Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Urinary excretion of advanced glycation end products in dogs and cats
    Palaseweenun, Pornsucha ; Hagen-Plantinga, Esther A. ; Schonewille, Thomas J. ; Koop, Gerrit ; Butre, Claire ; Jonathan, Melliana ; Wierenga, Peter A. ; Hendriks, Wouter H. - \ 2020
    Journal of Animal Physiology and Animal Nutrition (2020). - ISSN 0931-2439
    advanced glycation end products - cats - diet - dogs - urinary excretion

    The present study was conducted with privately owned dogs and cats to investigate whether a relationship exists between the dietary AGEs and the urinary excretion of AGEs, as indication of possible effective absorption of those compounds in the intestinal tract of pet carnivores. For this purpose, data were collected from both raw fed and dry processed food (DPF) fed to dogs and cats, through spot urine sampling and questionnaires. Raw pet food (RF, low in AGE diets) was fed as a primary food source to 29 dogs and DPF to 28 dogs. Cats were categorized into 3 groups, which were RF (n = 15), DPF (n = 14) and dry and wet processed pet food (DWF, n = 25). Urinary-free carboxymethyllysine (CML), carboxyethyllysine (CEL) and lysinoalanine (LAL) were analysed using ultrahigh-performance liquid chromatography (UHPLC)—mass spectrometry, and were standardized for variable urine concentration by expressing the AGE concentrations as a ratio to urine creatinine (Ucr) concentration (µg/µmol Ucr). Urinary excretion of CML, CEL and LAL in dogs fed with DPF was 2.03, 2.14 and 3 times higher compared to dogs fed with RF (p <.005). Similar to the dogs, a significant difference in CML:Ucr, CEL:Ucr and LAL:Ucr between the three diet groups was observed in cats (p-overall < 0.005, ANOVA), in which the RF fed group excreted less AGEs than the other groups. Linear regression coefficients and SE of CML:Ucr, CEL:Ucr and LAL:Ucr showed that body weight and neuter status were significantly correlated with CML and CEL excretion, but not to LAL excretion. Our results revealed a significant correlation between dietary AGEs and urinary excretion of free CML, CEL and LAL, and also showed that endogenous formation of these AGEs occurs in both dogs and cats under physiological conditions.

    Zo kies je een gezonde en sociale hond
    Ruis, M.A.W. - \ 2019
    Wageningen : Wageningen University & Research - 21 p.
    animal welfare - pets - dogs - animal behaviour - animal housing - animal health - animal nutrition - animal breeding
    Deze interactieve brochure van Platform Fairfok geeft een overzicht van beschikbare informatie, diensten of producten van organisaties die zich actief inzetten voor de gezonde en sociale hond in Nederland.
    Fairfok Quiz : Basisschool
    Ruis, M.A.W. - \ 2018
    Wageningen : Dierenwelzijnsweb - 4 p.
    animal welfare - dogs - pets - domestic animals - animal health - animal behaviour - selective breeding - teaching materials - elementary schools
    Limits to genetic rescue by outcross in pedigree dogs
    Windig, J.J. ; Doekes, H.P. - \ 2018
    Journal of Animal Breeding and Genetics 135 (2018)3. - ISSN 0931-2668 - p. 238 - 248.
    conservation genetics - dogs - genetic defects

    Outcrossing should reduce inbreeding levels and associated negative effects in highly inbred populations. In this study, we investigated the effectiveness of different outcrossing schemes using computer simulations. The inbreeding rate estimated for a 25-year period of 2.1% per generation in a highly inbred dog breed reduced to 1.8% when a single litter was produced by an outcross without backcrosses. To reduce the inbreeding rate below 1%, more than eight of the 14 litters born yearly in the recipient breed had to be outcrossed. However, outcrossing in pedigree dogs is usually followed by backcrossing and generally involves one or a few litters. Backcrossing reduced the effect of outcrossing considerably. When two litters were produced by an outcross followed by one generation of backcross, the inbreeding rate was 2.0% per generation. Continuously outcrossing was more effective than a single or a few outcrosses. When each newborn litter during 25 years had a 5% chance of being produced by an outcross, the inbreeding rate reduced to −0.2%. To investigate the possibility that new alleles were introduced from the donor population into the recipient population, the fate of different type of alleles (varying from completely lethal to beneficial) before and after an outcross was investigated by first simulating 80 years of natural selection prior to the outcross and then different types of outcross. Because natural selection reduced the frequency of lethal alleles before outcrossing, the introduction of a lethal allele that was segregating in the donor breed but not in the recipient breed occurred rarely. Introduction of slightly detrimental alleles or neutral alleles occurred more frequently. In conclusion, outcrossing only had a limited short-term effect unless repeated continuously. Nevertheless, it may help to buy time in which the population structure can be changed so that the effective population size increases.

    Rabies in Ethiopia: modelling the burden and the effectiveness of control
    Beyene, Tariku Jibat - \ 2017
    Wageningen University. Promotor(en): H. Hogeveen, co-promotor(en): M.C.M. Mourits. - Wageningen : Wageningen University - ISBN 9789463432177 - 194
    cattle - dogs - rabies - farmers - cattle farming - vaccination - business economics - cost effectiveness analysis - ethiopia - east africa - rundvee - honden - hondsdolheid - boeren - rundveeteelt - vaccinatie - bedrijfseconomie - cost effective analysis - ethiopië - oost-afrika

    Rabies claims the lives of more than 24,000 people in Africa annually, but efforts to control the disease are still lacking, particularly in sub-Saharan Africa such as Ethiopia. The overall objective of this study was to support the design of an appropriate cost-effective rabies control policy in Ethiopia by providing insights in the health burden of the disease and its economic impacts, as well as an understanding of the relationship between intervention levels, implementation costs and potential returns.

    As most human rabies cases result from the bite of domestic dogs, the disease can be eliminated by mass canine rabies vaccination. An extensive literature review on mass canine vaccination programs in Africa indicated that most dogs in Africa are owned and therefore accessible for vaccination, but vaccination coverages strongly depend on the implemented cost schemes. Canine vaccination in Ethiopia is voluntarily based, i.e. “owner-charged”, resulting in one of the lowest coverages in the world.

    To assess the current burden of rabies in Ethiopia a retrospective study was conducted by collecting data on human rabies exposure over the period of one year through extensive bite case searching in three representative districts of Ethiopia. Extrapolation of the results to national level indicated an annual average of 3,000 human deaths and 97,000 rabies-exposed persons treated at an average costs of 21 USD per case, causing 2 million USD on treatment costs per year and a health loss of about 93,000 DALYs. About 77% of the exposure cases visited a health centre, while only 57% received sufficient doses of post exposure treatment. Important factors that influenced victim’s medical treatment seeking behaviour were ownership status of the biting dog, severity of the bite, body part bitten, monthly spending and distance to the nearest health centre whereas the likelihood of receiving sufficient doses of treatment were determined by monthly spending and distance to health centre. The district in which victims lived appeared to have a relevant influence on the likelihood of seeking medical treatment but not on the likelihood of treatment compliance. By means of a structured questionnaire administered to cattle-owning households the economic impact of rabies in livestock was assessed. Herd-level incidence rates appeared higher in the mixed crop-livestock system (21%) than in the pastoral system (11%). Average economic losses per herd due to rabies were estimated at 49 USD per year for the mixed-crop livestock system, and at 52 USD per year for the pastoral system.

    In light of policy support for rabies control, an evaluation of the cost-effectiveness of control strategies was performed by the use of a dynamic epidemiological model coupled with an economic analysis to predict the human health impact and economic benefit (reducing human treatment costs and livestock rabies-related losses) across a range of vaccination scenarios. Human exposures, human deaths, and rabies-related livestock losses decreased monotonically with increasing vaccination coverage. In the evaluated urban and rural districts, 50% coverage was identified as most likely scenario to provide the greatest net health benefits at the WHO-recommended willingness-to-pay threshold over a time frame of 10 years. The additional economic benefit from rabies control in livestock justified the additional costs of vaccination campaigns with higher coverages than would have been efficient from a strict human health perspective, highlighting the importance of applying a broad perspective with regard to the evaluation of vaccination benefits.

    Open normen licht bij het bedrijfsmatig houden van gezelschapsdieren : praktische handvatten voor de controle op het voldoen aan ethologische en fysiologische behoeften van honden en konijnen
    Ruis, Marko A.W. ; Borg, Joanne A.M. van der - \ 2017
    Wageningen : Wageningen Livestock Research (Wageningen Livestock Research rapport 981) - 42
    honden - konijnen - licht - kunstlicht - dierenwelzijn - dierhouderij - gezelschapsdieren - diergedrag - huisvesting, dieren - diergezondheid - dogs - rabbits - light - artificial light - animal welfare - animal husbandry - pets - animal behaviour - animal housing - animal health
    This report describes the development of practical tools for inspectors to monitor compliance with the target welfare regulations with regard to provison of light for dogs and rabbits that are kept and sold commercially. On the basis of a literature study on the influence of light on the welfare and functioning of dogs and rabbits, and in the context of the situation in practice, tools were developed to supervise and advice in a systematic way. By this the inspector can make an informed assessment about whether or not enforcing rules on the provision of light.
    Farewell symposium Kor Oldenbroek
    Windig, Jack - \ 2017
    animal welfare - pets - dogs - animal breeding methods - genetics - animal health
    Breeding healthy dogs with genomics / Presentation
    Socio-economic modelling of rabies control in Flores Island, Indonesia
    Wera, Ewaldus - \ 2017
    Wageningen University. Promotor(en): Henk Hogeveen, co-promotor(en): Monique Mourits. - Wageningen : Wageningen University - ISBN 9789463430586 - 182
    rabies - rabies virus - control programmes - control methods - dogs - indonesia - decision making - vaccination - hondsdolheid - hondsdolheidvirus - bestrijdingsprogramma's - bestrijdingsmethoden - honden - indonesië - besluitvorming - vaccinatie

    Rabies is a zoonotic viral disease that can cause encephalomyelitis both in animals and humans. Since its introduction in Flores Island, Indonesia in 1997, it has been a serious public health threat with significant economic consequences. To control the disease, annual dog vaccination campaigns have been implemented to vaccinate all dogs free of any charge. Nevertheless, the campaigns have not been successful in eliminating rabies from the island.

    The main objective of this dissertation was to support future decisions on the control of rabies in Flores Island by providing insight into the role of socio-demographic and psychological factors of dog owners in the uptake of rabies control measures and by analyzing the cost-effectiveness of alternative mass dog vaccination strategies.

    By means of a cost accounting model, the costs of the currently applied rabies control measures in Flores Island were estimated at US$1.12 million (range: US$0.60–1.47 million) per year. The costs of culling roaming dogs resulted in the highest cost portion (39%), followed by the costs of post-exposure treatment (35%) and mass vaccination (24%).

    Risk factors associated with the uptake level of rabies control measures were analysed based upon an extensive survey among 450 dog-owners in the regencies of Sikka and Manggarai. Only 52% of these dog owners had at least one of their dogs vaccinated during the 2012 vaccination campaign. Vaccination uptake was significantly higher for dog owners who resided in Sikka, kept female dogs for breeding, had a monthly income of more than one million rupiah, and had easy access to their village.

    A study based on the Theory of Planned Behaviour demonstrated that the actual intention of dog owners to participate in a free-of-charge vaccination campaign was high (> 90%). The attitude item ‘vaccinating dogs reduces rabies cases in humans’, and the perceived behavioural control items ‘availability of time’ and ‘ability to confine dogs’ were shown to be significantly associated with this intention level. Relevant considerations to improve the participation level in future vaccination campaigns are therefore appropriate time management as well as the provision of skills to confine dogs during the vaccination.

    The cost-effectiveness of different mass dog vaccination strategies was evaluated by means of a deterministic model simulating transmission of rabies virus through the dog population of one village. Annual vaccination using a short-acting vaccine at a coverage of 50% was far from being cost-effective, suggesting that the currently applied rabies control in Flores Island is not an efficient investment in reducing human rabies burden. An increased investment in either an increase in the current coverage or in a switch from the short-acting vaccine to the long-acting vaccine type would certainly pay off.

    Welzijn honden : Houden van honden - Dierenwelzijn in beeld
    Borg, J.A.M. van der - \ 2016
    dierenwelzijn - huisdieren - honden - diergezondheid - diergedrag - diervoeding - huisvesting, dieren - animal welfare - domestic animals - dogs - animal health - animal behaviour - animal nutrition - animal housing
    De hond is het oudste gedomesticeerde dier. Van wolf via oerhond naar de hedendaagse huishond, met als resultaat een explosie aan rassen. De kleinste is de Chihuahua met amper 500 gram, en de grootste de Duitse dog, met tachtig kilogram. Naar schatting leven 1.5 miljoen honden in Nederland. Hoe goed honden gehouden en verzorgd worden is bepalend voor het hondenwelzijn. Welzijn gaat over natuurlijk gedrag, gezondheid en functioneren en gevoel. Uiteindelijk gaat het om de kwaliteit van leven zoals door het dier ervaren. Welzijn meet je het beste door naar gedrag en gezondheid te kijken. Daarbij zijn goede voeding en huisvesting basisvoorwaarden. Deze vier aspecten zijn onderdeel van de Welfare Quality aanpak voor het meten van welzijn aan dieren zelf.
    Dat doet hij normaal nooit! : Les over welzijn van honden
    Ruis, M.A.W. - \ 2016
    Wageningen : Wageningen Livestock Research - 4
    dierenwelzijn - gezelschapsdieren - honden - huisvesting, dieren - diergedrag - diergezondheid - lesmaterialen - animal welfare - pets - dogs - animal housing - animal behaviour - animal health - teaching materials
    Fokken, wat is dat?
    Oldenbroek, Kor - \ 2016
    animal welfare - pets - dogs - animal health - animal behaviour - animal breeding - genetics
    Hereditary disorders in pedigree dogs and look-a-likes
    Zeeland, C.W.M. Van; Beerda, B. - \ 2015
    Wageningen UR, Wetenschapswinkel (Rapport / Wetenschapswinkel Wageningen UR 317) - ISBN 9789461738882 - 51
    dogs - dog breeds - genetic disorders - pedigree - disease prevalence - animal breeding - animal welfare - animal health - pets - honden - hondenrassen - genetische stoornissen - stamboom - ziekteprevalentie - dierveredeling - dierenwelzijn - diergezondheid - gezelschapsdieren
    Inteelt-scanner voor rashonden
    Windig, Jack - \ 2015
    breeds - animal genetics - kinship - animal breeding - dogs - animal health - animal welfare - genetic disorders - pets
    Leerboek fokkerij en genetica voor het HBO
    Oldenbroek, Kor - \ 2015
    teaching materials - animal breeding - animal genetics - animal breeding methods - livestock farming - professional education - animal welfare - animal health - animal production - pets - dogs - cats - dairy cattle - pigs - poultry - horses
    Erfelijke problemen bij honden los je met fokkerijmaatregelen op!
    Oldenbroek, Kor - \ 2015
    animal welfare - animal health - pets - domestic animals - dogs - animal behaviour - animal breeding - education - genetic disorders - hereditary diseases - dog breeds
    Studium Generale “Fairfok the Dog” : oplossing erfelijke rashondenproblematiek; van theorie naar praktijk
    Hopster, Hans - \ 2015
    animal welfare - pets - animal health - animal breeding - education - domestic animals - dogs - dog breeds - hereditary diseases - genetic disorders - animal behaviour
    Genome-wide survey indicates involvement of loci on canine chromosomes 7 and 31 in patellar luxation in flat-coated retrievers
    Lavrijsen, I.C.M. ; Leegwater, P.A.J. ; Wangdee, C. ; Steenbeek, F.G. van; Schwencke, M. ; Breur, G.J. ; Meutstege, F.J. ; Nijman, I.J. ; Cuppen, E. ; Heuven, H.C.M. ; Hazewinkel, H.A.W. - \ 2014
    BMC Genetics 15 (2014). - ISSN 1471-2156
    dogs - breed - frequency - association - enrichment
    Background: Patellar luxation is an orthopedic disorder in which the patella moves out of its normal location within the femoral trochlea of the knee and it can lead to osteoarthritis, lameness, and pain. In dogs it is a heritable trait, with both environmental and genetic factors contributing to the phenotype. The prevalence of patellar luxation in the Dutch Flat-Coated Retriever population is 24%. In this study, we investigated the molecular genetics of the disorder in this population. Results: Genome-wide association analysis of 15,823 single nucleotide polymorphisms (SNPs) in 45 cases and 40 controls revealed that patellar luxation was significantly associated with a region on chromosome CFA07, and possibly with regions on CFA03, CFA31, and CFA36. The exons of the genes in these regions, 0.5 Mb combined, were analyzed further. These exons from 15 cases and a pooled sample from 15 controls were enriched using custom genomic hybridization arrays and analyzed by massive parallel DNA sequencing. In total 7257 variations were detected. Subsequently, a selection of 144 of these SNPs were genotyped in 95 Flat-Coated Retrievers. Nine SNPs, in eight genes on CFA07 and CFA31, were associated with patellar luxation (P <10(-4)). Genotyping of these SNPs in samples from a variety of breeds revealed that the disease-associated allele of one synonymous SNP in a pseudogene of FMO6 was unique to Flat-Coated Retrievers. Conclusion: Genome-wide association analysis followed by targeted DNA sequencing identified loci on chromosomes 7 and 31 as being involved in patellar luxation in the Flat-Coated Retriever breed.
    Een onderzoek naar erfelijke gebreken bij rashonden en lookalikes
    Wageningen UR Wetenschapswinkel, - \ 2014
    Wetenschapswinkel Wageningen UR
    honden - hondenrassen - huisdieren - gezelschapsdieren - dierenwelzijn - diergezondheid - genetische stoornissen - dierveredeling - fokdoelen - dogs - dog breeds - domestic animals - pets - animal welfare - animal health - genetic disorders - animal breeding - breeding aims
    De Stichting Dier & Recht stelt op haar website dat consumenten beter een hond van een kruising uit het asiel kunnen halen, dan voor veel geld een rashond kopen. Rashonden lijken vaker een erfelijk gebrek te hebben, maar is dat echt zo en lopen rashonden dezelfde risico’s als lookalikes?
    Genetic management : from science to practice
    Windig, Jack - \ 2014
    animal genetic resources - animal breeding - dogs - kempen heath sheep - veluwe heath sheep - sheep - golden retriever - biodiversity
    Rapportage kwalitatief onderzoek 'Identificatie en Registratie van honden'
    Niekerk, T.G.C.M. van; Potters, P. ; Meeusen, M.J.G. - \ 2014
    Wageningen : Wageningen UR Livestock Research (Rapport / Wageningen UR Livestock Research 818) - 27
    honden - gezelschapsdieren - identificatie - registratie - dierenwelzijn - puppy's - diergezondheid - huisdieren - dogs - pets - identification - registration - animal welfare - puppies - animal health - domestic animals
    Het onderhavige rapport is een verslag van een kwalitatief onderzoek onder (potentiële) hondenbezitters met als belangrijkste doelstelling om inzicht krijgen in de kennis, houding en gedrag van (huidige en toekomstige) hondenbezitters t.a.v. het chippen en registeren van honden.
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