Changes in body composition as a result of chemotherapy : Comparing women with and without breast cancer
Berg, Maaike M.G.A. van den - \ 2017
Wageningen University. Promotor(en): E. Kampman; M. Visser, co-promotor(en): R.M. Winkels; J.H.M. de Vries. - Wageningen : Wageningen University - ISBN 9789463436984 - 140
body composition - neoplasms - cancer - drug therapy - breast cancer - body weight - intake - diet - meta-analysis - toxicity - lichaamssamenstelling - neoplasma's - cancer - geneesmiddelenbehandeling - borstkanker - lichaamsgewicht - opname (intake) - dieet - meta-analyse - toxiciteit
Because of the improved survival rate, both short term and long term adverse effects of breast cancer treatment have become increasingly important. Body weight and body composition before, during, and after chemotherapy may influence side effects during treatment and survival. The aims of this thesis were to assess among stage I-IIIB breast cancer patients: 1) the association between pre-treatment body composition and dose-limiting toxicities during chemotherapy, 2) potential changes in body weight and body composition during and after chemotherapy compared to changes in age-matched women without cancer in the same time period, and 3) dietary intake during chemotherapy compared to age-matched women without cancer in the same time period.
Chapter 2 describes the association between pre-treatment body composition and dose-limiting toxicities during chemotherapy. Data from 172 breast cancer patients who participated in the COBRA-study were analysed. Body composition was measured using a total body Dual Energy X-ray Absorption (DEXA) scan. Information regarding dose-limiting toxicities was abstracted from medical records. A higher BMI (kg/m2) and a higher fat mass (kg and percentage) were associated with an increased risk of dose-limiting toxicity, while lean body mass (kg) was not associated with risk of toxicities.
Chapter 3 presents the findings of a meta-analysis on changes in body weight during chemotherapy in breast cancer patients. The meta-analysis showed an overall gain in body weight of 2.7 kg (95% CI: 2.0-3.3) during chemotherapy, with a high degree of heterogeneity (I2= 94.2%). Weight gain in breast cancer patients was more pronounced in papers published before 2000 and studies including cyclophosphamide, methotrexate and 5-fluorouracil as chemotherapy regime.
Chapter 4 describes changes in body weight and body composition during and after chemotherapy. Data from 145 patients and 121 women of an age-matched comparison group, participating in the COBRA-study were analysed. Body composition was measured using DEXA-scan at three time points during the study period. For the patient group, these tie points were: before start of chemotherapy, shortly after chemotherapy, and 6 months after chemotherapy. For the comparison group these measurements were conducted over a similar time frame: baseline, 6 months after baseline, and 12 months after baseline. In addition, we identified determinants of changes in body weight and body composition.
Shortly after chemotherapy, patients had a significantly higher body weight, BMI, and lean body mass than women in the comparison group, while fat mass was similar. Six months after chemotherapy no differences in body weight or body composition were observed between the patient and comparison group. A younger age, better appetite during chemotherapy, and an ER-receptor negative tumour were associated with greater changes in body weight over time. A younger age and better appetite during chemotherapy were associated with greater changes in fat mass over time, while the only determinant associated with greater changes in lean body mass over time was a better appetite during chemotherapy.
Chapter 5 describes the dietary intake and food groups before and during chemotherapy of breast cancer patients compared with women without cancer. In addition we assessed the association between symptoms and energy intake. Data from 117 breast cancer patients and 88 women without breast cancer who participated in the COBRA-study were used. Habitual dietary intake before chemotherapy was assessed using a food frequency questionnaire. Two 24-hr dietary recalls were used to assess actual dietary intake during chemotherapy for patients and within 6 months for the comparison group. Shortly after the 24-hr dietary recall, participants filled out questionnaires about symptoms. Before chemotherapy, dietary intake was similar for both groups. During chemotherapy, breast cancer patients reported significantly lower total energy, total fat, total protein, and alcohol intake than women without cancer, which could be explained by a lower intake of specific food groups.
Overall results from this thesis suggest that pre-treatment fat mass is associated with dose-limiting toxicities during chemotherapy. Weight gain during chemotherapy appeared to be more modest than we expected based on literature and changes in body composition during chemotherapy consist mainly of an increase in lean body mass, which is only temporary and returned to baseline within 6 months after chemotherapy. A higher appetite during chemotherapy was associated with changes in body weight and body composition. A younger age at diagnosis was associated with greater changes in body weight and fat mass, but not with changes in lean body mass. In addition, an ER-receptor negative tumour was associated with greater changes in body weight, but not with changes in fat mass or lean body mass. During chemotherapy women with breast cancer have a lower intake of energy, fat, protein and alcohol compared to age-matched women without cancer, which was expressed in a lower intake of specific food groups. The results of this thesis do not suggest that dietary intake is associated with weight gain during chemotherapy.
“Everything tastes different” : The impact of changes in chemosensory perception on food preferences, food intake and quality of life during chemotherapy in cancer patients
Vries, Yfke Carlijn de - \ 2017
Wageningen University. Promotor(en): Kees de Graaf; H.W.M. van Laarhoven, co-promotor(en): R.M. Winkels; Sanne Boesveldt. - Wageningen : Wageningen University - ISBN 9789463436090 - 169
perception - sensory evaluation - food intake - quality of life - food preferences - neoplasms - taste - macronutrients - drug therapy - breast cancer - perceptie - sensorische evaluatie - voedselopname - kwaliteit van het leven - voedselvoorkeuren - neoplasma - smaak - macronutriënten - geneesmiddelenbehandeling - borstkanker
Taste and smell changes are common side effects during chemotherapy in cancer patient and may have an impact on food preferences, food intake and quality of life. However, these relations have hardly been studied systematically in specific cancer populations. The overall aim of this thesis was to assess how the sense of taste and smell change upon treatment with chemotherapy in breast cancer and oesophagogastric cancer patients, and to investigate their consequences in terms of food preferences, food intake and quality of life.
To measure food preferences for both macronutrients and tastes, the Macronutrient and Taste Preference Ranking Task (MTPRT) was developed. in chapter 2, it was shown that by inducing sensory specific satiety for a standardized sweet and savoury meal, it is possible to detect shifts in preferences for both tastes and macronutrients with the MTPRT, and that these results are reproducible.
In Chapter 3 we studied objective and subjective taste and smell perception and food preferences in advanced oesophagogastric cancer patients undergoing palliative chemotherapy. The result showed that only objective taste function decreases during chemotherapy, but other chemosensory measures were unchanged. A lower subjective taste perception was related to a lower preference for high-protein products. Therefore it is important to consider patients’ taste perception, when providing dietary advice to OGC patients
Chapter 4 describes a study with similar outcome measures as chapter 3, but in breast cancer patients at several time points during and after chemotherapy, and compared to a healthy control group. The study showed that breast cancer patients like high-protein, high-fat, sweet and savoury products less during chemotherapy, thus showing altered preferences for macronutrients, but not for tastes. Furthermore, results showed a temporary decrease in taste and smell perception during chemotherapy. These findings show that patients should be informed prior to treatment on chemosensory changes, and that these changes should be monitored during treatment due to the consequences for nutritional intake and quality of life
In chapter 5 we assessed the dietary intake of breast cancer patients before and during chemotherapy compared to a healthy control group, and associations with experienced symptoms during chemotherapy. It was shown that symptoms induced by chemotherapy were associated with lower total energy, protein and fat intake, which was manifested by a lower intake of specific food groups. Therefore, to ensure an optimal dietary intake during chemotherapy, it is important to monitor nutritional status and symptom burden during chemotherapy in breast cancer patients.
To better understand the impact of chemosensory changes during chemotherapy on daily life, 13 advanced oesophagogastric cancer patients were interviewed (see chapter 6). Patients described a substantial impact of chemosensory and food-related changes on daily life (by changing daily routines), social life (eating being less sociable) and roles in the household (changing roles in cooking and grocery shopping).
Finally, in chapter 7, we assessed the association between self-reported taste and smell perception and quality of life in breast cancer patients. A worse taste and smell perception was associated with a worse global quality of life, role, social and emotional functioning shortly after chemotherapy. In patients treated with trastuzumab, a worse taste and smell perception was still associated with quality of life, social and role functioning half a year after chemotherapy had ended.
From the studies in this thesis we can conclude that chemotherapy mainly affects the sense of taste. The subjective perception of taste was associated with a lower preference for food products and lower energy intake. This indicates that it is not necessarily an actual change in the sense of taste or smell that has an impact on patients, but flavour perception as a whole and potentially a lower enjoyment of food. Moreover, these perceived changes in taste and smell can have a substantial impact on cancer patients’ lives, in a practical way by changing daily patterns of eating, but also socially and in roles in the household. A changed chemosensory perception during chemotherapy may lead to a worsened nutritional status, and could thereby negatively impact the response to chemotherapy. Therefore chemosensory perception should be monitored during chemotherapy. Future studies should further investigate the mechanisms behind chemosensory changes, factors that contribute to subjective taste perception and possible interventions to alleviate chemosensory changes during chemotherapy.
Bacteriophages: therapeuticals and alternative applications : Onderzoeksrapport commissie genetische modificatie
Vlugt, R.A.A. van der; Verbeek, M. - \ 2008
Bilthoven : Cogem (CGM 2008-03) - 75
bacteriofagen - taxonomie - geneesmiddelenbehandeling - medische behandeling - bacteriophages - taxonomy - drug therapy - medical treatment
Gevoeligheid voor diverse antibiotica van coagulase negatieve staphylococcen, geisoleerd uit melkmonsters van Nederlands rundvee
Sampimon, O.C. ; Vernooij, J.C.A. ; Mevius, D.J. ; Sol, J. - \ 2007
Tijdschrift voor Diergeneeskunde 132 (2007)7. - ISSN 0040-7453 - p. 200 - 204.
coagulase negative staphylococci - antibiotica - mastitis - rundermastitis - subklinische mastitis - coagulasetest - meervoudige resistentie tegen geneesmiddelen - geneesmiddelenbehandeling - geneesmiddelresistentie - rundvee - coagulase negative staphylococci - antibiotics - mastitis - bovine mastitis - subclinical mastitis - coagulase test - multiple drug resistance - drug therapy - drug resistance - cattle - aureus - susceptibility - herds
During recent years the prevalence of coagulase-negative staphylococci in milk samples from Dutch dairy cows has increased. In 1999 16.2% of the bacteria isolated from milk collected from cows with subclinical mastitis were coagulasenegative staphylococci. In 2004 this proportion was 42.2%. The proportion of coagulase-negative staphylococci of the bacteria isolated from milksamples from cows with clinical mastitis was 7.3% in 1999 and 14.1% in 2004. In this study, the susceptibility of 108 coagulase-negative staphylococci to oxacillin, cefquinome, streptomycin, neomycin, penicillin, and the combination of nafcillin, penicillin, and streptomycin was tested. The isolates were cultured from milk collected from cows with mastitis and typed using the Api-Staph system. Eight species were identifi ed. Staphylococcus chromogenes was the predominant species (41.7%), followed by Staphylococcus xylosus (15.7%) and Staphylococcus simulans (10.2%). With the agar dilution method all strains proved to be sensitive to cefquinome and 90% to oxacillin. Three isolates (2.8%) were mecA-positive. Despite the agar dilution results, these three isolates should be considered resistant to all beta-lactam antibiotics (penicillins, penicillins combined with a beta-lactamase inhibitor and all generations of cephalosporins). In the agar diffusion test, all isolates proved to be sensitive to the combination of nafcillin-penicillin-streptomycin, 99% were sensitive to neomycin and 1% intermediate sensitive, and 95% were sensitive to streptomycin, 4% resistant, and 1% intermediate sensitive. The coagulase-negative staphylococci were highly resistant to penicillin (37.4%), although the level of resistance varied between species, from 0% for Staphylococcus simulans to 100% for taphylococcus saprophyticus. Because coagulase-negative staphylococci are resistant to several antibiotics, sensitivity testing is important for targeted treatment of mastitis
|Maagdarmwormen : stop met koppelbehandeling
Eysker, M. ; Borgsteede, F.H.M. - \ 2004
Het Schaap 2004 (2004)2. - ISSN 0165-3156 - p. 24 - 27.
haemonchus contortus - trichostrongylidae - nematoda - dierparasitaire nematoden - nematodeninfecties - nematodenbestrijding - wormen - helminthosen - veterinaire helmintologie - anthelmintica - schapen - schapenhouderij - schapenziekten - maagdarmziekten - veterinaire producten - weerstand - geneesmiddelresistentie - geneesmiddelenbehandeling - ziektepreventie - epidemiologie - ziekteoverdracht - diergeneeskunde - veeartsenijkunde - ziektebestrijding - dierziektepreventie - haemonchus contortus - trichostrongylidae - nematoda - animal parasitic nematodes - nematode infections - nematode control - helminths - helminthoses - veterinary helminthology - anthelmintics - sheep - sheep farming - sheep diseases - gastrointestinal diseases - veterinary products - resistance - drug resistance - drug therapy - disease prevention - epidemiology - disease transmission - veterinary science - veterinary medicine - disease control - animal disease prevention
Uitleg over de epidemiologie van maagdarmwormen bij schapen, en adviezen om de ontwikkeling van resistentie tegen wormmiddelen te voorkomen. De huidige praktijk van preventieve behandeling van ooien en lammeren werkt de ontwikkeling van resistentie juist in de hand. Om de selectiedruk voor resistentie bij de wormen te verlagen is het belangrijk om niet meer alle schapen tegelijk te behandelen en wormmiddelen uit de verschillende groepen (benzimidazolen; imidithiazoles; avermectines en milbemycines) af te wisselen. Ook een cocktail van middelen is effectief tegen resistentieontwikkeling
Semen collection and preservation in African catfish, Clarias gariepinus
Viveiros, A. - \ 2002
Wageningen University. Promotor(en): E.A. Huisman; J. Komen; H. Woelders. - S.l. : S.n. - ISBN 9789058085610 - 144
clarias gariepinus - vissen - visteelt - sperma - strippen - spermaconservering - cryopreservering - hormonen - geneesmiddelenbehandeling - voortplantingsstoornissen - genetische bronnen van diersoorten - clarias gariepinus - fishes - fish culture - semen - stripping - semen preservation - cryopreservation - hormones - drug therapy - reproductive disorders - animal genetic resources
Stock improvement using quantitative and molecular genetics is an essential part of nowadays production of farm animals and fish. To achieve this in aquaculture, germplasm of both parental sexes should be obtained in a life-saving manner. In captivity, male African catfish, Clariasgariepinus , do not release semen under abdominal massage and have to be sacrificed to obtain sperm from the macerated testes. Of course, this is regarded as a major constrains by the catfish farming sector. Against this background, the research of the present thesis had a two-pronged approach and aimed (a) to induce semen release and facilitate stripping of semen under abdominal massage, and (b) to optimize protocols for cryopreserving semen of the African catfish. To facilitate hand-stripping of semen, several maturational hormones that increase plasma gonadotropin levels and drugs that stimulate contractions of the reproductive tract, such as oxytocin, were tested. The response to some of these treatments was compared between normal males and males that possessed undeveloped seminal vesicles - a possible block of the sperm flow during abdominal massage. Based on the results, it is unlikely that catfish males kept in captivity are not strippable because of a lack of gonadotropin surge. Fertile semen was hand-stripped from males that possessed undeveloped seminal vesicles but not from normal males, suggesting that seminal vesicles actually block the sperm flow during hand-stripping. However, stripping was possible only after treatment with pituitary extract. Oxytocin may play a role in sperm transport in catfish, but more research is needed to optimize dose and latency time. To optimize protocols for semen cryopreservation, different cryoprotectors, cooling rates and temperatures at which plunging into liquid nitrogen occurred, were evaluated. Catfish semen showed good tolerance to freezing and thawing. Hatching rates similar to the fresh semen were obtained with semen frozen in 10% methanol, at a cooling rate of -2, -5 or -10ºC/min to -40ºC and plunged into liquid nitrogen as soon as semen temperature reached -38ºC. Samples plunged into liquid nitrogen from a semen temperature above -30ºC or below -50ºC produced decreasing hatching rates. Post-thaw semen could be diluted at least 200 times without loosing fertilization capacity. Cryopreservation of semen is a valuable tool for selection and conservation of genetic diversity in catfish species.
Gezocht: alternatieven voor formaldehyde bij ontsmetting van broedeieren
Deeming, Ch. ; Lourens, A. - \ 1998
Praktijkonderzoek voor de Pluimveehouderij 9 (1998)3. - ISSN 0924-9087 - p. 12 - 16.
eieren - behandeling - formaldehyde - geneesmiddelenbehandeling - antiseptica - ontsmettingsmiddelen - geneesmiddeleffecten - broedeieren - eggs - treatment - formaldehyde - drug therapy - antiseptics - disinfectants - drug effects - hatching eggs
In broederijen worden broedeieren over het algemeen ontsmet met formaldehyde. Jarenlang is men al op zoek naar een alternatief voor deze behandeling. In dit artikel worden de voor- en nadelen van de formaldehydebehandeling van broedeieren uiteengezet en wordt aangegeven waarom een introductie van een nieuw middel en een nieuwe toepassingsmethode op zich laten wachten.
Milieusparend reinigen melkwinningsapparatuur
Verheij, J.G.P. ; Wolters, G.M.V.H. - \ 1993
Lelystad : Proefstation voor de Rundveehouderij, Schapenhouderij enPaardenhouderij (Publikatie / Proefstation voor de Rundveehouderij, Schapenhouderij en Paardenhouderij 80) - 16
melkmachines - onderhoud - schoonmaken - geneesmiddelenbehandeling - antiseptica - ontsmettingsmiddelen - geneesmiddeleffecten - milieuhygiëne - milking machines - maintenance - cleaning - drug therapy - antiseptics - disinfectants - drug effects - environmental hygiene
Bij het melken van koeien is een situatie ontstaan waarbij de reiniging van de melkwinningsappara-tuur wel een goede melkkwaliteit mogelijk maakt, maar dit gaat ten koste van een (te) grote milieubelasting.
|Formaline - ontsmetting van eendagskuikens : noodzaak of overbodige handeling?
Harn, J. van - \ 1992
De Pluimveehouderij 22 (1992)42. - ISSN 0166-8250 - p. 23 - 23.
antiseptica - kuikens - ontwikkeling - ontsmettingsmiddelen - geneesmiddeleffecten - geneesmiddelenbehandeling - formaldehyde - groei - diergeneeskunde - antiseptics - chicks - development - disinfectants - drug effects - drug therapy - formaldehyde - growth - veterinary science
Ontsmette en niet ontsmette kuikens verschillen niet in uitval. Wel is de oorzaak van de uitval anders.
Onderzoek naar de aanwezigheid van antimicrobiele residuen en pathogene bacterien in uiers van slachtrunderen
Nouws, J.F.M. ; Katoen, S. ; Vermunt, A.E.M. - \ 1992
Wageningen : RIKILT-DLO (Rapport / DLO - Rijks-Kwaliteitsinstituut voor Land- en Tuinbouwprodukten (RIKILT-DLO), Afdeling Microbiologie en Biotechniek 92.39) - 15
melkklieren - uiers - tepels - geneesmiddelenbehandeling - antiseptica - ontsmettingsmiddelen - staphylococcus - mammary glands - udders - teats - drug therapy - antiseptics - disinfectants - staphylococcus
Onderzoek van slachtkonijnen op aanwezigheid van antimicrobiele residuen
Nouws, J.F.M. ; Smulders, A. ; Rappallini, M. ; Smaalen, M. van; Eekelaar, K. - \ 1992
Wageningen : RIKILT-DLO (Rapport / DLO - Rijkskwaliteitsinstituut voor Land- en Tuinbouwprodukten (RIKILT-DLO) 92.42) - 8
analyse - dierlijke producten - antiseptica - controle - ontsmettingsmiddelen - geneesmiddeleffecten - geneesmiddelenbehandeling - konijnenvlees - testen - diergeneeskunde - analysis - animal products - antiseptics - control - disinfectants - drug effects - drug therapy - rabbit meat - testing - veterinary science
De bepaling van nicarbazin in ei- en voederextracten met HPLC en on-line UV-Vis Diode Array detectie
Keukens, H.J. ; Aerts, M.M.L. ; Traag, W. - \ 1985
Wageningen : RIKILT (Rapport / RIKILT 85.110) - 3
dierlijke producten - chemische samenstelling - ingrediënten - eieren - eierproducten - voer - samenstelling - pluimvee - kippen - vervalsing - besmetting - verouderen - gebreken - achteruitgang (deterioration) - diergeneeskunde - geneesmiddelenbehandeling - antiseptica - ontsmettingsmiddelen - geneesmiddeleffecten - afval - residuen - vuilnis - animal products - chemical composition - ingredients - eggs - egg products - feeds - composition - poultry - fowls - adulteration - contamination - aging - defects - deterioration - veterinary science - drug therapy - antiseptics - disinfectants - drug effects - wastes - residues - refuse
Doel van dit onderzoek is: analyse van een aantal ei- en voederextracten op nicarbazin ter bevestiging van de analyseresultaten van de Gezondheidsdienst voor Pluimvee in Doorn. Nagaan in hoeverre confirmatie aan de hand van een UV-spectrum mogelijk is.
Bestrijding van ringworm bij rundvee : beproeving van het nieuwe middel natamycine
Kommerij, R. - \ 1976
Lelystad : Proefstation voor de Rundveehouderij (Rapport / Proefstation voor de Rundveehouderij 40) - 16
antiseptica - rundvee - dermatologie - ontsmettingsmiddelen - geneesmiddeleffecten - geneesmiddelenbehandeling - mycosen - huidziekten - diergeneeskunde - antiseptics - cattle - dermatology - disinfectants - drug effects - drug therapy - mycoses - skin diseases - veterinary science
|Bactericidal action of some disinfectants (esp. on Pseudomonas aeruginosa), especially in the dairy and brewing industry, and some related topics
Anonymous, - \ 1972
Wageningen : [s.n.] (Literatuurlijst / Centrum voor landbouwpublikaties en landbouwdocumentatie no. 3442)
antiseptica - bieren - bibliografieën - bierbereiding - schoonmaken - melk- en zuivelapparatuur - ontsmettingsmiddelen - desinfectie - geneesmiddeleffecten - geneesmiddelenbehandeling - voedselindustrie - voedseltechnologie - onderhoud - melkbewerking - parasitologie - antiseptics - beers - bibliographies - brewing - cleaning - dairy equipment - disinfectants - disinfection - drug effects - drug therapy - food industry - food technology - maintenance - milk processing - parasitology
|Payzone (Panazon, nitrovin) in veevoeder
Anonymous, - \ 1969
Wageningen : [s.n.] (Literatuurlijst / Centrum voor landbouwpublikaties en landbouwdocumentatie no. 3125)
antiseptica - bibliografieën - samenstelling - ontsmettingsmiddelen - geneesmiddeleffecten - geneesmiddelenbehandeling - voer - hormonen - antiseptics - bibliographies - composition - disinfectants - drug effects - drug therapy - feeds - hormones