Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Effect van klimaatverandering en vergrijzing op waterkwaliteit en drinkwaterfunctie van Maas en Rijn
    Sjerps, Rosa M.A. ; Laak, T.L. ter; Zwolsman, G.J. - \ 2016
    H2O online (2016)augustus.
    climatic change - drinking water - water quality - surface water - pesticides - radiography - drug residues - water pollution - river meuse - river rhine - prognosis - klimaatverandering - drinkwater - waterkwaliteit - oppervlaktewater - pesticiden - radiografie - geneesmiddelenresiduen - waterverontreiniging - maas - rijn - prognose
    Door de vergrijzing zal de emissie van geneesmiddelen en röntgencontrastmiddelen naar het oppervlaktewater toenemen. De effecten van toenemende emissies op de waterkwaliteit worden versterkt bij lage rivierafvoeren, die naar verwachting steeds vaker en langduriger zullen optreden in een veranderend klimaat. In deze studie zijn prognoses gemaakt van de toekomstige concentraties van een aantal relevante organische microverontreinigingen in de Rijn en Maas in het jaar 2050. De voorspelde concentraties van diverse geneesmiddelen en röntgencontrastmiddelen in de Rijn en de Maas overschrijden de ERM-streefwaarden voor oppervlaktewater als bron van drinkwater. Sporen van enkele organische microverontreinigingen kunnen doordringen in het drinkwater.
    Microbial Removal of the Pharmaceutical Compounds Ibuprofen and Diclofenac from Wastewater
    Langenhoff, A.A.M. ; Inderfurth, N.S. ; Veuskens, T. ; Schraa, G. ; Blokland, M. ; Kujawa-Roeleveld, K. ; Rijnaarts, H.H.M. - \ 2013
    BioMed Research International 2013 (2013). - ISSN 2314-6133 - 9
    biodegradatie - geneesmiddelen - afvalwater - afvalwaterbehandeling - bioremediëring - afvalwaterbehandelingsinstallaties - verwijdering - oppervlaktewater - geneesmiddelenresiduen - biodegradation - drugs - waste water - waste water treatment - bioremediation - waste water treatment plants - removal - surface water - drug residues - personal care products - activated carbon - batch experiments - aquatic environment - metabolites - systems - sludge - acid - transformation
    Studies on the occurrence of pharmaceuticals show that the widely used pharmaceuticals ibuprofen and diclofenac are present in relevant concentrations in the environment. A pilot plant treating hospital wastewater with relevant concentrations of these pharmaceuticals was evaluated for its performance to reduce the concentration of the pharmaceuticals. Ibuprofen was completely removed, whereas diclofenac yielded a residual concentration, showing the necessity of posttreatment to remove diclofenac, for example, activated carbon. Successively, detailed laboratory experiments with activated sludge from the same wastewater treatment plant showed bioremediation potential in the treatment plant. The biological degradation pathway was studied and showed a mineralisation of ibuprofen and degradation of diclofenac. The present microbes were further studied in laboratory experiments, and DGGE analyses showed the enrichment and isolation of highly purified cultures that degraded either ibuprofen or diclofenac. This research illuminates the importance of the involved bacteria for the effectiveness of the removal of pharmaceuticals in a wastewater treatment plant. A complete removal of pharmaceuticals from wastewater will stimulate water reuse, addressing the worldwide increasing demand for clean and safe fresh water.
    The (un)certainty of selectivity in liquid chromatography tandem mass spectrometry
    Berendsen, B.J.A. ; Stolker, A.A.M. ; Nielen, M.W.F. - \ 2013
    Journal of the American Society for Mass Spectrometry 24 (2013). - ISSN 1044-0305 - p. 154 - 163.
    drug residues - lc-ms - identification - confirmation - spectra - library - fragmentation - system - food
    We developed a procedure to determine the "identification power" of an LC-MS/MS method operated in the MRM acquisition mode, which is related to its selectivity. The probability of any compound showing the same precursor ion, product ions, and retention time as the compound of interest is used as a measure of selectivity. This is calculated based upon empirical models constructed from three very large compound databases. Based upon the final probability estimation, additional measures to assure unambiguous identification can be taken, like the selection of different or additional product ions. The reported procedure in combination with criteria for relative ion abundances results in a powerful technique to determine the (un)certainty of the selectivity of any LC-MS/MS analysis and thus the risk of false positive results. Furthermore, the procedure is very useful as a tool to validate method selectivity. Figure
    Veterinary drugs and growth promoting agents in animal products : annual report 2011 of the National Reference Laborator
    Stolker, A.A.M. ; Sterk, S.S. - \ 2012
    Wageningen : RIKILT - Intstitute of Food Safety (Report / RIKILT 2012.008)
    dierlijke producten - veterinaire producten - geneesmiddelenresiduen - groeibevorderaars - vleeskwaliteit - animal products - veterinary products - drug residues - growth promoters - meat quality
    This report of the National Reference Laboratory (NRL) for residues of veterinary drugs and growth promoting agents in products of animal origin according to Council Directive 96/23/EC describes the activities employed in 2011. The main tasks of the NRL are the communication with Routine Field Laboratories (RFL), the preparation of quality control samples and the advisory function for the Competent Authority and RFL. Furthermore the NRL organizes comparative tests, ensure that the RFL observes the residue limits, disseminates information obtaines from the European Union Reference Laboratories (EURLs) and participate in training organized by the Commission or by the EURLs.
    Label-Free and Multiplex Detection of Antibiotic Residues in Milk Using Imaging surface Plasmon Resonance-Based immunosensor
    Rebe, S. ; Bremer, M.G.E.G. ; Haasnoot, W. ; Norde, W. - \ 2009
    Analytical Chemistry 81 (2009)18. - ISSN 0003-2700 - p. 7743 - 7749.
    linked-immunosorbent-assay - beta-lactam antibiotics - biosensor immunoassay - food-products - drug residues - fluoroquinolones - aminoglycosides - antibody - muscle - tests
    Monitoring of antimicrobial drug residues in foods relies greatly on the availability of adequate analytical techniques. Currently, there is a need for a high-throughput screening method with a broad-spectrum detection range. This paper describes the development of a microarray biosensor, based on an imaging surface plasmon resonance (iSPR) platform, for quantitative and simultaneous immunodetection of different antibiotic residues in milk. Model compounds from four major antibiotic families: aminoglycosides (Neomycin, Gentamicin, Kanamycin, and Streptomycin), sulfonamides (Sulfamethazine), fenicols (Chloramphenicol), and fluoroquinolones (Enrofloxacin) were detected using a single sensor chip. By multiplexing seven immunoassays in a competitive format, we were able to measure all the target compounds at parts per billion (ppb) levels in buffer and in 10×-diluted milk. The assays for Neomycin, Kanamycin, Streptomycin, Enrofloxacin, and Sulfamethazine were sensitive enough for milk control at maximum residue levels as established in the European Union. The overall performance of the biosensor was determined to be comparable to that of conventional four-channel surface plasmon resonance (SPR)-based biosensors, in terms of assay sensitivity and robustness. Combining the advantages of a SPR sensor and a microarray, utilization of the biosensor described here offers a promising alternative to the existing methods and is highly relevant for multianalyte food profiling.
    De gele strontvlieg op zijn hoogtepunt
    Lahr, J. - \ 2008
    Nature Today 2008 (2008)14-7-2008.
    dierlijke meststoffen - scathophaga stercoraria - fauna - bodem - geneesmiddelenresiduen - nadelige gevolgen - ecotoxicologie - animal manures - scathophaga stercoraria - fauna - soil - drug residues - adverse effects - ecotoxicology
    Wie door weilanden en natuurgebieden wandelt komt ze regelmatig tegen: koeienvlaaien, paardenvijgen en schapenkeutels. Verse mest kan je in het voorbijgaan vaak herkennen door de wolk van vliegjes die er van opstijgt en die soms hinderlijk in je gezicht komt. Een van die vliegjes is de gele strontvlieg die nu door het koelere weer op zijn hoogtepunt zit
    Annual report 2006/2007 of the National Reference Laboratory for residues of veterinary drugs in products of animal origin according to 96/23/EC
    Zuidema, T. ; Stolker, A.A.M. - \ 2008
    Wageningen : RIKILT Wageningen UR (Report / RIKILT, Institute of Food Safety 2008.002) - 36
    geneesmiddelenresiduen - veterinaire producten - dierlijke producten - referentienormen - kwaliteitscontroles - drug residues - veterinary products - animal products - reference standards - quality controls
    Nieuwe verontreinigingen in de bodem : een verkennende literatuurstudie naar de mogelijke risico's van hormoonverstoorders en diergeneesmiddelen
    Lahr, J. - \ 2007
    Wageningen : Alterra (Alterra-rapport 1619) - 80
    bodemverontreiniging - hormoonverstoorders - geneesmiddelen - geneesmiddelenresiduen - verontreinigende stoffen - risicoschatting - voedselkwaliteit - literatuuroverzichten - veterinaire producten - bodemkwaliteit - soil pollution - endocrine disruptors - drugs - drug residues - pollutants - risk assessment - food quality - literature reviews - veterinary products - soil quality
    een verkennende studie van de wetenschappelijke literatuur naar het voorkomen en de mogelijke risico’s van hormoonverstorende stoffen (inclusief hormonen) en diergeneesmiddelen in het bodemmilieu. De belangrijkste conclusie is dat er nog veel onbekend is over het voorkomen van deze stoffen in de bodem. Dit komt vooral doordat er zeer weinig metingen zijn verricht. Omdat er geen inzicht bestaat in de concentratieniveaus en ook nauwelijks in de effecten, zijn de risico’s van deze stoffen voor bodemgezondheid, voedselkwaliteit en de gezondheid van landbouwhuisdieren moeilijk in te schatten. Verder is de omvang van de verontreiniging met de meeste van deze stoffen onbekend en kan dus de schaal van de problematiek moeilijk worden vastgesteld
    Proficiency study for penicillins in porcine tissues
    Berendsen, B.J.A. ; Zuidema, T. - \ 2007
    Wageningen : RIKILT (Report / RIKILT, Institute of Food Safety 2007.007) - 52
    penicillinen - varkensvlees - vleeskwaliteit - laboratoriumproeven - geneesmiddelenresiduen - penicillins - pigmeat - meat quality - laboratory tests - drug residues
    Behavioural responses of Gammarus pulex (Crustacea, Amphipoda) to low concentrations of pharmaceuticals
    Lange, H.J. de; Noordoven, W. ; Murk, A.J. ; Lürling, M.F.L.L.W. ; Peeters, E.T.H.M. - \ 2006
    Aquatic Toxicology 78 (2006)3. - ISSN 0166-445X - p. 209 - 216.
    gammarus pulex - aquatisch milieu - geneesmiddelen - waterorganismen - geneesmiddelenresiduen - gedrag - oppervlaktewater - waterverontreiniging - ecotoxicologie - biologische monitoring - gammarus pulex - aquatic environment - drugs - aquatic organisms - drug residues - behaviour - surface water - water pollution - ecotoxicology - biomonitoring - serotonin reuptake inhibitors - sewage-treatment plants - released chemical cues - waste-water - impedance conversion - clofibric acid - surface waters - daphnia-magna - toxicity
    The continuous discharge of pharmaceuticals and personal care products into the environment results in a chronic exposure of aquatic organisms to these substances and their metabolites. As concentrations in surface waters are in the ng/L range, and sometimes in the low microg/L range, they are not likely to result in lethal toxicity. However, prolonged exposure to low concentrations of anthropogenic chemicals may lead to sublethal effects, including changes in behaviour. The aim of this study was to assess the effect of three pharmaceuticals, the antidepressant fluoxetine, the analgesic ibuprofen and the anti-epileptic carbamazepine, and one cationic surfactant, cetyltrimethylammonium bromide (CTAB), on the activity of the benthic invertebrate Gammarus pulex (Crustacea: Amphipoda: Gammaridae). We used the multispecies freshwater biomonitor to assess changes in activity of G. pulex in a quantitative manner. Exposure to low concentrations (10-100ng/L) of fluoxetine and ibuprofen resulted in a significant decrease in activity, whereas the activity of G. pulex at higher concentrations (1microg/L-1mg/L) was similar to the control. Response to carbamazepine showed a similar pattern, however, differences were not significant. The tested surfactant CTAB evoked a decrease in activity at increasing concentration. These behavioural effect concentrations were 10(4) to 10(7) times lower than previously reported LOECs and in the range of environmentally occurring concentrations. The potential consequences of this decreased activity for G. pulex population growth and benthic community structure and the exposure to mixtures of pharmaceuticals deserves further attention.
    Diergeneesmiddelen in aquacultuur
    Korytar, P. ; Leslie, H.A. - \ 2006
    IJmuiden : RIVO (Rapport / Wageningen IMARES C026/06) - 14
    visteelt - aquacultuur - veterinaire producten - mebendazol - oxolinezuur - farmacokinetiek - geneesmiddelenresiduen - geneesmiddelen - fish culture - aquaculture - veterinary products - mebendazole - oxolinic acid - pharmacokinetics - drug residues - drugs
    De Nederlandse visteelt heeft nog niet de beschikking over toegestane diergeneesmiddelen, terwijl de noodzaak om bepaalde middelen te gebruiken in de praktijk bestaat. Deze middelen zijn met name: flumequine, mebendazole, oxolinezuur, oxytetracycline, praziquantel en trimethosulfmix. Wat op dit moment niet duidelijk is is de farmacokinetiek van deze middelen voor de vissoorten die in Nederland gekweekt worden. Deze informatie is van belang om te voorkomen dat residuen van de geneesmiddelen in voor consumptie bestemde visproducten terecht komen. Om meer inzicht te krijgen in bestaande farmacokinetische data voor de meest gebruikte middelen is een literatuuronderzoek uitgevoerd.
    Legislative and Institutional Framework for the Food Safety Control of Live Animals in China
    Zhang XiaoYong, Xiaoyong ; Roest, J. van der - \ 2003
    Den Haag : LEI (Rapport / LEI : Domein 6, Policy ) - ISBN 9789052428192 - 47
    wetgeving - agrarische economie - overheidsbeleid - voedselveiligheid - dierlijke producten - dieren - geneesmiddelenresiduen - monitoring - china - Nederland - legislation - agricultural economics - government policy - food safety - animal products - animals - drug residues - monitoring - china - Netherlands
    In 2002, both China and the EU suffered from a trade dispute over animal products. The aim of the report is to document this framework, in order to make a constructive contribution towards bridging the gap of understanding and accessibility of the countries' procedures in particular and of their trade relations in general. This report illustrates how the Chinese legal and institutional system differs from that in the EU. Laws, administrative documents and regulations are all part of the Chinese legal system and have an equally binding force. The Ministry of Agriculture (MoA) and the General Administration for Quality Supervision, Inspection and Quarantine (AQSIQ) are the two most important institutions monitoring food safety in China.
    Veiligheid onder de loep. Diergeneesmiddelresiduen in voedingsmiddelen van dierlijke oorsprong
    Waal, E.J. de; Klaveren, J.D. van - \ 2002
    Pharmaceutisch Weekblad 137 (2002)16. - ISSN 0031-6911 - p. 576 - 580.
    doxycycline - drug residues - food - legislation - veterinary drugs
    Safety scrutinised. Residues of veterinary medicines in foodstuff from animal origin. The use of veterinary medicinal products in food producing animals may give rise to residues in tissues and/or products destined for human consumption. To ensure consumer safety, an assessment of the safety of residues is carried out. This assessment results in the establishment of Maximum Residue Limits (MRLs) for food commodities. Based on the experience gained, the European regulatory authorities are now prepared to accept identical MRLs in different species. Further changes in the risk assessment process are anticipated. At the national level, veterinary drug residue monitoring programs are executed. No public health risks have been identified in The Netherlands.
    Ontwikkeling van een concept voor extractie van residuen van dierbehandelingsmiddelen uit ei en eiproducten voor opsporing van een breed scala van middelen welke van belang zijn voor een onbelemmerde afzet van deze producten
    Keukens, H.J. ; Zuidema, T. ; Beek, W.M.J. - \ 1999
    Wageningen : DLO-Rijks-Kwaliteitsinstituut voor land- en tuinbouwprodukten (RIKILT-DLO) (Rapport / RIKILT-DLO 99.009) - 17
    veterinaire producten - extractie - eieren - eierproducten - hplc - geneesmiddelenresiduen - analytische scheikunde - veterinary products - extraction - eggs - egg products - hplc - drug residues - analytical chemistry
    Statistical instruments for dietary risk assessment concerning acute exposure to residues and contaminants
    Voet, H. van der; Boer, W.J. de; Keizer, L.C.P. - \ 1999
    Unknown Publisher
    voedselbesmetting - pesticidenresiduen - statistiek - risicoschatting - residuen - geneesmiddelenresiduen - food contamination - pesticide residues - statistics - risk assessment - residues - drug residues
    In vitro toxicological studies and real time analysis of residues in food : final report
    Kuiper, H.A. ; Andersen, J.R. - \ 1995
    Wageningen : RIKILT-DLO - ISBN 9789056010089 - 163
    voedselanalyse - in vitro - experimenten - wetgeving - cellijnen - geneesmiddelenresiduen - food analysis - in vitro - experiments - legislation - cell lines - drug residues
    In vitro toxicological studies and real time analysis of residues in food : reports of exchange visits 1992
    Kuiper, H.A. ; Lamers, I. - \ 1994
    Wageningen : RIKILT-DLO - ISBN 9789056010041 - 103
    voedselanalyse - in vitro - experimenten - bèta-adrenerge agonisten - clenbuterol - steroïden - sulfonamiden - ochratoxinen - fumonisinen - geneesmiddelenresiduen - food analysis - in vitro - experiments - beta-adrenergic agonists - clenbuterol - steroids - sulfonamides - ochratoxins - fumonisins - drug residues
    In vitro toxicological studies and real time analysis of residues in food : reports of exchange visits 1991
    Kuiper, H.A. ; Lamers, I. - \ 1991
    Wageningen : RIKILT-DLO - ISBN 9789056010010 - 75
    voedselanalyse - in vitro - experimenten - geneesmiddelenresiduen - cytochroom p-450 - levercellen - pesticidenresiduen - food analysis - in vitro - experiments - drug residues - cytochrome p-450 - liver cells - pesticide residues
    Ontwikkeling bepalingsmethode voor residuen van nitro-imidazolen in kippe-eieren : uitscheidingsexperimenten bij leghennen
    Egberink, I. ; Aerts, M.M.L. ; Kan, C.A. ; Holthuis, J. - \ 1987
    Wageningen : RIKILT (Rapport / RIKILT 87.02) - 79
    geneesmiddelenresiduen - nitroimidazolen - drug residues - nitroimidazoles
    Doel van dit onderzoek is: het opzetten van een multi-analysemethode in eieren voor de meest toegepaste nitro-imidazolen. In de praktijk toetsen van de methode door uitscheidingsexperimenten. Vaststellen in hoeverre residuen van nitroimidazolen in eieren aanwezig zijn na eenmalige orale toediening.
    Onderzoek naar het voorkomen van hormonen - anabolica in injectievloeistoffen en andere preparaten, afkomstig uit de illegale handel
    Berghmans, M.C.J. ; Ruig, W.G. de - \ 1984
    Wageningen : RIKILT (Rapport / RIKILT 84.56) - 14
    anabolen - hormonen - geneesmiddelenresiduen - rundvee - anabolics - hormones - drug residues - cattle
    Doel van dit onderzoek is: inzicht te krijgen in welke hormonen/anabolica men thans toedient bij mannelijke en vrouwelijke dieren. In dit rapport wordt een overzicht gegeven van de werkwijze van het onderzoek en de daaruit voortvloeiende resultaten.
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