Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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The Newly Developed Elderly Nutrient-Rich Food Score Is a Useful Tool to Assess Nutrient Density in European Older Adults
Berendsen, Agnes A.M. ; Kramer, Charlotte S. ; Groot, Lisette C.P.G.M. de - \ 2019
Frontiers in Nutrition 6 (2019). - ISSN 2296-861X
diet - diet quality - elderly - nutrient density - nutrient profiling - nutrient-rich food index

Objective: To develop a nutrient-rich food (NRF) score that captures dietary reference values for older adults and to validate this against a diet index that was specifically designed to assess adherence to dietary guidelines for the older population. Design: A cross-sectional study within the Dutch National Food Consumption Survey (DNFCS, n = 735 men and women aged 70–94 years, enrolled between October 2010 and February 2012) and within the NU-AGE study (n = 250 men and women aged 65–79 years, enrolled between April 2012 and March 2013). Dietary intake was assessed by means of two non-consecutive dietary record assisted 24-h recalls and 7-day food records, respectively. Structured questionnaires collected data on lifestyle and socio-economic information. Anthropometrics were measured by trained dieticians or research assistants. We evaluated Elderly NRF (E-NRF) scores against the NU-AGE index, a measure of adherence to European dietary guidelines for the aging population. The E-NRF scores were composed of nutrients that: (1) have been shown to be of inadequate intake in the aging population (>20%), (2) were defined as nutrients of public health relevance, and (3) were associated with relevant health outcomes. Results: The E-NRF score that best predicted the NU-AGE index included seven nutrients to encourage (protein, dietary fiber, folate, vitamin D, calcium, magnesium, potassium) and three nutrients to limit (saturated fat, sodium and mono- and disaccharides) on a 100-kcal basis, the E-NRF7.3 score (model R2 0.27 in DNFCS and 0.41 in NU-AGE). Food groups contributing the most to the individual E-NRF7.3 scores were vegetables, bread, potatoes and milk and milk products. Conclusion: The E-NRF7.3 score is a useful tool for assessing nutrient density of diets within the older population. No index has previously been developed with the aim of evaluating nutrient density of diets and foods specifically capturing dietary reference values for older adults.

Sugar Beet Pectin Supplementation Did Not Alter Profiles of Fecal Microbiota and Exhaled Breath in Healthy Young Adults and Healthy Elderly
An, Ran ; Wilms, Ellen ; Smolinska, Agnieszka ; Hermes, Gerben D.A. ; Masclee, Ad A.M. ; Vos, Paul de; Schols, Henk A. ; Schooten, Frederik J. van; Smidt, Hauke ; Jonkers, Daisy M.A.E. ; Zoetendal, Erwin G. ; Troost, Freddy J. - \ 2019
Nutrients 11 (2019)9. - ISSN 2072-6643
aging - dietary fiber - elderly - exhaled air - microbiota - pectin - young adults

Aging is accompanied with increased frailty and comorbidities, which is potentially associated with microbiome perturbations. Dietary fibers could contribute to healthy aging by beneficially impacting gut microbiota and metabolite profiles. We aimed to compare young adults with elderly and investigate the effect of pectin supplementation on fecal microbiota composition, short chain fatty acids (SCFAs), and exhaled volatile organic compounds (VOCs) while using a randomized, double-blind, placebo-controlled parallel design. Fifty-two young adults and 48 elderly consumed 15 g/day sugar beet pectin or maltodextrin for four weeks. Fecal and exhaled breath samples were collected before and after the intervention period. Fecal samples were used for microbiota profiling by 16S rRNA gene amplicon sequencing, and for analysis of SCFAs by gas chromatography (GC). Breath was used for VOC analysis by GC-tof-MS. Young adults and elderly showed similar fecal SCFA and exhaled VOC profiles. Additionally, fecal microbiota profiles were similar, with five genera significantly different in relative abundance. Pectin supplementation did not significantly alter fecal microbiota, SCFA or exhaled VOC profiles in elderly or young adults. In conclusion, aside from some minor differences in microbial composition, healthy elderly and young adults showed comparable fecal microbiota composition and activity, which were not altered by pectin supplementation.

The MemTrax Test Compared to the Montreal Cognitive Assessment Estimation of Mild Cognitive Impairment
Hoek, Marjanne D. Van Der; Nieuwenhuizen, Arie ; Keijer, Jaap ; Ashford, J.W. - \ 2019
Journal of Alzheimers Disease 67 (2019)3. - ISSN 1387-2877 - p. 1045 - 1054.
Alzheimer's disease - continuous performance task - dementia - elderly - memory - mild cognitive impairment - screening

Cognitive impairment is a leading cause of dysfunction in the elderly. When mild cognitive impairment (MCI) occurs in elderly, it is frequently a prodromal condition to dementia. The Montreal Cognitive Assessment (MoCA) is a commonly used tool to screen for MCI. However, this test requires a face-to-face administration and is composed of an assortment of questions whose responses are added together by the rater to provide a score whose precise meaning has been controversial. This study was designed to evaluate the performance of a computerized memory test (MemTrax), which is an adaptation of a continuous recognition task, with respect to the MoCA. Two outcome measures are generated from the MemTrax test: MemTrax speed and MemTrax correct. Subjects were administered the MoCA and the MemTrax test. Based on the results of the MoCA, subjects were divided in two groups of cognitive status: normal cognition (n = 45) and MCI (n = 37). Mean MemTrax scores were significantly lower in the MCI than in the normal cognition group. All MemTrax outcome variables were positively associated with the MoCA. Two methods, computing the average MTX score and linear regression were used to estimate the cutoff values of the MemTrax test to detect MCI. These methods showed that for the outcome MemTrax speed a score below the range of 0.87 - 91 s -1 is an indication of MCI, and for the outcome MemTrax correct a score below the range of 85 - 90% is an indication for MCI.

Molecular assessment of muscle health and function : The effect of age, nutrition and physical activity on the human muscle transcriptome and metabolom
Hangelbroek, Roland W.J. - \ 2017
Wageningen University. Promotor(en): A.H. Kersten; C.P.G.M. de Groot, co-promotor(en): M.V. Boekschoten. - Wageningen : Wageningen University - ISBN 9789463437103 - 205
muscles - age - nutrition - physical activity - transcriptomes - metabolomes - elderly - creatine - phosphocreatine - vitamin d - atrophy - spieren - leeftijd - voeding - lichamelijke activiteit - transcriptomen - metabolomen - ouderen - creatine - fosfocreatine - vitamine d - atrofie

Prolonged lifespan and decreased fertility will lead to an increased proportion of older adults in the world population (population aging). An important strategy to deal with population aging has been to promote healthy aging; not only to prevent mounting health care costs, but also to maintain independence and quality of life of older populations for as long as possible. Close to the opposite of the healthy aging is frailty. A major component of (physical) frailty is sarcopenia: age-related loss of muscle mass. Decreased muscle size and strength has been associated with a wide variety of negative health outcomes, including increased risk of hospitalization, physical disability and even death. Therefore, maintaining muscle size and strength is very important for healthy aging. Nutrition and physical activity are possible strategies to maintain or even improve muscle function with age.

The effect of nutrition, age, frailty and physical activity on the function of skeletal muscle is complex. A better understanding of the molecular mechanisms involved can provide new insights in potential strategies to maintain muscle function over the life course. This thesis aims to investigate these mechanisms and processes that underlie the effects of age, frailty and physical activity by leveraging the sensitivity and comprehensiveness of transcriptomics and metabolomics.

Chapter 2 and 3 describe the effects of age, frailty and resistance-type exercise training on the skeletal muscle transcriptome and metabolome. Both the transcriptome and metabolome show significant differences between frail and healthy older adults. These differences are similar to the differneces between healthy young men and healthy older adults, suggesting that frailty presents itself as a more pronounced form of aging, somewhat independent of chronological age. These age and frailty related differences in the transcriptome are partially reversed by resistance-type exercise training, in accordance with the observed improvement in muscle strength. Regression analysis revealed that the protocadherin gamma gene cluster may be important to skeletal muscle function. Protocadherin gamma is involved in axon guidance and may be upregulated due to the denervation-reinnervation cycles observed in skeletal muscle of older individuals. The metabolome suggested that resistance-type exercise training led to a decrease in branched-chain amino acid oxidation, as shown by a decrease in amino acid derived carnitines. Lastly, the blood metabolome showed little agreement with the metabolome in skeletal muscle, indicating that blood is a poor read-out of muscle metabolism.

We assessed the effect of knee immobilization with creatine supplementation or placebo on the skeletal muscle transcriptome and metabolome in chapter 4. Knee immobilization caused muscle mass loss and strength loss in all participants, with no differences between creatine and placebo groups. Knee immobilization appeared to induce the HDAC4-myogenin axis, which is primarily associated with denervation and motor neuron diseases. The metabolome showed changes consistent with the decreased expression of energy metabolism genes. While acyl-carnitine levels tended to decrease with knee immobilization, one branched-chain amino acid-derived acyl carnitine was increased after knee immobilization, suggesting increased amino acid oxidation.

Vitamin D deficiency is common among older adults and has been linked to muscle weakness. Vitamin D supplementation has been proposed as a strategy to improve muscle function among older populations. In chapter 5, supplementation with vitamin D (calcifediol, 25(OH)D) is investigated as nutritional strategy to improve muscle function among frail older adults. However, we observed no effect of vitamin D on the muscle transcriptome. These findings indicate the effects of vitamin D supplementation on skeletal muscle may be either absent, weak, or limited to a small subset of muscle cells.

Transcriptomic changes due to different forms of muscle disuse are compared in chapter 6 (primarily knee immobilization and bed rest). The goal was to determine the similarities and differences among various causes of muscle atrophy in humans (primarily muscle disuse). Both knee immobilization and bed rest led to significant changes in the muscle transcriptome. However, the overlap in significantly changed genes was relatively small. Knee immobilization was characterized by ubiquitin-mediated proteolysis and induction of the HDAC4/Myogenin axis, whereas bed rest revealed increased expression of genes of the immune system and increased expression of lysosomal genes. Knee immobilization showed the highest similarity with age and frailty-related transcriptomic changes. This finding suggests that knee immobilization may be the most suitable form of disuse atrophy to assess the effectiveness of strategies to prevent age-related muscle loss in humans.

The transcriptome and metabolome are incredibly useful tools in describing the wide array of biological systems within skeletal muscle. These systems can be modulated using physical activity (or lack thereof) as well as nutrition. This thesis describes some of these processes and highlights several unexplored genes and metabolites that may be important for maintaining or even optimizing muscle function. In the future, it may be possible to optimize both exercise and nutrition for each individual using these techniques; or even better, cheaper and less invasive alternatives.

Dietary patterns for healthier cognitive ageing
Berendsen, Agnes A.M. - \ 2017
Wageningen University. Promotor(en): C.P.G.M. de Groot; E.J.M. Feskens, co-promotor(en): O. van de Rest. - Wageningen : Wageningen University - ISBN 9789463436014 - 190
meal patterns - feeding habits - aging - cognition - health - food supplements - dementia - nutritional intervention - elderly - elderly nutrition - nutrition and health - maaltijdpatronen - voedingsgewoonten - verouderen - kenvermogen - gezondheid - voedselsupplementen - dementie - maatregel op voedingsgebied - ouderen - ouderenvoeding - voeding en gezondheid

With ageing of our population and the accompanying increase in the number of people living with dementia, it is important to find modifiable risk factors to postpone the onset of cognitive decline. Diet has been proposed such a modifiable risk factor. To date, numerous studies have been conducted demonstrating a possible role of specific nutrients and foods in cognitive functioning. However, as people do not consume single nutrients, the research field has shifted towards studying dietary patterns in which synergistic effects of single nutrients and/or foods can be studied. The main aim of this thesis was to study the association of healthful dietary patterns with cognitive functioning. In addition, nutrient intake inadequacies were assessed and the potential to change dietary intake in older adults aged 65 years and older was studied.

Chapter 2 describes nutrient intake of 245 Dutch adults aged 65-80 years. We identified the contribution of nutrient dense foods, fortified foods and dietary supplements to the total intake of micronutrients. Nutrient density of foods was evaluated using the Nutrient Rich Food score 9.3. Nutrient intake inadequacies were observed for vitamin D, vitamin B6 and selenium. Conventional foods were the main source of vitamin D, vitamin B6 and selenium intake. Foods with the highest nutrient density contributed most to total vitamin B6 intake. In order to optimize nutrient intakes of elderly, combinations of natural food sources, fortified foods and dietary supplements should be considered.

Chapter 3 provides a systematic review of the literature on human studies up to May 2014 that examined the role of dietary patterns in relation to cognitive decline or dementia. The results demonstrate that better adherence to a Mediterranean diet was associated with less cognitive decline, dementia or Alzheimer’s Disease (AD) in four out of six cross-sectional studies, six out of 12 longitudinal studies, one trial and three meta-analyses. Other healthy dietary patterns, among which the Healthy Diet Indicator, have shown to be associated with reduced cognitive decline and/or a reduced risk of dementia in all six cross-sectional studies and six out of eight longitudinal studies. The conclusion of this literature review was that more conclusive evidence is needed to come to more targeted and detailed dietary guidelines to prevent or postpone cognitive decline.

In chapter 4 the association between the Healthy Diet Indicator (HDI) and cognitive functioning in older adults from three different cohort studies was investigated. The cohorts included in total 21,837 subjects from Europe (SENECA and the Rotterdam Study [RS]) and the Unites States (Nurses’ Health Study [NHS]). Cognitive functioning was measured using the Mini-Mental State Examination (MMSE) in SENECA and RS, and the Telephone Interview for Cognitive Status (TICS) in NHS. In all three cohorts, the HDI was not significantly associated with cognitive decline, nor with cognitive function.

In chapter 5 the association of long-term adherence to the Dietary Approaches to Stop Hypertension (DASH) diet with cognitive function and decline in older American women was examined. A total of 16,144 women from the Nurses’ Health Study, aged ≥70 years, who underwent cognitive testing a total of 4 times by telephone from 1995-2001 (baseline), with multiple dietary assessments between 1984 and the first cognitive exam were studied. Greater adherence to long-term DASH score was significantly associated with better average global cognition, verbal memory and TICS score at older ages, but not with cognitive decline.

In chapter 6, the same cohort as in chapter 5 was studied to examine the association between long-term adherence to a recently developed Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet with cognitive function and decline. Higher MIND diet scores were associated with better verbal memory at older ages, but not with cognitive decline over 6 years in global cognition, verbal memory or TICS.

Chapter 7 provides an overview of the NU-AGE (NUtrients and AGEing) dietary intervention study. The NU-AGE study is a randomized one-year intervention in 1,250 apparently healthy, independently living European subjects aged 65 to 80 years. Subjects were randomised into either the intervention group or the control group. Participants in the intervention group received dietary advice aimed at meeting the dietary recommendations of the ageing population. At the start of this thesis, the NU-AGE study was the first dietary intervention investigating the effect of a whole diet and providing targeted dietary recommendations for optimal health and quality of life in apparently healthy European elderly.

In chapter 8, we evaluated if the NU-AGE intervention could be effective to shift the dietary intake of apparently healthy older adults aged 65-80 years living in Italy, the UK, the Netherlands, Poland, and France towards a more healthful diet. The NU-AGE index was created to assess adherence to the NU-AGE diet. At baseline and after one-year follow-up dietary intake was assessed by means of 7-day food records. In total, 1,296 participants were randomized and 1,145 participants completed the intervention (571 in intervention group, 570 in control group). After one-year follow-up, the intervention group improved mean intake of 13 out of 16 dietary recommendations of the NU-AGE diet (p<0.05) with a significant increase of the total NU-AGE index, compared to the control group (mean change in NU-AGE index 21.3±15.9, p<0.01). The NU-AGE dietary intervention, based on dietary recommendations for older adults, may be a feasible strategy to improve dietary intake in an ageing European population.

Chapter 9 shows the results of the NU-AGE parallel randomized dietary intervention study on cognitive functioning in the Dutch NU-AGE subpopulation, including 252 older adults aged 65-80 years (123 intervention, 129 control). The primary outcome was one-year change in global cognition and in four cognitive domains as measured through a comprehensive neuropsychological test battery. Comparing the intervention with the control group, there was no effect of the intervention on cognitive functioning.

In chapter 10 the main findings of this thesis were summarized and a reflection on methodological aspects was given. When grading the reported associations in previous studies and studies in this thesis, it was concluded that there is probable evidence for a role of the Mediterranean diet on cognitive functioning. For the DASH and MIND diet there is a possible link with cognitive functioning; for the HDI and the NU-AGE diet there is no sufficient evidence yet to conclude that there is a relation with cognitive functioning. Not only is there a need for well-designed intervention and prospective studies, we also call for communication strategies to the general public about the consumption of healthier diets to not only impact cardiovascular but also potentially impact brain health as many individuals will face progressive cognitive decline in the near future.

Understanding heterogeneity in decision-making among elderly consumers: the case of functional foods
Zanden, Lotte D.T. van der - \ 2017
Wageningen University. Promotor(en): J.C.M. van Trijp, co-promotor(en): P.W. Kleef; R.A. de Wijk. - Wageningen : Wageningen University - ISBN 9789463431439 - 161
voedselopname - ouderen - voedselsamenstellingtabellen - voedselverrijking - ouderenvoeding - leeftijdsgroepen - marketing - marketing van voedingsmiddelen - ziekenhuisdiëten - besluitvorming - consumenten - voedselconsumptie - food intake - elderly - food composition tables - food enrichment - elderly nutrition - age groups - marketing - food marketing - hospital diets - decision making - consumers - food consumption

The population of elderly has grown considerably over the past few decades, due to reduced birth rates and increased life expectancy. Old age is, however, still associated with a higher incidence of various health conditions that pose a threat to quality of life and result in high healthcare costs. Various products and services could help elderly to stay active and healthy for longer if they were adopted, such as mobility aids, home modifications and functional foods. A key challenge is to position products and services like these on the market in such a way that elderly can see their value and will start using them. In doing this, it is crucial to know what elderly need and to understand how they make decisions. This thesis therefore aims to provide a deeper understanding of decision-making among elderly consumers. It does so using functional foods as an example, and concentrates on answering the following research questions: 1) Which types of wants, inferences and intentions characterize the elderly consumer population? 2) What are relevant ways to distinguish between elderly consumers? and 3) How can elderly consumers be motivated to form consumption intentions for products and services aimed at promoting their wellbeing?

An experience-sampling paradigm shows that there are age-related differences in both desires (i.e. wants), such as the desire for food, and goals, such as the goal to work (i.e. intentions), but not in the way these wants and intentions interact with each other (Chapter 2). Young and old consumers experience the same types of conflict between their wants and intentions. The extent of conflict does change with age however, such that older adults experience conflict less often and less strongly than younger adults. This age-related difference can be partly explained by the way in which consumers perceive the time they have left in their lives. Those who perceive time as limited, experience more conflict. Zooming in on product-specific decision-making, a series of focus groups indicates that elderly consumers overall want to use healthy products that they use frequently as a basis for enrichment with protein (Chapter 3). Most elderly do not display intentions to purchase and use such products, however, either because they do not feel the need to use functional foods or because they hold various negative inferences regarding functional foods, such as a high price or bad taste. Importantly, elderly consumers differ strongly in their wants, inferences and intentions, suggesting that segmentation of this population is warranted.

A narrative review reveals that there are various ways to segment the elderly consumer population, for example based on age, future time perspective or purchase behaviour, and every approach has its strengths and weaknesses (Chapter 4). Based on the objectives of a segmentation approach one can, however, make an informed decision regarding which segmentation base to use. In the functional food market, elderly consumers may best be segmented using a segmentation base on the food or product level (i.e. rather than the person level) that results in segments in which consumers have similar needs and wants, for example the attributes benefits that consumers seek. A segmentation study shows that using such a segmentation base results in segments that provide concrete instructions for the development of functional foods (Chapter 5). The resulting segments of elderly have unique preferences that do not necessarily reflect those of the average elderly consumer and thereby provide useful insights that can help increase our understanding of elderly consumers.

Segmentation also provides a basis for tailoring products to the needs and wants of elderly consumers. A segmentation study illustrates that such tailoring can increase elderly consumers’ willingness to try protein-enriched foods for the first time (i.e. trial purchase), as well as their willingness to use such products on a more regular basis (i.e. repeat purchase) (Chapter 5). For a small group of elderly, tailoring proves to be ineffective, however, as they categorically reject all types of protein-enriched foods presented to them. These elderly are relatively uninterested in the concept of functional foods, which may be due to negative inferences surrounding such products. Overcoming the activation of such negative inferences may be useful in motivating elderly consumers to use protein-enriched foods. A field study in a hospital setting shows that the implementation of a verbal prompt intervention that motivates consumers to make decisions without much can increase the consumption of protein (Chapter 6). By understanding and capitalizing on cognitive biases in human decision-making, interventions like these can motivate consumers to form consumption intentions even when they hold negative inferences about products or services.

Overall, this thesis shows that although elderly consumers share an age bracket they are strongly heterogeneous in their wants, inferences and intentions. This heterogeneity is robust, as it can even be observed when zooming in on decision-making regarding a specific product category (i.e. protein-enriched foods). Our understanding of the elderly consumer population increases by studying this heterogeneity, as it provides insights beyond those that apply to the group of elderly that reflect the average. In studying heterogeneity, it pays off to focus on bases that are predictive of behaviour while demographic characteristics like age provide only few insights. Industry and health institutions can also benefit from an increased understanding of the composition of the elderly population and how they make decisions. Such understanding may provide them with concrete instructions for the development and commercialization of products and services for this growing group of consumers.

How to measure health improvement? : assessment of subtle shifts in metabolic phenotype
Fazelzadeh, Parastoo - \ 2017
Wageningen University. Promotor(en): A.H. Kersten; J.P.M. van Duynhoven, co-promotor(en): M.V. Boekschoten. - Wageningen : Wageningen University - ISBN 9789463430739 - 187
health promotion - improvement - measurement - metabolic profiling - elderly - obesity - microarrays - rna - peripheral blood mononuclear cells - gezondheidsbevordering - verbetering - meting - metabolische profilering - ouderen - obesitas - microarrays - rna - perifere mononucleaire bloedcellen

Human health is impacted by a complex network of interactions between biological pathways, mechanisms, processes, and organs, which need to be able to adapt to a continuously changing environment to maintain health. This adaptive ability is called ‘phenotypic flexibility’. It is thought that health is compromised and diseases develop when these adaptive processes fail. As the product of interactions between several factors such as genetic makeup, diet, lifestyle, environment and the gut microbiome, the ‘metabolic phenotype’ provides a readout of the metabolic state of an individual. Understanding these relationships will be one of a major challenges in nutrition and health research in the next decades. To address this challenge, the development of high-throughput omics tools combined with the application of elaborate statistical analyses will help characterize the complex relationship of (bio) chemicals in human systems and their interaction with other variables including environment and lifestyle to produce the measured phenotype. An important aim of this thesis was to identify phenotype shifts by looking at effect of prolonged resistance-type exercise training on skeletal muscle tissue in older subjects and the possible shift toward the features of younger subjects as a reference for a healthier phenotype. A second aim was to identify phenotype shifts by looking at the response to a challenge in obese subjects and the possible shift toward lean subjects as a reference for a healthier phenotype.

Chapter 2 and 3 of this thesis show how the significant remaining plasticity of ageing skeletal muscle can adapt to resistance-type exercise training. The data indicate that frail and healthy older subjects have two distinct phenotypes according to the skeletal muscle tissue metabolite profiles and that exercise training shifts aged muscle towards a younger phenotype. We showed that the effect of exercise on amino acid derived acylcarnitines (AAAC’s) in older subjects points towards decreased branched chain amino acid catabolism, likely due to compromised activation of the branched chain α-keto acid hydrogenase (BCKDH) complex. Furthermore, we found that the protocadherin gamma gene cluster might be involved in aged-muscle denervation and re-innervation. Finally, plasma was found to be a poor indicator of muscle metabolism, emphasizing the need for direct assessment of metabolites in muscle tissue.

Chapter 4 of this thesis examines whether a mixed meal challenge response provides a readout for a shift in phenotype upon weight loss in obese male subjects. We concluded that weight loss moderately affects the mixed meal challenge response of both plasma metabolome and transcriptome of peripheral blood mononuclear cells in obese subjects. Measurements at the fasted and postprandial state also provide us with a different type of information.

In Chapter 5 it is demonstrated that the global testing of pathways could provide a concise summary of the multiple univariate testing approach used in Chapter 4. In Chapter 6 it is discussed how the findings of this thesis increase our understanding of how to measure phenotypic flexibility as a proxy of health. In this thesis it is shown that the correlations between tissue and plasma metabolites are rather weak, emphasising the need to perform organ-specific studies. Availability of less invasive/painful sampling techniques and the use of small amounts of tissue would enable larger scale human studies on adipose tissue and skeletal muscle to more accurately define phenotypical shifts due to diet or lifestyle interventions. With respect to the assessment of phenotypical flexibility by omics approaches, significant complications can be expected in trying to relate plasma metabolism to PBMC gene expression. Organ-focussed approaches that integrate multiple omics levels using system biology approaches are considered to be a lot more promising.

Undernutrition management and the role of protein-enriched meals for older adults
Ziylan, Canan - \ 2016
Wageningen University. Promotor(en): Lisette de Groot; Stefanie Kremer; Annemien Haveman-Nies. - Wageningen : Wageningen University - ISBN 9789462579323 - 148
elderly - elderly nutrition - undernutrition - enrichment - protein - eating patterns - feeding behaviour - meals - nursing homes - ouderen - ouderenvoeding - ondervoeding - verrijking - eiwit - eetpatronen - voedingsgedrag - maaltijden - verpleeghuizen

Undernutrition is a major health problem in the growing elderly population. It is estimated that one in ten Dutch community-dwelling older adults is suffering from undernutrition, and one in three Dutch older adults who receive home care. Undernutrition may lead to many negative consequences, ranging from fatigue and falls to impaired immune function and death. This makes undernutrition an obvious target for preventive measures.

Undernutrition can be defined as “a state of nutrition in which a deficiency or excess (or imbalance) of energy, protein, and other nutrients causes measurable adverse effects on tissue/body form (body shape, size and composition) and function, and clinical outcome”. In addition, it is often described as protein energy malnutrition. Adequate protein intake may to some extent prevent and reverse this process. However, throughout ageing, it becomes increasingly difficult to reach adequate protein intake due to higher protein needs and lower protein intakes. Finding solutions to assist older adults in reaching their optimal protein intake is necessary.

In our overall research project, we considered 1.2g protein per kg weight per day (g/kg/d) as adequate protein intake. In Dutch community-dwelling older adults, protein intake is around 1.0 g/kg/d, implying room for improvement. However, it is possible that many of these older adults deal with physiological changes, medical conditions, and physical and mental limitations that impair their appetite and food provision. For these older adults with higher protein needs, merely recommending that they eat more would not be realistic. It would be more realistic to explore strategies that increase protein intake without having to increase food intake. This calls for the exploration of instruments that match the needs and preferences of older adults: protein-enriched regular products.

One particular group that can be identified as a target group for such products, are older adults who receive home care. Undernutrition prevalence is high in this group, which may be explained by their health problems that led to this dependence on home care. Likewise, many of these older adults also depend on meals-on-wheels. These meals-on-wheels recipients, regardless of whether they receive home care or not, often risk undernutrition too. In both these (overlapping) care-dependent groups, difficulties in adhering to energy and protein recommendations can be discerned. For this reason, enriching the readymade meals that these older adults receive may contribute to the prevention of protein undernutrition by increasing protein intake while keeping food intake the same. Here, protein enrichment instruments can be used to prevent undernutrition, but only when implemented in a timely manner. Adequate undernutrition management systems are therefore necessary to facilitate timely intervention, ensuring that the developed protein-enriched meals are actually offered and effective. For this reason, the overall aim of our research project was to gain insight into the current state of undernutrition management in community-dwelling older adults in the Netherlands and explore the role of protein-enriched regular products as a supportive instrument in protein undernutrition management.

In Study 1 (chapter 2) we explored the experiences of 22 Dutch nutrition and care professionals and researchers with undernutrition awareness, monitoring, and treatment among community-dwelling older adults. This qualitative study among, for example, dietitians, general practitioners, nurse practitioners, and home care nurses provided insight into the current bottlenecks within the existing undernutrition management guidelines. In these telephone interviews, these experts also discussed the current dietary behaviour problems of older adults and their impact on undernutrition risk. The experts’ experiences implied that undernutrition awareness is limited, among both older adults and care professionals. In addition, the interviewees were unclear about which professionals are responsible for monitoring and which monitoring procedures are preferred. The dietitians feel that they become involved too late, leading to decreased treatment effectiveness. In general, the interviewees desired more collaboration and a coherent and feasible allocation of responsibilities regarding undernutrition monitoring and treatment. This implied that the available guidelines on undernutrition management require more attention and facilitation.

In the following mixed-methods study (chapter 3), with interviews, we qualitatively explored the dietary behaviour and undernutrition risk of 12 Dutch elderly meals-on-wheels clients, one of the largest at-risk groups. We followed up on this information by quantifying the topics that emerged from the qualitative exploration of experienced bottlenecks in performing adequate dietary behaviour. For this, we used a survey among 333 meals-on-wheels clients. The interviews with elderly meals-on-wheels clients made clear that they have fixed and habitual eating patterns, while at the same time their appetite had decreased throughout the years. This was confirmed by the survey finding that regular portion size meals were perceived as too large by the oldest group aged over 75y. In addition, as the professionals suggested earlier, the interviewed elderly clients indeed showed limited awareness of undernutrition risk. Simultaneously, the survey showed that almost one in four elderly meals-on-wheels clients was undernourished. These findings led to the conclusion that staying close to the identified dietary habits may facilitate small yet effective modifications within these habits to prevent inadequate nutritional intake. Still, the limited awareness of undernutrition risk was expected to play a limiting role in whether clients believe they need dietary modifications. Consequently, informing them about this need could facilitate their motivation to implement modifications.

After learning about the general dietary behaviour of these older adults, we used this information for Study 3 (chapter 4). We developed two kinds of protein-enriched readymade meals that are in line with the needs and preferences of older adults: one of regular size (450g) and one of reduced size (400g). We tested these meals in a lab setting in 120 community-dwelling older adults in a single-blind randomised crossover trial. One day a week at lunchtime, for four weeks, participants had to consume and evaluate a readymade meal. Overall, regardless of portion size, the protein-enriched meals led to higher protein intakes in vital older adults in a lab setting during lunch. In this crossover study, the participants liked the protein-enriched meals and the regular meals equally. However, we did not find the expected lower ratings of satiety after the reduced-size meals, while one reduced-size enriched meal and another regular-size enriched meal led to higher ratings of subsequent satiety. This higher satiety in the enriched meals could lead to compensational behaviour on the remainder of the day.

After establishing that the protein-enriched meals were effective and acceptable in the lab setting, we moved to the homes of older adults to test the meals in a longer-term study in Study 4 (chapter 5). In this double-blind randomised controlled trial of two weeks, we also included protein-enriched bread to assess whether both this bread and the meals could increase daily protein intake to 1.2g/kg/d in 42 community-dwelling older adults to reach optimal protein intake. We found that the enriched products again led to higher protein intakes and a high liking. The mean protein intake per day was 14.6g higher in the intervention group, which amounted to a protein intake of 1.25g/kg/d, compared with 0.99g/kg/d in the control group. In addition, the meals scored 7.7 out of 10, while the bread scored 7.8 out of 10, which both were comparable with their regular counterparts. Lastly, we found no negative effect of compensational behaviour throughout the day. These promising findings indicated that we achieved a good match between older adults’ needs and preferences regarding protein intake.

In the general discussion of this thesis (chapter 6), we combined our learnings from the four studies to reflect on protein undernutrition management in community-dwelling older adults and the possible role of protein-enriched regular products. We have discussed a conceptual framework consisting of three wheels of protein undernutrition management. In the first wheel regarding awareness, we proposed that limited awareness of adequate nutrition and body composition forms the largest bottleneck in undernutrition management. When this awareness is generated among both older adults and professionals, it will benefit the second wheel of monitoring. Here, we argued that a policy and the actual facilitation of that policy are required for this monitoring to succeed. When the monitoring is performed adequately, in the third wheel, the appropriate treatment can be carried out. We discussed that personalisation and evaluation of this treatment are important conditions. All in all, the public health implications that we have discussed on the basis of our findings can be summarised by the three key messages that could help us ace in adequate protein undernutrition management: address awareness in both older adults and professionals, facilitate continuous collaboration between professionals, and offer protein-enriched products expediently.

Nutritional interventions to preserve skeletal muscle mass
Backx, Evelien M.P. - \ 2016
Wageningen University. Promotor(en): Lisette de Groot; L.J.C. van Loon. - Wageningen : Wageningen University - ISBN 9789462579149 - 158
musculoskeletal system - nutritional intervention - skeletal muscle - vitamin d - creatine - leucine - nandrolone - protein intake - young adults - elderly - overweight - athletes - preservation - skeletspierstelsel - maatregel op voedingsgebied - skeletspier - vitamine d - creatine - leucine - nandrolon - eiwitinname - jongvolwassenen - ouderen - overgewicht - atleten - behoud

Muscle mass is the main predictor for muscle strength and physical function. The amount of muscle mass can decline rapidly during periods of reduced physical activity or during periods of energy intake restriction. For athletes, it is important to maintain muscle mass, since the loss of muscle is associated with decreased muscle strength, decreased physical performance and a longer recovery period. In the older and more clinically compromised populations, the consequences of muscle loss can substantially impact metabolic health, physical functioning, quality of life and mortality rates. In this thesis, the effects of different nutritional interventions on the preservation of muscle mass are being evaluated.

Vitamin D deficiency (serum 25-hydroxyvitamin D or 25(OH)D) has been associated with increased muscle loss and reduced muscle strength. In chapter 2, we identified seasonal changes in 25(OH)D concentration in elite athletes. We observed that 25(OH)D concentrations were highest at the end of summer (113±26 nmol/L), and lowest at the end of winter (78±30 nmol/L). Athletes that had a sufficient 25(OH)D concentration (>75 nmol/L) at the start of the study, still had a high risk (20%) of being deficient (<50 nmol/L) in late winter. Thus, a sufficient 25(OH)D concentration in summer does not guarantee a sufficient status in winter. In chapter 3, we assessed 25(OH)D concentrations in 128 highly-trained athletes and found that 70% had a deficient or insufficient 25(OH)D concentration at the end of the winter season. Supplementation with 2200 IU/d vitamin D resulted in a sufficient 25(OH)D concentration in 80% of the athletes after 12 months and was therefore a better dosage to improve 25(OH)D concentration than 400 or 1100 IU/d.

In the following chapters, we assessed the effects of creatine supplementation (chapter 4), leucine supplementation (chapter 5) and nandrolone administration (chapter 6) on the preservation of muscle mass during a short period of muscle disuse. For all of these compounds there is prior evidence for their efficacy in augmenting muscle mass and strength gains in combination with resistance-type exercise training and all have been suggested to attenuate the loss of muscle mass during a period of muscle disuse. During 7 days of single-leg immobilization, muscle mass decreased by ~6% and muscle strength decreased by ~8%. Surprisingly, none of the tested compounds attenuated the loss of muscle mass during 7 days of single-leg immobilization in healthy, young men.

In chapter 7, we performed a fully controlled dietary intervention to assess the impact of a high protein intake on the preservation of lean body mass during 12 weeks of energy intake restriction. Sixty-one overweight and obese men and women were randomly assigned to either a high protein diet (1.7 g/kg/d) or a normal protein diet (0.9 g/kg/d) during 12 weeks of 25% energy intake restriction. During the dietary intervention, subjects lost 9±3 kg body weight with a concomitant 2±2 kg decline in lean body mass with no differences between the two intervention groups. Thus, increasing protein intake above habitual intake levels (0.9 g/kg/d) did not preserve lean body mass during a period of energy intake restriction.

Finally, in chapter 8 we reflected on the main findings described in this thesis. In this chapter, we point out that the populations studied were all healthy and well-nourished. We conclude that in these populations, additional creatine, leucine and protein beyond habitual intakes did not preserve muscle mass. Older and/or malnourished individuals might be more responsive to these nutritional interventions. Future research could also focus on the combined effects of two or more nutritional compounds during disuse that are known to affect different mechanisms. Moreover, we speculate that the tested nutritional compounds could be effective in accelerating the regain of muscle mass and strength after a period of muscle loss. However, it should be noted that muscle loss during disuse occurs at a rate that is several-fold greater than muscle (re)gain during resistance type exercise training. Therefore, it is imperative that we continue our endeavors to identify nutritional or pharmaceutical compounds or exercise mimetics that may help to prevent or attenuate disuse atrophy.

Older adults, mealtime-related emotions, and functionalities : tailoring protein-enriched meals
Uijl, Louise C. den - \ 2016
Wageningen University. Promotor(en): Kees de Graaf, co-promotor(en): Stefanie Kremer; Gerry Jager. - Wageningen : Wageningen University - ISBN 9789462578920 - 178
meals - emotions - elderly nutrition - elderly - smell - food preferences - protein - proteins - questionnaires - young adults - chocolate - maaltijden - emoties - ouderenvoeding - ouderen - reuk - voedselvoorkeuren - eiwit - eiwitten - vragenlijsten - jongvolwassenen - chocolade

Background and aim

Dietary proteins are of special interest for the heterogeneous group of older adults, since these people do not always have an adequate protein intake. When protein-rich products are better aligned with the requirements of older persons, an adequate nutrient intake is more likely. In this thesis we therefore explored two approaches for tailoring protein-enriched meals to older consumer subgroups; emotion-based and functionality-based. We expected a better ‘product-cluster fit’ (i.e. a more positive meal experience) when the clusters’ meal associations are congruent to their mealtime expectations.


We conducted an online survey in which vital community-dwelling older adults (n=392) reported their mealtime-related emotions and mealtime functionality. Using a hierarchical clustering analysis we described clusters within our population. Subsequently, we explored the extent to which the expectations of these clusters can be applied for the development of tailored protein-enriched meals. For the emotion-based approach, we conducted two central location tests (CLTs, n=461) to explore older adults’ food-evoked emotions. For the functionality-based approach we conducted in-depth interviews in order to get further insights regarding functional mealtime expectations and attitudes towards proteins and protein-enrichment. Based on the latter insights we tailored PE meal concepts to two functionality-based segments. In a final home-use test, the members of the functionality-based segments (n=91) prepared and evaluated the tailored PE meal concepts.


The emotion-based approach resulted in four clusters; pleasurable averages, adventurous arousals, convivial indulgers, and indifferent restrictives. These emotions that these segments associated with their mealtimes varied along the two dimensions valence and arousal. However, from both CLTs we learned that the variation in valence-arousal as observed for mealtime-related emotions was not observed for emotions related to actual foods. The latter makes it challenging to identify products that evoke emotions congruent to the mealtime expectations of the emotion-based clusters.

With regard to the functionality-based approach, we encountered three clusters; physical nutritioners, cosy socialisers, and thoughtless averages. The cosy socialisers value the social interactions and cosiness during their mealtimes, whereas the physical nutritioners focus more on the health and nutrient aspects of meals. Thoughtless averages have the least distinctive mealtime expectations. We translated these functional mealtime expectations into two PE meal concepts; one tailored to cosy socialisers and one tailored to physical nutritioners. These meal concepts were well-accepted by the participants. However, congruency between mealtime expectations and functional meal associations did not result in a better ‘product-cluster fit’.


Given the challenge to identify congruency between the meal associations and the mealtime expectations of the emotion-based clusters, we consider the emotion-based approach to be not yet actionable enough as a basis for tailoring PE products to older consumers. In contrast, the functionality-based approach appeared to be more promising, since the functional meal expectations could be translated to well-accepted tailored PE meal concepts. However, the effectivity of our functionality-based approach was not yet confirmed in this thesis, since congruency between functional meal associations and functional meal expectations did not necessarily result in a better ‘product-cluster fit’. Future studies, focussing on e.g. other meal types, are recommended to further explore mealtime functionality as a basis for tailoring PE meals to older consumer subgroups.

Cater with Care : impact of protein-enriched foods and drinks for elderly people
Beelen, J. - \ 2016
Wageningen University. Promotor(en): Lisette de Groot; Frans Kok, co-promotor(en): Nicole de Roos. - Wageningen : Wageningen University - ISBN 9789462578814 - 142
undernutrition - hospital catering - hospitals - protein - elderly - protein intake - food - beverages - diet studies - dietetics - dietitians - randomized controlled trials - ondervoeding - ziekenhuiscatering - ziekenhuizen - eiwit - ouderen - eiwitinname - voedsel - dranken - dieetstudies - diëtetiek - diëtisten - gestuurd experiment met verloting

Protein undernutrition is a major health concern for older adults, especially for those who are ill. There is growing consensus for a protein intake target of 1.2 - 1.5 gram per kg bodyweight per day (g/kg/d) for these older adults. However, this target is not reached by the majority of older adults. Therefore, more effective and novel strategies to increase protein intake are warranted, including the use of protein-enriched foods and drinks. This thesis evaluated the impact of the developed protein-enriched foods and drinks on protein intake and physical performance among older adults. The studies in this thesis were done as part of the Cater with Care® project; a collaboration between the university, care organizations, and partners from the food industry. The industrial partners developed the products, focusing each on different product categories: Carezzo Nutrition developed bread, pastry, and fresh juices and soups; The Kraft Heinz Company focused on long shelf-life and convenience foods; and the Veal Promotion Foundation produced veal meat.

To fit the products to the needs of the target group, interviews with undernourished older adults (at home or hospitalized) and with dietitians were conducted (chapter 2). These interviews showed that undernutrition awareness is low among older adults. To treat undernutrition by changing their eating habits, older adults need to be aware of their health problem, they need to be willing to change, and they need to be able to understand and implement the dietitian’s advices. This process takes time while undernutrition should be treated immediately. For immediate treatment, enriched products could be used, without first creating awareness. According to the interviewees, enriched products should fit within older adults’ eating habits, and have small portion sizes.

To gain insights in food choices of hospitalized older adults (65 years and older) an observational study was conducted. In this study, energy and protein intakes of 80 hospitalized older patients at low and high risk of undernutrition were assessed (chapter 3). Patients who received an energy- and protein-rich menu, because of their risk of undernutrition, were better able to reach the protein and energy targets than patients with a low risk of undernutrition receiving a standard menu. Based on these results we proposed that all hospitalized older adults – both at low and high risk of undernutrition – should receive an energy- and protein-rich menu.

Subsequently, a pilot study was done in a care home and a rehabilitation center with the aim to explore the potential of the developed protein-enriched products to increase protein intake (chapter 4). Participants did not compensate their consumption of regular protein-rich foods (e.g. dairy, cheese) upon the introduction of protein-enriched foods and drinks. The 22 institutionalized elderly (mean age 83 years) consumed 12 gram protein per day more than they did before the intervention. Consequently, more people met the protein target of 1.2 g/kg/d than before the intervention. We concluded that protein-enriched products enabled institutionalized elderly to reach protein intake targets. Furthermore, we gained valuable feedback to improve the assortment of protein-enriched products for the effectiveness study.

In the final study, effects of the protein-enriched products on protein intake and physical performance were studied in a randomized controlled trial during hospitalization and subsequent recovery at home. During the hospital period in which 147 older patients participated, patients that received protein-enriched products increased their protein intake compared to the control group that already received a protein-rich hospital menu (chapter 5). As a result, 79% of the intervention group reached a protein intake of 1.2 g/kg/d, compared to 48% of the control group. Finally, effects of the protein-enriched products were tested at home, for a longer period (chapter 6). Half of the hospital phase participants (n = 75) continued the intervention at home for 12 weeks. The protein-enriched products were successfully implemented in the daily menu of the older adults: the intervention group had a higher average protein intake (1.5 ± 0.6 g/kg/d) than the control group (1.0 ± 0.4 g/kg/d) during the 12-week intervention period. Seventy-two percent of the intervention group reached a protein intake of 1.2 g/kg/d during the 12-week intervention, compared to 31% of the control group. Protein intake of the intervention group was mainly increased by the following protein-enriched products: bread, dairy drinks, dairy desserts, soups, and fruit juices. However, despite the successful improvement of protein intake, we found no added value on physical performance in the first 6 months after hospitalization.

It was concluded that with the protein-enriched familiar foods and drinks, we have a feasible, acceptable, and appetizing long-term strategy to increase protein intake of older adults in various settings. We envisage a beneficial role of these protein-enriched products in combination with physical activity in older adults with lower protein intakes.

Wonen op de zorgboerderij : dag en nacht profiteren van de kwaliteiten van de boerderij
Ferwerda-van Zonneveld, R.T. ; Hassink, J. ; Migchels, G. ; Veen, E.J. ; Meulen, H.A.B. van der; Teenstra, E.D. - \ 2015
Wageningen : Wageningen UR - 51
zorgboerderijen - sociale zorg - multifunctionele landbouw - huisvesting op het platteland - leefvormen - financieren - doelgroepen - agrarische bedrijfsvoering - dagopvang - ouderen - gehandicapten - jeugd - social care farms - social care - multifunctional agriculture - rural housing - living arrangements - financing - target groups - farm management - day care - elderly - people with disabilities - youth
Deze brochure gaat in op varianten van wonen op een zorgboerderij aan de hand van concrete voorbeelden.
Alleen sterkere smaak verhoogt eetlust niet
Doets, E.L. ; Kremer, S. - \ 2015
Resource: weekblad voor Wageningen UR 10 (2015)6. - ISSN 1874-3625 - p. 8 - 8.
ondervoeding - eiwitdepletie - ouderen - voedselvoorkeuren - voedselkwaliteit - productontwikkeling - smaak - voedselverpakking - voeding - voedingsonderzoek - ouderenvoeding - undernutrition - protein depletion - elderly - food preferences - food quality - product development - taste - food packaging - nutrition - nutrition research - elderly nutrition
Vijf tot tien procent zelfstandige ouderen is ondervoed. Ouderen waarderen voeding waarschijnlijk beter als verschillende aspecten zoals textuur, smaak en uiterlijk tegelijkertijd worden verbeterd. Dit schrijven Esmée Doets en Stefanie Kramer, onderzoekers bij Food & Biobased Research, in een overzichtsstudie in het tijdschrift Food Quality and Preference.
Langer fit met beter eten
Smit, A. ; Groot, C.P.G.M. de; Kremer, S. ; Ziylan, C. ; Peppelenbos, H.W. - \ 2015
WageningenWorld (2015)1. - ISSN 2210-7908 - p. 10 - 15.
ouderen - ouderenvoeding - voeding en gezondheid - ondervoeding - voedingstoestand - eiwitrijke voedingsmiddelen - voedselverrijking - voedselconsumptie - gezondheidsbevordering - elderly - elderly nutrition - nutrition and health - undernutrition - nutritional state - protein foods - food enrichment - food consumption - health promotion
Ouderen die zelfstandig thuis wonen, lopen het risico ondervoed te raken. Wageningen UR onderzoekt hoe dat is te voorkomen met producten en maaltijden die verrijkt zijn met extra eiwit. Maar hoe breng je die op de markt? De meeste ouderen voelen zich niet oud en zijn zich totaal niet bewust van hun voedingsstatus.
Healthy aging through a healthy diet : never too old to eat healthy?!
Jankovic, N. - \ 2015
Wageningen University. Promotor(en): Ellen Kampman; Edith Feskens; Lisette de Groot, co-promotor(en): Anouk Geelen. - Wageningen : Wageningen University - ISBN 9789462572508 - 159
voeding en gezondheid - gezondheidsvoedsel - ouderen - dieetrichtlijnen - eetpatronen - analytische methoden - ziektepreventie - ouderenvoeding - nutrition and health - health foods - elderly - dietary guidelines - eating patterns - analytical methods - disease prevention - elderly nutrition


Background: The world’s population is aging and with it the prevalence of chronic diseases, especially cardiovascular diseases and cancer, increases. A long lasting life is envisaged without the burden of disease. Therefore, current research focuses on risk factors, such as a healthy diet, which may decrease the occurrence of chronic diseases even at advanced age. Earlier studies, examining the role of a healthy diet in the elderly, applied different analysis strategies. In consequence, comparability across studies is limited and prevent an overall conclusion on the role of a healthy diet in elderly.

Methods and subjects: Eleven prospective cohort studies among elderly people (N=396,391) from Europe and the United States, collaborating in the CHANCES consortium, were analysed. Most cohorts eligible for our analysis, assessed diet once at baseline. Therefore, we first assessed the stability of dietary patterns, derived with reduced rank regression (RRR), in the Zutphen Elderly Study. In the remainder of this thesis, healthy diets were defined based on the 2003 World Health Organization (WHO) “nutrient intake goals” and the 2007 World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) food group recommendations. The recommendations were operationalized, using the Healthy Diet Indicator (HDI) and the WCRF/AICR diet score. The association between a healthy diet and risk of all-cause mortality and CVD mortality, was studied using the WHO recommendations, which aim at the prevention of chronic diseases in general. The cancer specific WCRF/AICR recommendations were applied to study the association between a healthy diet and cancer risk. Diet disease associations were assessed in each cohort separately, using Cox-proportional hazards regression. Cohort specific hazard ratios (HR) were pooled by random effects meta-analysis.

Results: The results of the Zutphen Elderly Study showed that dietary patterns, derived by RRR, remained stable over a period of five years. In the CHANCES project a total of 84,978 person years were accumulated, during a median follow-up time ranging between 7 and 15 years across cohorts. An increase of 10 HDI points (range total score 0 to 70 points) was significantly associated with a decreased risk of all-cause mortality (HR: 0.90 and 95% confidence interval (CI): 0.87-0.93). The HR estimate was equivalent to a two year increase in life expectancy. We found a significant inverse association between an increase of 10 HDI points and CVD mortality for Southern European countries and the US (HR: 0.85, 95 % CI: 0.83-0.87), whereas no significant association was found for Northern and Central and Eastern Europe. An increase of 1 point for the WCRF/AICR diet score (range 0-4) was associated with a significantly 6% decreased risk in developing any type of cancer. Greatest risk reduction was found between a 1 point increase in WCRF/AICR diet score and colorectal cancer (HR: 0.84, 95% CI:0.80-0.89).

Conclusion: Dietary indices based on globally defined dietary recommendations by WHO and WCRF/AICR were found to be associated with all-cause and CVD mortality and cancer risk in old age. Public health interventions targeted on the elderly should not focus on one definition of a “healthy diet” but rather a smart combination of available evidence, to optimally account for CVD as well as cancer specific outcomes.

Nutrition and cognition in older adults : studies on the role of glucose, sucrose, protein, vitamin B12 and folic acid
Zwaluw, N.L. van der - \ 2014
Wageningen University. Promotor(en): Lisette de Groot, co-promotor(en): Ondine van de Rest; Rosalie Dhonukshe-Rutten. - Wageningen : Wageningen University - ISBN 9789462571075 - 184
ouderenvoeding - voeding - ouderen - kenvermogen - glucose - sucrose - eiwittoevoegingen - vitamine b12 - dementie - elderly nutrition - nutrition - elderly - cognition - glucose - sucrose - protein supplements - vitamin b12 - dementia

The age-related cognitive decline and the increase in dementia patients are large problems in societies with growing ageing populations. No cure is present for dementia, while the available medication only focuses on alleviating symptoms. It is therefore of major importance to find risk factors that can modify the development of cognitive decline and dementia. Pre-clinical and observational studies suggest a role for nutrients. Evidence derived from randomized controlled trials (RCTs) is, however, limited and equivocal with most studies showing no effect and only a few studies showing a beneficial effect of a nutritional intervention. In the current thesis, we investigated the acute and longer-term effects of different nutrients, i.e. glucose and sucrose, protein, resistance-type exercise training with or without protein, and vitamin B12 and folic acid in order to optimize and preserve cognitive functions in non-demented elderly people.

A comprehensive literature review was performed on the acute effects of glucose and sucrose on cognitive performance (Chapter 2). Glucose is the most important fuel for the brain, and as such, manipulation of the supply of glucose may affect cognitive functions. The main conclusion of our review was that a glucose load may have a short-term beneficial effect on episodic memory. Enhancing effects on other cognitive domains were less clear, partly due to the small number of studies examining these effects. Limited research was also done on the possible effects of sucrose on cognitive functions. Therefore, we investigated the acute effects of 50 g of glucose and 100 g of sucrose on a broad spectrum of cognitive functions reflecting performance on episodic memory, working memory, attention and information processing speed, and executive functions (Chapter 3). This was done by a cross-over study in 43 elderly participants who had self-reported memory complaints. In contrast to the conclusion of our review, we did not observe an effect of glucose or sucrose on episodic memory, though we showed a beneficial effect of sucrose on attention and information processing speed.

Protein supplementation was the next nutritional intervention that was investigated. Several amino acids are precursors for neurotransmitters, and their supply may affect the synthesis and release of these neurotransmitters, and may consequently affect cognitive performance. A 24-week randomized placebo-controlled trial was carried out in 65 frail and pre-frail elderly people (Chapter 4). The protein supplementation included twice a day 15 grams of protein in the form of a drink. Reaction time improved more in the protein group compared to the placebo group, but the scores on the cognitive domains, i.e. episodic memory, attention and working memory, information processing speed, and executive functions, or the other single test scores, did not differ between treatment groups. In addition, we investigated the effects of 24 weeks resistance-type exercise training with and without protein supplementation in pre-frail and frail elderly people (Chapter 5). Exercise training without extra protein (n=62) improved performance on the domain attention and working memory. Exercise training together with protein supplementation (n=65) improved performance on information processing speed.

Last, the role of vitamin B12 and folate on cognitive health was investigated. Low levels of these nutrients can increase homocysteine levels, which is a suggested risk factor for cognitive decline. The effect of daily supplementation with 500 µg vitamin B12 and 400 µg folic acid was investigated in 2,919 participants for two years (Chapter 6). Global cognitive function and episodic memory were assessed in the total study population, whereas extensive neuropsychological testing was done in a subpopulation (n=856). B-vitamin supplementation did not improve cognitive domain scores. Only a small, though significant, effect was observed on global cognitive performance, measured by the Mini-Mental State Examination, but this was suggested to be due to chance. Brain MRI scans were made in a subgroup (n=218) after two years of intervention to obtain volumetric measures of grey and white matter, and total brain volume (Chapter 7). We investigated the cross-sectional associations between follow-up levels of folate, homocysteine and three vitamin B12 status biomarkers, e.g. methylmalonic acid, holotranscobalamin and serum vitamin B12, and brain volumes. Fully adjusted regression models showed a borderline significant association between plasma homocysteine and total brain volume, with a stronger association in the group that received B-vitamin supplementation. Serum B12 and holotranscobalamin were not associated with brain volumes, whereas high methylmalonic acid levels were associated with lower brain volumes in the group that received B-vitamins. In contrast, higher folate levels were associated with lower total brain volumes. In addition, when comparing the group that received two years of B-vitamin supplementation and those who did not, we observed lower brain volumes in the B-vitamin group, which might be a result of a difference in age between the two groups.

To conclude, the nutritional intervention studies showed little evidence for a beneficial effect on cognitive performance in relatively healthy older adults. Given the large problem of dementia, research on modifiable risk factors, including nutrition, should continue, with well thought out research methods, including large and long-term observational and intervention studies with high-sensitive study populations and early biomarkers (e.g. imaging techniques) for cognitive decline in combination with neuropsychological tests. In this way, nutrition can be added to the list of lifestyle factors that can fight dementia.

Ouderen eten beter dankzij eiwitrijke yoghurt
Boelsma, Esther - \ 2014
elderly - elderly nutrition - protein foods - appetite - yoghurt - bread - nutrition and health
Rapportage onderzoeksproject Genieten aan tafel : een toegepast onderzoek naar maaltijdbeleving in verpleeghuizen
Zeinstra, G.G. ; Atten, M.N. van; Ziylan, C. ; Boelsma, E. ; Peppelenbos, H.W. ; Brok, P. den - \ 2014
Wageningen : Wageningen UR - Food & Biobased Research (Rapport / Wageningen UR Food &amp; Biobased Research 1483) - ISBN 9789462570535 - 86
verpleeghuizen - ouderenvoeding - ouderen - perceptie - volksgezondheid - ziektepreventie - maaltijden - nederland - ondervoeding - voedselconsumptie - nursing homes - elderly nutrition - elderly - perception - public health - disease prevention - meals - netherlands - undernutrition - food consumption
Er komen steeds meer ouderen in Nederland. Zij doen over het algemeen een groter beroep op de gezondheidszorg, wat tot stijgende zorgkosten leidt en een lagere kwaliteit van leven. Eten en drinken speelt een belangrijke rol bij de preventie van ziekte. Hoewel er steeds meer aandacht is voor de voedingsstatus van ouderen en screeningsprocedures steeds meer toegepast worden, laten de laatste metingen in Nederland zien dat 17% van de cliënten in instellingen ondervoed is en dat 28% risico loopt op ondervoeding. Om ziekte en daarmee verhoogde zorgkosten te voorkomen, en om de kwaliteit van leven te optimaliseren, is preventie van ondervoeding bij ouderen noodzakelijk. Het onderzoek ‘Genieten aan tafel’ beoogde de maaltijdbeleving van verpleeghuiscliënten te optimaliseren, met als doel om eetlust, voedingsstatus, functionele status en kwaliteit van leven te verbeteren en zo zorgkosten te verminderen.
Voeding en beweging ter preventie van cognitieve achteruitgang
Severs, A. ; Rest, O. van de; Groot, C.P.G.M. de; Loon, L.J.C. van - \ 2014
VoedingsMagazine 27 (2014)1. - ISSN 0922-8012 - p. 18 - 20.
ouderen - ouderenvoeding - eiwittoevoegingen - dementie - kenvermogen - lichaamsbeweging - voeding en gezondheid - voedingsstoffen - elderly - elderly nutrition - protein supplements - dementia - cognition - exercise - nutrition and health - nutrients
Dementie wordt een steeds groter en kostbaarder probleem door de vergrijzing. Wetenschappers zijn naarstig op zoek naar mogelijkheden om het tij te keren. Zo ook Ondine van de Rest, onderzoeker aan Wageningen University. Haar onderzoek is gericht op de rol van voeding bij leeftijdsgerelateerde cognitieve achteruitgang. Samen met prof. dr.Lisette de Groot, hoogleraar voeding voor de oudere mens aan Wageningen Universiteit, en Prof. Dr. Luc van Loon, hoogleraar fysiologie van inspanning aan Maastricht Universiteit, voerde ze binnen het Top Instituut Food and Nutrition (TIFN) een interventiestudie uit bij ouderen naar het effect van eiwitsuppletie en beweging op de cognitie.
Hoe voeden we de oudere mens?
Staveren, W.A. van; Groot, C.P.G.M. de - \ 2014
VoedingsMagazine 27 (2014)1. - ISSN 0922-8012 - p. 21 - 23.
ouderenvoeding - voeding en gezondheid - voedselconsumptie - eetpatronen - voedingsstoffen - ouderen - elderly nutrition - nutrition and health - food consumption - eating patterns - nutrients - elderly
Wat zijn de effecten van voedingspatronen en nutriënten op de gezondheid, het functioneren, en de kwaliteit van leven van ouderen? Het onderzoeksteam van prof. Wija van Staveren en prof. Lisette de Groot in Wageningen heeft de afgelopen kwart eeuw observationele en interventiestudies uitgevoerd om die vragen te beantwoorden. Een symposium in Wageningen inventariseerde wat met dit en ander onderzoek is bereikt op het gebied van voeding voor ouderen.
Vitaal naar de eindstreep
Tieland, C.A.B. ; Rest, O. van de; Groot, C.P.G.M. de - \ 2013
WageningenWorld 2013 (2013)4. - ISSN 2210-7908 - p. 26 - 29.
voeding en gezondheid - ouderen - verouderen - vitaminetekorten - vetzuren - eiwit - gezondheidsbevordering - nutrition and health - elderly - aging - vitamin deficiencies - fatty acids - protein - health promotion
Hoe worden we gezond oud? Trainen en extra eiwitten werken, blijkt uit onderzoek van de afdeling Humane voeding. Over het effect van vitamines en omega-3 vetzuren is het laatste woord nog niet gezegd.
Bones, brains and B-vitamins : the impact of vitamin B12, folate and homocysteine on bone health and cognitive function in elderly
Wijngaarden, J.P. van - \ 2013
Wageningen University. Promotor(en): Lisette de Groot, co-promotor(en): Rosalie Dhonukshe-Rutten. - Wageningen : Wageningen UR - ISBN 9789461737151 - 192
botontkalking - kenvermogen - ouderen - beenderen - vitamine b12 - foliumzuur - homocysteïne - vitaminetoevoegingen - botbreuken - voedingstoestand - osteoporosis - cognition - elderly - bones - vitamin b12 - folic acid - homocysteine - vitamin supplements - bone fractures - nutritional state


An elevated homocysteine level has been indicated as a risk factor for cardiovascular disease, cognitive decline, and fractures. Supplementation of vitamin B12 and folic acid in order to normalize homocysteine levels might be of substantial public health importance as this might reduce the risk for several age-related conditions. This thesis focuses on two health outcomes frequently associated with elevated homocysteine levels and low levels of vitamin B12 and folate: osteoporosis and cognitive decline later in life.


Findings are presented in the context of a model which links dietary intake to biomarkers of nutritional status and subsequently to health outcomes. Two systematic reviews with meta-analyses investigated the current status of knowledge about the association of vitamin B12 intake and status with cognitive function, and the association of homocysteine, vitamin B12 and folate status with bone health. Baseline data of the B-PROOF study were used to assess 1) the association of vitamin B12 intake with status according to four biomarkers (vitamin B12, holotranscobalamin (holoTC), methylmalonic acid (MMA) and homocysteine), 2) the mutual association among these four vitamin B12 biomarkers and 3) the association between homocysteine, vitamin B12 biomarkers, folate and cognitive function. The effect of 2-year daily vitamin B12 (500 μg) and folic acid (400 μg) supplementation on fracture risk was assessed in the B-PROOF study, a large (N=2919) randomized controlled trial in elderly people (aged ≥65 years) with an elevated homocysteine level (≥12.0 µmol/L).


The systematic review of the literature showed no or inconsistent associations of vitamin B12 intake with cognitive function. Furthermore, serum vitamin B12 was not associated with risk of dementia, global cognition or memory. Studies on MMA and holoTC reported significant associations with risk of dementia, Alzheimer’s disease and global cognition. A meta-analysis showed that serum/plasma vitamin B12 per 50 pmol/L was borderline significantly associated with a lower fracture risk (RR=0.96, 95% CI = 0.92-1.00) and that homocysteine was significantly associated with a higher fracture risk (RR=1.04, 95% CI = 1.02-1.07). Meta-analyses regarding vitamin B12, folate and homocysteine levels and BMD did not show significant associations.

In the B-PROOF study a doubling of vitamin B12 intake was associated with 9% higher levels of vitamin B12, 15% higher holoTC, 9% lower MMA and 2% lower homocysteine, saturation of biomarkers occurs with dietary intakes of >5 μg B12. Levels of MMA and homocysteine were higher when vitamin B12 levels were below 330 pmol/L and when holoTC levels were below 100 pmol/L, with a steep elevation when levels of vitamin B12 and HoloTC were below 220 and 50 pmol/L respectively. At baseline, levels of vitamin B12 and holoTC were not associated with cognitive function in any cognitive domain. Levels of homocysteine (β= -0.009), folate (β= 0.002), MMA (β= -0.163) and the wellness score – a vitamin B12 biomarker combination score - (β= 0.048) were significantly associated with the domain of episodic memory. Additionally, homocysteine (β= -0.015) and the wellness score (β= 0.103) were significantly associated with the domain information processing speed.

The B-PROOF intervention did not lower the risk of fracture in the total population (HR=0.84, 95% CI = 0.58-1.22). Per protocol subgroup analysis of elderly aged >80 years, showed a lower risk of fracture in the intervention group (HR=0.28, 95% CI 0.10-0.74). We observed more cancer cases in the intervention group (HR=1.55, 95% CI = 1.04-2.30) compared to the placebo group. We cannot rule out the possibility of accelerated cancer progression as a possible negative side effect.


Our literature reviews and observational data confirm an association of levels of homocysteine, vitamin B12 and folate with cognitive function and fracture risk in elderly. Supplementation with vitamin B12 and folic acid did not lower the risk of fracture in the total study population. Though positive effects on fracture incidence emerged in elderly aged >80 years, these benefits should be weighed against potential risks.

Anthropometrics and ageing : impact of weight status on health
Hollander, E.L. de - \ 2013
Wageningen University. Promotor(en): Lisette de Groot, co-promotor(en): W.J.E. Bemelmans. - S.l. : s.n. - ISBN 9789461736888 - 176
antropometrie - antropometrische dimensies - lichaamsgewicht - verouderen - ouderen - gezondheid - anthropometry - anthropometric dimensions - body weight - aging - elderly - health

Background: Weight status is one of the factors that influence healthy ageing. It is often assessed with anthropometric measures such as body mass index (BMI) and waist circumference (WC), which indicate underweight or excess fat. Both are associated with adverse health outcomes in adults. The first paper of this thesis investigates whether this association is consistent over calendar time, to check for possible influences of improved healthcare procedures over time. In old age, this association is unclear. Using several anthropometric measures, the subsequent five papers examine the impact of weight status and development of weight status on coronary heart disease (CHD), mortality, and quality of life (QoL) among the elderly and during ageing.

Methods: A meta-regression analysis of 31 international cohort studies (n=389,212) was used to estimate the multivariable adjusted relative risk (RR) of CHD for an increased BMI and whether the RR was different between calendar periods (i.e. studies that started before 1985 and studies that started after 1985) taking account of the age of the population. Associations of BMI and changes in eight anthropometric measures with all-cause and cause-specific mortality in old age were studied by means of multivariable Cox regression analyses using data from the Survey in Europe on Nutrition and the Elderly: a concerted action study including 70–77-year-olds (n=1,061–1,970). Moreover, the association of WC with all-cause and cause-specific mortality was studied by means of a meta-analysis of 29 international cohort studies including 65–74-year-olds (n=58,609). For an ageing population, we used the Doetinchem Cohort Study including 20–70-year-olds (n=3,408–4,135) and three to four repeated measures of weight and height over a period of 10 to 15 years. In this study population, we used a multivariable regression analysis to examine the association of changes in weight and long-term BMI patterns with QoL (measured by the SF-36 questionnaire).

Results: After simultaneous inclusion of calendar period and age of the population in the model, the meta-regression analysis showed no difference in the RR of CHD in the association with a high BMI between calendar periods. However, a 10-year increment in population age lowered the 1.28 [95%confidence interval (CI): 1.22–1.34] RR of CHD for a five-BMI-unit increment by 29% (95%CI: -55 to -5). Among the elderly, BMI was associated with all-cause mortality, cardiovascular disease (CVD) mortality, and mortality due to causes other than CVD, cancer, and respiratory diseases (p<0.05). A BMI below 24 kg/m2and above 30 kg/m2were the thresholds at which risks of cause-specific mortality were increased by 10%. WC was associated with all-cause, CVD, cancer, and respiratory disease mortality (p<0.05). At the levels for abdominal obesity (102 cm, men; 88 cm, women), the risk of all-cause and CVD mortality was not significantly increased, or only modestly. A risk of 2.0 (clinically relevant) for all-cause and CVD mortality was associated with a WC of 132 and 123 cm in men, and 116 and 105 cm in women, respectively. By using a combination of WC and BMI categories with the combination of a small WC (94 cm, men; 80 cm, women) and a healthy weight (20.0–24.9 kg/m2) as the reference, we observed the highest all-cause and CVD mortality risk of approximately 2.0 for underweight (<20.0 kg/m2; in combination with a small WC), and abdominal obesity within healthy ranges of BMI. Changes in BMI and WC were not associated with all-cause and CVD mortality, except for a decrease in WC ≥3.1 cm in the association with all-cause mortality (1.52, 95%CI: 1.01–2.31). Similarly, a decrease in weight ≥3.2 kg was associated with a 1.48 (95%CI: 0.99–2.20) increased all-cause mortality risk. Moreover, both a decrease and an increase in mid-upper arm circumference (MUAC) were associated with all-cause mortality and CVD mortality. A decrease of ≥1.6 cm and 0.6–1.6 cm in MUAC was associated with a 1.81 (95%CI: 1.17–2.79) and a 1.66 (95%CI: 1.10–2.49) all-cause mortality risk. An increase of ≥1.3 cm in MUAC was associated with a 1.52 (95%CI: 1.00–2.31) all-cause mortality risk and a 1.94 (95%CI: 1.00–3.75) CVD mortality risk. In an ageing population, we found that weight gain, especially weight gain of >6 kg, resulted in a decline in QoL. Weight loss (>2 kg) did not result in large changes in QoL. However, both weight gain and weight loss were adversely associated with changes in QoL as compared to a stable weight (changes ≤2 kg). From examination of long-term BMI patterns, the lowest QoL was observed for the ‘persistent obesity (≥30 kg/ m2)’ pattern. The BMI patterns, ‘persistent obesity’, ‘developing overweight (25.0–29.9 kg/m2’, ‘developing obesity’, and ‘switching between BMI categories’ scored 1.8–11.6 points (p<0.05) lower on QoL than the ‘persistent healthy weight (18.5–24.9 kg/m2)’ pattern. The BMI pattern ‘persistent overweight’ generally did not differ from the ‘persistent healthy weight’ pattern. These findings were consistent among age groups.

Conclusions: Although the risk of CHD in the association with BMI attenuated with increasing age, we found associations of BMI and WC with all-cause and cause-specific mortality among the elderly. These anthropometric measures can be used as single predictors of mortality for the elderly, but higher cut-off points for BMI and WC to indicate underweight and excess fat should be considered. Moreover, a combination of these two anthropometric measures can be recommended, as that would provide more information of the body composition than one anthropometric alone. With regard to assessing changes in body composition, MUAC might be recommended for the elderly. Furthermore, a stable weight is best for health maintenance among all ages, provided this stable weight does not fall within the extreme values of weight, i.e. too light or too heavy. In all, our results underscore the value of anthropometric measures in the management of weight and the importance of the maintenance of a stable weight during ageing.

Dietary strategies to augment muscle mass in the elderly
Tieland, C.A.B. - \ 2013
Wageningen University. Promotor(en): Lisette de Groot; L.J.C. van Loon. - S.l. : s.n. - ISBN 9789461735676 - 150
eiwittoevoegingen - lichaamsbeweging - spiergewicht - lichamelijke fitheid - ouderen - maatregel op voedingsgebied - protein supplements - exercise - muscle weight - physical fitness - elderly - nutritional intervention

Background: The world population is aging rapidly. This growth of the aging population is accompanied by an increased number of frail elderly people who are at risk of adverse health outcomes such as disability, co-morbidity and mortality. A dominant feature of frailty is the age related loss of muscle mass, strength and performance, also called sarcopenia. Resistance-type exercise training and dietary protein supplementation are considered promising strategies to reverse sarcopenia and subsequent frailty. However, strong evidence for the impact of protein supplementation with or without resistance exercise in frail elderly people is scarce. Well-designed intervention studies in frail elderly people are needed to define new leads for the development of nutritional and exercise interventions to effectively prevent or treat the progressive loss of muscle mass, strength and physical performance with aging. Therefore, the aims of this thesis are to study 1) the impact of protein supplementation and 2) the impact of protein supplementation during prolonged resistance-type exercise training on muscle mass, strength and physical performance in frail elderly people.

Methods: First, we studied various characteristics of dietary protein intake, including the distribution of dietary protein intake throughout the day, and the use of protein-containing food sources in various elderly populations. With this knowledge, we designed two large intervention trials to study the impact of dietary protein supplementation with or without prolonged resistance-type exercise training on muscle mass, strength and physical performance in frail elderly people. In addition, we assessed the usefulness of handgrip strength as a measure of post exercise strength differences and studied the association of vitamin D status and vitamin D intake on muscle mass, strength and physical performance in a frail elderly population.

Results: Dietary protein intake in frail and institutionalized elderly people were especially low at breakfast and lunch. Supplementing protein at breakfast and lunch did not increase muscle mass but improved physical performance in frail elderly people. Resistance-type exercise training improved muscle leg strength and physical performance, but not handgrip strength. Supplementing protein at breakfast and lunch was required to significantly increase muscle mass during prolonged resistance-type exercise training in frail elderly people. Furthermore, low vitamin D status and vitamin D intake were associated with impaired physical performance.

Conclusions: Although dietary protein supplementation does not increase muscle mass, it represents a promising strategy to improve physical performance in frail elderly people. Prolonged resistance-type exercise training represents an effective strategy to improve strength and physical performance, but dietary protein supplementation is required to allow muscle mass gain during exercise training in frail elderly people.

Healthy Ageing: prevention of loneliness among elderly people : evaluation of a complex intervention in public health practice
Honigh - de Vlaming, R. - \ 2013
Wageningen University. Promotor(en): Lisette de Groot; Pieter van 't Veer, co-promotor(en): Annemien Haveman-Nies. - S.l. : s.n. - ISBN 9789461735041 - 214
ouderen - verouderen - levensomstandigheden - sociale integratie - sociologie - interventie - volksgezondheid - nederland - elderly - aging - living conditions - social integration - sociology - intervention - public health - netherlands

Concerns about the ageing population and formal responsibilities of local governments to promote social cohesion and to enhance participation of vulnerable groups in society placed loneliness prevention high on the local policy agenda of Dutch municipalities in the past decade. The study described in this thesis was part of the Healthy Ageing programme of the Academic Collaborative Centre AGORA and aimed to contribute to more effective, evidence-based and problem-oriented approaches to healthy ageing at the local level.

The general aim of this thesis was to evaluate the effectiveness of a local intervention project – called Healthy Ageing – targeting loneliness among non-institutionalised elderly people. Healthy Ageing consisted of five intervention components, namely, a mass media campaign, information meetings, psychosocial group courses, social activities organised by neighbours, Neighbours Connected, and training of intermediaries.

First, the influence of socio-demographic and health characteristics on changes in loneliness over time and municipal differences in the prevalence of loneliness were investigated. Data were gathered from 9,641 persons who participated in the Elderly Health Survey of the community health service, GGD Noord- en Oost- Gelderland (former GGD Gelre-IJssel), in 2005 or 2010. Second, the overall-effect of Healthy Ageing on the initial outcome loneliness literacy, intermediate outcome social support, and ultimate outcome loneliness was evaluated using a quasi-experimental pre-test post-test design, including an intervention and control community. Baseline and follow-up measurements, in 2008 and 2010 respectively, were available for 858 non-institutionalized elderly people. The Loneliness Literacy Scale was developed within the context of this thesis and was pre-tested in a separate study among 303 elderly persons who also participated in the quasi-experimental study. Finally, delivery, reach, and acceptance of the individual intervention components was studied in several satellite studies. Data were collected by different means, e.g. project records and surveys among participants. Furthermore, the acceptability of the mass media communication materials, information meetings, and psychosocial courses of Healthy Ageing was studied by in-depth interviews with 14 clients of the meal delivery service in the intervention community.

Overall and across municipalities, average loneliness scores did not significantly differ between 2005 and 2010. However, among the subgroup with mobility disabilities, loneliness was significantly higher in 2010. Furthermore, mobility disabilities and marital status were the most important factors explaining differences between municipalities. With regard to the evaluation of Healthy Ageing, the satellite studies showed that the reach and intensity of the intervention components were modest. Furthermore, from the interviews it appeared that the mass media communication materials were not successful in attracting attention because interviewees did not expect health information from these communication channels, the perceived personal relevance of the message was low, and the presentation was not attractive. Moreover, the content of the intervention components was not well received because the objectives and intervention components did not connect well with the priority group’s daily life. In addition, it appeared from the quasi-experimental study that 39% of the study participants from the intervention community was familiar with Healthy Ageing at follow-up. Overall, the intervention group scored more favourably on the loneliness literacy subscales, motivation (4.4%), perceived social support (8.2%), and subjective norm (11.5%) than the control group. However, no overall effects were observed for the intermediate and ultimate outcomes, total social support and loneliness after two years.

Given the modest overall intervention exposure, the effect of Healthy Ageing on the loneliness literacy subscale, motivation, is plausible, whereas on the subscales, perceived social support and subjective norm, probable, and on the subscale, self-efficacy, unlikely. Furthermore, whether the initial effects will carry forward to the intermediate and ultimate outcomes needs to be confirmed. The modest effects of Healthy Ageing can partly be explained by the challenges on organisational level which delayed and suppressed project implementation. Furthermore, the project might have benefited from a more systematic approach in order to ensure better alignment between the intervention components and formulated objectives. Finally, target group differentiation is highly recommended. This evaluation of Healthy Ageing illustrates how researchers can cope with the evaluation challenges of complex interventions which cannot be fully controlled. In turn, this provides valuable lessons for the development of intervention programmes and evaluation designs in public health practice.

Gemeenten en zorgboerderijen : een kansrijke combinatie binnen de Wmo voor mensen met dementie, mits...
Bruin, S. ; Hop, P. ; Molema, C. ; Nowak, S. ; Baan, C. ; Oosting, S.J. - \ 2013
Bilthoven : Rijksinstituut voor Volksgezondheid en Milieu
zorgboerderijen - sociale zorg - langdurige zorg - sociale voorzieningen - dementie - ouderen - social care farms - social care - long term care - social services - dementia - elderly
Boerderijen en mensen met dementie: het lijkt geen voor de hand liggende combinatie. Toch is er een aanzienlijk aantal zorgboerderijen waar mensen met dementie terecht kunnen voor dagopvang. Zorgboerderijen bieden mensen met dementie een zinvolle en prettige dagbesteding in een landelijke omgeving. Hun mantelzorgers worden daarmee tijdelijk ontlast van de zorg. Hiermee kunnen zorgboerderijen mogelijk bijdragen aan het langer thuis wonen van mensen met dementie; één van de doelstellingen van het beleid van de rijksoverheid op het gebied van de langdurige zorg.
Eten en drinken bij dementie
Wapenaar, J. ; Groot, C.P.G.M. de - \ 2013
Amsterdam : Reed Business Education - ISBN 9789035235397 - 88
dementie - humane voeding - voeding - voeding en gezondheid - gezondheidszorg - ouderen - dementia - human feeding - nutrition - nutrition and health - health care - elderly
Voor veel mensen met dementie is eten en drinken moeilijk. Goede zorg bij eten en drinken is essentieel om mensen met dementie zo gezond mogelijk te houden en hun kwaliteit van leven hoog te houden. Verzorgenden, verpleegkundigen en voedingsassistenten krijgen met dit boek praktische handvatten om hun cliënten te kunnen ondersteunen. Ze leren met dit boek hoe ze kunnen helpen bij het eten en drinken en hoe ze het thema eten en drinken kunnen gebruiken om de kwaliteit van leven van mensen met dementie te verbeteren.
Voeding voor wie lang fit wil blijven
Groot, C.P.G.M. de - \ 2012
In: Voeding voor vitale 50-plussers Wageningen : Food Valley - ISBN 9789081609371 - p. 9 - 9.
ouderenvoeding - voeding en gezondheid - ouderen - productontwikkeling - gezondheidsbevordering - voedingsstoffenbehoeften - elderly nutrition - nutrition and health - elderly - product development - health promotion - nutrient requirements
Goede voeding kan helpen ouderdomskwalen te voorkomen, ook voor wie al 50-plus is. En tot die categorie behoren steeds meer mensen, in Nederland en daarbuiten. Ook gaat met de jaren de behoefte aan sommige voedingsstoffen omhoog. Volop kansen voor productontwikkeling dus.
Beweging wordt efficiënter met juiste voeding
Tieland, Michael - \ 2012
elderly - nutrition and health - exercise - physical activity - proteins - dietary protein - elderly nutrition
Approaches for setting micronutrient recommendations : a case study of vitamin B12 for adults and elderly people
Doets, E.L. - \ 2012
Wageningen University. Promotor(en): Pieter van 't Veer; Lisette de Groot, co-promotor(en): Adrienne Cavelaars. - S.l. : s.n. - ISBN 9789461732354 - 204
vitamine b12 - dieetrichtlijnen - aanbevolen dagelijkse hoeveelheden - volwassenen - ouderen - europa - harmonisatie - vitamin b12 - dietary guidelines - recommended dietary allowances - adults - elderly - europe - harmonization

Background: Most countries in Europe provide recommendations on the micronutrient composition of diets to fulfil requirements of nearly all individuals in the general apparently healthy population. However as each country uses its own methods for deriving such recommendations, there is large variation between countries in the recommended micronutrient intakes. The objectives of this thesis are to signal key issues for harmonizing approaches for establishing micronutrient recommendations for adults and elderly across Europe and to illustrate standardized and transparent review methods that can be used to summarize and evaluate the evidence-base for setting recommendations, using vitamin B12 as a case micronutrient.
Methods: First the need for harmonization is substantiated by a descriptive study on the variation in published micronutrient recommendations across Europe. In addition methodological factors were identified that should be considered for alignment of recommended intakes across Europe. Secondly, the evidence-base for establishing recommended vitamin B12 intakes was summarized in two systematic reviews. One review focused on requirements for the compensation of daily obligatory losses (factorial approach) and the other review evaluated the relation of vitamin B12 intake and status with cognitive performance (dose-response approach). Whether interactions between folate and vitamin B12 on cognitive performance should be considered for establishing recommended vitamin B12 intakes was evaluated using data from 2203 Norwegian elderly from the Hordaland Homocysteine Study.
Results: For harmonizing approaches for establishing micronutrient recommendations, standard methods are needed to a)-select health indicators and define adequate biomarker concentrations, b)-make assumptions about inter-individual variation in requirements, c)-derive bioavailability factors, and d)-select and interpret evidence on requirements. The first systematic review showed that daily vitamin B12 losses in apparently healthy adults and elderly probably range between 2.6-3.9 µg and bioavailability from the usual diet may range between 29 and 37% rather than the generally assumed 50%.
Dose-response evidence from 2 randomized controlled trials and 19 prospective cohort studies showed no or inconsistent associations between vitamin B12 intake or status and dementia, Alzheimer’s Disease, global cognitive function or domain-specific cognitive function in adults and elderly people. Cross-sectional analyses in the Norwegian cohort study showed that low plasma vitamin B12 in combination with high folate was associated with better cognitive performance. However, these associations were not observed for sensitive markers of vitamin B12 status.
Conclusion: The main conclusion of this thesis is that evidence underlying current recommended vitamin B12 intakes is old and has large uncertainties, whereas the available evidence on the relation between vitamin B12 and cognitive performance is yet not convincing and thereby limits its use as an outcome for estimating vitamin B12 requirements.
The relation between vitamin B12 intake and markers of vitamin B12 status seems the best alternative, but sound statistical methods to define recommendations based on these dose-response data should be further developed.

Vitamine B12, D, foliumzuur en leeftijdgerelateerde aandoeningen
Brouwer, E.M. ; Wijngaarden, J.P. van - \ 2011
Voeding Nu 4 (2011)13. - ISSN 1389-7608 - p. 20 - 21.
ouderen - botbreuken - gezondheidsbescherming - ziektepreventie - vitaminen - supplementen - foliumzuur - vitamine b12 - vitamine d - deficiëntie - voeding en gezondheid - elderly - bone fractures - health protection - disease prevention - vitamins - supplements - folic acid - vitamin b12 - vitamin d - deficiency - nutrition and health
Dat vitaminen en mineralen een positieve invloed uit kunnen oefenen op specifieke lichaamsprocessen is bekend. Twee promovendi van Wageningen Universiteit richten zich op het mogelijke verband tussen vitamine B12, foliumzuur en vitamine D en verschillende leeftijdgerelateerde aandoeningen. De associatie tussen een verhoogd homocysteïnegehalte en een verhoogd risico op fracturen was aanleiding voor een groot trial onderzoek onder ouderen. Dit B-PROOF onderzoek loopt nog.
De smaak en eetlust van ouderen
Kremer, S. - \ 2011
Kennis Online 8 (2011)okt. - p. 8 - 8.
voedselconsumptie - ouderen - smaak - eetlust - smaakpanels - food consumption - elderly - taste - appetite - taste panels
Onderzoekers van Food and Biobased Research zijn deze zomer gestart met een langlopend smaakonderzoek onder zevenhonderd ouderen. 'We weten nog onvoldoende hoe we de eetlust kunnen stimuleren en wat 55-plussers aanspreekt', zegt onderzoeker Stefanie Kremer. De voedingsindustrie kijkt belangstellend mee.
Towards salutogenichealth promotion : organizing healthy ageing programs at the local level
Lezwijn, J. - \ 2011
Wageningen University. Promotor(en): Cees van Woerkum, co-promotor(en): Lenneke Vaandrager; Annemarie Wagemakers. - [S.l.] : S.n. - ISBN 9789085859864 - 200
gezondheidsbevordering - voorzieningen tbv de gezondheid op regionaal niveau - gezondheidsprogramma's - ouderen - verouderen - health promotion - community health services - health programs - elderly - aging
Als gevolg van landelijke wetgeving, zoals de Wet Publieke Gezondheid (WPG) en de Wet Maatschappelijke Ondersteuning (WMO), hebben gemeenten meer verantwoordelijkheden gekregen ten aanzien van hun oudere populatie. Het onderzoek beschreven in het proefschrift ‘Towards salutogenic health promotion. Organizing healthy ageing programs at the local level’ moet bijdragen aan het opdoen van kennis over hoe lokale programma’s ten behoeve van gezond ouder worden te ontwikkelen, te implementeren en te evalueren. Drie punten bleken belangrijk bij het ontwikkelen, implementeren en evalueren van gezondheidsprogramma’s voor gezond ouder worden. De perceptie van ouderen zelf: De ideeën die ouderen zelf hebben ten aanzien van gezond ouder worden zijn belangrijk. Een salutogene benadering biedt handvaten om de perceptie van ouderen ten aanzien van nieuwe gezondheidsprogramma’s te onderzoeken. Samenwerken voor gezond ouder worden. Samenwerken draagt bij aan het opbouwen van kennis nodig om gezondheidsprogramma’s te ontwikkelen. Samenwerking is echter niet vanzelfsprekend. Daarom zou samenwerking een expliciet onderdeel moeten zijn van gezondheidsprogramma’s. Combineren van bewijs. Door samenwerking met verschillende partijen is het mogelijk om verschillende vormen van bewijs te combineren. Een voorbeeld hiervan is het programma ‘Voor Elkaar in de Buurt’.
Aanbevolen hoeveelheden gebasseerd op schattingen (interview met C.P.G.M. de Groot)
Geerts, A. ; Groot, C.P.G.M. de - \ 2010
VoedingsMagazine 23 (2010)2. - ISSN 0922-8012 - p. 24 - 26.
voedingsnormen - ouderen - ouderenvoeding - aanbevolen dagelijkse hoeveelheden - voedselconsumptie - voeding en gezondheid - feeding standards - elderly - elderly nutrition - recommended dietary allowances - food consumption - nutrition and health
Eind 2009 werden de 'Vraag het de Expert'-bijeenkomsten over senioren gehouden. 'Besef dat de aanbevolen hoeveelheden voedingsmiddelen gebaseerd zijn op schattingen. Een kritische reflectie op de getallen die je hanteert is belangrijk', zei prof. dr. Lisette de Groot tegen de diëtisten in de zaal. De gebruikte voedingsnormen zijn niet zonder meer geschikt voor de beoordeling van voedselconsumptiegegevens van individuen.
Social relationships and healthy ageing : epidemiological evidence for the development of a local intervention programme
Croezen, S. - \ 2010
Wageningen University. Promotor(en): Pieter van 't Veer; Lisette de Groot, co-promotor(en): Annemien Haveman-Nies. - [S.l. : S.n. - ISBN 9789085856917 - 128
gezondheid - verouderen - ouderen - sociale participatie - interventie - gezondheid op regionaal niveau - gemeenschapsprogramma's - gezondheidsbeleid - sociale relaties - health - aging - elderly - social participation - intervention - community health - community programs - health policy - social relations
In view of the growing number of older people in our society and the related consequences for health and well-being, research focussing on healthy ageing is essential. Already, the associations between supportive social relationships and healthy ageing have been established. However, there is as yet no consensus about whether or not it is the structure of the social network, its function- ing or a combination that is most important for health, and in addition, about which aspects of structure and function are important.

The main objective of this thesis was to investigate aspects of the structure and functioning of social relationships and their influence on mental, physical and social health in older people. This was relevant to obtain scientific evidence for practice-based research to support local policy making on healthy ageing.

Different characteristics and functions of social relationships, such as frequency of contact, different sources of social network ties, satisfaction with relationships, positive and negative perceptions of social support and social engagement have been analysed in cross-sectional and prospective studies. Cross-sectional data are from six community health services in the eastern part of the Netherlands. The overall sample size constituted of 24,936 people aged 65 and over (response 79%). Prospective data are from the Doetinchem Cohort Study. The first examination round (1987-1991) comprised 12,448 men and women aged 20 to 59 years. The overall response rate was 62% for the baseline measurement and 79%, 75% and 78% for rounds 2, 3 and 4 respectively.

Cross-sectional analyses showed that satisfaction with the social contacts was strongly related to physical (OR 2.36; 95% CI 2.11-2.64), mental (OR 4.65; 95% CI 4.20-5.15) and self-perceived health (OR 2.52; 95% CI 2.29-2.78). Longitudinal analyses underlined this finding by showing that unfavourable levels of social support were predictive for health-compromising behaviours and poor health over a 10-year period of follow-up, and for increased mortality risk over a 15- year period of follow-up (HR 1.57; 95% CI 1.03-2.39). Furthermore, neighbours were found to be an important source of the social network ties of older people in relation to physical (OR 1.87; 95% CI 1.68-2.07), mental (OR 1.53; 95% CI 1.39-1.69) and self-perceived health (OR 1.42; 95% CI 1.30-1.54).

Further exploration of the relationship between social support and loneliness using structural equation modelling identified that social support in everyday situations may serve as a good start- ing point for health promotion activities to prevent loneliness. To better target health promotion activities for healthy ageing, analyses were performed to group older people into subgroups with similar social engagement activity patterns. Five clusters were identified: 1) less socially engaged elderly; 2) less socially engaged caregivers; 3) socially engaged caregivers; 4) leisure-engaged elderly; and 5) productive-engaged elderly. Older people who were not engaged in any social activity other than the care for a sick person, were identified as a possible target group, given the relatively high share of unhealthy people among them. In this non-socially engaged target group, the prevalence of loneliness was 48%, compared to 30% in the socially engaged groups; poor self-perceived health: 41% compared to 14%; poor mental health: 25% compared to 9%; poor physical health: 27% compared to 2%.

Well-functioning social relationships were favourably associated with health. By integrating all results, the local data have strengthened the scientific evidence-base for local policy making and have contributed to the development of an evidence-based community intervention supporting social participation among older people.
Thuis op de zorgboerderij : handreiking kleinschalig wonen voor ouderen met dementie
Roest, A.E. ; Oltmer, K. ; Driest, P. ; Jans, A. - \ 2010
[S.l.] : Taskforce Multifunctionele Landbouw
welzijnsvoorzieningen - gezondheidszorg - ouderen - dementie - zorgboerderijen - multifunctionele landbouw - welfare services - health care - elderly - dementia - social care farms - multifunctional agriculture
Nederland telt momenteel rond de 1.000 zorgboerderijen. Zorgboerderijen verlenen zorg aan mensen met een verstandelijke of lichamelijke beperking, jongeren met ontwikkelingsproblemen, mensen met verslavings- of GGZ-achtergrond en/of mensen met burn-out. Rond de 150 zorgboerderijen richten zich op ouderen met dementie. Deze doelgroep zal in de komende decennia het sterkst in omvang toenemen en daarmee ook de kansen voor de zorgboerderijen op een zorgvraag met een redelijk zekere financiering. De zorgboerderijen gericht op ouderen met dementie bieden vooral dagbesteding. Slechts een handjevol zorgboerderijen biedt intensievere vormen van zorg en ondersteuning, waaronder woonvoorzieningen, aan ouderen die een grote zorgbehoefte hebben en niet meer zelfstandig kunnen wonen. De meeste van deze ouderen hebben een vorm van dementie
Mogelijkheden voor reductie van medicijngebruik door gezonde voeding(sproducten) in zorginstellingen
Sluis, A.A. van der; Peppelenbos, H.W. ; Witkamp, R.F. ; Rompelberg, C.J.M. ; Jong, N. de; Verhagen, H. - \ 2009
Wageningen : AFSG - 29
verpleeghuizen - geneesmiddelen - voedingsstof-geneesmiddel interacties - voeding en gezondheid - gezondheidszorginstellingen - ouderen - voedingstoestand - nursing homes - drugs - nutrient drug interactions - nutrition and health - health maintenance organizations - elderly - nutritional state
De nadruk van dit rapport ligt op de volgende twee vragen: 1) In hoeverre kan voeding het gebruik van geneesmiddelen in het algemeen in verpleeghuizen beïnvloeden? Hierbij valt onderscheid te maken in: a) Wat is de rol van omgevingsinvloeden (sociale context)? b) Voedingsproducten: welke specifieke producten kunnen medicijngebruik verminderen? 2) Wat is de kostenefficiëntie van de vervanging van medicijnen door gezonde voedingsproducten? In hoeverre betekent investeren in voeding een besparing op medicijnen of verpleging?
Maak kennis met elkaars werkwijze en vakgebied : Vraag het de Expert: Senioren’ bijeenkomsten
Groot, C.P.G.M. de - \ 2009
VoedingsMagazine 22 (2009)5. - ISSN 0922-8012 - p. 21 - 23.
ouderen - gezondheid - diëtisten - gezondheidsbevordering - voeding en gezondheid - elderly - health - dietitians - health promotion - nutrition and health
About 4.2 million people over 55 years of age ('senior citizens') are currently living in the Netherlands, and anticipations are that their number will increase to 6 million by the year 2035. Like for other age groups, behavioural change yields health benefits for older people. Smoking cessation, a healthier diet and more physical exercise have positive health effects. Even if people do not pick up such behavioural change until after the age of 65, that change can still be effective. For example, men who quit smoking when they are 65 years old, live 1.4-2.0 years longer, and women even 2.7-3.7 years. For all people healthy ageing is a precondition for a happy life. Healthy ageing also implies living independently a life of good quality and taking part in society. The chance of realizing that is greater when senior citizens are coached by primary care professionals
Aanwijzingen voor effecten op functionele eindpunten : vitaminesuppletie voeding van ondervoede ouderen
Groot, C.P.G.M. de - \ 2009
VoedingsMagazine 2009 (2009)6. - ISSN 0922-8012 - p. 16 - 18.
vitaminetoevoegingen - ondervoeding - ouderen - voedingstoestand - ouderenvoeding - voeding en gezondheid - vitamin supplements - undernutrition - elderly - nutritional state - elderly nutrition - nutrition and health
Protein or energy supplementation of the diet of malnourished older people leads to body weight gain and an improved nutritional status. There are no indications for an effect on functional endpoints. In contrast, according to Prof. Lisette de Groot (Wageningen University), vitamin supplementation reportedly leads to functional improvements
Fish fatty acids and mental health in older people
Rest, O. van de - \ 2009
Wageningen University. Promotor(en): Lisette de Groot; Frans Kok, co-promotor(en): Marianne Geleijnse. - [S.l. : S.n. - ISBN 9789085854715 - 200
geestelijke gezondheid - mentale vaardigheid - depressie - visoliën - meervoudig onverzadigde vetzuren - ouderen - verouderen - omega-3 vetzuren - mental health - mental ability - depression - fish oils - polyenoic fatty acids - elderly - aging - omega-3 fatty acids
It has been suggested that the intake of fish and marine n-3 polyunsaturated fatty acids could protect against age-related cognitive decline and impaired mental well-being. However, results from observational studies are inconclusive and data from randomized controlled trials in older people without clinical dementia or depression are scarce. The objective of this thesis was to investigate the effect of daily supplementation with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on cognitive performance and mental well-being in an older non-clinical population. We also examined the effect of fish oil on gene expression profiles in white blood cells to identify early changes in pathways possibly related to mental health. Furthermore, we assessed the association of fish and EPA+DHA intake with mental health in different aging populations.

The effect of low and high doses of EPA+DHA (400 and 1,800 mg per day, respectively) on cognitive performance, several measures of mental well-being, and gene expression was examined in a 26-week randomized, double-blind, placebo-controlled trial. This study was conducted in 302 individuals aged 65 years or older with no clinical diagnosis of dementia or depression. Furthermore, the cross-sectional association between fatty fish and EPA+DHA intake with cognitive performance and the association with cognitive change during 6 years of follow-up was assessed in 1,025 aging US men who participated in the Veterans Affairs Normative Aging Study (NAS). In addition, the associations of EPA+DHA and fish intake with depressive symptoms and dispositional optimism were assessed in 644 free-living Dutch subjects with a history of myocardial infarction.

Daily intake of low or high doses of EPA+DHA did not affect cognitive performance, mental well-being, anxiety, or quality of life, after 13 or 26 weeks of intervention. However, treatment with EPA+DHA for 26 weeks altered gene expression in white blood cells to a more anti-inflammatory and more anti-atherogenic profile. In elderly US men we found no association of fatty fish or EPA+DHA intake with cognitive performance or 6-year cognitive change. Intake of EPA+DHA was positively associated with dispositional optimism in subjects with a history of myocardial infarction. There was also a tendency for less depressive symptoms with a higher EPA+DHA or fish intake, but this association was no longer statistically significant after controlling for confounders.

Supplemental intake of EPA+DHA is unlikely to have a short-term impact on cognitive performance or mental well-being of older people without a clinical diagnosis of dementia or depression. Whether long-term intake of EPA+DHA and fish could be beneficial to the maintenance of cognitive performance or mental well-being of older people in Western populations still needs to be established.
Flavor enhancement of food as a stimulant for food intake in elderly people
Essed, N.H. - \ 2009
Wageningen University. Promotor(en): Kees de Graaf; Wija van Staveren. - [S.l. : S.n. - ISBN 9789085854913 - 160
voedselopname - eetlust - smaakversterkers - voedselconsumptie - eten - ouderen - ouderenvoeding - sensorische evaluatie - food intake - appetite - flavour enhancers - food consumption - eating - elderly - elderly nutrition - sensory evaluation

It is often speculated that the age related decline in taste and smell performance can add to the decreased food intake among elderly by causing a change in liking of food. Flavor enhancement (by adding a taste and/or an odor to enhance or intensify the flavor of the food) has been suggested to counteract for the diminished taste and smell performance in order to increase liking and subsequently intake among elderly people. However, there is no clear relationship between an impaired taste and smell functioning and flavor enhancement. In addition, the results of studies on the effect of flavor enhancement on intake are inconsistent. In this thesis we investigated the effect of flavor enhancement on liking and/or food intake in elderly people and the relationship between an altered taste and/or smell performance and liking of flavor-enhanced foods.

When flavor enhancement is used as an approach to stimulate intake, it is important to know how elderly respond to a daily repeated exposure of a food. We first examined the effect of repeated exposure to fruit drinks with different sweet intensities on intake, pleasantness and boredom in young and non-institutionalized elderly adults. Second, the relationship between an impaired taste and smell performance and the liking and intake of tomato soup enhanced with MSG (0.12%) and celery powder (3 g) was studied. Third, the effect of flavor enhancement on liking and intake has been examined in nursing home elderly people that received MSG (0.3%) and/or flavors (700 mg) sprinkled over the protein component of their hot meal during 16 weeks. As last, to study the effect of a determined optimal preferred amount of MSG on food intake, we added 0.5% MSG (optimal amount) to mashed potatoes and 2% MSG to spinach and ground beef and measured the intake of these foods among institutionalized elderly.

The results showed that the elderly experienced no increase in boredom and pleasantness after daily repeated exposure to fruit juices. Elderly with an impaired taste and/or smell functioning did not show an increase in liking and intake of the flavor-enhanced soup. Thus, no relationship was established between an impaired chemosensory performance and flavor enhancement. Flavor enhancement also did not increase liking and energy intake of the hot meal after 16 weeks nor did an optimal preferred amount of MSG increase intake of mashed potatoes, spinach and ground beef.

A standardized flavor enhancement of foods did not prove an effective approach to increase food intake in frail elderly people. Therefore we reviewed the literature to obtain a recent picture on the causes of taste and smell loss in the elderly and to examine if the available methods to measure these losses are adequate. Results of the review showed that elderly are a heterogeneous group with various degrees of taste and smell loss and that the applied methods can distinguish the variations. This result implies a more individual, tailored taste and/or flavor enhancement of foods when it is part of a treatment or used in the prevention of undernutrition. We proposed a future strategy for flavor enhancement of foods in which we embedded the results of this review.

Anticiperend landschapsbeleid. Katern 2: Demografie en wonen
Veeneklaas, F.R. ; Custers, M.H.G. - \ 2009
Wageningen : Alterra (Alterra rapport nr. 1875) - 55
landschap - demografie - beleid - vestigingspatronen - regionale planning - ouderen - landschapsbeheer - landscape - demography - policy - settlement patterns - regional planning - elderly - landscape management
Het aantal ouderen neemt toe. Bij veel ouderen groeit de financiële armslag, maar dat gaat gepaard met een kleinere dagelijkse actieradius. Verwacht mag worden dat dit tot meer aandacht zal leiden voor de kwaliteit van de directe woonomgeving. Voor het landschapsbeleid biedt dit uitgelezen mogelijkheden. Toegankelijkheid is hierbij wel een punt van zorg. Dit is één van de verwachtingen in het nieuwste katern in de serie ‘Anticiperend Landschapsbeleid’
Very long-chain n-3 polyunsaturated fatty acids: a head start to win some years between the ears?
Dullemeijer, C. - \ 2009
Wageningen University. Promotor(en): Frans Kok; R.J. Brummer, co-promotor(en): I.A. Brouwer. - [S.l.] : S.n. - ISBN 9789085853770 - 136
vetzuren met een lange keten - hersenen - cognitieve ontwikkeling - mentale vaardigheid - visoliën - ouderen - vaatziekten - omega-3 vetzuren - kenvermogen - long chain fatty acids - brain - cognitive development - mental ability - fish oils - elderly - vascular diseases - omega-3 fatty acids - cognition
Very long-chain n-3 (or omega-3) polyunsaturated fatty acids have attracted considerable public interest during the past few years for their potential beneficial role in cognitive performance. The proposed benefits stretch from advantages in developing brains of infants and children to preventing cognitive decline at old age.
In this thesis, we first examined the role of very long-chain n-3 PUFA at the beginning of the lifespan. We investigated the effects of dietary very long-chain n-3 PUFA on the fatty acid composition of the several brain lobes in juvenile pigs, and showed that a diet enriched with fish oil resulted in higher proportions of DHA in the frontal, parietal and occipital brain lobes compared with the temporal brain lobe. These findings suggest a region-specific incorporation of DHA in the developing brain, which may guide future research into the mechanism by which very long-chain n-3 PUFA may in involved in brain development and function.
Subsequently, we investigated the role of very long-chain n-3 PUFA near the end of the lifespan. In a population of older adults, we investigated the association between very long-chain n-3 PUFA and cognitive decline over three years in multiple cognitive domains. We demonstrated that higher plasma proportions of very long-chain n-3 PUFA were associated with less decline in the cognitive domains sensorimotor speed and complex speed, but not in memory, information-processing speed and word fluency, compared with lower plasma proportions of very long-chain n-3 PUFA. These results suggest a beneficial role of very long-chain n-3 PUFA in the speed-related cognitive domains, which justifies future research in this area with sensitive cognitive outcome measurements that provide domain-specific information.
Finally, we touched upon the role of very long-chain n-3 PUFA in the macrovascular and the microvascular blood supply in the head region. We showed that plasma very long-chain n-3 PUFA were not associated with changes in carotid intima-media thickness and common carotid distension in a healthy older adult population. This may suggest that the role of very long-chain n-3 PUFA in a healthy population extends in particular to the smaller blood vessels. The role of very long-chain n-3 PUFA in the microcirculation of the brain could therefore be an interesting future direction of research. Although we did not directly investigate the role of very long-chain n-3 PUFA in the brain microcirculation, we did investigate whether plasma very long-chain n-3 PUFA were associated with age-related hearing loss over a period of three years in older adults. Since microvascular disease may decrease the blood supply to the highly vascularised cochlea, this may result in age-related hearing loss. We showed that higher plasma proportions of very long-chain n-3 PUFA were indeed associated with less age-related hearing loss compared with lower plasma proportions of very long-chain n-3 PUFA which implies that the hypothesis of improved microcirculation, if proven correct, may have far-reaching consequences.
In summary, this thesis showed that very long-chain n-3 PUFA have region-specific effects on the developing brain and that higher plasma proportions of very long-chain n-3 PUFA were associated with less decline in the speed-related cognitive domains and less age-related hearing loss. Further research is required to establish the role of very long-chain n-3 PUFA in the developing as well as the aging brain and to investigate the underlying mechanisms.

“Very long-chain n-3 polyunsaturated fatty acids: a head start to win some years between the ears?” PhD-thesis by Carla Dullemeijer, Top Institute Food and Nutrition and Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands, May 15, 2009
Mediterranean diet and the metabolic syndrome
Bos, M.B. - \ 2009
Wageningen University. Promotor(en): Lisette de Groot; Edith Feskens, co-promotor(en): Jeanne de Vries. - [S.l.] : S.n. - ISBN 9789085853756 - 96
stofwisselingsstoornissen - diabetes mellitus - hart- en vaatziekten - dieet - middellandse-zeegebied - ouderen - maatregel op voedingsgebied - metabolic disorders - diabetes mellitus - cardiovascular diseases - diet - mediterranean region - elderly - nutritional intervention
Mediterranean diet and the metabolic syndrome

Background: The metabolic syndrome refers to a clustering of risk factors including
abdominal obesity, hyperglycaemia, low HDL-cholesterol, hypertriglyceridaemia,
and hypertension and it is a risk factor for diabetes mellitus type 2 and cardiovascular
disease. In this thesis we studied whether a Mediterranean diet favourably affects the
metabolic syndrome.
Methods: We assessed the association between a Mediterranean diet and the metabolic
syndrome in apparently healthy elderly European subjects (SENECA study) and in
a Dutch study population that was oversampled with subjects with impaired glucose
tolerance or diabetes mellitus type 2 (CoDAM study). In addition, we conducted a
controlled-feeding trial to compare the effects of replacing a high saturated fatty acids
(SFA) diet with a high monounsaturated fatty acids (MUFA) diet or a Mediterranean
diet on characteristics of the metabolic syndrome: HDL-cholesterol, triglycerides and
glucose metabolism (glucose concentration and insulin sensitivity).
Results: In both the SENECA study and the feeding trial we find support for the
hypothesis that a Mediterranean diet has a beneficial effect on two characteristics of
the metabolic syndrome, namely HDL-cholesterol and triglyceride concentrations.
In addition, the findings of the SENECA study suggested that subjects with good
adherence to a Mediterranean diet had a lower prevalence of the metabolic syndrome
(prevalence ratio 0.81, 95%CI 0.65; 1.03) and a smaller waist circumference (-1.1 cm,
95%CI -2.4; 0.3) than subjects with poor adherence. In the CoDAM study, we did not
find these associations. In none of our studies we found support for the hypothesis
that a Mediterranean diet has a beneficial effect on glucose concentration, insulin
sensitivity or blood pressure.
Conclusion: This thesis finds support for a beneficial effect on two out of five
characteristics of the metabolic syndrome and also suggests a beneficial effect on a
third characteristic (abdominal obesity). We therefore conclude that a Mediterranean
diet may help to prevent the metabolic syndrome and consequently diabetes mellitus
type 2 and cardiovascular disease.
Zorgzame voeding : ouderen, voeding en gezondheid : een inventarisatie
Strous, M.B. ; Westeneng, E. - \ 2009
Wageningen : Agrotechnology & Food Sciences Group - 41
ouderenvoeding - ouderen - ondervoeding - gezondheidszorg - huisartsen - voeding en gezondheid - elderly nutrition - elderly - undernutrition - health care - general practitioners - nutrition and health
AFSG en Van Hall Larenstein hebben samen een inventarisatie uitgevoerd gericht op voeding en ouderenzorg. Omdat de ziektedruk bij ouderen toeneemt ligt de focus van deze studie op de rol van voeding in de periode voor, tijdens en na ziekte en operatie. Gedurende het onderzoek is duidelijk geworden dat er in de instellingen al relatief veel aandacht is voor voeding. Maar slechts 7% van de ouderen woont in een instelling, de grootste groep ouderen woont zelfstandig. De grootste verbeterslag is dan ook te halen bij deze ouderen
Zorgzame voeding : ouderen, voeding en gezondheid : een inventarisatie
Strous, M.B. - \ 2009
Wageningen : Agrotechnology & Food Sciences Group
ouderen - ondervoeding - gezondheidszorginstellingen - thuiszorg - voeding en gezondheid - elderly - undernutrition - health maintenance organizations - home care - nutrition and health
In Nederland wonen 2,3 miljoen mensen van 65 jaar en ouder. Dit aantal neemt de komende decennia fors toe: in 2030 wonen er in ons land bijna vier miljoen ouderen. De vraag om zorg neemt daardoor toe: verzorging in zorginstellingen, maar ook zorg rondom ziekte en herstel. Kan goede voeding de herstelperiode na ziekte verkorten? Of de kwaliteit van leven beïnvloeden? Deze vragen vormen de basis van deze verkennende studie door Wageningen UR – AFSG en Van Hall Larenstein, uitgevoerd voor het programma Voeding en Gezondheid van de Groene Kennis Coöperatie (GKC)
Depressie en hart- en vaatziekten: De rol van voeding, leefstijl en gezondheid
Kamphuis, M.H. ; Geerlings, M.I. ; Tijhuis, M.A.R. ; Kalmijn, S. ; Grobbee, D.E. ; Kromhout, D. - \ 2009
Hart Bulletin 40 (2009)1. - ISSN 0301-8202 - p. 14 - 17.
depressie - hart- en vaatziekten - levensstijl - voedselconsumptie - mannen - ouderen - voeding en gezondheid - depression - cardiovascular diseases - lifestyle - food consumption - men - elderly - nutrition and health
Depressie is geassocieerd met een hoger risico op hart- en vaatziekten (HVZ). In dit onderzoek is prospectief onderzocht of depressieve symptomen verband houden met sterfte aan HVZ bij oudere mannen. Daarnaast is de rol onderzocht van leefstijl, voedingsfactoren en gezondheidstoestand in deze relatie
Vitaliteitmonitor gezond ouder worden 65+ : Op weg naar bevordering van welzijnsbeleving en gezonder ouder worden in het kader van het levensloopbestendig wonen
Bakker, I.M. ; Elings, M. - \ 2009
Wageningen : Wetenschapswinkel Wageningen UR (Rapport / Wetenschapswinkel Wageningen UR 246) - 20
ouderen - gezondheid - sociaal welzijn - huisvesting - gezondheidsvoorzieningen - welzijnsvoorzieningen - levensloop - zorg - elderly - health - social welfare - housing - health services - welfare services - life course - care
De Wetenschapswinkel van Wageningen Universiteit en Researchcentrum heeft voor Stichting CON (Stichting Coördinatie Wonen, Welzijn en Zorg Ouderen Noordwijk) uitgezocht op welke wijze zij welzijnsdiensten en producten kan inzetten, om de kans op ziekte en de behoefte aan zorg en ondersteuning bij ouderen te reduceren. Bovendien is onderzocht welke interventies mogelijk geschikt zijn voor de doelgroep. De hoofddoelstelling was het identificeren van specifieke speerpunten op het gebied van wonen, welzijn en zorg die nog beter aansluiten bij de behoeftes van ouderen in het algemeen, en bovendien mogelijk kostenbesparend zijn
Zorgen op het platteland
Blaeij, A.T. de; Vader, J. ; Elst-van der Lans, M.W.M. van der - \ 2008
Agri-monitor 2008 (2008)juni. - ISSN 1383-6455 - 2
plattelandsontwikkeling - plattelandsbevolking - plattelandssamenleving - rurale welzijnszorg - sociaal welzijn - ouderen - vrijwilligerssector - vrijwilligers - zorg - sociale zorg - rural development - rural population - rural society - rural welfare - social welfare - elderly - voluntary sector - volunteers - care - social care
Ouderen hebben vaak zorg nodig. Doordat het platteland sneller vergrijst dan andere gebieden neemt de vraag naar zorg hier sterker toe. Het tekort aan vrijwilligers op het platteland leidt ertoe dat de informele zorg en daardoor de leefbaarheid onder druk komen te staan. Voor het werven van potentiële vrijwilligers moeten vrijwilligersorganisaties en overheid voorwaarden creëren waardoor de potentiële vrijwilligers daadwerkelijk actief worden.
Met smaak ouder worden
Kremer, Stefanie - \ 2008
taste - tastes - elderly - food consumption - taste research
Food for the ageing population
Raats, M.M. ; Groot, C.P.G.M. de; Staveren, W.A. van - \ 2008
London : Woodhead Publishing (Woodhead publishing in food science, technology and nutrition ) - ISBN 9781845691936 - 652
ouderenvoeding - ouderen - ouderdom - verouderen - elderly nutrition - elderly - old age - aging
The world’s ageing population is increasing and food professionals will have to address the needs of older generations more closely in the future. This unique volume reviews the characteristics of the ageing population as food consumers, the role of nutrition in healthy ageing and the design of food products and services for the elderly. Chapters in Part one discuss aspects of the elderly’s relationship with food such as appetite and ageing, ageing and sensory perception, food and satisfaction with life, and the social significance of meals. The second part of the book reviews the role of nutrition in extending functionality into later years, with chapters on topics such as undernutrition and conditions such as Alzheimer's disease, bone and joint health and eye-related disorders. Concluding chapters address the issues of food safety and the elderly, designing new foods and beverages for the ageing and nutrition education programmes.
Voeding en gezond ouder worden
Groot, C.P.G.M. de; Visser, M. de - \ 2008
Voeding Nu 10 (2008)12. - ISSN 1389-7608 - p. 34 - 34.
verouderen - humane voeding - voedingsonderzoek - overgewicht - ondergewicht - ouderen - voeding en gezondheid - aging - human feeding - nutrition research - overweight - underweight - elderly - nutrition and health
Door de toenemende vergrijzing is meer aandacht voor de voedingsproblemen van ouderen noodzakelijk. Een slechte nutriëntenstatus en onder- of overgewicht als gevolg van een disbalans tussen energie-inneming en -verbruik komen vaak voor. De omvang en gevolgen van deze voedingsproblemen worden in dit artikel kort besproken
Een zorg(e)loze oude dag op het platteland : vergrijzing en vrijwilligerswerk op het platteland
Vader, J. ; Blaeij, A.T. de; Elst, M. van der; Dijk, J.J. van - \ 2008
Den Haag : LEI (Rapport / LEI : Werkveld 4, Rurale economie en ruimtegebruik ) - ISBN 9789086152353 - 68
landbouwbeleid - platteland - plattelandsbevolking - plattelandsgemeenschappen - ouderen - gepensioneerden - leeftijdsgroepen - vrijwilligers - dienstverlening door vrijwilligers - vrijwilligerssector - sociale voorzieningen - sociale participatie - levensomstandigheden - nederland - agricultural policy - rural areas - rural population - rural communities - elderly - retired people - age groups - volunteers - voluntary services - voluntary sector - social services - social participation - living conditions - netherlands
Vergrijzing en veranderingen in het vrijwilligerswerk zijn twee belangrijke ontwikkelingen op het platteland, die elkaar tevens beïnvloeden. Het gat tussen vraag naar en aanbod van vrijwilligerswerk dreigt, mede door vergrijzing, groter te worden. Dit rapport beschrijft de mogelijke gevolgen van vergrijzing voor vrijwilligerswerk en informele zorg op het platteland. Hiervoor is een literatuurstudie uitgevoerd, evenals een data-analyse. Daarnaast is door gesprekken met vrijwilligers lokale kennis verkregen over de gevolgen van vergrijzing voor vrijwilligerswerk op het platteland.
WASP D6.2 Specified application requirements and prototype selection (with annex I_IV)
Lokhorst, C. ; Mol, R.M. de; Wells, Hannah ; Mazzu, Marco ; Frumento, F. ; Corongiu, A. ; Savio, Walther ; Ipema, A.H. ; Sorniotti, A. ; Gomez, L.D. - \ 2007
Brussel : Europese Unie - 45
wegen - verkeer - ouderen - volksgezondheid - rundvee - diergezondheid - draadloze sensornetwerken - zorg - roads - traffic - elderly - public health - cattle - animal health - wireless sensor networks - care
Seniorenvoeding biedt volop kansen voor midden- en kleinbedrijf
Dhonukshe-Rutten, R.A.M. - \ 2007
Voeding Nu 9 (2007)9. - ISSN 1389-7608 - p. 15 - 17.
ouderenvoeding - ouderen - voedingsmiddelen - marketing - voedselindustrie - gezondheidsvoedsel - consumentenvoorkeuren - voedselvoorkeuren - elderly nutrition - elderly - foods - food industry - health foods - consumer preferences - food preferences
De komende dertig jaar groeit het aantal vijftigplussers in Nederland met 45 procent naar 7,1 miljoen. De groep zal bijna twee keer zoveel vermogen hebben als het gemiddelde Nederlandse huishouden. Een nieuwe markt met kansen. Ooit dacht de consument bij seniorenvoeding vooral aan de saaie keuken van een bejaardenhuis of een sondevoeding voor oudere patiënten. Tegenwoordig is dat anders. De huidige senioren zijn vaak vitale consumenten, met veel aandacht voor hun kwaliteit van leven, die geld overhebben voor een goede voeding. Senioren blijken een gat in de markt, zo bleek tijdens het symposium dat het Innovatiecentrum Gezonde Voeding (ICGV) deze zomer in Venlo hield
WASP Scenario choice: Deliverable D6.1, EU KP6 IST-034963
Mol, R.M. de; Eijk, O.N.M. van; Goense, D. ; Hogewerf, P.H. ; Ipema, A.H. ; Lokhorst, C. ; Frumento, E. ; Mazzu, Marco ; Wells, Hannah ; Savio, Walther ; Wrona, K. - \ 2007
Brussel : Information Science Technologies - 56
wegen - verkeer - ouderen - volksgezondheid - rundvee - diergezondheid - draadloze sensornetwerken - roads - traffic - elderly - public health - cattle - animal health - wireless sensor networks
Dietary patterns, biological risk factors and survival in elderly European men and women
Knoops, K.T.B. - \ 2007
Wageningen University. Promotor(en): Wija van Staveren; Daan Kromhout, co-promotor(en): Lisette de Groot. - [S.l.] : S.n. - ISBN 9789085046912 - 208
dieet - risicofactoren - risicoschatting - mortaliteit - overleving - voedingstoestand - voeding - ouderen - ouderdom - verouderen - europa - diet - risk factors - risk assessment - mortality - survival - nutritional state - nutrition - elderly - old age - aging - europe
Background: The percentage of the population aged 65 and over, which started to rise sharply in the last decades of the past century, is continuing to rise. However, up until now, little is known about dietary factors and diet-related biological factors in elderly in relation to survival in old age. Aim: The aim of this thesis is to investigate the associations between dietary patterns, diet-related biological risk factors and survival. Study population: Data from two prospective studies were used, the Healthy Ageing: a longitudinal study in Europe (HALE) and the Normative Aging Study (NAS). The HALE project which involves individuals enrolled in the Survey in Europe on Nutrition and the Elderly: a Concerned Action (SENECA) and the Finland, Italy, the Netherlands, Elderly (FINE) studies, includes 1507 apparently healthy men and 832 women in 11 European Countries, aged 70 to 90 years at baseline and who were followed for 10 years. The NAS is a longitudinal study which started in 1963 by recruiting men, 21 to 80 years of age and free of heart disease and other major health problems, around Boston. Data collected in 1993 and later were used. Results: We observed that after fortification with folic acid, folate intake and plasma folate concentration increased significantly in three groups with different dietary patterns, derived by cluster analysis. Homocysteine tended to decrease in the group with a relatively high alcohol consumption, low fruit and vegetable dietary pattern in the NAS study. Dietary patterns defined by three European indexes were significantly associated with all-cause mortality in the HALE project. A Mediterranean type of diet was associated with an approximately 20 % lower mortality rates in both apparently healthy elderly and in post-myocardial infarction patients. Healthy lifestyle factors (moderate alcohol consumption, being physically active and non-smoking) were also inversely associated with all-cause mortality. Weight loss was significantly associated with increased all-cause mortality in the study centres of Northern Europe while weight gain was weakly associated with increased mortality in these centres in the FINE study. HDL-cholesterol was inversely associated with mortality from cardiovascular diseases and all-causes in the HALE project. Associations between HDL and mortality were strongest in women. Conclusion: A healthy diet is associated with lower mortality risk in elderly. Besides a healthy diet, it is important for elderly people to be physically active, use alcohol in moderation and quit smoking. It is also important to maintain constant body weight and to keep blood cholesterol at a desirable level, especially to keep HDL-cholesterol high.
Determinants of cognitive decline in older European men
Gelder, B.M. van - \ 2007
Wageningen University. Promotor(en): Daan Kromhout, co-promotor(en): M.A.R. Tijhuis; S. Kalmijn. - [S.l.] : S.n. - ISBN 9789085046493 - 157
cognitieve ontwikkeling - mentale vaardigheid - dieet - ouderen - ouderdom - mannen - europa - kenvermogen - sociale factoren - cognitive development - mental ability - diet - elderly - old age - men - europe - cognition - social factors
Voeding versus veroudering
Groot, C.P.G.M. de - \ 2006
VoedingsMagazine 19 (2006)3. - ISSN 0922-8012 - p. 8 - 10.
humane voeding - ouderen - ouderenvoeding - gezondheid - voedingstoestand - verouderen - organisatie van onderzoek - human feeding - elderly - elderly nutrition - health - nutritional state - aging - organization of research
In her inaugural speech when accepting the office of professor by special appointment at Wageningen University, Lisette de Groot unfolds her intentions. Research on all levels (from descriptive research on a population level and individual interventions to studies on a cellular level) should bring a bit closer the target goal of curbing functional decline as a consequence of ageing processes
Milde vitamine B12 deficiëntie en het cognitief functioneren van ouderen : de effectiviteit van orale supplementen
Eussen, S.J.P.M. - \ 2006
Wageningen University. Promotor(en): Wija van Staveren; W.H.L. Hoefnagels, co-promotor(en): Lisette de Groot. - [S.l.] : S.n. - ISBN 9085044316 - 142
vitamine b12 - vitaminetekorten - mentale vaardigheid - verstandelijk gehandicapt - vitaminetoevoegingen - bijvoeding - ouderen - ouderdom - kenvermogen - vitamin b12 - vitamin deficiencies - mental ability - mental retardation - vitamin supplements - supplementary feeding - elderly - old age - cognition
Nutritional care in old age: the effect of supplementation on nutritional status and performance
Manders, M. - \ 2006
Wageningen University. Promotor(en): Wija van Staveren; W.H.L. Hoefnagels, co-promotor(en): Lisette de Groot. - [S.l. ] : S.n. - ISBN 9085043956 - 134
ouderenvoeding - voedselsupplementen - bijvoeding - voedingstoestand - slechte voeding - ouderen - ouderdom - elderly nutrition - food supplements - supplementary feeding - nutritional state - malnutrition - elderly - old age
Food perception and food liking with age
Kremer, S. - \ 2006
Wageningen University. Promotor(en): J.H.A. Kroeze; Kees de Graaf. - [S.l.] : S.n. - ISBN 9085044189 - 155
voedselvoorkeuren - eetpatronen - perceptie - smaak - sensorische evaluatie - ouderen - ouderdom - food preferences - eating patterns - perception - taste - sensory evaluation - elderly - old age
The elderly population is rapidly growing worldwide. In sensory and nutrition research, age-associated losses in sensory function are believed to change the perception of food, to decrease food liking and consequently to decrease food intake of the elderly, although data in support of this line of assumptions are currently scarce. Consequently, there is a growing need to understand more about age related changes both in food perception and food liking. Therefore, the present thesis describes research on food perception, food liking and sensory acuity with increasing age. The results demonstrate that the elderly indeed perceive foods differently compared to the young, mainly as less intense in flavour and in creaminess/fattiness. However, their food liking is not reduced, despite these age-related changes in perception. It is concluded that decreased sensory acuity, although causing losses in perception of the elderly, is obviously not causing a reduced food liking and thus may not be the predominant reason for a diminished food intake.
Gezond werken tot je 67ste : overzichtsrapport maatregelen in Nederland
Maas, E. van der; Vaandrager, L. - \ 2005
Woerden : NIGZ (NIGZ- Werk & gezondheid 2) - 32
ouderen - arbeid (werk) - participatie - leeftijd - gezondheid op het werk - elderly - labour - participation - age - occupational health
In dit rapport worden de volgende onderwerpen behandeld: de wetgeving waarop gezond en veilig werken, maar ook het bevorderen van arbeidsparticipatie van ouderen, is gebaseerd; landelijke projecten en programma’s, die onder andere gericht zijn op kennisverspreiding en het beïnvloeden van vooroordelen over oudere werknemers; belangrijke spelers in het veld, op het gebied van kenniscentra, onderzoeksinstellingen en commerciële bureaus; praktijkvoorbeelden van organisaties die leeftijdsbeleid inzetten om op een verantwoorde manier met oudere werknemers binnen de organisatie om te gaan
Veel tijd, nooit weg, een onderzoek naar aangepaste vakanties
Welt, G. ; Renes, R.J. - \ 2005
Wageningen : Wageningen UR, Wetenschapswinkel (Rapport / Wetenschapswinkel Wageningen UR 216) - ISBN 9067549304 - 66
vakanties - vrije tijd - aanpassing - toeristenindustrie - ouderen - gehandicapten - nederland - sociale zorg - holidays - leisure - adjustment - tourist industry - elderly - people with disabilities - netherlands - social care
Onderzoek in opdracht van Stichting Mens en Samenleving, die zich richt op het aanbieden van vakanties voor ouderen, gehandicapten en chronisch zoeken. SMS wil deze activiteit verbeteren en uitbreiden. Dit onderzoek analyseert: de doelgroep, de aanbieders van aangepaste vakantie, de zorg die erbij nodig is, de groen ruimte in dit verband
Folate and age-related disease
Durga, J. - \ 2004
Wageningen University. Promotor(en): Frans Kok; Evert Schouten, co-promotor(en): P. Verhoef. - [S.I.] : S.n. - ISBN 9085040914
foliumzuur - voeding - homocysteïne - hart- en vaatziekten - hart- en vaatstoornissen - ouderen - volwassenen - folic acid - nutrition - homocysteine - cardiovascular diseases - cardiovascular disorders - elderly - adults
Vitamine B12 en cognitieve functies
Eussen, S.J.P.M. ; Groot, C.P.G.M. de; Hoefnagels, W.H.L. ; Staveren, W.A. van - \ 2004
Voeding Nu 4 (2004)4. - ISSN 1389-7608 - p. 29 - 31.
ouderen - vitamine b12 - vitaminetekorten - voedingsstoffentekorten - voedingstoestand - deficiëntie - cognitieve ontwikkeling - mentale vaardigheid - supplementen - toevoegingen - wetenschappelijk onderzoek - elderly - vitamin b12 - vitamin deficiencies - nutrient deficiencies - nutritional state - deficiency - cognitive development - mental ability - supplements - additives - scientific research
Vitamine B12-deficiëntie is een relatief veel voorkomend probleem bij ouderen. Wageningen Universiteit onderzoekt wat de optimale hoeveelheid vitamine B12 in capsules zou moeten zijn om een vitamine B12-deficiëntie te behandelen en of deze hoeveelheid B12 gunstige effecten heeft op het cognitief functioneren bij ouderen met een vitamine B12-deficiëntie
Gezelligheid doet eten? : Ambiance tijdens de maaltijden van ouderen in instellingen.
Nijs, K.A.N.D. ; Graaf, C. de; Vanneste, V. ; Staveren, W.A. van - \ 2004
Voeding Nu 6 (2004)4. - ISSN 1389-7608 - p. 23 - 25.
maaltijden - ouderen - voedingstoestand - kwaliteit van het leven - sociale indicatoren - verpleeghuizen - klanttevredenheid - bedrijfsvoering - kwaliteitszorg - institutionele huishoudens - wetenschappelijk onderzoek - meals - elderly - nutritional state - quality of life - social indicators - nursing homes - consumer satisfaction - management - quality management - institutional households - scientific research
Wageningen Universiteit heeft een project opgezet om de ambiance tijdens de maaltijden in verpleeghuizen te verbeteren. Onderzocht is op welke wijze de ambiance kan worden verbeterd en wat de bewoners en personeel daarvan vinden. De bedoeling van het project is om een succesvolle methode in meerdere verpleeghuizen te implementeren. Een goede sfeer tijdens de maaltijden heeft namelijk een positief effect op de voedingstoestand en kwaliteit van leven van verpleeghuisbewoners. De eerste reacties van bewoners en personeel zijn positief
Vitamin B12: a novel indicator of bone health in vulnerable groups
Dhonukshe-Rutten, R.A.M. - \ 2004
Wageningen University. Promotor(en): Wija van Staveren, co-promotor(en): Lisette de Groot. - [S.I.] : S.n. - ISBN 9085041074
voeding - ouderen - voedselsamenstelling - vitaminen - vitamine b12 - beenderen - skelet - beendervorming - botontkalking - gezondheid - nutrition - elderly - food composition - vitamins - vitamin b12 - bones - skeleton - bone formation - osteoporosis - health
Acute respiratory infections in elderly people: the role of micronutrients and lifestyle
Graat, J.M. - \ 2003
Wageningen University. Promotor(en): Frans Kok; Evert Schouten. - [S.l.] : S.n. - ISBN 9058089223 - 152
ademhalingsziekten - influenza - verkoudheid - longontsteking - sporenelementen - vitaminen - vitamine e - levensstijl - ouderen - ouderdom - respiratory diseases - influenza - common cold - pneumonia - trace elements - vitamins - vitamin e - lifestyle - elderly - old age
Fibrinolysis, inflammation and cardiovascular disease; Epidemiological studies on Plasminogen activator inhibitor-type 1 and C-reactive protein
Hoekstra, T. - \ 2003
Wageningen University. Promotor(en): Frans Kok; Evert Schouten, co-promotor(en): Marianne Geleijnse. - [S.l.] : S.n. - ISBN 9058087786
plasminogen activator - remmers - c-reactief eiwit - ontsteking - fibrinolyse - hart- en vaatziekten - epidemiologische onderzoeken - genetische factoren - ouderen - plasminogen activator - inhibitors - c-reactive protein - inflammation - fibrinolysis - cardiovascular diseases - epidemiological surveys - genetic factors - elderly
Voeding en gezondheid - vitaminevoorziening en vitaliteit van ouderen
Staveren, W.A. van; Groot, C.P.G.M. de - \ 2003
Nederlands Tijdschrift voor Geneeskunde 147 (2003)16. - ISSN 0028-2162 - p. 748 - 752.
ouderen - ouderenvoeding - vitaminetekorten - voedingsstoffentekorten - vitaminetoevoegingen - elderly - elderly nutrition - vitamin deficiencies - nutrient deficiencies - vitamin supplements - randomized controlled trial - nursing-home residents - nutrient-dense foods - dietary-supplements - physical exercise - infections - bone
The increasing number of elderly people above 65 years of age is extremely heterogenous with regard to sickness and health. As a result, the nutritional needs and food consumption also vary. "Anorexia of aging", leading to nutritional deficiencies, is a common syndrome in the elderly people and may be either caused by or result in loss of functions and accelerated aging. Early detection of malnutrition and intervention with supplements or an adequate diet should stop the negative health spiral. A limited number of intervention trials, including Dutch ones, have demonstrated a positive effect on the nutritional and immune status. However, the improvement in physical and mental functions as a result of supplementation is less clear. The results of larger current trials on the effect of supplementation with, for excample, vitamin D, folic acid, vitamin B12 and complete enriched products will provide more clarity in the future on the necessity of supplementation for elderly people
The increasing number of elderly people above 65 years of age is extremely heterogeneous with regard to sickness and health. As a result, the nutritional needs and food consumption also vary. 'Anorexia of aging', leading to nutritional deficiencies, is a common syndrome in the elderly people and may be either caused by or result in loss of functions and accelerated aging. Early detection of malnutrition and intervention with supplements or an adequate diet should stop the negative health spiral. A limited number of intervention trials, including Dutch ones, have demonstrated a positive effect on the nutritional and immune status. However, the improvement in physical and mental functions as a result of supplementation is less clear. The results of larger current trials on the effect of supplementation with, for example, vitamin D, folic acid, vitamin B-12 and complete enriched products will provide more clarity in the future on the necessity of supplementation for elderly people.
Impact of nutritional supplements on health indices in elderly people
Wouters-Wesseling, W. - \ 2002
Wageningen University. Promotor(en): W.A. van Staveren; J.G. Bindels; C.P.G.M. de Groot. - S.l. : S.n. - ISBN 9789058086815 - 159
voedselsupplementen - ouderenvoeding - ouderen - ouderdom - gezondheid - maatregel op voedingsgebied - voedingsonderzoek - food supplements - elderly nutrition - elderly - old age - health - nutritional intervention - nutrition research

Life expectancy in both the Western and non-western population has been increasing over the past centennial, due to improved hygiene, the discovery of medicines such as antibiotics and economic welfare. The consequence for society of this ageing of our population is an increased need for medical and social care and thus a burden of costs for health care. At the level of individual people an increased life expectancy is appealing, but only if accompanied by a preservation of a certain health status. Low intakes or plasma levels of nutrients have been related to several areas of physiological decline often observed in elderly people.

This thesis describes the effects of provision of a complete nutritional supplement to elderly who are at risk for impaired nutritional status. Two studies in the population of psychogeriatric nursing home residents demonstrated that both short and longer-term use of a nutritional supplement was well accepted and tolerated in this target group. Furthermore, body weight and plasma levels of micronutrients increased upon supplementation.

The results of a 6-months randomised placebo controlled intervention study in elderly living in homes for the elderly or sheltered housing are also reported. The effect of a nutritional supplement (containing macro- and micronutrients) or a non-energetic placebo on health indices was evaluated. The group receiving the supplement had significant improvements in plasma vitamin levels, weight, sleep, immune function, antioxidant levels and cognitive function. The objective for subjects to maintain intake from the regular diet was reached, and thus their total nutrient intake increased when using the supplement.

In conclusion, the provision of a nutritional supplement can improve several health indices in elderly people who are at risk of nutritional deficiencies. Therefore, the strategy to improve health of elderly people should incorporate the option of providing nutritional supplements.

Elder care, old-age security and social change in rural Yogyakarta, Indonesia = De zorg voor en bestaanszekerheid van ouderen tegen de achtergrond van sociale veranderingen in ruraal Yogyakarta, Indonesië
Keasberry, I.N. - \ 2002
Wageningen University. Promotor(en): A. Niehof. - S.l. : S.n. - ISBN 9789058087249 - 407
ouderen - ouderdom - thuiszorg - gezondheidszorg - sociale zekerheid - platteland - indonesië - sociale verandering - elderly - old age - home care - health care - social security - social change - rural areas - indonesia

This thesis describes the significance of the living conditions and care arrangements of older persons for their old-age security in the villages of Kebonagung (regency of Bantul) and Giriwungu (regency of Gunung Kidul) in the Special Region of Yogyakarta, Indonesia.

The world population is ageing. The United Nations designated the year 1999 as 'The Year of the Older Person', thereby recognising and reaffirming that the global population is ageing at an unprecedented rate. This is also the case for the population of Indonesia. In 1996, the Indonesian archipelago counted about 206.3 million people of which two-thirds live on the island of Java. The proportion of older people is still small compared to that of Western countries, but is increasing at a remarkably high rate. The elderly population was projected to increase by 191 percent between 1996 and 2025. The Special Region of Yogyakarta, a province in the central part of Java, is a front-runner in the ageing process.

In combination with demographic change, the processes of social and economic change are affecting the Indonesian society. Traditionally, Javanese children are obligated to take care of their parents, especially when their parents have stopped working. When Javanese people became old and were no longer heads of complete households, no longer had young children, and were no longer economically productive, they used to live with their children or siblings' children or grandchildren. In practice this often meant that the youngest child, preferably a daughter, stayed behind in the parental house and co-resided with the parents after marriage. The intergenerational relationships guaranteed the parents' care and support in their old age. However, we expect that these kinds of living arrangements are changing as a consequence of processes of social change and that this will also affect the elder care practices. Households and families that have always provided the support and care for the large majority of elderly people in Indonesia are becoming smaller. Members of families are living further apart as a consequence of increased mobility and migration. It is no longer self-evident that women are working at home or around the house, since the participation of women in paid labour is increasing. In the context of rapid social and economic change, traditional support mechanisms can no longer be fully relied upon for the care of older people. In the near future, Indonesian people will be less certain that their children will care for them in their old age.

Older persons in Indonesia are as yet little studied and there is a lack of theoretical conceptualization on (elder) care in developing countries. To enable formulation of appropriate policies, it is, however, necessary to understand how elder care and support are arranged. The amount of literature on older persons in Indonesia is limited. Most of the studies use the decennial national censuses and intercensal surveys of the Indonesian Central Bureau of Statistics ( Biro Pusat Statistik ) and are not based on actual data collection, especially of qualitative data. The majority of the studies are about Java or the whole of Indonesia. They studied the subjects of demographic ageing, socio-economic conditions and well-being of older persons, nutritional health and institutional care. There are no comprehensive studies available that focus on older persons' living conditions, care arrangements and old-age security in rural Indonesia.

The present study is part of the 'Household and family care for the elderly in an ageing society' project. The research project focuses on the issues of the socio-economic position of older people, the amount and kind of care and support needed by older people, the role of households, families and significant others in providing elder care, now and in the immediate future. The research project was set up with a comparative perspective towards rural and urban Yogyakarta on the one hand and rural Indonesia and a rural area in the Netherlands on the other hand. The different study areas share the common problem of the societal consequences of the ageing process. However, it was assumed that given the different demographic and socio-economic contexts, patterns of household and family care for older people as well as the socio-economic position of older people would differ.

Developing countries in Asia offer a wide variety of cultural practices regarding care for and intergenerational relationships of older people. The Javanese have a bilateral kinship system that is generally characterised by the values of showing respect ( hormat ) and maintaining harmonious social appearances ( rukun ) towards older and senior relatives. The majority of the population adheres to Islam, a religion that emphasises intergenerational concern, kindness and mutual obligations, especially in matters of subsistence and general care.

In Indonesia, rapid population growth is placing great strain on the government. However, the government provides limited special services for particular groups of older persons, and relies on private and charitable groups to assist in providing for the needy. Social security programmes are typically limited to government-employed individuals with complementary special welfare programmes for the impoverished and the impaired. To be able to anticipate future needs of older persons and to formulate appropriate policies, it is important to know more about the living conditions of older persons and their care arrangements with household members, kin, friends and neighbours. The former government of Suharto (1966-1998) acknowledged the problem of the 'low priority' given to ageing and having 'inadequate information' about older persons and the problems they experience.

The present research seeks to address both the issue of inadequate information and knowledge, and the absence of theoretical conceptualization. Therefore, the research objective has a descriptive and a theoretical component. This research aims to:

  1. Gain insight into the lives of older persons, particularly regarding the care they provide themselves and receive from others at the micro-level (household-kin-community). Moreover, it aims to identify the transitions in elder care to be better able to anticipate the needs for elder care in Indonesia in the future.
  2. Develop a theoretical framework for care that will be applicable in Indonesia and countries of similar socio-economic and cultural setting. The theoretical framework starts from the assumptions and concepts found in the literature, which are adapted to and tested in the local situation.

This thesis has a societal and practical relevance for policymakers, who are expected to develop programmes and social services to accommodate the problems of old age and improve the lives of older people in rural Indonesia. It has a scientific and theoretical relevance for researchers, who want to study older persons and elder care in developing countries from a comparative perspective.

The central question of the research is as follows:

How does social change affect older persons' lives, and what is the significance of care arrangements and support relations for old-age security?

This question is broken down into a number of subsidiary questions, which will be dealt with in the following sections. Each research question will be answered by summarising the results of the research bearing on that point.

Characteristics of older person's lives

There is a need to know more about the living conditions of older persons, to know more about the socio-demographic, health and economic characteristics of the lives of older persons. The first research question was, therefore, more generally phrased as:

    1. How can the lives of older persons be characterised?
    2. Chapter 6 describes the socio-demographic status of persons aged fifty-five years and older, who live in the Javanese villages of Kebonagung and Giriwungu in the Special Region Yogyakarta, Indonesia. The age distribution of the sample shows a slightly irregular pattern with relatively few people under 60 years old and more than could be expected above the age of 75. The sex distribution is skewed with more women than men in each age group, except the age group of 70-74. The older persons are 69 years old on average and they have more female than male peers. Most older persons say that they are Muslim. However, in practice they combine Islam with animistic and Hinduistic elements in a syncretic belief system in which the slametan plays a central part. The majority of the older persons did not receive any schooling, because there was no school in the village when they were young, and schooling was a privilege for the happy few. Almost two-thirds of the older persons are married and one-third are widowed. Their marriages were often arranged by the parents on the basis of practical reasons. The majority of the older persons live with their spouse and/or others, who usually are child(ren), a child-in-law and/or grandchildren. In general, an elderly household consists of nearly five persons and is a three-generation household. Most older persons have three children still alive of whom at least one lives with them or in the same village.

      Chapter 7 describes the health characteristics of older persons. We measured the relatively objective health situation with scales for nutritional health and ability to perform the personal/instrumental activities of daily life. Most respondents have a moderate nutritional health and are usually able to perform the personal and instrumental activities of daily life. However, older persons could improve their health by adding more nutritional value and variation to their diet. Subjective health was measured by self-reports of physical and mental well-being, capacity of the senses, minor and chronic illnesses. In general, older persons are in good health, although they suffer from at least one minor illness and half of them suffer from a chronic illness. Most respondents can use all their sense organs; problems are mostly related to seeing and hearing.

      We only found a few cases of demented, bedridden or destitute persons. Although mental well-being is difficult to assess, we hypothesised possible reasons for the low prevalence of dementia. Indonesian people seldom reach the ages characterised by dependency and dementia. Besides, older persons continue to be useful around the house and farm, and, therefore, may retain the capability to perform (instrumental) activities. They gradually reduce their activities and do not abruptly stop working. People generally stay in their own houses and are mentally involved with (grand) children, which may prevent them from becoming estranged from their environment as would occur if they moved to an institution.

      Chapter 8 describes the resources and assets that determine the livelihood of older persons. Resources are the immediate means necessary for livelihood generation. Access to work, individual income, household income, food crops, (fruit) trees, and water sources are important for the satisfaction of older person's daily needs. About half of the older respondents spend most of their time on work from which they earn an income in cash or in kind. A quarter spent most of their time on household activities, and another quarter performed other activities at home. These people could be called retired. Here retirement stands for not spending most of the time on income-generating activities. We found that people retire at the average age of 64 years while the life expectancy at birth is 65 years. Hence, we may say that in the rural areas of the Special Region Yogyakarta older people tend to work until they die.

      The individual income of older persons is lower than the officially set mean value of basic daily needs. The elderly household income is higher than the official minimum wage for a standardised household of two adults and two children. However, the research data and formal standards are difficult to compare due to measurement differences concerning rural and urban environments, informal and formal work, income in cash and in kind, and household composition. Nevertheless, for three-quarter of the older persons in the research the individual income is sufficient for their daily needs. For one-quarter it is not sufficient because they have an uncertain income or many needs to fulfil.

      Assets consist of a wide range of tangible and intangible stores of values or claims to assistance that can be converted into money if necessary. Ownership of a house made of durable building materials, household items, fertile farmland, and livestock is important for meeting basic needs, and for additional resources in times of need. In Kebonagung the houses in which older persons live are made of better materials and have better facilities than in Giriwungu. More than half of the elderly households do not have access to enough farmland (corrected for type of irrigation) to meet their basic needs. Almost ten percent of the households are considered landless, and most of these are in Kebonagung. People in Kebonagung more often have income from sources other than agricultural production than in Giriwungu.

      Patterns of elder care

      We are primarily interested in the care arrangements and support network relations of older persons; specifically the care activities that older persons provide for themselves, that people in their personal network can provide for them, and the care they can provide for others. The care arrangement is defined as the totality of all settlements about the care and support activities between an older person and others. The support network relations are narrowed down to the supporting ties of the older person with household members, other kin, neighbours and friends, social organisations and neighbourhood groups. The individual care arrangements and support relations of older persons result in patterns of elder care. Hence, the second research question was phrased as:

    3. What patterns of elder care can be distinguished?
    4. Chapter 9 describes the living arrangements and daily care practices within elderly households. The availability, coresidence and proximity of children together make up the living arrangements of older persons. It does not mean that care and support is automatically provided to an older person when s/he lives with a child or has children living nearby. However, living with children indicates a possible source of care and support, and it influences the perspective and expectations of older persons with regard to support. Very few people have no children, but the majority of these childless people live with other relatives. The childless people who live alone are all women and, given the absence of a social security scheme, they are probably most vulnerable when they are in need of support. Most older persons live with or close to (some of) their children and hence apply for support from them. However, a large majority does not need help with the personal or instrumental activities of daily life, because they can still perform them without difficulty. The few persons who need help with the personal or instrumental activities, are mainly supported by a coresiding daughter. Although other studies report a preference of older parents for coresidence with a daughter, we only found a weakly significant confirmation of this hypothesis. We found that older mothers seem to prefer living together with a son. The distance at which children live from their parents does not seem to have implications for the daily care that parents receive. Most care is still provided by children, who live with the parents or live in the same village. However, we found some indication that respondents who have nobody near who can help, are reluctant to confess that they need help.

      Chapter 10 describes the relations of material, emotional and social support in and beyond the elderly household. Material support consists of money and material goods. Less than half of the older persons receives monetary support and only a quarter receive support in kind such as food or clothes. In general material support is received regularly: monetary support every three weeks and support in kind every ten days approximately. The main sources of financial support are sons. It is common practice that financial responsibilities and power are gradually transferred from the older persons to the younger persons in the extended household. We have hypothesised that migrated children would support their parents more by sending money home. Indeed, the proximity of children has implications for the financial care that parents receive. Parents with children living at a larger distance receive significantly higher yearly amounts of money than parents with children living nearby.

      Emotional support was operationalised as advice, trust and social contact exchanged outside the household. It was difficult to ask questions about advice and trust, because Javanese people do not easily talk about private matters. The responses to questions about social contact were easier to obtain. The majority of the older persons talked with neighbours and friends every other day. The different words for small talk ( omong-omong ), visiting for pleasure ( main, dolan ) and visiting a sick person ( besuk ) have different connotations and uses. We observed that children who live far away from their parents do not visit them regularly. Not even when the children live in Yogyakarta, which is only fifteen to twenty-five kilometres away from the study areas. They don't even return home at Lebaran at the end of the Fasting month ( Idul Fitri ), when children are expected to show respect to older persons and are expected to visit and bring presents to their parents.

      The social activities in which an older person participates constitute a social network and create a potential source of support. The social activities, which are most popular among older persons, are organised by the neighbourhood. The social networks of gotong royong (mutual assistance group), arisan dan simpan pinjam (saving and credit group), ronda (nights patrol group), Dasa Wisma (women's information group), pengajian (Koran recitation group) and lingkungan (social circle of direct neighbours) provide financial or labour support in a direct and reciprocal way. However, a person is only assured of support from these networks as long as at least one household member participates. Therefore, these social activities are not beneficial for the oldest people, who cannot participate anymore and who do not live together with a participating household member. Older persons who live alone, do not live with a child, or only have children living at a large distance are the most vulnerable to a lack of emotional and social support.

      Old-age security and livelihood strategies

      To be able to assess, act on and prevent problems with care for older persons, it is useful to have indicators for old-age security. Old-age security is defined as the relative state of security of older persons, which refers to their food security, health security, physical security, economic security and emotional security. We are interested in how secure older persons feel and what factors influence this security. Hence, the third research question was formulated as follows:

    5. What factors affect old-age security?
    6. Chapter 11 describes how we developed the old-age security scale, as an indicator of the older person's subjective feelings of security. We hypothesised that older women, female widows and the oldest persons will be more vulnerable to insecurity, but this was not confirmed. Gender, age or marital status have no effect on perceived old-age security. We also hypothesised that older persons will be less secure in Giriwungu than in Kebonagung. However, we found that it was just the other way around. This study shows that economic factors are less important than social factors for feelings of security of older persons. The main indicators proved to be the ability to perform the (instrumental) activities of daily life (IADL) and health. Besides, the economic asset of farmland acreage is a determinant of perceived old-age security.

      We assume that persons have strategies to provide for a secure and quiet old age. A livelihood strategy is defined as the ability to maintain and improve (old age) security while maintaining or enhancing the assets and resources on which households depend. The fourth research question was formulated as follows:

    7. What livelihood strategies secure old age?
    8. Chapter 11 describes the strategies of care arrangement, remarriage, moving house, support mobilisation and delayed property transfer. The care arrangement strategy of having many children to provide for a secure old age seems to have an effect on the perceived old-age security. However, the effect cannot be explained by the coresidence of the children. The effect can partly be explained by the care received for personal activities of daily life, which is usually provided within the elderly household or by non-coresiding children. We could not demonstrate the existence of a strategy of remarriage, house move or delayed property transfer. The strategy of mobilising monetary support or support in kind has no effect on perceived old-age security. Only the mobilisation of material support from other kin, and talks with non-coresiding children or neighbours/friends have an effect. These indicators seem more important than several objective indicators for the perceived old-age security. Older persons feel more secure when they live with an adult child, who can take care of them personally within the household and when they can talk frequently to children who live outside the household.

      Effects of social change

      It is assumed that care arrangements and support relations change under the influence of social change. When care arrangements and support relations of older persons change, this will affect the old-age security. As discussed in Chapter 2, social change is defined as a complex of interrelated natural, cultural, societal and individual transitions. Of all processes of social change, we assume that migration and longevity will have a major impact on familial elder care in rural areas. When young persons leave the village to seek work and a livelihood in a city, older persons stay behind without children who traditionally provided care in old age. When older persons live longer, they will generally need more care in the final stage of their lives. The last research question was, therefore, phrased as follows:

    9. How do processes of social change affect elder care and old-age security?

To investigate the effects of social change older persons' lives, elder care and old-age security, a comparative element was included in the study design by the selection of two villages. The village of Kebonagung with low or no out-migration is more prosperous, but still has its main employment in agriculture along with other paid jobs. The village of Giriwungu with high emigration is poor and, because of its less fertile soils, has limited agricultural possibilities. We assumed that the impact of social change would be most noticeable in Giriwungu. Hence, we assumed that in Giriwungu the lives of older persons would be more negatively affected, older persons would be without traditional care providers and less secure in old age. However, the following results do not support the assumption that Giriwungu is the village experiencing a higher rate of emigration of younger persons than Kebonagung. In Kebonagung, older persons have smaller households, more often live alone, have no coresiding children and less often have a child living in the same village.

In Giriwungu more older persons are still working. They are usually farmer, who gradually reduce their activities without having to stop working. In Kebonagung the activities of older persons are more evenly distributed between farm and other work. In Giriwungu elderly households cultivate a larger variation of crops and have more different types of livestock. In Kebonagung people have specialised in wet-rice cultivation and there are more landless people. Landless people who are dependent on cash income are more at risk when they become older and can no longer earn an income and provide for their own subsistence. In Giriwungu elderly households appear to invest more in agricultural stores of value, such as livestock and hardwood trees. In Kebonagung elderly households appear to invest in household items and housing quality. Although the household income in cash and in kind in Giriwungu is about half that of Kebonagung, farmland ownership (corrected for irrigation facilities) in Giriwungu is five times that of Kebonagung. Cassava is an important crop in Giriwungu. Although it has low monetary value, it is a buffer crop that is kept in the field and can always be eaten, which makes people in Giriwungu more food secure.

We hypothesised that older persons would feel more secure in Kebonagung, because their children would not need to leave the village and, therefore, could still take care of their parents. Our hypothesis was mainly based on economic assumptions. However, contrary to our hypothesis, older persons in Giriwungu feel more secure because they live with at least one child, have children living in the same village and own more farmland. These factors are more important to the perceived old-age security than the negative factors of having a poor IADL capacity, more often needing IADL support and having to work hard as a farmer. These effects could not be ascribed to the impact of social change.

A theoretical framework ofelder care

The theoretical framework of this study is based on concepts known in literature, in particular Tronto's theory of care (1993). The theory starts from a broad definition of care: "On the most general level, we suggest that caring be viewed as a species activity that includes everything that we do to maintain, continue, and repair our 'world' so that we can live in it as well as possible . That world includes our bodies, our selves, and our environment, all of which we seek to interweave in a complex, life-sustaining web". Tronto distinguishes four analytically separate, but interconnected, phases in the caring process. These are caring about, taking care of, care-giving and care-receiving. These concepts are all verbs, to emphasise that care is an activity, a social practice. Tronto insists that the activity of caring is largely defined culturally, and will vary among different cultures.

To enable the assessment of Tronto's theory of care in Indonesia and to study the issues of care in the field, we developed an analytical framework that consists of the older person's individual attributes, care arrangements, support relations, old-age security and livelihood strategies. The specific caring activities are operationalised by the personal activities of daily life (ADL), instrumental activities of daily life (IADL), monetary support, material support, emotional support and social support. These concepts of care activities are not culturally specific and therefore, applicable in any country. However, what is involved in the activity of caring, for example in instrumental care, has to be investigated empirically. The individual attributes affect old-age security directly and indirectly through the livelihood strategies that an older person has. Investing in relationships and building up care arrangements is a life-long practice, which will result in the provision of 'good care' and a secure old age. As such, it is a strategy that will enhance the chances of enjoying a supported old age.

Het effect van vitamine E en multivitamine-mineralen op acute luchtweginfecties bij ouderen
Graat, J.M. - \ 2002
Infectieziekten bulletin 13 (2002)9. - ISSN 0925-711X - p. 348 - 353.
ademhalingsziekten - vitaminen - vitamine e - ouderen - vitaminetoevoegingen - respiratory diseases - vitamins - vitamin e - elderly - vitamin supplements
Improved immune response in elderly individuals after micronutrient supplementation has been reported. However, efficacy trials with infectious disease as outcome are scarce and inconclusive. The author investigated the effect of multivitamins-minerals and vitamin E on the incidence and severity of acute respiratory infections in elderly individuals
The twisting force of aged consumers when opening a jar
Voorbij, A.I.M. ; Steenbekkers, L.P.A. - \ 2002
Applied Ergonomics 33 (2002). - ISSN 0003-6870 - p. 105 - 109.
stopflessen - consumenten - ouderen - ergonomie - producten - innovaties - verpakkingen - verpakkingsmaterialen - jars - consumers - elderly - ergonomics - products - innovations - wrappings - packaging materials
Many people experience difficulty when opening a vacuum-sealed jar. Yet solutions to the problem continue to be tool-based rather than exploring the possibility of innovative changes in product packaging. Improvements depends on gaining knowledge of the capabilities of users, and of using that knowledge as a base for product innovation
The composition of a graph on the decline of total body strength with age based on pushing, pulling, twisting and gripping force
Voorbij, A.I.M. ; Steenbekkers, L.P.A. - \ 2001
Applied Ergonomics 32 (2001)3. - ISSN 0003-6870 - p. 287 - 292.
ergonomie - ouderen - sterkte - krachten - verouderen - ergonomics - elderly - strength - forces - aging - men
This study is part of a large project on design-relevant characteristics of ageing users. A total of 750 young and elderly, male and female subjects were tested. All subjects were able to live independently. Differences between the sexes were mapped as well as changes in force with age. The relationships between five different isometric forces (pushing, pulling, twisting and left and right gripping) were investigated. The possibilities of extending information on these forces to other forces and other subject groups were also studied. The results indicate that the different types of force are closely related. A strength score was devised. We conclude that calculation of unmeasured forces by means of a general strength score could be possible. Furthermore, we found that the percentage decrease in strength with age is similar for men and women. (C) 2001 Elsevier Science Ltd. All rights reserved.
Elder care and intergenerational relationships in rural Yogyakarta, Indonesia
Keasberry, I.N. - \ 2001
Ageing and Society 21 (2001)5. - ISSN 0144-686X - p. 641 - 665.
ouderen - zorg voor ouders - plattelandsgemeenschappen - ouder-kind relaties - generaties - netwerken voor persoonlijke ondersteuning - sociale verandering - indonesië - zorg - sociale zorg - leefvormen - elderly - parent care - rural communities - parent child relationships - generations - personal support networks - social change - indonesia - care - social care - living arrangements
In Indonesia, as in most other societies, intergenerational relationships are considered most important for elder care. Children are expected to take care of their elderly parents. However, processes of social change such as industrialisation, urbanisation and migration can have a negative impact on care for elderly people, particularly in rural areas. This paper addresses the issue of the living and care arrangements of older people and possible changes therein. A number of hypotheses and research questions pertaining to this issue are discussed. An Elderly Household Survey was carried out among people aged 55 years and older in two different villages in the Special Region of Yogyakarta. The data concern the living and care arrangements according to the respondent’s sex, age and village. The principle finding is that most older people still live with at least one child or with other kin, or have at least one child living in the same village. Hence, they still have a potential care provider in their immediate vicinity. The situation, however, especially of women aged over 75 years, seems to be problematic.
Dietary quality, lifestile factors and healthy ageing in Europe
Haveman-Nies, A. - \ 2001
Wageningen University. Promotor(en): W.A. van Staveren; C.P.G.M. de Groot. - S.l. : S.n. - ISBN 9789058085344 - 127
dieetonderzoeken - levensstijl - ouderenvoeding - verouderen - ouderdom - mortaliteit - europa - nederland - diëten - ouderen - dietary surveys - diets - elderly - lifestyle - elderly nutrition - aging - old age - mortality - europe - netherlands

Keywords: dietary quality, dietary patterns, lifestyle factors, smoking, physical activity, elderly, mortality, Mediterranean Diet Score, Healthy Diet Indicator, healthy ageing, self-rated health, functional status

The contribution of diet and lifestyle factors to healthy ageing was investigated in European elderly, born between 1913 and 1918, of the SENECA study. First, the Mediterranean Diet Score (MDS), Healthy Diet Indicator (HDI), and cluster analysis were validated as measures of quality of dietary patterns in the SENECA study as well as the Framingham study. Cluster analysis, MDS, and HDI showed strong similarities in the classification of persons into dietary quality groups. High-quality diets were associated with nutritional status and health-related indicators. It is concluded that dietary quality can be assessed using diet scores as well as cluster analysis, the approaches being complementary.

The relationships of the three lifestyle factors diet, physical activity, and smoking habits to survival and maintenance of health at old age were investigated, using Cox's proportional hazards analysis and logistic regression. Single unhealthy lifestyle behaviours were related to an increased mortality risk. For men, the mortality risk for a low-quality diet was 1.2 (95 percent confidence interval (CI): 0.9, 1.7), for inactivity 1.4 (95% CI: 1.1, 1.7), and for smoking 2.1 (95% CI: 1.6, 2.6). For women, the mortality risk for smoking was 1.8 (95% CI: 1.1, 2.7), for inactivity 1.8 (95% CI: 1.3, 2.4), and for a low-quality diet 1.3 (95% CI: 0.9, 1.8). The risk of death was increased for all combinations of two unhealthy lifestyle behaviours. Men and women with three unhealthy lifestyle behaviours had a three to four-fold increase in mortality risk. Self-rated health and functional status both declined in men and women with healthy and unhealthy lifestyle habits over a 10-year follow-up period, but the deterioration in health was delayed by the healthy lifestyle behaviours, non-smoking and physical activity. Inactive men had a 2.8 (90% CI: 1.3, 6.2) times increased risk for a decline in self-rated health and a 1.9 (90% CI: 0.9, 3.9) times increased risk to become dependent. Smoking men had a two-fold increased risk (90% CI: 1.0, 4.1) for a decline in self-rated health and a 2.2 (90% CI: 1.1, 4.5) times increased risk to become dependent. In women, inactivity was related to a 2.6 (90%CI: 1.4, 4.9) times increased risk to become dependent.

In conclusion, a lifestyle characterised by non-smoking, physical activity and a high-quality diet contributes to healthy ageing. A healthy lifestyle at older ages is positively related to a reduced mortality risk and to a delay in the deterioration in health status. This postponement of the onset of major morbidity is likely to go together with a compressed cumulative morbidity. It is concluded that health promotion at older ages can contribute to healthy ageing.

Zorg; wie doet er wat aan : een studie naar zorgarrangementen van ouderen
Luijkx, K.G. - \ 2001
Wageningen University. Promotor(en): A. Niehof; C. de Hoog. - S.l. : S.n. - ISBN 9789058084064 - 250
ouderen - ouderdom - mensen - thuiszorg - gezondheidszorg - sociaal welzijn - nederland - platteland - elderly - old age - people - home care - health care - social welfare - rural areas - netherlands

As a result of fertility decline and increasing life expectancy, the age structure of the Dutch population is changing, with a larger proportion and number of elderly persons and declining proportions and numbers of younger adults. Hence, the number of people in need of care is growing. While -at the same time- the number of people that can provide care declines and numerous independently living elderly are on waiting lists for professional care. Concerns about care for the elderly in the future prompted us to do research about the topic of care for independently living elderly. Given the rural orientation of Wageningen University the research was focused on rural elderly. The age groups included were persons aged 75 years and older. The following research questions were formulated:

What is the picture of instrumental and social-emotional care for rural elderly, who still live independently and are aged 75 and older? Which characteristics of the elderly and which of the informal care givers influence the care that elderly receive? Which problems in the care of the elderly can arise in the future and how could these be solved?

Data collection for this research proceeded in two stages. First, qualitative research was done to gain insight into the care for the elderly. Eleven elderly people and six informal carers ( mantelzorgsters ) were interviewed. In consequence of the qualitative research, the instrumental-care situation, the instrumental-care arrangement and the social-emotional-care arrangement were defined and hypotheses for the quantitative research were specified. For the quantitative research, the second stage of data collection, a survey was done among a random sample of people aged 75 years and over, stratified according to sex and marital status, living in seven rural municipalities in the Netherlands. We were able to analyse the cases of 465 elderly (response rate of 62,6%). Besides, interviews were conducted with 235 carers who give informal care to elderly persons from the sample. Below we will report about the main findings of the research.

The instrumental-care situation

The instrumental-care situation pictures the degree to which the elderly receive instrumental care from people beyond the own household. Elderly people in self-caring households care for themselves and in households consisting of more than one person for each other. Elderly people in cared-for households receive much care of people who are no household members. They themselves cannot do much. In between are elderly persons in households that just can manage ( redzaam ). These elderly care largely for themselves, but in addition receive substantial care from people beyond their own household. They receive more instrumental care than self-caring elderly and less than cared-for elderly. In the quantitative sample 27,5% of the people aged 75 years and over can be called self-caring, 50,1% managing and 22,4% cared-for.

The quantitative research shows that the instrumental-care situation is significantly related to the variables of household composition, age and health indicators of the elderly. Elderly who live alone and older elderly receive more instrumental care from people who are no household member than elderly who share their household with someone else and younger elderly. At first sight the instrumental-care situation is not influenced by the sex of the elderly person. However, the female elderly in the sample are less healthy than the male elderly. Thus, for a comparison we have to control for health status. When women and men with a comparable health situation are compared, we can see that women receive less instrumental care than men. Besides, elderly who are less mobile receive more care than elderly who are more mobile.

These results enable us to put the instrumental-care situation in a live course perspective. When people become older their health tends to decline. Thus, the three types of the instrumental-care situation can be seen as phases in the life course.

Characteristics of informal carers are no predicting factors for the instrumental-care situation of elderly. When people give informal care it does not seem to matter whether they are woman or man and whether they are family or not. Furthermore, the quality of the relationship does not influence the amount of instrumental care elderly receive. The qualitative research has shown that children give informal care even when they experience the relationship with their parents not very positively. The obligations attached to kinship relations seem to be more important than the quality of the relationship.

The instrumental-care arrangement

The instrumental-care arrangement pictures the proportion of informal carers and professional carers in the care elderly receive. We defined the instrumental-care arrangement only for the elderly that just can manage. In comparison with the sample, the degree to which these elderly receive instrumental care varies less. The qualitative research shows that elderly who receive predominantly informal care refer to this care in terms of self-care. This way they emphasise that the care they receive from their daughter or son is closely to them. Elderly who receive predominantly formal care emphasis their feeling of independence in the care relationship. From a professional care giver they receive care, pay for it and do not further have a relationship with her. Because of this elderly experience this care, in comparison with informal care, less as a threat to their independence.

Managing elderly with an informal safety net receive only or predominantly instrumental care of informal carers. Managing elderly with a formal safety net receive only or predominantly formal (professional) care. In the quantitative sample 36,0% of the managing elderly can be called managing with a informal safety net (18,0% of the sample) and 64,0% managing with a formal safety net (32,1% of the sample). The care they receive is diverse. Managing elderly with a formal safety net almost all are supported with the heavy tasks in the household such as vacuum cleaning and cleaning the windows. In comparison with the care managing elderly with an informal safety net, they receive fixed care. The care for elderly people with an informal safety net is more diverse and seems to be more adjusted to their individual needs and wishes.

The quantitative research shows that the instrumental-care arrangement is significantly related to the normative values and characteristics of the social network of the elderly. Elderly who believe that children (in-law) ought to give informal care and elderly who think traditionally about sex roles have more often an informal safety net than elderly who have other normative values about these topics. Furthermore, elderly who have a social network that consist for more than half of children, elderly who have more children and elderly who have more children without paid employment receive more often predominantly informal care than elderly for whom this is not true.

Characteristics that can not be influenced by the elderly such as their sex, their age and their health do not influence significantly the instrumental-care arrangement. This enables us to conclude that elderly choose for either informal or formal care.

Like the instrumental-care situation, the instrumental-care arrangement is not predicted by characteristics of informal carers. These results also show that when people give informal care it does not matter whether they are woman or man and whether they are family or not. Furthermore, the instrumental-care arrangement is not significantly related to reciprocity. The qualitative research has shown that material reciprocity is important to informal carers because they experience it as an expression of appreciation. Especially the meaning and intention of material reciprocity seems to be important.

The social-emotional-care arrangement

The social-emotional-care arrangement pictures the degree to which the elderly receive social-emotional care and the proportion of kin and non-kin in this care process. Self-oriented elderly receive hardly any social-emotional care from people beyond the own household. Family-oriented elderly receive this type of care predominantly from family members who do not live in their household. They share the joyful and the more serious parts of social-emotional care with their children and other family members. Community-oriented elderly receive social-emotional care predominantly from non-kin. In comparison with the care for family-oriented elderly, the care for community-oriented elderly is more focused on the joyful parts. In the quantitative sample 19,6% of the elderly people can be called self-oriented, 36,3% family-oriented and 44,1% community-oriented.

The quantitative research shows that the social-emotional-care arrangement is significantly related to several variables. Elderly women are more often family-oriented and elderly men are more often community-oriented. Also elderly whose social network consists for more than half of family members and elderly who have more children are more often family-oriented than elderly for whom this is not the case. Furthermore, health indicators are related to the social-emotional-care arrangement. Elderly who use more technical aids and elderly who cannot drive a car are more often family-oriented than elderly who use less technical aids and elderly who can drive a car.

In contrast with instrumental care, characteristics of informal carers predict the social-emotional care elderly receive from people beyond the own household. Informal carers who say that the elderly appreciate the given care and informal carers who talk about their own problems with the elderly have more often a relationship with a community-oriented elderly than informal carers who do not experience immaterial reciprocity. Furthermore, informal carers who experience the care giving as a burden have more often a relationship with a family-oriented elderly than informal carers who do not experience it as a burden.

Looking at the predicting factors for social-emotional care, we see that this care diverts from instrumental care. Social-emotional care is significantly related to the sex, the number of children and the health situation of the elderly, but also to characteristics of informal carers, such as immaterial reciprocity and the experienced burden. Furthermore, the results show that the relationships with family-oriented elderly are more experienced as relationships containing obligations than the relationships with community-oriented elderly. In comparison to community-oriented elderly, family-oriented elderly seem to have less to offer to their informal carers. They are in poorer health and give less social-emotional care to their informal carers. Because of their better health, community-oriented elderly are much more able to visit other people and seem to give more social-emotional care to others.


Our research shows that family members are an important source of care for the elderly. When they provide instrumental care, this care is more adjusted to the individual needs and wishes of the elderly people than the care provided by formal (professional) carers. When they provide social-emotional care, this care also includes the more serious aspects of this care. Furthermore, our data show that the quality of the relationship is not significantly related to the care that informal carers provide. The qualitative research has shown that children care for their parents even when they experience the relationship with them as not very positively.

Prospective studies on diet and coronary heart disease : the role of fatty acids, B-vitamins and arginine
Oomen, C.M. - \ 2001
Wageningen University. Promotor(en): D. Kromhout; F.J. Kok; E.J.M. Feskens. - S.l. : S.n. - ISBN 9789058084484 - 164
hartziekten - vetzuren - diëten - vitamine b complex - ouderen - arginine - nederland - heart diseases - fatty acids - diets - vitamin b complex - elderly - arginine - netherlands

In this thesis, the results of prospective studies on fatty acids, B-vitamins and arginine and the occurrence of coronary heart disease have been described. The results presented are mainly based on the Zutphen Elderly Study. In this study of 939 men aged 64-84 years, detailed information was available on dietary intake, biological risk factors, incidence of major chronic diseases, vital status and causes of death between 1985 and 1995. In addition, data of 5 cohorts from Finland, Italy and the Netherlands, and of all 16 cohorts of the Seven Countries Study were used to investigate specific hypotheses on diet-heart relations in an international setting.

Using repeatedly collected data of serum cholesterol, dietary and lifestyle factors in the Zutphen Elderly Study, we observed that changes in intake of saturated fat, polyunsaturated fat, dietary cholesterol and alcohol, and changes in weight were significantly related to changes in total and/or HDL cholesterol concentrations. The strengths of the observed associations are comparable to those obtained in experimental studies performed in younger populations. This indicates that public health strategies on dietary interventions and weight reduction in order to improve cholesterol concentrations are relevant also at old age.

The average trans fatty acid intake decreased 2.4% of energy in the Zutphen Elderly Study between 1985 and 1995, mainly due to industrial lowering of the trans fatty acid content in edible fats. Such a decrease in trans fatty acids intake is compatible with a 23% reduction in risk of coronary heart disease. Changes in food composition with respect to the trans fatty acid content are therefore important from a public health perspective.

Using the Finnish, Italian and Dutch data of the Seven Countries study, fatty fish consumption was estimated to reduce the relative risk of coronary heart disease mortality with 34%. For total or lean fish consumption no effect was observed. People at risk for coronary heart disease are therefore advised to eat fish, preferably fatty fish at least once a week, to reduce their risk for coronary heart disease.

We did not find evidence for a protective effect of intake ofα-linolenic acid on coronary heart disease incidence in the Zutphen Elderly Study. However, the strong association between the intake ofα-linolenic acid and trans fatty acids complicated studying this relationship. Of the B-vitamins, only the intake of folate and vitamin B6 were independently inversely associated with homocysteine in the Zutphen Elderly Study. In this cohort, intake of different B-vitamins did not protect against coronary heart disease, although there is a suggestion for a protective effect of vitamin B2. Arginine intake was not associated with the risk of coronary heart disease mortality, neither in the Seven Countries Study, nor in the Zutphen Elderly Study. Results of prospective and intervention studies are needed before definite statements can be made about the potential protective effect on coronary heart disease of B-vitamins, arginine andα-linolenic acid.

Vitamin E supplementation and atherosclerosis : epidemiological studies in elderly and smokers
Waart, F. de - \ 2000
Agricultural University. Promotor(en): F.J. Kok; A.F.H. Stalenhoef; H. Wollersheim. - S.l. : S.n. - ISBN 9789058081742 - 144
vitamine e - voedselsupplementen - atherosclerose - epidemiologische onderzoeken - ouderen - tabak roken - vitamin e - food supplements - atherosclerosis - epidemiological surveys - elderly - tobacco smoking

The antioxidant vitamin E may have beneficial effects on several indicators of human health. We studied the impact on atherosclerosis, immune response and total mortality in smokers and elderly people, who are at risk for increased oxidative stress. Vitamin E may exert its effect on atherosclerosis by protecting low density lipoprotein (LDL) against lipid peroxidation. Moreover, lipid peroxidation may also negatively influence the immune response. In addition to its antioxidant function, vitamin E may be beneficial through effects on cellular function, e.g., by preserving endothelium-dependent vaso-relaxation or decreasing cytokine production.

Observational studies . In a cross-sectional study among 158 male lifelong smokers aged 50 to 75 years, adjusted vitamin E intake and plasma levels were not associated with intima media wall thickness (IMT) of the common carotid artery. IMT ,which is a marker for atherosclerosis, was measured non-invasively by using the B-mode ultrasound technique. In a prospective study among 638 independently living elderly aged 65 to 85, no significant association was observed between cholesterol adjusted serum levels of vitamin E and 7.2 years total mortality. (Hazard ratio for lowest tertile vs. highest of 1.11, 95% confidence interval 0.74 to 1.65).

Intervention trials. In a randomized placebo-controlled double-blind trial among 218 lifelong male smokers, 400 IU (364 mg) vitamin E was administered daily for two years. A non significant (p=0.34) reduced progression of carotid IMT by 47% was observed compared to a significant spontaneous progression in the placebo group of 0.030 mm (p=0.006). Results were adjusted for initial IMT values and traditional CVD risk factors. Vitamin E significantly reduced the in vitro susceptibility of LDL to oxidation, which was not related to progression.

In this trial results were stratified by genetic predisposition. Smokers lacking the detoxifying enzyme activity of glutathion S -transferase µ (genotype GSTM1- 0 ) were compared with those with the positive genotype (GSTM1- 1 ). In the GSTM1- 0 group vitamin E reduced the proportion of smokers with increased carotid IMT by 62% (p=0.06) for the left posterior and by 73% (p=0.01) for the left anterior wall. No effects were observed for the IMT at the right side.

In a 3-month randomized double-blind placebo-controlled trial among 83 apparently healthy elderly, aged 67-87 years, 100 mg vitamin E supplementation significantly decreased the percentage of oxidized linoleic acid in LDL (10.4%) compared to the placebo group (4.6%). In this trial vitamin E supplementation did not affect the cellular and humoral immune response.

In conclusion , no supportive evidence is provided that vitamin E supplementation has beneficial effects on atherosclerosis and immune response among smokers and elderly. The observations for GSTM1- 0 genotype needs further confirmation. The protective effect of vitamin E on LDL oxidation in vitro lacks validation in vivo. Research on biomarkers of lipid oxidation and arterial damage needs priority to more adequately assess the clinical relevance and optimal intake of vitamin E.

Clearance of emergency exits for use by the elderly, a proposal for an addition to a Dutch standard
Voorbij, A.I.M. ; Steenbekkers, L.P.A. ; Snijders, C.J. - \ 1999
International journal for consumer and product safety 6 (1999)4. - ISSN 1387-3059 - p. 171 - 182.
veiligheid - normen - veiligheidsinrichtingen - noodgevallen - ouderen - ergonomie - krachten - safety - standards - safety devices - emergencies - elderly - ergonomics - forces
The maximum pulling and pushing forces of a sample of 750 persons between 20 and 30 and over 50 years of age are presented. Both forces were measured in a free standing position that was related to opening a heavy door, which makes it possible to use the information in a standard on emergency exits. An addition is proposed to NEN 6082:1997 concerning human abilities to open unfastened, hinged doors that are on an escape route
Design-relevant ergonomic data on Dutch elderly
Steenbekkers, L.P.A. ; Beijsterveldt, C.E.M. van; Dirken, J.M. ; Houtkamp, J.J. ; Molenbroek, J.F.M. ; Voorbij, A.I.M. - \ 1999
International journal for consumer and product safety 6 (1999)3. - ISSN 1387-3059 - p. 99 - 115.
ergonomie - ouderen - productontwikkeling - verouderen - nederland - ergonomics - elderly - product development - aging - netherlands
Aims of this study were to describe and quantify physical, psychomotor, sensory and cognitive capacities of elderly (according to age group and sex) that are relevant to the design of durable daily-life products, and to derive design guidelines from these data
Using home-grown food is associated with higher nutrient intake in elderly people across Europe
Pearson, J.M. ; Schlettwein-Gsell, D. ; Groot, C.P.G.M. de; Staveren, W. van - \ 1999
Journal of consumer studies and home economics 23 (1999)1. - ISSN 0309-3891 - p. 27 - 35.
voeding - ouderenvoeding - voedingsstoffenopname (mens en dier) - voedingstoestand - ouderen - voedselconsumptie - consumptiepatronen - europa - welzijn - nutrition - elderly nutrition - nutrient intake - nutritional state - elderly - food consumption - consumption patterns - europe - well-being
Focus of this further analysis of the SENECA (Survey in Europe on Nutrition and the Elderly, a Concerted Action) baseline data was to determine whether significant differences exist between those who used home-grown foods and those who did not, and to determine the impact of a series of sociodemographic measures on the use of home-grown foods, self-assessed quality of life and activity level, and levels of nutriture
De bijdrage van tussendoortjes aan de dagelijkse vitaminen- en mineraleninneming van Culemborgse ouderen
Haveman-Nies, A. ; Groot, C.P.G.M. de; Staveren, W.A. van - \ 1999
Tijdschrift voor Gezondheidswetenschappen 77 (1999)4. - ISSN 1388-7491 - p. 235 - 241.
snacks - voedselconsumptie - eetpatronen - consumptiepatronen - maaltijdpatronen - voedingsstoffenopname (mens en dier) - vitaminen - mineralen - ouderen - nederland - food consumption - eating patterns - consumption patterns - meal patterns - nutrient intake - vitamins - minerals - elderly - netherlands
Sensible aging : nutrient dense foods and physical exercise for the vulnerable elderly
Jong, N. de - \ 1999
Agricultural University. Promotor(en): W.A. van Staveren; F.J. Kok; C.P.G.M. de Groot. - S.l. : S.n. - ISBN 9789058081247 - 191
voedingsprogramma's - ouderen - lichamelijke activiteit - nederland - nutrition programmes - elderly - physical activity - netherlands

As a consequence of present western health policy, an increasing number of elderly people live in the community. A particularly vulnerable group among the total elderly population are the so-called 'frail elderly' who have a reduced physiologic reserve and are classified at risk. Increasing knowledge about their nutritional and health status is necessary, as well as the investigation of results of feasible interventions, aiming at keeping the frail as healthy and strong as possible in their own surroundings.

The core of this thesis describes the results of a 17-week randomized placebo controlled intervention trial in frail elders (n=161). The effects of nutrient dense foods (enriched with 25-100% of the Dutch RDA of multiple vitamins and minerals) vs regular foods, and an all-round exercise program vs a social program on indicators of the nutritional and health status have been investigated. Indicators such as sensory performance, appetite, dietary intake, body composition, blood nutrient and functional biochemical health indices were examined. Additionally, the nutrient dense foods were evaluated on hedonic aspects.

After 17 weeks of intervention, subjects receiving nutrient dense foods significantly increased their blood vitamin levels (p<0.001) and decreased their homocysteine level (25%, p<0.001). The latter may indicate the existence of a subclinical nutrient deficiency. The results also suggest beneficial effects on bone mass and density for those consuming enriched foods, compared to controls, although this should be confirmed by future studies. Exercise preserved lean body mass compared to non-exercisers (0.5 kg, p<0.02). This was partly related to maintenance of energy intake.

In conclusion, application of physiologically dosed micronutrient enriched foods aimed at improving the density of the frail elderly diet, may have beneficial effects on the nutritional and health status and could be part of a feasible public health program. Exercise may have a complementary effect. Longer term research is needed to investigate the maintenance of functional biochemical health indices and quality of life.

ISBN 90-5808-124-9

Aging in balance : physical exercise and nutrient dense foods for the vulnerable elderly
Chin A Paw, M. - \ 1999
Agricultural University. Promotor(en): F.J. Kok; W.A. van Staveren; E.G. Schouten. - S.l. : s.n. - ISBN 9789058081254 - 176
lichamelijke activiteit - ouderen - voedingsprogramma's - nederland - physical activity - elderly - nutrition programmes - netherlands

The main goal of prevention and health care for elderly people is optimizing 'quality of life'. Frail older persons have limited reserves and are therefore at an increased risk of a decline in health, which may lead to dependency and disability. This thesis focuses on the health-related effects of physical exercise and nutrient dense foods among non-institutionalized frail older people. First, criteria for identification of frailty were investigated using prospective cohort data. It was concluded that physical inactivity in combination with weight loss seems a practical and inexpensive screening criterion to identify functionally vulnerable persons among non-institutionalized elderly. Second, the results of a 17-weeks randomized controlled trial on a specific exercise and nutritional program in 217 frail, independently-living elderly (aged 67-96) are presented.

The exercise program proved of benefit for functional status and immune response. Performance on 7 functional tests had significantly improved (+8%) in trained compared to non-trained subjects (-8%). The beneficial effect on the sum score of 7 fitness tests was also significant but smaller. Cellular immune response was measured by the delayed-type hypersensitivity skin test response against 7 recall antigens. The number of positive responses declined in non-exercising subjects (-26%) compared to an unchanged responsiveness among exercising subjects. Effects on self-rated disabilities, psychological well-being and self-rated health could not be demonstrated. Seventeen weeks of consumption of micronutrient enriched foods at physiological doses (25-100% of the RDA) did not affect functional status, cellular immune response or psychological well-being.

In conclusion, exercise programs can be developed which are effective in preventing, slowing down or reversing the age-related decline in physical functioning and cellular immune response. Moreover, subjects highly appreciated the exercise program and the majority favored continuing program participation.


Gerontotechnologie aan de Technische Universiteit Delft.
Steenbekkers, L.P.A. ; Beijsterveldt, C.E.M. van; Dirken, J.M. ; Houtkamp, J.J. ; Molenbroek, J.F.M. ; Voorbij, A.I.M. - \ 1998
Tijdschrift voor Ergonomie 23 (1998)4. - ISSN 0921-4348 - p. 98 - 105.
ergonomie - aangepaste technologie - huishoudelijke uitrusting - ouderen - fysische eigenschappen - mentale vaardigheid - nederland - ergonomics - appropriate technology - household equipment - elderly - physical properties - mental ability - netherlands
Omdat voor het ontwerpen van dagelijkse gebruiksgoederen gegevens nodig zijn over capaciteiten en karakteristieken van toekomstige gebruikers, zijn 79 fysieke, psychomotorische, sensorische en cognitieve variabelen gemeten bij 627 Nederlanders tussen 50 en 94 jaar
Als alledaagse handelingen voor ouderen een struikelblok worden: gebruikersfactoren of ontwerptekortkomingen?
Hoonhout, H.C.M. ; Steenbekkers, L.P.A. - \ 1998
Tijdschrift voor Ergonomie 23 (1998). - ISSN 0921-4348 - p. 106 - 116.
dagelijkse vaardigheden - ergonomie - ouderen - productontwikkeling - nederland - daily living skills - ergonomics - elderly - product development - netherlands
Aan de hand van resultaten van het Delftse Gerontotechnologie-project worden de problemen waarmee ouderen bij dagelijkse activiteiten geconfronteerd worden geanalyseerd
Dietary patterns and health in the elderly : a north - south comparison in Europe
Huijbregts, P.P.C.W. - \ 1997
Agricultural University. Promotor(en): D. Kromhout; E.J.M. Feskens. - S.l. : Huijbregts - ISBN 9789054856436 - 141
voedselhygiëne - voedingstoestand - consumptiepatronen - gezondheid - bevolking - ouderen - ouderdom - europa - food hygiene - nutritional state - consumption patterns - health - human population - elderly - old age - europe

The aim of this thesis was to gain more insight into the role of dietary intake as a determinant of different aspects of health, e.g. cognitive function, functional status, self-rated health and mortality. Dietary patterns, obtained from cluster analysis or a healthy diet indicator (HDI), were used instead of single nutrients to investigate these associations. The results are based on different datasets. The largest part was performed in five population-based samples from three European countries participating in the Seven Countries Study: East and West Finland, Zutphen in The Netherlands, and Crevalcore and Montegiorgio in Italy. Around 1970, this dataset consisted of more than 3000 men aged 50-69 years. Around 1990 more than 1000 of the men aged 70-89 years participated in the follow-up. Another dataset used, comprised the information of 272 men and women aged 64-87 years in 1971, from a general practice in Rotterdam, The Netherlands.

The first part of the thesis concerned the use and the comparison of cluster analysis and the healthy diet indicator. Using cluster analysis, groups with different dietary patterns can be discerned, which have different profiles of risk factors for cardiovascular diseases. Furthermore, an association was observed with 17-year all-cause mortality among men. The HDI, a score which is based on uniform cut-off values derived from recommendations of a WHO study group, appeared to be less dependent from the dataset under study. It was also associated with 17-year all-cause mortality in men but not in women.

The remaining part of the thesis concerned the associations of dietary intake with several determinants of health status at old age in the combined datasets of Finland, Italy, and The Netherlands. Cross- sectional analysis of the dietary intake at old age (collected around 1990) indicated that the general patterns of dietary intake of the different cultures could still be recognised. A retrospective comparison with the dietary intake at middle age (around 1970) lead to the conclusion that since then, the dietary pattern of the Finnish and Dutch cohorts had changed slightly into the direction of a more healthy diet, e.g. less atherogenic, while the diet of the Italian men had remained Mediterranean. A healthy diet, as calculated by the HDI, was associated with a reduced 20-year allcause and cardiovascular mortality in the three different cultures. Furthermore, there was a tendency towards a better cognitive function among the elderly men with a better HDI in four out of five cohorts. Physical disabilities were accompanied by lower energy intake in elderly men in all three countries. This association was largely, but not completely, due to a lower physical activity. Self-rated health seemed to be a very culture dependent variable, since more than 80% of the elderly men in Finland felt moderately or not healthy, while this was only 20% and 10% in Italy and The Netherlands respectively. Only in Italy, a low self-rated health was associated with a lower energy intake. Since the studies on cognitive funtion, physical disabilities and self-rated health were designed crosssectional it cannot be decided whether the observed associations were causal or not.

In conclusion, the studies presented in this thesis underline the importance of dietary intake in the maintenance of health at old age (e.g. mortality, cognitive function, functional status, self-rated health). Instead of calculating the associations of several health outcomes with single nutrients, a dietary pattern approach was used. The results of this international study on diet and health suggests that a healthy dietary pattern might have a beneficial effect on health status, but longitudinal studies are needed to confirm this assumption.

Regular physical activity in old age : effect on coronary heart disease risk factors and well-being
Schuit, A.J. - \ 1997
Agricultural University. Promotor(en): F.J. Kok; E.G. Schouten. - S.l. : Schuit - ISBN 9789054857112 - 163
gezondheidszorg - medische voorzieningen - sociale voorzieningen - therapie - sport - voedselhygiëne - voedingstoestand - consumptiepatronen - vaatziekten - bloedstoornissen - hart- en vaatziekten - hart- en vaatstoornissen - ouderen - ouderdom - nederland - health care - medical services - social services - therapy - sport - food hygiene - nutritional state - consumption patterns - vascular diseases - blood disorders - cardiovascular diseases - cardiovascular disorders - elderly - old age - netherlands

Background. Regular physical activity is considered an important aspect of a healthy lifestyle. It may improve fitness, physical competence and may lower the risk of coronary heart disease (CHD). However, until now, data on the effects of regular exercise on CHD risk factors in elderly are limited, and there is a particular lack of data about the training effects on recently indicated risk factors, such as fibrinolytic and coagulation factors, and factors involved in the autonomic regulation of the heart.

Methods . We have conducted a randomised, controlled intervention study, which addressed the effect of a 6 months training programme on 'classical' and 'new' CHD risk factors and well-being in 229 (intervention: 143 and control:86) apparently healthy, free- living elderly men and women (60-80 years).

Results . Physical fitness (maximal exercise capacity) improved significantly in subjects of the intervention group (mean increase 14.1 Watt , 95%Cl: 10.1-18.1, +9%), compared to the controls. Among the classical CHD risk factors, only the reduction in serum triglyceride concentration in women was significant (-0.11 mmol/L, 95%Cl: -0.22-0.0, -7%). Blood pressure, high- and low density lipoprotein and total serum cholesterol concentration changed in a favourable direction, but not significantly from the control group. No effect of training on body weight and fasting insulin concentration was found. Among the new risk factors, the concentration of tissue type plasminogen activator (t-PA), a fibrinolytic factor, was significantly increased (+0.07 IU/mL, 95%Cl: 0.0-0.14,+11%) in subjects of the intervention group, while plasminogen activator inhibitor (PAI-1, inhibitor of fibrinolysis) was reduced, but not significantly different from the controls. These changes reflect an increase in fibrinolytic activity. However, fibrinogen concentration increased (+0.18 g/L 95%Cl 0.04-0.32,+6%). In addition, heart rate variability was increased and heart-rate- adjusted-QT interval was reduced in subjects of the intervention group (P<0.05). Both changes probably represent increase in parasympathetic activity and a more favourable autonomic regulation of the heart. Finally, physical self-efficacy was significantly improved in the subjects of the intervention group. Symptoms of depression were reduced, but not significantly different from the controls.

Conclusion . Regular physical activity beneficially affected CHD risk factors, physical fitness and self-efficacy, which are important determinants of the quality of life and longevity in elderly. The magnitude of the benefits on CHD incidence remain unclear, since there is little information on the predictive value of the new risk factors in elderly. However, since elderly, in general, have advanced atherosclerosis and autonomic dysbalance, the improvements of these factors may be of particular importance in this age- group. In conclusion, our observations underline the importance of a public health policy aiming at stimulating regular physical activity in elderly people

Changes in food patterns and health in Europeans in their 8th decade
Schroll Bjoernsbo, K. - \ 1997
Agricultural University. Promotor(en): W.A. van Staveren; C.P.G.M. de Groot. - S.l. : Schroll Bjoernsbo - ISBN 9789054857617 - 170
voedselhygiëne - voedingstoestand - consumptiepatronen - gezondheid - bevolking - ouderen - ouderdom - europa - food hygiene - nutritional state - consumption patterns - health - human population - elderly - old age - europe
Knowledge of specific food patterns of elderly people is important for relating diet to nutritional status and disease and for the identification of groups at risk of under- or over-consumption of specific nutrients. The standardised methodology employed in the SENECA surveys (Survey in Europe on Nutrition and the Elderly a Concerted Action) provided a unique opportunity to study cross-cultural differences in nutritional issues and lifestyle factors affecting health and performance of elderly people in Europe. This thesis explores food patterns in elderly Europeans and their impact on health. For the evaluation of the nutrient quality and the healthfulness of food patterns in elderly Europeans two approaches were applied: The Nutrient Adequacy Ratio, and a diet score, based on eight dietary components with a likely protective function for a number of chronic diseases. For a better insight in food patterns in addition to a conventional description, cluster analysis was employed.

Food intake data from 1221 dietary histories recoded by the Eurocode system was used to identify specific food patterns within each of the SENECA towns. On the pooled level food patterns across centres emerged. Food patterns varied between and within European settings and the two types of variation appeared to be of the same magnitude.
Food patterns were stable with age in 245 women from the Danish, Dutch, Swiss and Spanish SENECA towns. Minor changes attributable to period were, however, found. Also, foods contributing to the intake of specific nutrients were found to vary between SENECA towns. In addition to food choice, food handling affected the actual nutrient intake, and should, therefore, be considered in the nutritional evaluation of elderly people.
Weight loss showed to be an indicator of poor health in Danish (n = 115) and Dutch (n = 12 1) elderly people, but energy intake as an intermediary factor could not be proven in this study. Nevertheless, a further analysis of the Danish data showed that, both quantity and quality of food intake matter in the prevention of disability in 115 elderly Danes.

In conclusion, this thesis underlines the importance of food patterns of elderly people today for their ability to perform activities of daily living tomorrow. Inadequate nutrient intake appeared to result from a combination of low energy intake and unfavourable food patterns. Vulnerable groups of elderly people may gain from stimulation of physical activity and recommendations on nutritious foods.

Coagulation factor 7 in elderly people : genetic disposition and diet
Mennen, L.I. - \ 1997
Agricultural University. Promotor(en): F.J. Kok; D.E. Grobbee; E.G. Schouten. - S.l. : S.n. - ISBN 9789054857433 - 112
vaatziekten - bloedstoornissen - hart- en vaatziekten - hart- en vaatstoornissen - voedselhygiëne - voedingstoestand - consumptiepatronen - genetische stoornissen - erfelijke ziekten - ouderen - ouderdom - vascular diseases - blood disorders - cardiovascular diseases - cardiovascular disorders - food hygiene - nutritional state - consumption patterns - genetic disorders - hereditary diseases - elderly - old age
In elderly people an increase in thrombotic tendency may lead to a increase in the risk of a coronary event. Coagulation factor VII affects this thrombotic tendency and has been recognised as a risk indicator for coronary heart disease. It is not known whether the level of factor VII can be influenced at older age. From studies in young subjects it is clear that dietary fat and the R/Q353 polymorphism (alleles R and Q) are the main determinants of factor VII. We studied the relation of factor VII with diet in elderly men and women, taking the R/Q353 polymorphism into account.

In a cross-sectional study among 1158 elderly men and women (>55 y) factor VII coagulant activity (FVII:C) and total factor VII (FVIIt) were investigated in relation to serum-triglycerides, the R/Q353 polymorphism and the habitual diet. FVII:C was inversely associated with dietary fibre and protein and positively with saturated fat intake and serum-triglycerides. These associations were much stronger in subjects with the RR genotype compared to those carrying the Q allele; if the mean intake of dietary fibre would increase with 10 g a day, FVII:C would be expected to decrease with 7.6 % in elderly people homozygous for the R allele versus only 1.9 % decrease in those carrying the Q allele. FVIIt was inversely related to intake of dietary fibre and positively to serumtriglycerides, again the associations being stronger in subjects with the RR genotype. In a cross-over study among elderly women (>60 y, 35 RQ/QQ, 56RR) the postprandial response of activated factor VII (FVIIa) to several fat-rich (50 g) breakfasts was evaluated. The response of (FVIIa) was very similar for meals rich in palmitic acid, rich in stearic acid or rich in linoleic/linolenic acid with a ratio of 3:1 or 15:1. The increase in FVIIa ranged from 14.9 (95% CI: 10.6,19.2) IUmL after the stearic rich breakfast to 21.1 (16.6,25.6) IU/mL after the linoleic/linolenic 15:1 rich breakfasts. After the fat-free control breakfast FVIIa decreased with 8.7 (6.3,11.1) IU/mL. The mean absolute total response to the fatrich breakfasts combined was 37 IU/mL in subjects with the RR genotype and 16.1 IU/mL in subjects carrying the Q allele. Also the response relative to the fasting (FVIIa) level differed significantly between the genotype groups (RR: 42%, RQ/QQ: 32%). Serumtriglycerides concentration was not associated with FVIIa.

In elderly people, factor VII is influenced by dietary fibre, total dietary fat and serumtriglycerides and not by fat type. The R/Q353 polymorphism strongly modifies these effects. This indicates that an increase in dietary fibre and a decrease in dietary fat intake may reduce the risk of a coronary event by reducing the level of factor VII particularly in elderly people with the RR genotype.

Ouderen, zorg en welzijn: een pleidooi voor een vergelijkende benadering. (Elderly, care and well-being: a plea for a comparative approach).
Niehof, A. - \ 1997
Medische Antropologie 9 (1997)1. - ISSN 0925-4374 - p. 7 - 22.
ouderen - geriatrie - sociaal welzijn - sociale zekerheid - sociologie - verwantschap - gezinnen - gezinsleven - gezinsstructuur - sociale antropologie - cultuur - cultuursociologie - sociale voorzieningen - welzijnsvoorzieningen - ouderdom - wereld - sociale zorg - sociale problemen - welzijn - sociaal onderzoek - vergelijkend onderzoek - sociaal werk - elderly - geriatrics - social welfare - social security - sociology - kinship - families - family life - family structure - social anthropology - culture - cultural sociology - social services - welfare services - old age - world - social care - social problems - well-being - social research - comparative research - social work
Als gevolg van bevolkingsveroudering, optredend in zowel westerse als niet~westerse samenlevingen, treden er structurele veranderingen op in de aanratsverhoudingen tussen de verschillende leeftijdsgroepen. Dit is van invloed op het welzijn en de positie van ouderen. Het mondiale karakter van dit verschijnsel nodigt uit tot het hanteren van een vergelijkende benadering bij de bestudering ervan. Hiermee wordt geenDurkheimiaanse sociale morfologie van hele maatschappijen bedoeld, maar een vergelijking op het niveau van relevante instituties. In dit geval: huishouden, familie en verwantschap. De gevarieerde sociale en culturele context waarbinnen deze instituties functioneren, vertoont enkele voor vergrijzende samenlevingen specifieke kenmerken, zoals het ontstaan van een 'derde leeftijd(-sfase)'. De vergelijkende benadering zoafs hier voorgesleid vereist her terzijde schuiven van een aantal binaire opposities, zoals traditioneel tegenover modem, wesiers regenover niet-westers, publiek tegenover privé, en antropologie tegenover sociologie, omdat deze zijn voortgekomen uit een inmiddels verouderd moderniseringsparadigma. Zij vertroebelen in plaats van verhelderen onze blik. In de uitwerking van deze vergelijkende benadering voor het thema van ouderen en welzijn wordt met name aandacht besteedt aan de rol van verwantse/tapsrelaties en aan processen en typen van zorgverlening.
Scholing en inzetbaarheid van oudere werknemers. (Schooling and employability of older workers).
Groot, W. ; Maassen van den Brink, H. - \ 1997
ESB Economisch Statistische Berichten 82 (1997)4114. - ISSN 0013-0583 - p. 568 - 570.
industrie - arbeidsmarkt - arbeidskrachten - opleiding - werkers - werk - arbeidsproductiviteit - onderwijs - personeel - ouderen - menopauze - Nederland - bijscholing - industry - labour market - labor force - training - workers - work - labour productivity - education - personnel - elderly - menopause - Netherlands - continuing training
Ingegaan wordt op de vraag of scholing er inderdaad toe leidt dat oudere werknemers langer blijven werken en op de vraag waarom ze minder vaak aan bedrijfsgerelateerde scholing deelnemen dan jongeren
Kwaliteitsaspecten van maaltijdsystemen : een vergelijkend onderzoek naar warme-, koelverse- en diepvriesmaaltijden voor ouderen
Woerkum, M. van; Hobbelink, A. - \ 1996
Wageningen : Wetenschapswinkel (Adviesbrief / Landbouwuniversiteit, Wetenschapswinkel 133)
catering - centrale keukens - basisproducten - gemeenschapsontwikkeling - consumptiepatronen - borden - ouderen - voedsel - voedselhygiëne - voedselbereiding - voedingsmiddelen - gezondheidszorg - thuiszorg - thuisbezorgde maaltijden - ziekenhuiscatering - ziekenhuizen - huishoudens - keukens - maaltijden - Nederland - verpleeghuizen - voedingstoestand - ouderdom - overheidsdiensten - keukengerei - institutionele huishoudens - central kitchens - commodities - community development - consumption patterns - dishes - elderly - food - food hygiene - food preparation - foods - health care - home care - home delivered meals - hospital catering - hospitals - households - kitchens - meals - Netherlands - nursing homes - nutritional state - old age - public services - cooking utensils - institutional households
Prospective studies on coronary heart disease in the elderly : the role of classical and new risk factors
Weijenberg, M.P. - \ 1996
Agricultural University. Promotor(en): D. Kromhout; E.J.M. Feskens. - S.l. : Weijenberg - ISBN 9789090092096 - 161
vaatziekten - bloedstoornissen - hart- en vaatziekten - hart- en vaatstoornissen - epidemieën - epidemiologie - ouderen - ouderdom - nederland - vascular diseases - blood disorders - cardiovascular diseases - cardiovascular disorders - epidemics - epidemiology - elderly - old age - netherlands
In this thesis associations between biological risk factors and the occurrence of coronary heart disease in elderly persons are described. The focus is on classical (i.e. total and high density lipoprotein cholesterol and blood pressure) and some new (i.e. homocysteine, white blood cell count and serum albumin) biological risk factors. The studies are based on two Dutch cohorts. One is a cohort of 292 men and women, aged 64 to 87 years in 1971, from a general practice in Rotterdam, with a mortality follow-up of 17 years. The other is the Dutch cohort of the Seven Countries Study which consists of 939 men aged 64 to 84 years in 1985 from the town of Zutphen. The morbidity and mortality follow- up embraced five years.

In general, the classical risk factors were important predictors of coronary heart disease occurrence in elderly people. Systolic blood pressure was a strong independent long-term predictor of coronary heart disease mortality in elderly women, but the long-term association was less clear in elderly men. Total cholesterol was also significantly associated with long-term mortality from coronary heart disease in elderly women, but in men the association tended to be inverted U -shaped, i.e. men with cholesterol levels in the median tertile of the cholesterol distribution had a higher risk than those with levels in the first and third tertile. Regarding the Zutphen study, the short-term associations with incidence of coronary heart disease were usually weaker than with mortality from the disease. Elevated systolic and diastolic blood pressure, and especially isolated systolic hypertension, were important short-term predictors of sudden cardiac death in elderly men. For mortality from coronary heart disease, which was not additionally recorded as sudden, U -shaped associations with systolic and diastolic blood pressure levels were observed, i.e. men with the lowest blood pressure levels and those with the highest blood pressure levels and using antihypertensive medication had the highest risk. Serum total cholesterol was related to short-term coronary heart disease mortality in elderly men. For incidence of the disease, an association was only observed in a subgroup of the population with serum albumin levels below the median. High density lipoprotein cholesterol was not predictive of mortality from coronary heart disease, but there appeared to be an association with the incidence of the disease.

Concerning the new risk factors, serum homocysteine appeared to be associated with mortality from coronary heart disease in elderly men in the first one-and-a-half years of follow-up only. A strong association with mortality from cerebrovascular disease was observed in normotensive men. In addition, an association with an increased risk of cognitive impairment was suggested. Both white blood cell count and serum albumin were important predictors of coronary heart disease independent of the classical risk factors for coronary heart disease. The association with serum albumin could only partly be explained by baseline health status indicators.

The experience obtained from the studies described in this thesis has made clear that elderly people are a heterogenous group with respect to risk factor levels as well as coronary heart disease risk. It would therefore be desirable to have a measure of susceptibility for coronary heart disease to identify elderly people who are at increased risk of the disease. Our studies suggest that white blood cell count and serum albumin, routine clinical blood chemistry values, may be useful in this respect in addition to the classical risk factors. Future studies should aim at assessing the effectiveness of a multifactorial approach of risk factor management on coronary heart disease and all-cause mortality as well as on quality of life in older men and women.

Adviezen voor ouderen krijgen test in praktijk.
Chin A Pow, M. ; Jong, N. de - \ 1996
Voeding 57 (1996)9. - ISSN 0042-7926 - p. 26 - 28.
cellen - consumptiepatronen - ouderen - voedsel - voedseladditieven - voedselsamenstelling - voedselhygiëne - voedingsmiddelen - voedingseducatie - voedingsinformatie - voedingstoestand - voedingswaarde - ouderdom - eigenschappen - kwaliteit - veroudering - cells - consumption patterns - elderly - food - food additives - food composition - food hygiene - foods - nutrition education - nutrition information - nutritional state - nutritive value - old age - properties - quality - senescence
Vitamine- en mineralensuppletie voor ouderen.
Staveren, W.A. van - \ 1996
Voeding 57 (1996)6. - ISSN 0042-7926 - p. 11 - 12.
consumenteninformatie - consumenten - vraag - ouderen - voedsel - voedseladditieven - voedingsmiddelen - anorganische verbindingen - menopauze - mineralen - onderzoek - zouten - specerijen - stimulerende middelen - sporenelementen - vitaminen - consumer information - consumers - demand - elderly - food - food additives - foods - inorganic compounds - menopause - minerals - research - salts - spices - stimulants - trace elements - vitamins
Physical activity and health characteristics : a survey among Dutch elderly women and men
Hombergh, C.E.J. van den - \ 1995
Agricultural University. Promotor(en): F.J. Kok; W.A. van Staveren; E.G. Schouten. - S.l. : Van den Hombergh - ISBN 9789054853770 - 97
geriatrie - ouderen - gezondheid - hygiëne - voedselhygiëne - voedingstoestand - consumptiepatronen - lichamelijke activiteit - ouderdom - nederland - geriatrics - elderly - health - hygiene - food hygiene - nutritional state - consumption patterns - physical activity - old age - netherlands

To study physical activity of elderly people and its relationship with health characteristics, a cross-sectional study was conducted in 1991/1992 in Arnhem, the Netherlands, among 515 women and 497 men, aged 65 to 85 years. Habitual physical activity was assessed with a questionnaire, previously validated for elderly, and including questions on household activities, sports and other physically active leisure time activities like walking, bicycling and gardening. Health characteristics were assessed by interview (reported disability, chronic diseases, perceived health and respiratory complaints) and physical examination (anthropometry, blood pressure measurements, electrocardiography, and spirometry).

Light housework was carried out by 90% of the women and 61% of the men. 87% of the women and 91% of the men were involved in sports or other physically active leisure time activities. Physical activity (including household activities) is related to favorable health characteristics e.g. absence of disability and chronic diseases, and high subjective health in both women and men. Only in men it is as well associated with high heart rate variability, high forced vital capacity and high forced expiratory volume in one second. Performance of household activities might be regarded as an indicator of independence. We found non-performers to be characterized by high age, high socio-economic status, unfavorable reported health, and living with someone else, the latter only for men.

Our findings suggest that physically inactive elderly are in general characterized by older age and a less favorable health. From this cross-sectional study it is not clear whether physical activity may positively affect health, or the reverse or whether both effects are present. Independence, represented by performance of household activities, probably is primarily influenced by health. Longitudinal studies are needed to clarify the direction of causal pathways. For reasons of maintaining health, well- being and independence, we recommend promotion of physical activity in old age. In addition we suggest to stimulate independence of men by training them in preparing cooked meals and doing other traditionally "female" housework.

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