Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Evaluation of food and nutrient intake assessment using concentration biomarkers in European adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence study
    Vandevijvere, S. ; Geelen, A. ; Gonzalez-Gross, M. ; Veer, P. van 't; Dallongeville, J. ; Mouratidu, T. ; Dekkers, A. ; Börnhorst, C. ; Breidenassel, C. - \ 2013
    The British journal of nutrition 109 (2013)4. - ISSN 0007-1145 - p. 736 - 747.
    serum cholesteryl esters - n-3 fatty-acids - dietary-intake - energy-intake - additional measurements - micronutrient intake - biochemical markers - adipose-tissue - vitamin-c - validation
    Accurate food and nutrient intake assessment is essential for investigating diet–disease relationships. In the present study, food and nutrient intake assessment among European adolescents using 24 h recalls (mean of two recalls) and a FFQ (separately and the combination of both) were evaluated using concentration biomarkers. Biomarkers included were vitamin C, ß-carotene, DHA+EPA, vitamin B12 (cobalamin and holo-transcobalamin) and folate (erythrocyte folate and plasma folate). For the evaluation of the food intake assessment 390 adolescents were included, while 697 were included for the nutrient intake assessment evaluation. Spearman rank and Pearson correlations, and validity coefficients, which are correlations between intake estimated and habitual true intake, were calculated. Correlations were higher between frequency of food consumption (from the FFQ) and concentration biomarkers than between mean food intake (from the recalls) and concentration biomarkers, especially for DHA+EPA (r 0·35 v. r 0·27). Most correlations were higher among girls than boys. For boys, the highest validity coefficients were found for frequency of fruit consumption (0·88) and for DHA+EPA biomarker (0·71). In girls, the highest validity coefficients were found for fruit consumption frequency (0·76), vegetable consumption frequency (0·74), mean fruit intake (0·90) and DHA+EPA biomarker (0·69). After exclusion of underreporters, correlations slightly improved. Correlations between usual food intakes, adjusted for food consumption frequency, and concentration biomarkers were higher than correlations between mean food intakes and concentration biomarkers. In conclusion, two non-consecutive 24 h recalls in combination with a FFQ seem to be appropriate to rank subjects according to their usual food intake
    Dietary intake and biological measurement of folate: A qualitative review of validation studies
    Park, Y.H. ; Vollset, S.E. ; Boonstra, A. ; Chajes, V. ; Ueland, P.M. ; Slimani, N. - \ 2013
    Molecular Nutrition & Food Research 57 (2013)4. - ISSN 1613-4125 - p. 562 - 581.
    food-frequency questionnaire - neural-tube defects - plasma homocysteine concentrations - whole-blood folate - folic-acid - micronutrient intake - additional measurements - degradation-products - biochemical markers - statistical-methods
    Folate is a nutrient of major health significance, but its dietary intake assessment is particularly complex to quantify through traditional approaches. Attempts have been made to validate dietary instruments for assessing folate intake against circulating concentration biomarkers. However, this requires careful attention on various methodological issues. We conducted a qualitative review of 17 recently published validation studies to identify these issues. The majority of the tested instruments were self-administered food frequency questionnaires while the biomarker most frequently used was serum/plasma folate. Seasonality was not considered in most studies. Little attention was given to using updated food composition databases based on reliable chemical methods and including fortified foods and dietary supplements. Time sequence of the test instrument and the reference biomarker used was often ambiguous, and reference periods did not always match. Correlation coefficient was the metric most commonly used, and correlations between dietary folate intake and blood folate concentration varied from weak to moderate (r = 0.05–0.54). The correlations were stronger when dietary supplement use was considered, and when serum/plasma rather than red blood cell folate was used. This review summarises issues that need to be considered in future studies intending to validate instruments for dietary folate assessment against concentration biomarkers.
    Two non-consecutive 24 h recalls using EPIC-Soft software are sufficiently valid for comparing protein and potassium intake between five European centres – results from the European Food Consumption Validation (EFCOVAL) study
    Crispim, S.P. ; Vries, J.H.M. de; Geelen, A. ; Souverein, O.W. ; Hulshof, P.J.M. ; Lafay, L. ; Rousseau, A.S. ; Lillegaard, I.T.L. ; Andersen, L.F. ; Huybrechts, I. ; Keyzer, W. de; Ruprich, J. ; Dofkova, M. ; Ocké, M.C. ; Boer, E. de; Slimani, N. ; Veer, P. van 't - \ 2011
    The British journal of nutrition 105 (2011)3. - ISSN 0007-1145 - p. 447 - 458.
    dietary-survey methodology - 24-hour urinary nitrogen - intake distributions - biochemical markers - composite foods - biomarkers - nutrition - cancer - energy - adults
    The use of two non-consecutive 24 h recalls using EPIC-Soft for standardised dietary monitoring in European countries has previously been proposed in the European Food Consumption Survey Method consortium. Whether this methodology is sufficiently valid to assess nutrient intake in a comparable way, among populations with different food patterns in Europe, is the subject of study in the European Food Consumption Validation consortium. The objective of the study was to compare the validity of usual protein and K intake estimated from two non-consecutive standardised 24 h recalls using EPIC-Soft between five selected centres in Europe. A total of 600 adults, aged 45–65 years, were recruited in Belgium, the Czech Republic, France, The Netherlands and Norway. From each participant, two 24 h recalls and two 24 h urines were collected. The mean and distribution of usual protein and K intake, as well as the ranking of intake, were compared with protein and K excretions within and between centres. Underestimation of protein (range 2–13 %) and K (range 4–17 %) intake was seen in all centres, except in the Czech Republic. We found a fair agreement between prevalences estimated based on the intake and excretion data at the lower end of the usual intake distribution ( <10 % difference), but larger differences at other points. Protein and K intake was moderately correlated with excretion within the centres (ranges = 0·39–0·67 and 0·37–0·69, respectively). These were comparable across centres. In conclusion, two standardised 24 h recalls (EPIC-Soft) appear to be sufficiently valid for assessing and comparing the mean and distribution of protein and K intake across five centres in Europe as well as for ranking individuals.
    Design Characteristics of Food Frequency Questionnaires in Relation to Their Validity
    Molag, M.L. ; Vries, J.H.M. de; Ocke, M.C. ; Dagnelie, P.C. ; Brandt, P.A. van den; Jansen, S.C. ; Staveren, W.A. van; Veer, P. van 't - \ 2007
    American Journal of Epidemiology 166 (2007)12. - ISSN 0002-9262 - p. 1468 - 1478.
    dietary assessment methods - doubly-labeled water - energy-intake - nutrient intake - assessment instruments - history questionnaire - biochemical markers - urinary nitrogen - weighed records - womens health
    The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a meta-analysis of 40 validation studies, FFQs with longer food lists (200 items) were better than shorter FFQs at ranking subjects for most nutrients; results were statistically significant for protein, energy-adjusted total fat, and energy-adjusted vitamin C. The authors found that FFQs that included standard portions had higher correlation coefficients for energy-adjusted vitamin C (0.80 vs. 0.60, p <0.0001) and protein (0.69 vs. 0.61, p = 0.03) than FFQs with portion-size questions. However, it remained difficult from this review to analyze the effects of using portion-size questions. FFQs slightly underestimated gender differences in energy intake, although level of energy intake was underreported by 23% and level of protein intake by 17%. The authors concluded that FFQs with more items are better able to rank people according to their intake and that they are able to distinguish between subpopulations, even though they underestimated the magnitude of these differences.
    Biomarkers of quercetin-mediated modulation of colon carcinogenesis
    Dihal, A.A. - \ 2007
    Wageningen University. Promotor(en): Ivonne Rietjens, co-promotor(en): R.H. Stierum; Ruud Woutersen. - [S.l.] : S.n. - ISBN 9789085046783 - 240
    biochemische merkers - quercetine - colorectaal kanker - biochemical markers - quercetin - colorectal cancer
    Colorectal cancer (CRC) is hypothesized to be prevented by intake of fruits and vegetables that contain anti-carcinogenic compounds, including theflavonoidquercetinthat is found in apples and onions. In this thesis,quercetin'smechanisms of cancer-preventive action were studied both in vitro and in vivo . The in vitro experiments were performed using the human Caco-2 cell line as a model for CRC, andquercetinstabilized byascorbatein the culture medium. Unexpectedly,ascorbate-stabilizedquercetinshowed enhancement of cellular processes involved in CRC-development, including stimulated cell proliferation, reduced cell differentiation and enhancement of pathways that stimulate cell survival. Furthermore,transcriptomicsshowed thatquercetindownregulatedexpression of genes involved intumorsuppression and phase II metabolism, andupregulatedoncogenes. Comparison with Caco-2 cells exposed toquercetinin the absence ofascorbateshowed the opposite, i.e. anti-carcinogenic effects by thisflavonoid. This led to the hypothesis thatquercetin-induced reactive oxygen species that eradicatetumorcells were scavenged by vitamin C, causingtumorcell survival. Withoutascorbate, these reactive oxygen species may be responsible for anti-carcinogenic effects, pointing to beneficial effects of supposed adverse reactive intermediates.

    Subsequently, the CRC-modulating potency ofquercetinand its conjugaterutinwere investigated in a rat model for CRC.Quercetin, but not its conjugaterutindecreased thetumorincidence, which was associated with the blood plasma levels of this anti-oxidant, but not reflected by the putativepreneoplasticbiomarker lesions, designated aberrant crypt foci. The combination oftranscriptomicsand proteomics showed thatquercetininhibited the potentiallyoncogenicmitogen-activated proteinkinase(Mapk) pathway and enhanced expression oftumorsuppressor genes, cell cycle inhibitors, and genes involved inxenobioticmetabolism. In addition,quercetinaffected the energy production pathways, by increasing mitochondrial fatty acid degradation, and inhibitingglycolysis. This observation provided a new hypothesis pointing at another anti-carcinogenic mechanism forquercetin, based on an alteration in routes for energy metabolism, shifting them infavorof non-tumorlike pathways like mitochondrial fatty acid degradation at the cost of thetumor-likeglycolyticpathway for cellular energy supply.

    Overall, the studies presented in the present thesis provided new hypotheses for the mode of action ofquercetinas an anti-tumoragent, but it appeared that the actual dose needed to exert this beneficial effect amounted to about 60 - 100 times the already relatively high prescribed dose forquercetinsupplements. Therefore, it is concluded that health claims on the use ofquercetinas an anti-cancer agent need better scientific support.
    Validation of the assessment of folate and vitamin B12 intake in women of reproductive age: the method of triads
    Verkleij-Hagoort, A.C. ; Vries, J.H.M. de; Stegers, M.P.G. ; Lindemans, J. ; Ursem, N.T.C. ; Steegers-Theunissen, R.P.M. - \ 2007
    European Journal of Clinical Nutrition 61 (2007). - ISSN 0954-3007 - p. 610 - 615.
    food-frequency questionnaire - additional measurements - fundamental principles - micronutrient intake - biochemical markers - energy physiology - validity - supplement - risk - men
    Objective: To validate the folate and vitamin B12 intakes estimated by a food-frequency questionnaire (FFQ) designed to be used in a case-control study on the association between maternal dietary intake and the risk of having a child with a congenital heart defect. Design and subjects: The FFQ was filled out by 53 women of reproductive age. Immediately thereafter, blood samples were taken to determine serum folate, red blood cell (RBC) folate and serum vitamin B12 concentrations. Subsequently, three dietary 24-h recalls (24HR) were completed during a period of three successive weeks and used as a reference method. The recalls comprised two weekdays and one weekend day. Using the method of triads, validity coefficients were calculated by comparing nutrient intakes derived from the FFQ and 24HR with the corresponding nutritional biomarkers in blood. The validity coefficient is the correlation between the dietary intake reported by the FFQ and the unknown 'true' dietary intake. Results: The comparison of B-vitamin intakes reported by the FFQ and the mean of the 24HR revealed deattenuated correlation coefficients of 0.98 for folate and 0.66 for vitamin B12. The correlation coefficients between the B-vitamin intakes estimated by the FFQ and concentrations of serum folate, RBC folate and serum vitamin B12 were 0.20, 0.28 and 0.21, respectively. The validity coefficients for serum folate, RBC folate and serum vitamin B12 were 0.94, 0.75 and 1.00, respectively. The estimated folate and vitamin B12 intakes were comparable with the results of the most recent Dutch food consumption survey. Conclusions: The adapted FFQ is a reliable tool to estimate the dietary intake of energy, macronutrients, folate and vitamin B12 in women of reproductive age. Therefore, this FFQ is suitable for the investigation of nutrient-disease associations in future
    Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people
    Dhonukshe-Rutten, R.A.M. ; Pluijm, S.M.F. ; Groot, C.P.G.M. de; Lips, P. ; Smit, J.H. ; Staveren, W.A. van - \ 2005
    Journal of Bone and Mineral Research 20 (2005)6. - ISSN 0884-0431 - p. 921 - 929.
    hormone replacement therapy - hip fracture - osteoporotic fractures - postmenopausal women - mineral density - cobalamin deficiency - biochemical markers - methylmalonic acid - quantitative ultrasound - plasma homocysteine
    Hyperhomocysteinemia may contribute to the development of osteoporosis. The relationship of Hcy and vitamin B12 with bone turnover markers, BUA, and fracture incidence was studied in 1267 subjects of the Longitudinal Aging Study Amsterdam. High Hcy and low vitamin B12 concentrations were significantly associated with low BUA, high markers of bone turnover, and increased fracture risk
    Validatie van biomarkers voor de bepaling van effecten van doorvergiftiging in terrestrische fauna : effecten van TCDD en PAK in de huisspitsmuis (Crocidura russula)
    Bosveld, A.T.C. ; Bie, P.A.F. de - \ 2001
    Wageningen : Alterra (Alterra-rapport 154) - 75
    crocidura russula - benzopyreen - aromatische koolwaterstoffen - toxische stoffen - dioxinen - toxicologie - verontreiniging - biochemische merkers - biologische indicatoren - ecotoxicologie - crocidura russula - benzopyrene - aromatic hydrocarbons - toxic substances - dioxins - toxicology - pollution - biochemical markers - biological indicators - ecotoxicology
    Om eventuele effecten van PAK's bij kleine zoogdieren uit de wilde fauna te kunnen herkennen is in een viertal blootstellingstudies onderzocht wat de effecten zijn van benzo[a]pyreen (BaP) of een mengsel van negen verschillende polycyclische aromatische koolwaterstoffen (PAK). Daarnaast is het effect onderzocht van tetrachloordibenzo-p-dioxine (TCDD), als modelstof voor de veroorzakers van Ah receptor gemedieerde effecten. Het onderzoek is verricht aan de huisspitsmuis (Crocidura russula), een algemeen in het wild voorkomend klein zoogdier. In de verschillende studies zijn het verloop van het lichaamsgewicht en verschillen in orgaangewichten beschouwd naast de effecten op cytochroom P450 enzymen (EROD, MROD, PROD, BROD en specifieke testosteronhydroxylases) en de histopathologie van de geslachtsorganen.
    Polychlorinated biphenyls pattern analysis: potential nondestructive biomarker in vertebrates for exposure to cytochrome P450-inducing organochlorines
    Brink, N.W. van den; Ruiter-Dijkman, E.M. de; Broekhuizen, S. ; Reijnders, P.J.H. ; Bosveld, A.T.C. - \ 2000
    Environmental Toxicology and Chemistry 19 (2000)3. - ISSN 0730-7268 - p. 575 - 581.
    bodemverontreiniging - polychloorbifenylen - gewervelde dieren - niet-destructief testen - biochemische merkers - biologische monitoring - soil pollution - polychlorinated biphenyls - vertebrates - nondestructive testing - biochemical markers - biomonitoring
    Biomarkers are valuable instruments to assess the risks from exposure of organisms to organochlorines. In general, however, these biomarkers are either destructive to the animal of interest or extremely difficult to obtain otherwise. In this paper, we present a nondestructive biomarker for exposure to cytochrome P450-inducing organochlorines. This marker is based on a pattern analysis of metabolizable and nonmetabolizable polychlorinated biphenyl (PCB) congeners, which occur in several kinds of tissues (and even blood) that can be obtained without serious effects on the organism involved. The fraction of metabolizable PCB congeners is negatively correlated with exposure to PCBs, which are known to induce specific P450 isoenzymes. This relation can be modeled by a logistic curve, which can be used to define critical levels of exposure. In addition, this method creates an opportunity to analyze biomarker responses in archived tissues stored at standard freezing temperatures (-20°C), at which responses to established biomarkers deteriorate. Furthermore, this method facilitates attribution of the enzyme induction to certain classes of compounds.
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