Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Editorial : Diet, Inflammation and Colorectal Cancer
    Gessani, Sandra ; Duijnhoven, Fränzel J. Van; Moreno-Aliaga, Maria Jesus - \ 2019
    Frontiers in Immunology 10 (2019). - ISSN 1664-3224
    colorectal cancer - diet - dietary factors - inflammation - obesity
    Red and processed meat intake and risk of colorectal adenomas: a systematic review and meta-analysis of epidemiological studies
    Aune, D. ; Chan, D.S.M. ; Vieira, A. ; Navarro Rosenblatt, D. ; Vieira, R. ; Greenwood, D.C. ; Kampman, E. ; Norat, T. - \ 2013
    Cancer Causes and Control 24 (2013)4. - ISSN 0957-5243 - p. 611 - 627.
    dose-response metaanalysis - heterocyclic amines - dietary factors - life-style - hyperplastic polyps - carcinoma sequence - cigarette-smoking - burgundy france - dairy-products - sigmoid colon
    Background Current evidence indicates that red and processed meat intake increases the risk of colorectal cancer; however, the association with colorectal adenomas is unclear. Objective To conduct a systematic review and meta-analysis of epidemiological studies of red and processed meat intake and risk of colorectal adenomas as part of the Continuous Update Project of the World Cancer Research Fund. Design PubMed and several other databases were searched for relevant studies from their inception up to 31 December 2011. Summary relative risks (RRs) were estimated using a random effects model. Results Nineteen case–control studies and seven prospective studies were included in the analyses. The summary RR per 100 g/day of red meat was 1.27 (95 % CI 1.16–1.40, I2 = 5 %, n = 16) for all studies combined, 1.20 (95 % CI 1.06–1.36, I2 = 0 %, n = 6) for prospective studies, and 1.34 (95 % CI 1.12–1.59, I2 = 31 %, n = 10) for case–control studies. The summary RR per 50 g/day of processed meat intake was 1.29 (95 % CI 1.10–1.53, I2 = 27 %, n = 10) for all studies combined, 1.45 (95 % CI 1.10–1.90, I2 = 0 %, n = 2) for prospective studies, and 1.23 (95 % CI 0.99–1.52, I2 = 37 %, n = 8) for case–control studies. There was evidence of a nonlinear association between red meat (pnonlinearity <0.001) and processed meat (pnonlinearity = 0.01) intake and colorectal adenoma risk. Conclusion These results indicate an elevated risk of colorectal adenomas with intake of red and processed meat, but further prospective studies are warranted
    Meat and fish consumption, APC gene mutations and hMLH1 expression in colon and rectal cancer: a prospective cohort study (the Netherlands)
    Luchtenborg, M. ; Weijenberg, M.P. ; Goeij, A.F.P.M. de; Wark, P.A. ; Brink, M. ; Roemen, G.M.J.M. ; Lentjes, M.H.F.M. ; Bruine, A.P. de; Goldbohm, R.A. ; Veer, P. van 't; Brandt, P.A. van den - \ 2005
    Cancer Causes and Control 16 (2005)9. - ISSN 0957-5243 - p. 1041 - 1054.
    scale prospective cohort - colorectal-cancer - sporadic colon - microsatellite instability - adenomatous polyposis - k-ras - dietary factors - cluster region - carcinomas - tumors
    Objective:The aim of this study was to investigate the associations between meat and fish consumption and APC mutation status and hMLH1 expression in colon and rectal cancer. Methods:The associations were investigated in the Netherlands Cohort Study, and included 434 colon and 154 rectal cancer patients on whom case-cohort analyses (subcohort n = 2948) were performed. Results:Total meat consumption was not associated with the endpoints studied. Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96¿2.71, p-trend = 0.04 and 1.58, 95% CI 1.10¿2.25, p-trend = 0.01, respectively). Consumption of other meat (horsemeat, lamb, mutton, frankfurters and deep-fried meat rolls) was associated with an increased risk of rectal cancer without a truncating APC mutation (RR intake versus no intake 1.79, 95% CI 1.10¿2.90). No associations were observed for meat consumption and tumours lacking hMLH1 expression. Conclusions:Our data indicate that several types of meat may contribute differently to the aetiology of colon and rectal cancer, depending on APC mutation status but not hMLH1 expression of the tumour.
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