birth; 12 mothers were lost to follow-up postpartum (5 iron, 7 placebo). At baseline, 190 of 318 women (59.7%) were iron-deficient. In intention-to-treat analysis, comparison of women who received iron vs placebo, respectively, yielded the following results at birth: Plasmodium infection risk: 50.9% vs 52.1% (crude difference, -1.2%, 95% CI, -11.8% to 9.5%; P¿=¿.83); birth weight: 3202 g vs 3053 g (crude difference, 150 g, 95% CI, 56 to 244; P¿=¿.002); birth-weight-for-gestational-age z score: 0.52 vs 0.31 (crude difference, 0.21, 95% CI, -0.11 to 0.52; P¿=¿.20); and at 1 month after birth: maternal hemoglobin concentration: 12.89 g/dL vs 11.99 g/dL (crude difference, 0.90 g/dL, 95% CI, 0.61 to 1.19; P¿
    Protection against diarrhoea and fever without localising signs associated with asymptomatic Giardia lamblia infection is lost with multi-nutrient supplementation: a prospective study among rural Tanzanian children.
    Mank, T. ; Veenemans, J. ; Olomi, R.M. ; Wielders, J.P.M. ; Savelkoul, H.F.J. ; Verhoef, H. - \ 2011
    Protection against diarrhoea associatead with asymptomatic giardiasis is lost with multi-nutrient supplementation: a prospective study among rural Tanzanian children
    Mank, T. ; Veenemans, J. ; Olomi, R.M. ; Wielders, J.P.M. ; Savelkoul, H.F.J. ; Verhoef, H. - \ 2011
    In: Abstracts of the 7th European Congress on Tropical Medicine and International Health, Barcelona, Spain, 3-6 October 2011. - Blackwell Publishing Ltd. - p. 256 - 256.
    Protection against diarrhea associated with Giardia intestinalis is lost with Multi-Nutrient Supplementation: A Study in Tanzanian Children
    Veenemans, J. ; Mank, T. ; Ottenhof, M. ; Baidjoe, A.Y. ; Mbugi, E.V. ; Demir, A.Y. ; Wielders, J.P.M. ; Savelkoul, H.F.J. ; Verhoef, J.C.M. - \ 2011
    PLoS Neglected Tropical Diseases 5 (2011)6. - ISSN 1935-2727 - 10 p.
    israeli bedouin infants - lamblia infection - protozoal parasites - helicobacter-pylori - natural-history - young-children - bangladesh - childhood - disease - consequences
    Background - Asymptomatic carriage of Giardia intestinalis is highly prevalent among children in developing countries, and evidence regarding its role as a diarrhea-causing agent in these settings is controversial. Impaired linear growth and cognition have been associated with giardiasis, presumably mediated by malabsorption of nutrients. In a prospective cohort study, we aim to compare diarrhea rates in pre-school children with and without Giardia infection. Because the study was conducted in the context of an intervention trial assessing the effects of multi-nutrients on morbidity, we also assessed how supplementation influenced the relationship between Giardia and diarrhoea rates, and to what extent Giardia modifies the intervention effect on nutritional status. Methods and Findings - Data were collected in the context of a randomized placebo-controlled efficacy trial with 2×2 factorial design assessing the effects of zinc and/or multi-micronutrients on morbidity (n = 612; height-for-age z-score
    Serum 25-hydroxy-vitamin D3 concentrations increase during tuberculosis treatment in Tanzania
    Tostmann, A. ; Wielders, J.P.M. ; Kibiki, G.S. ; Verhoef, H. ; Boeree, M.J. ; Ven, A.J.A.M. van der - \ 2010
    The International Journal of Tubercolosis and Lung Disease 14 (2010)9. - ISSN 1027-3719 - p. 1147 - 1152.
    vitamin-d metabolism - pulmonary tuberculosis - immune regulation - human-monocytes - d deficiency - inhibition - rifampicin - interferon - infection - cyp3a4
    SETTING: Vitamin D deficiency is associated with susceptibility to active tuberculosis (TB) in many settings. In vitro studies and studies on human volunteers showed that two of the first-line anti-tuberculosis drugs, isoniazid and rifampicin, reduce 25-hydroxy vitamin D (25[OH]D) concentrations. OBJECTIVE: To study changes in vitamin D status during treatment of Tanzanian hospitalised patients with pulmonary TB (PTB). DESIGN: We compared serum 25[OH]D concentrations in 81 Tanzanian PTB patients before and after 2 months of treatment. RESULTS: Median serum 25[OH]D concentrations increased from 91 nmol/l at baseline to 101 nmol/l after 2 months of TB treatment (median increase 6.0 nmol/l, IQR -0.7-25.0, P = 0.001). Median serum parathyroid hormone concentrations increased from 1.6 to 2.0 pmol/l (median increase 0.46, IQR -0.2-1.1, P <0.001). CONCLUSION: 25[OH]D serum concentrations increased during the first 2 months of TB treatment in 81 PTB patients in northern Tanzania. Improved dietary intake and increased sunlight exposure may have contributed to the increased 25[OH]D concentrations
    Alterations in early cytokine-mediated immune regulation to Plasmodium falciparum infection in micronutrient deficient Tanzanian children: A cross-sectional survey
    Mbugi, E.V. ; Meijerink, M. ; Veenemans, J. ; McCall, M. ; Olomi, R.M. ; Shao, J.F. ; Wielders, J.P.M. ; Verhoef, H. ; Savelkoul, H.F.J. - \ 2009
    In: The 5th MIM Pan African Malaria Conference, Nairobi, Kenya, 2 - 6 November. - - p. 138 - 138.
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