Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Antibiotica nadelig voor afweerontwikkeling jonge big
Leneman, M. ; Smits, M.A. - \ 2015
Veehouder en Veearts 29 (2015)3. - p. 6 - 8.
varkenshouderij - biggen - diergezondheid - antibiotica - immuunsysteem - diergeneeskunde - pig farming - piglets - animal health - antibiotics - immune system - veterinary science
Dat er vanwege resistentie ontwikkeling terughoudend met antibiotica moet worden omgesprongen is inmiddels gemeengoed. Wetenschappelijk onderzoek bij biggen op onderzoeksbedrijf Sterksel en bij Wageningen UR Livestock Research wijst nu ook uit dat antibiotica toediening in de eerste levensfase een langdurige negatieve invloed op de afweer heeft.
Leverbot in kaart gebracht
Verkaik, J.C. ; Verwer, C. - \ 2015
V-focus 12 (2015)3. - ISSN 1574-1575 - p. 27 - 29.
melkveehouderij - leverbot - diergeneeskunde - diergezondheid - dierziektepreventie - besmetting - ziektebestrijding - dairy farming - liver flukes - veterinary science - animal health - animal disease prevention - contamination - disease control
Leverbotinfecties zijn in toenemende mate een knelpunt bij melkgevende koeien die weiden of vers gras op stal gevoerd krijgen. Leverbotinfecties brengen verliezen met zich mee die onderschat worden, zoals verminderde groei van jongvee, verminderde weerstand, verminderde melkproductie en afkeuring van levers van geslachte dieren.
Foot-and-mouth disease virus : the role of infection routes and species differences in the transmission of FMDV
Bravo De Rueda Cabrera, C. - \ 2015
Wageningen University. Promotor(en): Mart de Jong, co-promotor(en): Aldo Dekker; Phaedra Eble. - Wageningen : Wageningen University - ISBN 9789462573284 - 137
mond- en klauwzeervirus - mond- en klauwzeer - infectieziekten - ziekteoverdracht - ziektebestrijding - infectiebestrijding - soortverschillen - epidemiologie - diergeneeskunde - foot-and-mouth disease virus - foot and mouth disease - infectious diseases - disease transmission - disease control - infection control - species differences - epidemiology - veterinary science

ÁFoot-and-mouth disease is a contagious viral disease of cloven-hoofed animals (e.g. cattle, sheep, pigs) and can cause severe economic losses to the farm animal industries. The aim of this thesis was to quantify underlying mechanisms regarding transmission of FMDV. With data from past animal experiments we identified the factors which are associated with the amount of virus shed by infected animals and thus may be of importance for transmission of the virus. In an experimental study, the contribution of the environment on the transmission of FMDV was investigated by using a new mathematical model in which the contribution of the environment on transmission was incorporated. Roughly 44% of the transmission of FMDV occurred through the environment that was contaminated with se-excretions from FMDV infected animals. The role of the different species on the transmission of FMDV was investigated with a transmission study of FMDV between infected sheep and naïve cattle. Sheep were found to be less infectious than cattle but similarly susceptible. Using a so-called next-generation matrix, transmission of FMDV in mixed cattle-sheep populations (with different proportions of cattle and different proportions of vaccinated animals) was quantified and the effects of different vaccination strategies against FMDV were analysed. In mixed populations of cattle and sheep, transmission of FMDV is higher when more cattle are present. In populations with more than 14% cattle, targeting vaccination to cattle only can be sufficient to control FMDV.

The results of this thesis show that transmission of FMDV can occur via a contaminated environment, (without animal presence) and that sheep seem to play a limited role in the transmission of FMDV. These results can be used to improve the control measures to prevent and control FMDV in different animal populations.

Mechanisms underlying disease transmission between spatially separated animals
Bunnik, B.A.D. van - \ 2014
Wageningen University. Promotor(en): Mart de Jong, co-promotor(en): Thomas Hagenaars; Gonnie Nodelijk. - Wageningen : Wageningen University - ISBN 9789461739537 - 150
dieren - vleeskuikens - infectieziekten - ziekteoverdracht - gastheren (dieren, mensen, planten) - wiskundige modellen - epidemiologie - diergeneeskunde - animals - broilers - infectious diseases - disease transmission - hosts - mathematical models - epidemiology - veterinary science

Transmission of infections between spatially separated hosts is a common problem, not only during major outbreaks of livestock diseases, but also in many other settings such as the transmission of infectious diseases between plants and crops or in healthcare settings. During the last major epidemics of livestock diseases in the Netherlands and abroad, disease transmission events occurred despite movement bans and other (bio-)security measures, implying that indirect transmission plays a major role. A better understanding of indirect transmission is necessary to put in place evidence based bio-security measures against neighbourhood (indirect) transmission. To gain more insight in the mechanisms underlying indirect transmission a series of experimental studies combined with mathematical modelling were conducted of which the results are presented in this thesis. First the effect of acidification of drinking water on the transmission parameters of direct and indirect transmission of Campylobacter jejuni (C. jejuni) between broilers was studied. It was shown that acidified drinking water has an effect on indirect transmission but not on direct transmission of C. jejuni between broilers. The sender and receiver sub-process of indirect transmission was then studied in more detail and it was shown that a significant negative interaction effect between acidification of the sender and receiver sub-processes exists, indicating that there is no additional effect of acidification of the drinking water on both sides of the transmission process compared to acidified drinking water only on one side. To study the transport of the pathogen in the environment in more detail, a series of indirect transmission experiments was carried out and a model framework was developed to study indirect transmission between spatially separated hosts. These studies showed that indirect transmission of C. jejuni between broilers is best described by a multistage environmental route from sending to receiving animal, suggesting that indirect transmission occurs through progressive (but slow) contamination of the environment surrounding the source. Indirect transmission experiments where repeated with both C. jejuni and Escherichia coli and the results showed that for C. jejuni it takes much longer for the first effective (viable) bacterium to cross the small distance of approximately 75 cm than it does for Escherichia coli. A new modelling approach to study indirect transmission was developed guided by these indirect transmission experiments. This model is capable of accurately describing the pathogen dispersal process by a diffusive transport mechanism which includes pathogen mortality. Lastly, a range of dose-response models were compared and tested how well these fitted to the data from a dose-response experiment. Here it was shown that for interpolation purposes two relatively simple models are best capable of describing the data from the dose-response experiment. For extrapolation purposes, however, it was shown that from the models that were studied a model that abides by the independent action hypothesis is best.

Mechanisms of Avian Influenza virus transmission between farms: combining data collection and mathematical modelling
Ssematimba, A. - \ 2013
Wageningen University. Promotor(en): Mart de Jong, co-promotor(en): Thomas Hagenaars. - S.l. : s.n. - ISBN 9789461734549 - 148
aviaire influenzavirussen - ziekteoverdracht - pluimveehouderij - wiskundige modellen - epidemiologie - diergeneeskunde - nederland - avian influenza viruses - disease transmission - poultry farming - mathematical models - epidemiology - veterinary science - netherlands

The lack of sufficient knowledge on the mechanisms of between-farm spread of livestock diseases hampers the development of much needed effective and fast control strategies. Some of the mechanisms responsible for pathogen spread can be deduced from epidemic tracing reports and literature while others can only be hypothesized from findings of studies on daily farm practices throughout the production round. For outbreaks without known/traced transmission routes, the concept of ‘neighbourhood’ infection is often adopted. This concept was founded based on the distance-dependence of the transmission risk with geographical proximity to an infectious farm being the key determinant of risk. Mathematical modelling plays an important role in obtaining quantitative insights into the contributions of the different mechanisms to disease spread. This can be by ranking the contributions of the individual transmission routes and/or obtaining a generic distance-dependent transmission risk. The models can guide the design of control strategies by providing a means to assess the efficacy of intervention strategies. In this thesis, modelling was used to assess the contributions of the wind-borne route and the other (traced) between-farm contacts to the transmission of highly pathogenic avian influenza during an epidemic in the Netherlands in 2003. It was found that these two routes together could only explain approximately 31% of the infections/cases. Visits by epidemic control teams were the least risky indicating the effectiveness of their biosecurity protocols in preventing transmission. New data on day-to-day farm practices and farmer opinion was collected in an attempt to generate hypotheses on transmission pathways and mechanisms that were yet to be appreciated. Indeed relevant unappreciated practices were found. They include irregularities in compliance to biosecurity as well as a broad category of neighbourhood-related risks. A new modelling approach to study neighbourhood transmission was developed guided by indirect transmission experiments. It involves the approximation of the pathogen dispersal process by a diffusive transport mechanism. Applying this diffusion model to the outbreak data of 2003, it was found that assuming delayed transmission, as opposed to instantaneous transmission, is an important phenomenon to be considered when modelling disease spread between locations. This modelling approach has the added advantage of availing an opportunity to assess the performance of intervention strategies without detailed mechanism-specific information.

Missie CVI : wij beschermen de dier- en volksgezondheid door veterinair onderzoek op topniveau
Anonymous, - \ 2012
diagnostiek - volksgezondheid - Veterinary Science (General) - animal diseases - onderzoeksinstituten - diagnostics - melkveehouderij - public health - dierziekten - dairy farming - research institutes - Diergeneeskunde (algemeen) - diergeneeskunde - veterinary science - diagnostiek - volksgezondheid - Veterinary Science (General) - animal diseases - onderzoeksinstituten - diagnostics - melkveehouderij - public health - dierziekten - dairy farming - research institutes - Diergeneeskunde (algemeen) - diergeneeskunde - veterinary science
Presentatie op de landelijke onderwijsdag van Produktschap Zuivel op 27 november 2012.
Minder groei bij veterinair behandelde varkens
Peet-Schwering, C.M.C. van der; Binnendijk, G.P. - \ 2012
Veehouder en Dierenarts 26 (2012)4. - ISSN 1381-8007 - p. 8 - 10.
varkenshouderij - diergezondheid - slachtdieren - diergeneeskunde - behandeling - groei - pig farming - animal health - meat animals - veterinary science - treatment - growth
Vleesvarkens die gedurende het vleesvarkenstraject een keer veterinair behandeld zijn, groeien van opleg tot afleveren ruim 30 g/d langzamer dan vleesvarkens die niet veterinair behandeld zijn. Dit geldt voor zowel beren en borgen als zeugjes. Dit blijkt uit onderzoek dat in opdracht van het Productschap Vee en Vlees door Wageningen UR Livestock Research is uitgevoerd op VIC Sterksel.
Trends in veterinary antibiotic use in the Netherlands 2005-2011
Bondt, N. ; Puister-Jansen, L.F. ; Ge, L. ; Veen, H.B. van der; Bergevoet, R.H.M. ; Douma, B.E. ; Vliet, A.L.J. van; Wehling, K.W. - \ 2012
Den Haag : LEI Wageningen UR
antibiotica - veehouderij - dierhouderij - vee - diergeneeskunde - veterinaire praktijk - dierenwelzijn - diergezondheid - antibiotics - livestock farming - animal husbandry - livestock - veterinary science - veterinary practice - animal welfare - animal health
During the period 2009-2011 the total sales of antibiotics dropped nearly 32%, from 495 tonnes in 2009 to 338 tonnes in 2011 (FIDIN, 2012). This far exceeds the policy objective for 2011 set by the Dutch government, i.e., a 20% reduction in antibiotic use compared with 2009. Survey data on antibiotic use per animal species indicate a decrease in all five livestock sectors examined in 2011.
Q-koorts in Nederland: stand van zaken, resultaten van veterinair onderzoek en verwachtingen voor de komende jaren.
Roest, H.I.J. ; Hogerwerf, L. ; Brom, R. Van den; Oomen, T. ; Steenbergen, J.E. Van; Nielen, M. - \ 2011
Tijdschrift voor Diergeneeskunde 136 (2011)5. - ISSN 0040-7453 - p. 340 - 343.
q-koorts - coxiella burnetii - herkauwers - zoönosen - ziekteoverdracht - diergeneeskunde - geitenhouderij - schapenhouderij - vaccinatie - q fever - ruminants - zoonoses - disease transmission - veterinary science - goat keeping - sheep farming - vaccination
Overzicht van de stand van zaken humaan en veterinair anno 2011, enkele resultaten van onderzoek worden samengevat en er wordt een vooruitblik gegeven voor de komende jaren.
Ziekten van vissen, schaal- en schelpdieren, van belang voor de Nederlandse aquacultuur
Haenen, O.L.M. ; Engelsma, M.Y. ; Beurden, S.J. van; Werkman, P. - \ 2011
Lelystad : Centraal Veterinair Instituut van Wageningen UR - ISBN 9789461901019 - 163
visteelt - aquacultuur - schaal- en schelpdierenteelt - visziekten - diergezondheid - pathogenen - zoönosen - diagnostiek - diergeneeskunde - nederland - fish culture - aquaculture - shellfish culture - fish diseases - animal health - pathogens - zoonoses - diagnostics - veterinary science - netherlands
In de Nederlandse aquacultuur wordt een groot aantal vis- en schelpdiersoorten gekweekt en geteeld, daarnaast is er een zeer beperkte houderij van schaaldieren. Net als in andere dierlijke productiesectoren komen in de aquacultuursector verschillende ziekten voor die een belemmering kunnen vormen voor de productie. Dit boek geeft een overzicht van de belangrijkste vis-, schaaldier- en schelpdierziekten in Nederland.
Zuinig met antibiotica
Kuipers, A. ; Wemmenhove, H. - \ 2011
Veehouder en Dierenarts 25 (2011)1. - ISSN 1381-8007 - p. 20 - 21.
melkveehouderij - antibiotica - diergezondheid - diergeneeskunde - melkveebedrijven - dairy farming - antibiotics - animal health - veterinary science - dairy farms
Het antibioticagebruik op melkveebedrijven is in beeld gebracht. Hoe benutten we deze gegevens om zuiniger met antibiotica om te gaan en hoe denken dierenartsen hierop in te spelen? Speelt de keuze voor verschillende middelen een rol?
Zorgvuldige bestrijding van zeer besmettelijke dierziekten
Jong, M.C.M. de; Hagenaars, T.H.J. - \ 2010
In: Over zorgvuldige veehouderij. Veel instrumenten, één concert / Eijsackers, H., Scholten, M., Wageningen : Wageningen UR (Essaybundel 2010 ) - ISBN 9789085858959 - p. 64 - 75.
dierziekten - diergezondheid - ziektebestrijding - epidemieën - diergeneeskunde - veehouderij - vaccinatie - animal diseases - animal health - disease control - epidemics - veterinary science - livestock farming - vaccination
In dit hoofdstuk wordt de bestrijding besproken van uitbraken van zeer besmettelijke dierziekten, in het jargon 'aangifteplichtige ziekten' genoemd. Daarbij bediscussiëren de auteurs ook wat voor deze ziekten bestrijdingstechnisch mogelijk is. Of en hoe we dierziekten bestrijden, zijn maatschappelijke keuzes. Die keuzemogelijkheden worden beperkt door de technische mogelijkheden en vooral door de kennis over de effecten van de te nemen bestrijdingsmaatregelen.
Ernstige klinische problemen gedurende meerdere weken op een varkensbedrijf: wat als het KVP was geweest?
Backer, J.A. ; Spierenburg, M. ; Spek, A. van der; Elbers, A.R.W. - \ 2010
Tijdschrift voor Diergeneeskunde 135 (2010)20. - ISSN 0040-7453 - p. 750 - 756.
varkenshouderij - varkens - varkenspest - varkensziekten - virusziekten - diergeneeskunde - pig farming - pigs - swine fever - swine diseases - viral diseases - veterinary science - virus - transmission - netherlands
In the Spring of 2009, a veterinarian reported suspected classical swine fever (CSF) on a multiplier pig farm in the southern part of the Netherlands (close to the Belgian border). Over a 5-week period there had been a number of sick sows and an excessively high percentage of stillborn and preterm piglets. Sick animals were treated with anti-inflammatory drugs and antibiotics, but did not respond as well as anticipated. A visiting specialist team from the Food Safety Authority could not exclude CSF as the cause of the clinical problems and sent blood samples to the reference laboratory in Lelystad for a PCR test on CSF antigen. Fortunately, test results obtained 6 hours later were negative for CSF, and the disease control measures were lifted. It later appeared that porcine reproductive and respiratory syndrome (PRRSV) might have been responsible for the problems. But what if CSF had caused the clinical problems? A C SF-transmission model was used to simulate CSF outbreaks dependent on the duration of the high-risk period (HRP). As the duration of the HRP increased, there was an exponential growth in the number of pig farms infected during this period. Simulations also showed that with a longer HRP, the virus spread over greater distances from the source herd. It was also investigated whether a possible CSF outbreak could be detected on the basis of an increased mortality and hence increased number of cadavers sent to a rendering plant. However, the calculated mortality incidence was not sensitive enough to serve as an alarm signal. It is recommended that CSF-exclusion diagnostics be used much earlier in similar clinical situations on pig farms.
Antibioticagebruik in de veehouderij in 2009
Bondt, N. - \ 2010
antibiotica - diergeneeskunde - veterinaire producten - veehouderij - diergezondheid - antibiotics - veterinary science - veterinary products - livestock farming - animal health
Betrouwbare en actuele informatie over het veterinair antibioticagebruik is een absolute noodzaak. De wijze waarop en de mate waarin antibiotica bij dieren worden gebruikt is van invloed op de ontwikkeling van antibioticaresistentie in de veehouderij. In deze folder hebben LEI, onderdeel van Wageningen UR, en de FIDIN het antibioticagebruik in de Nederlandse veehouderij in 2009 en voorgaande jaren zo nauwkeurig mogelijk in beeld gebracht.
Beweegredenen van commerciële veehouders en hobbydierhouders om te vaccineren tegen Blauwtong tijdens een vrijwillige vaccinatiecampagne in 2008 en 2009 in Nederland
Elbers, A.R.W. ; Koeijer, A.A. de; Rijn, P.A. van - \ 2009
Lelystad : Wageningen UR, Centraal Veterinair Instituut (Rapport 09/CVI0311) - 27
diergezondheid - bluetonguevirus - vaccinatie - diergeneeskunde - infectieziekten - animal health - bluetongue virus - vaccination - veterinary science - infectious diseases
Onderzoek naar beweegredenen van veehouders om hun vee in te laten enten tegen het blauwtongvirus
Vaccination against Foot-and-Mouth Disease : differentiating strategies and their epidemiological and economic consequences
Backer, J.A. ; Bergevoet, R.H.M. ; Hagenaars, T.H.J. ; Bondt, N. ; Nodelijk, G. ; Wagenberg, C.P.A. van; Roermund, H.J.W. van - \ 2009
Wageningen : Wageningen UR (LEI report 2009-042) - ISBN 9789086153497 - 158
mond- en klauwzeer - diergeneeskunde - veterinaire producten - vaccinatie - rundveeteelt - geneesmiddeleffecten - economische impact - foot and mouth disease - veterinary science - veterinary products - vaccination - cattle farming - drug effects - economic impact
The effectiveness of different control strategies against Foot-and-Mouth Disease (FMD) were investigated using epidemiological and economic models. A quick and large-scale vaccination within a radius of at least 2km is as effective as preemptive 1-km ring culling to mitigate FMD epidemics. Control measures should primarily target cattle farms. After the epidemic, most seropositive animals are expected on sheep farms and vaccinated cattle farms. An effective end-screening strategy should focus on these farms. Market acceptance by trade partners of products of vaccinated animals can limit the economic consequences of outbreaks of FMD.De effectiviteit van bestrijdingstrategieën tegen Mond-en-Klauwzeer (MKZ) is onderzochtmet behulp van epidemiologische en economische modellen. Het blijkt dat snelle en op grote schaal toegepaste vaccinatie in een straal van 2 km rond geïnfecteerde bedrijven net zo effectief is als ruimen in een straal van 1 km rond geïnfecteerde bedrijven bij het bestrijden van MKZ-uitbraken. Controlemaatregelen moeten vooral worden gericht op rundveebedrijven. Na de epidemie zijn de meeste seropositieve dieren te verwachten. De eindscreening zal zich op schapenbedrijven en gevaccineerde rundveebedrijven moeten richten. Acceptatie door internationale handelspartners van producten van gevaccineerde dieren kan de economische gevolgen van een uitbraak van MKZ beperken.
Assessment report contract research Wageningen Animal Sciences Group
Folstar, P. ; Dekkers, J. ; Hartog, L.A. den; Neindre, P. le; Oldham, J. ; Peters, A. ; Thorns, C. ; Meulepas, W.J.A.M. - \ 2008
Wageningen : Wageningen UR - 79
landbouwkundig onderzoek - diergeneeskunde - zoölogie - dierhouderij - contracten - onderzoek - toegepast onderzoek - nederland - wetenschap - agricultural research - veterinary science - zoology - animal husbandry - contracts - research - applied research - netherlands - science
Phage therapy : harmless viruses help to combat bacterial infections
Bergen, M.A.P. van; Wagenaar, J.A. - \ 2008
Tijdschrift voor Diergeneeskunde 133 (2008)14-15. - ISSN 0040-7453 - p. 618 - 621.
diergeneeskunde - faagvectoren - geneeskunde - veterinary science - phage vectors - medicine - campylobacter-jejuni - bacteriophages - colonization
Multiresistentie van Brachyspira hyodysenteriae in Nederland
Duinhof, T.F. ; Dierikx, C.M. ; Bergen, M.A.P. van; Koene, M.G.J. ; Mevius, D.J. ; Veldman, K.T. ; Winne, R. de; Beers, H. van - \ 2008
Tijdschrift voor Diergeneeskunde 133 (2008)14-15. - ISSN 0040-7453 - p. 604 - 608.
varkenshouderij - varkens - diergeneeskunde - meervoudige resistentie tegen geneesmiddelen - pig farming - pigs - veterinary science - multiple drug resistance - decreased susceptibility - tiamulin
This case study describes the isolation of a multiresistant strain of Brachyspira hyodysenteriae in April 2007 in a Dutch sow herd with recurrent diarrhoea. Examination of faecal samples taken from 7-month-old breeding gilts with diarrhoea revealed the presence of resistance against tiamulin, lincomycin, tplosin, doxycycline, and tylvalosin (the active substance in Aivlosin (R)) in four of five samples. Tiamulin resistance has not been reported in the Netherlands before. The repeated use of tiamulin on the affected farm was assumed to be the main cause of the development of resistance to the drug. The farmer was advised to adopt a medication strategy and to implement management practices that would prevent an ongoing cycle of infection on the farm. It is important that the Dutch swine industry appreciates that tiamulin-resistant strains of B. hyodysenteriae may be found on other farms as well. The appropriate and prudent use of antibiotics is essential in order to prevent the development of resistance against the last option left to cure B. hyodysenteriae infections. valnemulin.
Parafilariose, een nieuwe parasitaire ziekte bij het rund
Wuijkhuise, L. van; Peutz, J. ; Roumen, M. ; Borgsteede, F.H.M. ; Kock, P. - \ 2007
Tijdschrift voor Diergeneeskunde 132 (2007)21. - ISSN 0040-7453 - p. 820 - 824.
parafilaria bovicola - ziektegeval-definities - diagnose - epidemiologische onderzoeken - rundveeziekten - musca autumnalis - diergeneeskunde - parafilaria bovicola - case definitions - diagnosis - epidemiological surveys - cattle diseases - musca autumnalis - veterinary science - imported charolais bull - bovicola tubangui 1934 - ivermectin - specificity - efficacy
In March 2007, cutaneous nodules were observed on the neck, shoulder and back of a breeding bull imported from France in November 2006. The nodules opened spontaneously and produced a haemorrhagic exudate. The cause was Parafilaria bovicola, a filariid nematode not endemic to the Netherlands. The worm can cause substantial economic loss because of the need to trim carcasses and because of the diminished value of hides. The infection is spread by the fly Musca autumnalis, which is common in the Netherlands. Because treatment does not stop the infection from spreading, the bull was culled to prevent the risk of infection of the national herd. To our knowledge, this is the first case of Parafilaria bovicola in the Netherlands.
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