Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Residue analysis of veterinary drugs and growth-promoting agents
    Stolker, A.A.M. ; Zuidema, T. ; Nielen, M.W.F. - \ 2007
    TrAC : Trends in Analytical Chemistry 26 (2007)10. - ISSN 0165-9936 - p. 967 - 979.
    tandem mass-spectrometry - performance liquid-chromatography - animal-food products - malachite green - antiinflammatory drugs - confirmatory analysis - leucomalachite green - nitrofuran residues - biological matrices - hair analysis
    Two major trends are observed in the analysis of veterinary drugs and growth-promoting agents. First is the selection of sample material for monitoring the use of registered veterinary drugs. Traditionally meat, kidney and liver were analyzed but, due to the food scandals in which meat was very often involved, the consumption of alternative products (e.g., eggs and fish) has become more popular and therefore more of interest for residue-monitoring programmes. Most food scandals started with contamination of animal feed, so feed has also gained interest for monitoring purposes. For the detection of unauthorized substances (e.g., growth-promoting agents), the matrix hair is frequently used because residues can be detected in hair even a long time after treatment. Second, the techniques used for residue analysis are moving from target-orientated methods, mainly based on liquid chromatography in combination with triple-quadrupole mass-spectrometric detection (LC-QqQ-MS), towards accurate mass full-scan MS techniques (e.g., time-of-flight (ToF)-MS and Fourier-transform(FT)-MS. Full-scan MS techniques enable retrospective analysis (i.e. without re-injecting the sample) and real multi-residue analysis (including different classes of veterinary drugs). The application of full-scan MS also has consequences for separation and extraction techniques, which have to be applicable to a broad range of compounds differing in physical and chemical properties. Experience shows that ToF-MS in combination with ultra-performance LC (UPLC) is very powerful for multi-residue analysis. The introduction of new MS techniques also has consequences for European Union (EU) criteria defined for confirmation of the identity of compounds. It is suggested that both mass-resolution and mass-accuracy data influence identity confirmation and both parameters should be implemented in the revision of European Commission Decision 2002/657/EC. (C) 2007 Elsevier Ltd. All rights reserved.
    Energetische kwaliteit en alternatieve weerstandsparameters bij melkkoeien = Energy quality and alternative parameters to detect resistance in dairy cows
    Smolders, E.A.A. ; Plomp, M. - \ 2007
    Lelystad : Animal Sciences Group (Rapport / Animal Sciences Group 45) - 35
    melkveehouderij - biologische landbouw - diergezondheid - methodologie - bloedanalyse - haaranalyse - energie - weerstand - karakteristieken - alternatieve methoden - dairy farming - organic farming - animal health - methodology - blood analysis - hair analysis - energy - resistance - characteristics - alternative methods
    Biologische melkveehouders hebben via het project Bioveem gevraagd om gangbare en alternatieve meetmethoden te toetsen op hun bruikbaarheid voor biologische veehouderijbedrijven. In het onderzoek op zes biologische melkveebedrijven heeft een ervaren ecotherapeut de koeien en bedrijven energetisch beoordeeld. Daarnaast is in bloed gezocht naar bruikbare weerstandsparameters. Verder zijn haren van de koeien met een biotensor geanalyseerd. De uitkomsten van de metingen zijn gelegd naast de visuele waarnemingen aan de koe zelf zoals kleur, glans, huidbeschadigingen, alertheid, lichaamsconditie, kreupelheid en gezondheidsaandoeningen. De conclusie is dat de biologische veehouders die inzicht willen krijgen in de (ziekte)weerstand van hun koeien, het beste weer kunnen leren hoe ze een koe moeten ‘scoren’ op o.a. kleur, glans, alertheid, conditie en afwijkingen.
    Effecten van combinaties van androgenen bij kalveren: histologie en detectie van residuen van hormoonesters in haren
    Groot, M.J. ; Nielen, M.W.F. - \ 2005
    Wageningen : RIKILT (Rapport / RIKILT 2005.008)
    androgenen - kalveren - histologie - residuen - haaranalyse - nadelige gevolgen - kennis - androgens - calves - histology - residues - hair analysis - adverse effects - knowledge
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