Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Speciation analysis of aqueous nanoparticulate diclofenac complexes by solid-phase microextraction
    Zielinska, K. ; Leeuwen, H.P. van; Thibault, S. ; Town, R.M. - \ 2012
    Langmuir 28 (2012)41. - ISSN 0743-7463 - p. 14672 - 14680.
    bovine serum-albumin - walled carbon nanotubes - drug binding-sites - capillary-electrophoresis - aquatic environment - antiinflammatory drugs - mass-spectrometry - metal-complexes - water samples - nd-spme
    The dynamic sorption of an organic compound by nanoparticles (NPs) is analyzed by solid-phase microextraction (SPME) for the example case of the pharmaceutical diclofenac in dispersions of impermeable (silica, SiO(2)) and permeable (bovine serum albumin, BSA) NPs. It is shown that only the protonated neutral form of diclofenac is accumulated in the solid phase, and hence this species governs the eventual partition equilibrium. On the other hand, the rate of the solid/water partition equilibration is enhanced in the presence of the sorbing nanoparticles of SiO(2) and BSA. This feature demonstrates that the NPs themselves do not enter the solid phase to any appreciable extent. The enhanced rate of attainment of equilibrium is due to a shuttle-type of contribution from the NP-species to the diffusive supply of diclofenac to the water/solid interface. For both types of nanoparticulate complexes, the rate constant for desorption (k(des)) of bound diclofenac was derived from the measured thermodynamic affinity constant and a diffusion-limited rate of adsorption. The computed k(des) values were found to be sufficiently high to render the NP-bound species labile on the effective time scale of SPME. In agreement with theoretical prediction, the experimental results are quantitatively described by fully labile behavior of the diclofenac/nanoparticle system and an ensuing accumulation rate controlled by the coupled diffusion of neutral, deprotonated, and NP-bound diclofenac species.
    Residue analysis of veterinary drugs and growth-promoting agents
    Stolker, A.A.M. ; Zuidema, T. ; Nielen, M.W.F. - \ 2007
    TrAC : Trends in Analytical Chemistry 26 (2007)10. - ISSN 0165-9936 - p. 967 - 979.
    tandem mass-spectrometry - performance liquid-chromatography - animal-food products - malachite green - antiinflammatory drugs - confirmatory analysis - leucomalachite green - nitrofuran residues - biological matrices - hair analysis
    Two major trends are observed in the analysis of veterinary drugs and growth-promoting agents. First is the selection of sample material for monitoring the use of registered veterinary drugs. Traditionally meat, kidney and liver were analyzed but, due to the food scandals in which meat was very often involved, the consumption of alternative products (e.g., eggs and fish) has become more popular and therefore more of interest for residue-monitoring programmes. Most food scandals started with contamination of animal feed, so feed has also gained interest for monitoring purposes. For the detection of unauthorized substances (e.g., growth-promoting agents), the matrix hair is frequently used because residues can be detected in hair even a long time after treatment. Second, the techniques used for residue analysis are moving from target-orientated methods, mainly based on liquid chromatography in combination with triple-quadrupole mass-spectrometric detection (LC-QqQ-MS), towards accurate mass full-scan MS techniques (e.g., time-of-flight (ToF)-MS and Fourier-transform(FT)-MS. Full-scan MS techniques enable retrospective analysis (i.e. without re-injecting the sample) and real multi-residue analysis (including different classes of veterinary drugs). The application of full-scan MS also has consequences for separation and extraction techniques, which have to be applicable to a broad range of compounds differing in physical and chemical properties. Experience shows that ToF-MS in combination with ultra-performance LC (UPLC) is very powerful for multi-residue analysis. The introduction of new MS techniques also has consequences for European Union (EU) criteria defined for confirmation of the identity of compounds. It is suggested that both mass-resolution and mass-accuracy data influence identity confirmation and both parameters should be implemented in the revision of European Commission Decision 2002/657/EC. (C) 2007 Elsevier Ltd. All rights reserved.
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