Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort
Praagman, J. ; Dalmeijer, G.W. ; Schouw, Y.T. van der; Soedamah-Muthu, S.S. ; Verschuren, W.M.M. ; Bueno-de Mesquita, H.B. ; Geleijnse, J.M. ; Beulens, J.W.J. - \ 2015
The British journal of nutrition 113 (2015). - ISSN 0007-1145 - p. 498 - 506.
coronary-heart-disease - lactic-acid bacteria - dairy-products - colorectal-cancer - consumption - stroke - metaanalysis - questionnaire - menaquinone - men
The objective of the present study was to investigate the relationship between total and subtypes of bacterial fermented food intake (dairy products, cheese, vegetables and meat) and mortality due to all causes, total cancer and CVD. From the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort, 34 409 Dutch men and women, aged 20–70 years who were free from CVD or cancer at baseline, were included. Baseline intakes of total and subtypes of fermented foods were measured with a validated FFQ. Data on the incidence and causes of death were obtained from the national mortality register. Cox proportional hazards models were used to analyse mortality in relation to the quartiles of fermented food intake. After a mean follow-up of 15 (sd 2·5) years, 2436 deaths occurred (1216 from cancer and 727 from CVD). After adjustment for age, sex, total energy intake, physical activity, education level, hypertension, smoking habit, BMI, and intakes of fruit, vegetables and alcohol, total fermented food intake was not found to be associated with mortality due to all causes (hazard ratio upper v. lowest quartile (HRQ4 v. Q1) 1·00, 95 % CI 0·88, 1·13), cancer (HRQ4 v. Q1 1·02, 95 % CI 0·86, 1·21) or CVD (HRQ4 v. Q1 1·04, 95 % CI 0·83, 1·30). Bacterial fermented foods mainly consisted of fermented dairy foods (78 %) and cheese (16 %). None of the subtypes of fermented foods was consistently related to mortality, except for cheese which was moderately inversely associated with CVD mortality, and particularly stroke mortality (HRQ4 v. Q1 0·59, 95 % CI 0·38, 0·92, Ptrend= 0·046). In conclusion, the present study provides no strong evidence that intake of fermented foods, particularly fermented dairy foods, is associated with mortality.
Prepregnancy dietary patterns and risk of developing hypertensive disorders of pregnancy: results from the Australian Longitudinal Study on Women’s Health
Schoenaker, D.A.J.M. ; Soedamah-Muthu, S.S. ; Callaway, L.K. ; Mishra, G.D. - \ 2015
American Journal of Clinical Nutrition 102 (2015)1. - ISSN 0002-9165 - p. 94 - 101.
coronary-heart-disease - cardiovascular-disease - mediterranean diet - gestational hypertension - preeclampsia - metaanalysis - consumption - cohort - supplementation - prevention
Background: Hypertensive disorders of pregnancy (HDPs), including gestational hypertension and pre-eclampsia, are common obstetric complications associated with adverse health outcomes for the mother and child. It remains unclear how dietary intake can influence HDP risk. Objective: We investigated associations between prepregnancy dietary patterns and risk of HDPs. Design: We selected 3582 women participating in the Australian Longitudinal Study on Women's Health, which is an observational population-based study. Women were not pregnant at baseline in 2003 and reported at least one live birth between 2003 and 2012. Diet was assessed by using a validated 101-item food-frequency questionnaire in 2003, and factor analysis was used to identify dietary patterns. HDPs were assessed by using the question, "Were you diagnosed or treated for hypertension during pregnancy?" Generalized estimating equation models were used to estimate RRs (95% CIs) adjusted for dietary, reproductive, sociodemographic, and lifestyle factors. Results: During 9 y of follow-up of 3582 women, 305 women (8.5%) reported a first diagnosis of HDPs in 6149 pregnancies. We identified 4 dietary patterns labeled as meat, high-fat, and sugar; Mediterranean-style; fruit and low-fat dairy; and cooked vegetables. In the adjusted model, the meat, high-fat, and sugar, fruit and low-fat dairy, and cooked vegetable dietary patterns were not associated with HDP risk. The Mediterranean-style dietary pattern (characterized by vegetables, legumes, nuts, tofu, rice, pasta, rye bread, red wine, and fish) was inversely associated with risk of developing HDPs (quartile 4 compared with quartile 1: RR, 0.58; 95% CI, 0.42, 0.81). Conclusions: In this population-based study of Australian women, we observed an independent protective dose-response association between prepregnancy consumption of a Mediterranean-style dietary pattern and HDP risk. Additional studies are recommended to confirm our findings by prospectively examining whether the implementation of the Mediterranean-style dietary pattern before pregnancy has a role in the prevention of HDPs.
Influence of droplet clustering on the rheological properties of emulsion-filled gels
Oliver, L. ; Berndsen, L. ; Aken, G.A. van; Scholten, E. - \ 2015
Food Hydrocolloids 50 (2015). - ISSN 0268-005X - p. 74 - 83.
large-deformation rheology - coronary-heart-disease - composite gels - saturated fat - viscoelastic properties - mechanical-properties - spheres
The aim of this work was to determine the effect and magnitude of fat droplet clustering on the rheological properties of emulsion-filled gels. To this end, we investigated experimentally the effect of fat hardness and emulsion droplet clustering in gelatin gels. Fat droplet clustering was induced or avoided by changing the temperature at which the emulsion was mixed with the gelatin. Rheological properties of the filled gels were investigated by uniaxial compression. The obtained experimental data show that next to changes in droplet hardness and matrix hardness, also droplet clustering contributes to the gel stiffness; even in the absence of discrete bonds between adjacent droplets. The experimental data was compared with the Kerner model, the Kerner model corrected by the effective volume fraction approach and the Kerner model considering an inhomogeneous distribution of the droplets. The Kerner model gives a good prediction for the gels filled with liquid droplets without clustering. The correction for an inhomogeneous distribution of the droplets best described the influence of emulsion droplet clustering in emulsion-filled gels, showing a quantitative evaluation on the role of droplet clustering in the rheological behaviour of emulsion-filled gels. This may provide guidelines for developing a strategy to control certain product properties.
Nitrate and nitrite in the diet: How to assess their benefit and risk for human health
Habermeyer, M. ; Roth, A. ; Guth, S. ; Rietjens, I.M.C.M. - \ 2015
Molecular Nutrition & Food Research 59 (2015)1. - ISSN 1613-4125 - p. 106 - 128.
n-nitroso compounds - neural-tube defects - nih-aarp diet - ischemia-reperfusion injury - fluke opisthorchis-viverrini - nitrosatable drug exposure - reduces blood-pressure - colorectal-cancer risk - coronary-heart-disease - inorganic nitrate
Nitrate is a natural constituent of the human diet and an approved food additive. It can be partially converted to nitrogen monoxide, which induces vasodilation and thereby decreases blood pressure. This effect is associated with a reduced risk regarding cardiovascular disease, myocardial infarction, and stroke. Moreover, dietary nitrate has been associated with beneficial effects in patients with gastric ulcer, renal failure, or metabolic syndrome. Recent studies indicate that such beneficial health effects due to dietary nitrate may be achievable at intake levels resulting from the daily consumption of nitrate-rich vegetables. N-nitroso compounds are endogenously formed in humans. However, their relevance for human health has not been adequately explored up to now. Nitrate and nitrite are per se not carcinogenic, but under conditions that result in endogenous nitrosation, it cannot be excluded that ingested nitrate and nitrite may lead to an increased cancer risk and may probably be carcinogenic to humans. In this review, the known beneficial and detrimental health effects related to dietary nitrate/nitrite intake are described and the identified gaps in knowledge as well as the research needs required to perform a reliable benefit/risk assessment in terms of long-term human health consequences due to dietary nitrate/nitrite intake are presented.
Profiling healthy eaters. Determining factors that predict healthy eating practices among Dutch adults
Swan, E.C. ; Bouwman, L.I. ; Hiddink, G.J. ; Aarts, N. ; Koelen, M. - \ 2015
Appetite 89 (2015). - ISSN 0195-6663 - p. 122 - 130.
coronary-heart-disease - life-style choices - socioeconomic inequalities - physical-activity - dietary patterns - social support - public-health - food choice - weight-gain - us adults
Research has identified multiple factors that predict unhealthy eating practices. However what remains poorly understood are factors that promote healthy eating practices. This study aimed to determine a set of factors that represent a profile of healthy eaters. This research applied Antonovsky's salutogenic framework for health development to examine a set of factors that predict healthy eating in a cross-sectional study of Dutch adults. Data were analyzed from participants (n¿=¿703) who completed the study's survey in January 2013. Logistic regression analysis was performed to test the association of survey factors on the outcome variable high dietary score. In the multivariate logistic regression model, five factors contributed significantly (p¿
Effect of cheese consumption on blood lipids: a systematic review and meta-analysisi of randomized controlled trials
Goede, J. de; Geleijnse, J.M. ; Ding, E.L. ; Soedamah-Muthu, S.S. - \ 2015
Nutrition Reviews 73 (2015)5. - ISSN 0029-6643 - p. 259 - 275.
coronary-heart-disease - low-density-lipoprotein - fecal fat excretion - cardiovascular-disease - serum-cholesterol - normolipidemic volunteers - clinical-trials - dietary-intake - dairy foods - milk-fat
Context: Cheese may affect lipids and lipoproteins differently than other high-fat dairy foods. Objective: The present systematic review and meta-analysis was performed to evaluate randomized controlled trials that examined the effect of cheese consumption compared with another food product on blood lipids and lipoproteins. Data Sources: A systematic literature search of the MEDLINE, Embase, Scopus, CAB Abstracts, the Cochrane Controlled Trials Register, and the website was performed. Study Selection: A total of 12 randomized controlled trials (RCTs) were identified that examined the effect of cheese consumption on blood lipids and lipoproteins in healthy adults. Data Extraction: A meta-analysis of 5 RCTs that compared the effects of hard cheese and butter, both of which had a similar ratio of polyunsaturated fatty acids to saturated fatty acids (P/S ratio), was performed. Data Synthesis: Compared with butter intake, cheese intake (weighted mean difference: 145.0 g/d) reduced low-density lipoprotein cholesterol (LDL-C) by 6.5% (-0.22 mmol/l; 95%CI: -0.29 to -0.14) and high-density lipoprotein cholesterol (HDL-C) by 3.9% (-0.05 mmol/l; 95%CI: -0.09 to -0.02) but had no effect on triglycerides. Compared with intake of tofu or fat-modified cheese, cheese intake increased total cholesterol or LDL-C, as was expected on the basis of the P/S ratio of the diets. There was insufficient data to compare intake of cheese with intake of other foods. Conclusion: Despite the similar P/S ratios of hard cheese and butter, consumption of hard cheese lowers LDL-C and HDL-C when compared with consumption of butter. Whether these findings can be attributed to calcium, specific types of saturated fatty acids, or the food matrix of cheese warrants further research.
A healthy diet is associated with less endothelial dysfunction and less low-grade inflammation over a 7-year period in adults at risk of cardiovascular disease
Henry, R.M.A. ; Ferreira, I. ; Greevenbroek, M.M.J. van; Kallen, C.J.H. van der; Twisk, J.W.R. ; Feskens, E.J.M. ; Schalkwijk, C.G. ; Stehouwer, C.D.A. ; Bussel, B.C.T. van - \ 2015
The Journal of Nutrition 145 (2015)3. - ISSN 0022-3166 - p. 532 - 540.
c-reactive protein - coronary-heart-disease - von-willebrand-factor - all-cause mortality - phenotypic heterogeneity - plasma-concentrations - adhesion molecules - amsterdam growth - artery-disease - vascular beds
Background: A healthy diet rich in fish, fruit, and vegetables, but moderate in alcohol and low in dairy products and meat, has been associated with a lower rate of incident cardiovascular disease (CVD). The underlying mechanisms, however, remain unclear. Endothelial dysfunction and low-grade inflammation play important roles in CVD. A healthy diet might modify these phenomena. Objective: We investigated the associations between the above food groups and overall biomarker scores of endothelial dysfunction and low-grade inflammation in a 7-y longitudinal study. Methods: Using longitudinal data from 557 participants at increased CVD risk from the CODAM (Cohort on Diabetes and Atherosclerosis Maastricht) Study, we assessed diet intake by food-frequency questionnaire and measured plasma biomarkers of endothelial dysfunction [von Willebrand factor, soluble vascular cell adhesion molecule 1, soluble endothelial selectin, soluble thrombomodulin, soluble intercellular adhesion molecule 1 (sICAM-1)] and low-grade inflammation [C-reactive protein, serum amyloid A, interleukin (IL)-6, IL-8, tumor necrosis factor a, and sICAM-1]. At baseline, participants were aged 59.6 ± 6.9 y. Measurements were performed then and after 7 y. Biomarkers were combined into overall scores (sum of z scores; higher scores indicating worse function). Longitudinal data were analyzed with generalized estimating equations and adjusted for sex, age, glucose metabolism, energy intake, body mass index, physical activity, alcohol consumption, and smoking. Results: Higher consumption of fish (per 100 g/wk), but not total consumption of vegetables, fruit, alcohol-containing beverages, dairy products, or meat, was associated with a lower overall endothelial dysfunction score over 7 y (ß: -0.027; 95% CI: -0.051, -0.004). No associations were observed with the overall low-grade inflammation score. Further food component analyses indicated that consumption of more lean fish (per 100 g/wk) and raw vegetables (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less endothelial dysfunction [(ß: -0.038; 95% CI: -0.072, -0.005), (ß: -0.095; 95% CI: -0.191, 0.000), and (ß: -0.070; 95% CI: -0.131, -0.009), respectively]. Consumption of more fresh fruit (per 100 g/d), wine (per 100 mL/wk), and poultry (per 100 g/d), and fewer high-fat dairy products (per 100 g/d) was associated with less low-grade inflammation [(ß: -0.074; 95% CI: -0.133, -0.015), (ß:-0.006; 95% CI: -0.013, 0.001), (ß:-0.247; 95% CI: -0.479, -0.014), and (ß:-0.100; 95% CI: -0.182, -0.019), respectively]. Conclusion: These data suggest that the dietary modification of endothelial dysfunction and low-grade inflammation, processes that are important in atherothrombosis, is possible.
Fatty acid and triglycerides profiling of retail organic, conventional and pasture milk: Implications for health and authenticity
Capuano, E. ; Gravink, R. ; Boerrigter-Eenling, G.R. ; Ruth, S.M. van - \ 2015
International Dairy Journal 42 (2015). - ISSN 0958-6946 - p. 58 - 63.
conjugated linoleic acids - coronary-heart-disease - fresh grass - dairy-products - cows - verification - metaanalysis - cholesterol - systems
Retail full fat high temperature short time pasteurised conventional, organic and “weidemelk” (Dutch quality label for milk from cows on pasture at least 6 h per day, 120 days per year) milk samples were collected on 2 sampling dates in winter and 4 sampling dates in summer 2013 and analysed for the fatty acid (FA) and the triglyceride (TAG) profile by gas chromatography-flame ionisation detection. FA profile of organic milk was significantly different from that of conventional and “weidemelk” milk both in summer and in winter and the differences between conventional and “weidemelk” milk were less remarkable or negligible. Analogously, the TAG profile of organic milk was different from that of the other two groups but the differences were weaker compared with FA profile. The differences in FA composition of retail full fat milk may have implications for consumers' health and may be used for the authentication of retail organic milk.
Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries
Buijsse, B. ; Boeing, H. ; Drogan, D. ; Schulze, M.B. ; Feskens, E.J.M. ; Amiano, P. ; The InterAct Consortium, A. - \ 2015
European Journal of Clinical Nutrition 69 (2015). - ISSN 0954-3007 - p. 455 - 461.
coronary-heart-disease - dietary-fat - postprandial glycemia - insulin sensitivity - meat consumption - nut consumption - saturated fat - epic-interact - metabolic syndrome - physical-activity
Background/Objectives: Diets high in saturated and trans fat and low in unsaturated fat may increase type 2 diabetes (T2D) risk, but studies on foods high in fat per unit weight are sparse. We assessed whether the intake of vegetable oil, butter, margarine, nuts and seeds and cakes and cookies is related to incident T2D. Subjects/Methods: A case-cohort study was conducted, nested within eight countries of the European Prospective Investigation into Cancer (EPIC), with 12¿403 incident T2D cases and a subcohort of 16¿835 people, identified from a cohort of 340¿234 people. Diet was assessed at baseline (1991–1999) by country-specific questionnaires. Country-specific hazard ratios (HRs) across four categories of fatty foods (nonconsumers and tertiles among consumers) were combined with random-effects meta-analysis. Results: After adjustment not including body mass index (BMI), nonconsumers of butter, nuts and seeds and cakes and cookies were at higher T2D risk compared with the middle tertile of consumption. Among consumers, cakes and cookies were inversely related to T2D (HRs across increasing tertiles 1.14, 1.00 and 0.92, respectively; P-trend
Effect of fat hardness on large deformation rheology of emulsion-filled gels
Oliver, L. ; Scholten, E. ; Aken, G.A. van - \ 2015
Food Hydrocolloids 43 (2015). - ISSN 0268-005X - p. 299 - 310.
coronary-heart-disease - protein isolate gels - composite gels - casein gels - viscoelastic properties - mechanical-properties - saturated fat - droplets - behavior - fracture
The aim of this work was to investigate the impact on the texture properties of emulsion-filled gels when saturated solid fat is replaced by unsaturated liquid oil. Whey protein aggregate, gelatin and micellar casein, were chosen to form different types of gel matrices and the fat hardness was varied by selection of the fat type and variation of the temperature. As emulsifier, either whey protein aggregates, whey protein or sodium caseinate was used. Texture properties of the filled gels were investigated by uniaxial compression. The fracture properties were affected by the presence of emulsion droplets, however the effect of fat hardness was small. The presence of emulsion droplets (either liquid or solid) increases the gel stiffness as compared to the emulsion-free gel, indicating that the droplets are an active part of the gel. An increase in solid fat content led to a moderate increase in gel stiffness for whey protein aggregate gels, which was in agreement with predictions according to the Palierne model for the effect of fat hardness on the stiffness of the filled gels. For the gelatin and micellar casein gels, the magnitude by which the gel stiffness increased as a function of the solid fat content was much larger than expected on the basis of this model. Microscopical observation suggested that this was caused by an inhomogeneous distribution of the fat droplets, due to droplet aggregation or/and concentration of the droplets in gel strands, which increases the effective volume fraction of the droplets in the matrix.
To what extent do primary care practice nurses act as case managers life style counselling regarding weight management?
Dillen, S. van; Hiddink, G.J. - \ 2014
BMC Family Practice 15 (2014). - ISSN 1471-2296 - 9 p.
randomized controlled-trial - primary-health-care - chronic disease management - promote physical-activity - coronary-heart-disease - general-practice - obesity management - secondary prevention - patient satisfaction - guidance practices
Background - In this review study, we are the first to explore whether the practice nurse (PN) can act as case manager lifestyle counselling regarding weight management in primary care. Methods - Multiple electronic databases (MEDLINE, PsycINFO) were searched to identify relevant literature after 1995. Forty-five studies fulfilled the inclusion criteria. In addition, all studies were judged on ten quality criteria by two independent reviewers. Results - Especially in the last three years, many studies have been published. The majority of the studies were positive about PNs’ actual role in primary care. However, several studies dealt with competency issues, including disagreement on respective roles. Thirteen studies were perceived as high quality. Only few studies had a representative sample. PNs’ role in chronic disease management is spreading increasingly into lifestyle counselling. Although PNs have more time to provide lifestyle counselling than general practitioners (GPs), lack of time still remains a barrier. In some countries, PNs were rather ambiguous about their role, and they did not agree with GPs on this. Conclusion - The PN can play the role of case manager lifestyle counselling regarding weight management in primary care in the UK, and wherever PNs are working under supervision of a GP and a primary health care team is already developed with agreement on roles. In countries in which a primary health care team is still in development and there is no agreement on respective roles, such as the USA, it is still the question whether the PN can play the case manager role.
Predicting major outcomes in type 1 diabetes: a model development and validation study
Soedamah-Muthu, S.S. ; Vergouwe, Y. ; Costacou, T. ; Miller, R.G. ; Zgibor, J. ; Chaturvedi, N. ; Snell-Bergeon, J.K. ; Maahs, D.M. ; Rewers, M. ; Forsblom, C. ; Harjutsalo, V. ; Groop, P.H. ; Fuller, J.H. ; Moons, K.G.M. ; Orchard, T.J. - \ 2014
Diabetologia 57 (2014)11. - ISSN 0012-186X - p. 2304 - 2314.
coronary-heart-disease - eurodiab prospective complications - all-cause mortality - cardiovascular-disease - pittsburgh epidemiology - risk-factors - intensive treatment - iddm complications - metabolic syndrome - association
Aims/hypothesis Type 1 diabetes is associated with a higher risk of major vascular complications and death. A reliable method that predicted these outcomes early in the disease process would help in risk classification. We therefore developed such a prognostic model and quantified its performance in independent cohorts. Methods Data were analysed from 1,973 participants with type 1 diabetes followed for 7 years in the EURODIAB Prospective Complications Study. Strong prognostic factors for major outcomes were combined in a Weibull regression model. The performance of the model was tested in three different prospective cohorts: the Pittsburgh Epidemiology of Diabetes Complications study (EDC, n¿=¿554), the Finnish Diabetic Nephropathy study (FinnDiane, n¿=¿2,999) and the Coronary Artery Calcification in Type 1 Diabetes study (CACTI, n¿=¿580). Major outcomes included major CHD, stroke, end-stage renal failure, amputations, blindness and all-cause death. Results A total of 95 EURODIAB patients with type 1 diabetes developed major outcomes during follow-up. Prognostic factors were age, HbA1c, WHR, albumin/creatinine ratio and HDL-cholesterol level. The discriminative ability of the model was adequate, with a concordance statistic (C-statistic) of 0.74. Discrimination was similar or even better in the independent cohorts, the C-statistics being: EDC, 0.79; FinnDiane, 0.82; and CACTI, 0.73. Conclusions/interpretation Our prognostic model, which uses easily accessible clinical features can discriminate between type 1 diabetes patients who have a good or a poor prognosis. Such a prognostic model may be helpful in clinical practice and for risk stratification in clinical trials.
Functional foods and cardiometabolic diseases : International Task Force for Prevention of Cardiometabolic Diseases
Assman, G. ; Buono, P. ; Valle, E. Della; Farinaro, E. ; Ferns, G. ; Krogh, V. ; Kromhout, D. - \ 2014
Nutrition, Metabolism & Cardiovascular Diseases 24 (2014)12. - ISSN 0939-4753 - p. 1272 - 1300.
coronary-heart-disease - n-3 fatty-acids - randomized controlled-trial - density-lipoprotein cholesterol - dietary fiber intake - cardiovascular risk-factors - stanol ester consumption - vitamin-e - plant sterols - fish consumption
Mounting evidence supports the hypothesis that functional foods containing physiologically-active components may be healthful. Longitudinal cohort studies have shown that some food classes and dietary patterns are beneficial in primary prevention, and this has led to the identification of putative functional foods. This field, however, is at its very beginning, and additional research is necessary to substantiate the potential health benefit of foods for which the diet–health relationships are not yet scientifically validated. It appears essential, however, that before health claims are made for particular foods, in vivo randomized, double-blind, placebo-controlled trials of clinical end-points are necessary to establish clinical efficacy. Since there is need for research work aimed at devising personalized diet based on genetic make-up, it seems more than reasonable the latter be modeled, at present, on the Mediterranean diet, given the large body of evidence of its healthful effects. The Mediterranean diet is a nutritional model whose origins go back to the traditional diet adopted in European countries bordering the Mediterranean sea, namely central and southern Italy, Greece and Spain; these populations have a lower incidence of cardiovascular diseases than the North American ones, whose diet is characterized by high intake of animal fat. The meeting in Naples and this document both aim to focus on the changes in time in these two different models of dietary habits and their fall out on public health.
Adherence to dietary guidelines and cardiovascular disease risk in the EPIC-NL cohort
Struijk, E.A. ; May, A.M. ; Wezenbeek, N.L.W.J. ; Fransen, H. ; Soedamah-Muthu, S.S. ; Geelen, A. ; Boer, J. ; Schouw, Y.T. van der; Bueno de Mesquita, H.B. ; Beulens, J.W.J. - \ 2014
International Journal of Cardiology 176 (2014)2. - ISSN 0167-5273 - p. 354 - 359.
coronary-heart-disease - major chronic disease - systematic analysis - for-americans - global burden - style diet - 21 regions - women - men - questionnaire
Background Global and national dietary guidelines have been created to lower chronic disease risk. The aim of this study was to assess whether greater adherence to the WHO guidelines (Healthy Diet Indicator (HDI)); the Dutch guidelines for a healthy diet (Dutch Healthy Diet-index (DHD-index)); and the Dietary Approaches to Stop Hypertension (DASH) diet was associated with a lower risk of cardiovascular disease (CVD), coronary heart disease (CHD) or stroke. Methods A prospective cohort study was conducted among 33,671 healthy Dutch men and women aged 20–70 years recruited into the EPIC-NL study during 1993–1997. We used Cox regression adjusted for relevant confounders to estimate the hazard ratios per standard deviation increase in score and 95% confidence intervals (CI) of the associations between the dietary guidelines and CVD, CHD and stroke risk. Results After an average follow-up of 12.2 years, 2752 CVD cases were documented, including 1630 CHD cases and 527 stroke cases. We found no association between the HDI (0.98, 95% CI 0.94; 1.02) or DHD-index (0.96, 95% CI 0.92; 1.00) and CVD incidence. Similar results were found for these guidelines and CHD or stroke incidence. Higher adherence to the DASH diet was significantly associated with a lower CVD (0.92, 95% CI 0.89; 0.96), CHD (0.91, 95% CI 0.86; 0.95), and stroke (0.90, 95% CI 0.82; 0.99) risk. Conclusion The HDI and the DHD-index were not associated with CVD risk, while the DASH diet was significantly associated with a lower risk of developing CVD, CHD and stroke.
Effect on using repeated measurements of a Mediterranean style diet on the strength of the association with cadiovascular disease during 12 years: the Doetinchem Cohort Study.
Hoevenaar-Blom, M.P. ; Spijkerman, A.M.W. ; Boshuizen, H.C. ; Boer, J.M.A. ; Kromhout, D. ; Verschuren, W.M.M. - \ 2014
European Journal of Nutrition 53 (2014)5. - ISSN 1436-6207 - p. 1209 - 1215.
coronary-heart-disease - risk - mortality - cancer - consumption - patterns
In cohort studies, often only one baseline measurement of dietary intake is available. This may underestimate the strength of the association with cardiovascular diseases (CVD). The main objective is to compare the strength of the association of a Mediterranean style diet with CVD using one baseline measurement of diet versus three repeated measurements over a 10-year period. We used dietary and lifestyle data of three rounds of the Doetinchem Cohort Study. At baseline, 7,769 persons aged 20-65 years were examined. Diet was assessed with a 178 item validated food-frequency questionnaire and operationalized with the Mediterranean Diet Score (MDS) ranging from 0 to 9. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95 % confidence intervals (CI). Analyses were adjusted for age, sex, and repeated measurements of smoking, sports, total energy intake, and educational level. Comparing an MDS of a parts per thousand yen5.5-9 to an MDS of 0-<3.5, baseline MDS was associated with a 23 % lower risk [HR 0.77 (95 % CI 0.53-1.11)] and the updated mean with a 35 % lower risk [HR 0.65 (0.43-0.97)] of a composite of fatal CVD, nonfatal myocardial infarction, and stroke (composite CVD). For fatal CVD, baseline MDS was associated with a 13 % lower risk [HR 0.87 (0.36-2.07)] and the updated mean with a 56 % lower risk [HR 0.44 (0.19-1.05)]. The strength of the association between a Mediterranean style diet and CVD is likely underestimated because most studies so far used only one baseline measurement.
Healthy diet indicator and mortality in Eastern European populations: prospective evidence from the HAPIEE cohort
Stefler, D. ; Pikhart, H. ; Jankovic, N. ; Kubinova, R. ; Pajak, A. ; Malyutina, S. ; Simonova, G. ; Feskens, E.J.M. ; Peasey, A. ; Bobak, M. - \ 2014
European Journal of Clinical Nutrition 68 (2014). - ISSN 0954-3007 - p. 1346 - 1352.
food-frequency questionnaire - coronary-heart-disease - physical-activity - risk-factors - elderly-men - carotenoids - biomarkers - nutrition - validity - quality
Background/Objectives: Unhealthy diet has been proposed as one of the main reasons for the high mortality in Central and Eastern Europe (CEE) and the former Soviet Union (FSU) but individual-level effects of dietary habits on health in the region are sparse. We examined the associations between the healthy diet indicator (HDI) and all-cause and cause-specific mortality in three CEE/FSU populations. Subjects/Methods: Dietary intakes of foods and nutrients, assessed by food frequency questionnaire in the Health, Alcohol and Psychosocial Factors in Eastern Europe (HAPIEE) cohort study, were used to construct the HDI, which follows the WHO 2003 dietary recommendations. Among 18¿559 eligible adult participants (age range: 45–69 years) without a history of major chronic diseases at baseline, 1209 deaths occurred over a mean follow-up of 7 years. The association between HDI and mortality was estimated by Cox regression. Results: After adjusting for covariates, HDI was inversely and statistically significantly associated with cardiovascular disease (CVD) and coronary heart disease (CHD) mortality, but not with other cause-specific and all-cause mortality in the pooled sample. Hazard ratios per one standard deviation (s.d.) increase in HDI score were 0.95 (95% confidence interval=0.89–1.00, P=0.068), 0.90 (0.81–0.99, P=0.030) and 0.85 (0.74–0.97, P=0.018) for all-cause, CVD and CHD mortality, respectively. Population attributable risk fractions for low HDI were 2.9% for all-cause, 14.2% for CVD and 10.7% for CHD mortality. Conclusions: These findings support the hypothesis that unhealthy diet has had a role in the high CVD mortality in Eastern Europe.
Comined effects of smoking and alcohol on metabolic syndrome: the lifelines cohort study
Slagter, S.N. ; Vliet-Ostaptchouk, J.V. ; Vonk, J.M. ; Boezen, H.M. ; Dullaart, R.P.F. ; Muller Kobold, A.C. ; Feskens, E.J.M. ; Beek, A.P. van; Klauw, M.M. van der; Wolffenbuttel, B.H.R. - \ 2014
PLoS ONE 9 (2014)4. - ISSN 1932-6203 - 9 p.
genome-wide association - nutrition examination survey - coronary-heart-disease - body-mass index - blood-pressure - waist circumference - cigarette-smoking - physical-activity - national-health - dietary-intake
Introduction - The development of metabolic syndrome (MetS) is influenced by environmental factors such as smoking and alcohol consumption. We determined the combined effects of smoking and alcohol on MetS and its individual components. Methods - 64,046 participants aged 18–80 years from the LifeLines Cohort study were categorized into three body mass index (BMI) classes (BMI1 drink/day) and tobacco showed higher triglycerides levels. Up to 2 drinks/day was associated with a smaller waist circumference in overweight and obese individuals. Consumption of >2 drinks/day increased blood pressure, with the strongest associations found for heavy smokers. The overall metabolic profile of wine drinkers was better than that of non-drinkers or drinkers of beer or spirits/mixed drinks. Conclusion - Light alcohol consumption may moderate the negative associations of smoking with MetS. Our results suggest that the lifestyle advice that emphasizes smoking cessation and the restriction of alcohol consumption to a maximum of 1 drink/day, is a good approach to reduce the prevalence of MetS. Figures
Common and rare single nucleotide polymorphisms in the LDLR gene are present in a black South African population and associate with low-density lipoprotein cholesterol levels
Zyl, T. ; Jerling, J.C. ; Conradie, K.R. ; Feskens, E.J.M. - \ 2014
Journal of Human Genetics 59 (2014). - ISSN 1434-5161 - p. 88 - 94.
coronary-heart-disease - plasma-lipid levels - receptor gene - familial hypercholesterolemia - messenger-rna - human genome - mutations - risk - stabilization - expression
The LDL receptor has an essential role in regulating plasma LDL-C levels. Genetic variation in the LDLR gene can be associated with either lower or moderately raised plasma levels of LDL-C, or may cause familial hypercholesterolemia. The prevalence of single-nucleotide polymorphisms (SNPs) in the LDLR in the black South African population is not known and therefore, we aimed to determine the genotypic variation of the LDLR in the study population as well as to define the association of the different genotypes with plasma LDL-C levels. A random selection of 1860 apparently healthy black South African volunteers aged 35–60 years was made in a cross-sectional study. Novel SNPs were identified in a subset of 30 individuals by means of automated sequencing before screening the entire cohort by means of the Illumina VeraCode GoldenGate Genotyping Assay on a BeadXpress Reader system. Twenty-five SNPs were genotyped, two of which were novel. A very rare SNP, rs17249141, in the promoter region was significantly associated with lower levels of LDL-C. Four other SNPs (rs2738447, rs14158, rs2738465 and rs3180023) were significantly associated with increased levels of LDL-C. We can conclude that some of the various SNPs identified do indeed associate with LDL-C levels
Stability of dietary patterns assessed with reduced rank regression; the Zutphen Elderly Study
Jankovic, N. ; Streppel, M.T. ; Kampman, E. ; Groot, C.P.G.M. de; Boshuizen, H.C. ; Soedamah-Muthu, S.S. ; Kromhout, D. ; Feskens, E.J.M. - \ 2014
Nutrition Journal 13 (2014). - ISSN 1475-2891
coronary-heart-disease - nutrient intake - swedish women - risk-factors - food - mortality - cancer - reproducibility - index - men
Background Reduced rank regression (RRR) combines exploratory analysis with a-priori knowledge by including risk factors in the model. Dietary patterns, derived from RRR analysis, can be interpreted by the chosen risk factor profile and give an indication of positive or adverse health effects for a specific disease. Our aim was to assess the stability of dietary patterns derived by RRR over time. Methods We used data from 467 men, aged 64–85 years, participating in the 1985 and 1990 examination rounds of the Zutphen Elderly Study. Backwards regression on risk factors and food groups was applied prior to the RRR analysis to exclude food groups with low predictability (from 36 to 19 food groups) for the chosen risk factor profile. For the final RRR analysis, dietary intake data from 19 food groups as predictor variables and 6 established risk factors for cardiovascular diseases (body mass index, systolic and diastolic blood pressure, high density lipoprotein and total cholesterol levels, and uric acid) were used. Results Three RRR dietary patterns were derived for both examination years: a “(low in) cereal fibre pattern”, an “alcohol pattern” and an “inconsistent pattern”. The “(low in) cereal fibre pattern” was most stable over time, with a correlation coefficient of 0.47 (95% CI: 0.38-0.53) between 1985 and 1990 measurements. Conclusion Dietary patterns as measured by RRR, after backwards regression, are reasonably stable over a period of five years. Thus, RRR appears to be an attractive method to measure long-term dietary exposure for nutritional epidemiological studies, with one dietary measurement at baseline.
No effect of n-3 fatty acids on high-sensitivity C-reactive protein after myocardial infarction: The Alpha Omega Trial
Hoogeveen, E.K. ; Geleijnse, J.M. ; Kromhout, D. ; Giltay, E.J. - \ 2014
European Journal of Preventive Cardiology 21 (2014)11. - ISSN 2047-4873 - p. 1429 - 1436.
soluble adhesion molecules - coronary-heart-disease - necrosis-factor-alpha - cardiovascular risk - fish-oil - docosahexaenoic acid - inflammatory markers - serum concentrations - supplementation - men
Background Persistent inflammation plays a role in the pathogenesis of atherosclerosis. n-3 Fatty acids may have anti-inflammatory effects. This study examined the effect of plant-derived alpha-linolenic acid (ALA) and marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on high-sensitivity C-reactive protein (hsCRP), a systemic marker of (low-grade) inflammation. Design/Methods A supplementary study in the Alpha Omega Trial: a multicenter, double-blind, randomized, placebo-controlled trial of low-dose n-3 fatty acids. Patients were enrolled from 2002 to 2006 and followed for 40 months. A total of 2425 patients, aged 60–80 years (79% men), with a history of myocardial infarction, were randomly assigned to margarines supplemented with a targeted additional intake of 400¿mg/day EPA and DHA, 2¿g/day ALA, EPA-DHA plus ALA, or placebo for 40 months. Results Patients consumed on average 19.8¿g margarine/day, providing an additional amount of 238¿mg/day EPA with 158¿mg/day DHA, 1.98¿g/day ALA, or both, in the active treatment groups. In the placebo group, the geometric mean hsCRP (95% confidence interval (CI)) was 1.84¿mg/l (95% CI: +1.70 to +2.00) at baseline and 1.98¿mg/l (95% CI: 1.82 to 2.15) after 40 months (p¿
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