Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Effect of atorvastatin on C-reactive protein and benefits for cardiovascular disease in patients with type 2 diabetes: analyses from the Collaborative Atorvastatin Diabetes Trial
Soedamah-Muthu, S.S. ; Livingstone, S.J. ; Charlton-Menys, V. ; Betteridge, D.J. ; Hitman, G.A. ; Neil, H.A.W. ; Bao, W. ; DeMicco, D.A. ; Preston, G.M. ; Fuller, J.H. ; Stehouwer, C.D.A. ; Schalkwijk, C.G. ; Durrington, P.N. ; Colhoun, H.M. - \ 2015
Diabetologia 58 (2015)7. - ISSN 0012-186X - p. 1494 - 1502.
placebo-controlled trial - acute coronary syndromes - cardiac outcomes trial - statin therapy - myocardial-infarction - on-treatment - follow-up - cholesterol - mortality - heart
Aims/hypothesis We investigated whether atorvastatin 10 mg daily lowered C-reactive protein (CRP) and whether the effects of atorvastatin on cardiovascular disease (CVD) varied by achieved levels of CRP and LDL-cholesterol. Methods CRP levels were measured at baseline and 1 year after randomisation to atorvastatin in 2,322 patients with type 2 diabetes (40–75 years, 69% males) in a secondary analysis of the Collaborative Atorvastatin Diabetes Study, a randomised placebo-controlled trial. We used Cox regression models to test the effects on subsequent CVD events (n¿=¿147) of CRP and LDL-cholesterol lowering at 1 year. Results After 1 year, the atorvastatin arm showed a net CRP lowering of 32% (95% CI -40%, -22%) compared with placebo. The CRP response was highly variable, with 45% of those on atorvastatin having no decrease in CRP (median [interquartile range, IQR] per cent change -9.8% [-57%, 115%]). The LDL-cholesterol response was less variable, with a median (IQR) within-person per cent change of -41% (-51%, -31%). Baseline CRP did not predict CVD over 3.8 years of follow-up (HRper SD log 0.89 [95% CI 0.75, 1.06]), whereas baseline LDL-cholesterol predicted CVD (HRper SD 1.21 [95% CI 1.02, 1.44]), as did on-treatment LDL-cholesterol. There was no significant difference in the reduction in CVD by atorvastatin, with above median (HR 0.57) or below median (HR 0.52) change in CRP or change in LDL-cholesterol (HR 0.61 vs 0.50). Conclusions/interpretation CRP was not a strong predictor of CVD. Statin efficacy did not vary with achieved CRP despite considerable variability in CRP response. The use of CRP as an indicator of efficacy of statin therapy on CVD risk in patients with type 2 diabetes is not supported by these data.
Response to Hoenselaar from Pedersen et al.: The importance of reducing SFA intake to limit CHD risk
Pedersen, J.I. ; Norum, K.R. ; James, P.T. ; Brouwer, I.A. ; Katan, M.B. ; Clarke, R. ; Elmadfa, I. ; Kris-Etherton, P.M. ; Kromhout, D. ; Margetts, B.M. ; Mensink, R.P. ; Rayner, M. ; Uusitupa, M. - \ 2012
The British journal of nutrition 107 (2012)3. - ISSN 0007-1145 - p. 452 - 454.
cardiovascular-disease - cholesterol - metaanalysis - association - lipids - heart - fat
Fight fat with DGAT
Stienstra, R. ; Kersten, A.H. - \ 2011
Journal of Lipid Research 52 (2011)4. - ISSN 0022-2275 - p. 591 - 592.
diacylglycerol acyltransferase-1 - triacylglycerol synthesis - leptin sensitivity - obesity - enzymes - heart
Enterococcus hirae-associated endocarditis outbreaks in broiler flocks: clinical and pathological characteristics and molecular epidemiology.
Velkers, F.C. ; Graaf-Blois, L. Van de; Wagenaar, J.A. ; Westendorp, S.T. ; Bergen, M.A.P. Van; Dwars, R.M. ; Landman, W.J.M. - \ 2011
Veterinary Quarterly 31 (2011)1. - ISSN 0165-2176 - p. 3 - 17.
amyloid arthropathy - bacterial endocarditis - durans infection - chickens - faecalis - identification - septicemia - encephalomalacia - arthritis - heart
Background: Enterococcus hirae-associated endocarditis, characterized by a peak in mortality during the second week of the grow-out, and occasionally lameness, was diagnosed at Dutch broiler farms. Objectives: Field cases were studied to increase knowledge on clinical and pathological characteristics, pathogenesis and epidemiology of these infections. Animals and methods. In total, 1266 birds of 25 flocks from 12 farms were examined. Post-mortem examinations, bacteriology, histopathology, PCR and DNA fingerprinting was carried out. Six flocks were followed longitudinally (n¿=¿1017 birds). Results: Average mortality was 4.1% for the entire grow-out, of which 36% was attributed to endocarditis. Fibrinous thromboendocarditis of the right atrioventricular (AV) valve was found in 24% of hearts, compared to 7% and 4% with lesions of left and both AV valves, respectively. Thrombotic lesions were found in 24% (n¿=¿432) of lungs, but only in larger branches of the Arteria pulmonalis. Occasionally, thrombi were found in the Arteria ischiadica externa and in liver and brain vessels. Enterococcus was cultured from 54% (n¿=¿176) of heart and in 75% (n¿=¿28), 62% (n¿=¿106) and 31% (n¿=¿16) of liver, bone marrow and lung samples, respectively. Further identification, using the Rapid ID Strep 32 API system and a PCR targeting mur-2 and mur-2(ed) genes was carried out on a subset of Enterococcus positive isolates (n¿=¿65): both techniques identified the isolates as Enterococcus hirae. Pulsed-field gel electrophoresis did not indicate evidence of clonality between farms and flocks. Conclusions: The relevance of these findings for pathogenesis and epidemiology of E. hirae infections is discussed. Clinical importance. This study may facilitate diagnosis of field cases and may contribute to the design of further research and development of control measures
Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors
Butelli, E. ; Titta, L. ; Giorgio, M. ; Mock, H.P. ; Matros, A. ; Peterek, S. ; Schijlen, E.G.W.M. ; Hall, R.D. ; Bovy, A.G. ; Luo, J. ; Martin, C. - \ 2008
Nature Biotechnology 26 (2008)11. - ISSN 1087-0156 - p. 1301 - 1308.
antioxidant capacity - pigmentation - gene - cyanidin - mice - biosynthesis - antirrhinum - ischemia - plasma - heart
Dietary consumption of anthocyanins, a class of pigments produced by higher plants, has been associated with protection against a broad range of human diseases. However, anthocyanin levels in the most commonly eaten fruits and vegetables may be inadequate to confer optimal benefits. When we expressed two transcription factors from snapdragon in tomato, the fruit of the plants accumulated anthocyanins at levels substantially higher than previously reported for efforts to engineer anthocyanin accumulation in tomato and at concentrations comparable to the anthocyanin levels found in blackberries and blueberries. Expression of the two transgenes enhanced the hydrophilic antioxidant capacity of tomato fruit threefold and resulted in fruit with intense purple coloration in both peel and flesh. In a pilot test, cancer-susceptible Trp53-/- mice fed a diet supplemented with the high-anthocyanin tomatoes showed a significant extension of life s
Close genetic proximity between cultivated and wild Bactris gasipaes Kunth. revealed by microsatellite markers in Western Ecuador.
Couvreur, T.L.P. ; Billotte, N. ; Lara, C. ; Vigouroux, Y. ; Ludena, B. ; Pham, J.L. ; Pintaud, J.C. - \ 2006
Genetic Resources and Crop Evolution 53 (2006)7. - ISSN 0925-9864 - p. 1361 - 1373.
palm - population - pejibaye - arecaceae - inference - heart
Bactris gasipaes Kunth (peach palm or Pejibaye) is the only domesticated palm of the Neotropics. The genetic relationships between the crop and its wild relatives are still unclear. We undertook field and laboratory work in order to describe differentiation and relationships between the wild and cultivated populations of the species in Western Ecuador, and their possible interactions. A volumetric study was undertaken on the fruits of both populations, as well as a population genetic analysis in order to clarify these relationships. Fruits from cultivated plants collected in the region of sympatry of wild and cultivated plants in North-West Ecuador showed intermediate volumes between those of reference samples for the wild and cultivated plants in allopatry. Using 8 microsatellite loci, we assessed 83 wild and cultivated individuals from Western Ecuador and cultivated plants from Amazonia and Central America as a reference for the cultivated form. We detected high polymorphism in the wild and cultivated samples and low, but significant level of genetic differentiation between wild and cultivated populations. The cultivated population in North-Western Ecuador showed close genetic proximity with the sympatric wild population, consistent with the volumetric study. These results have implications for hypotheses on evolution of this crop and for strategies of genetic conservation of the wild forms
Public health impact of community-based nutrition and lifestyle interventions
Verheijden, M.W. ; Kok, F.J. - \ 2005
European Journal of Clinical Nutrition 59 (2005)1. - ISSN 0954-3007 - p. S66 - S76.
cardiovascular-disease risk - smoking-cessation - african-americans - promotion - project - heart - prevention - program - reduction - education
Community-based interventions have increasingly received attention since researchers and public health professionals have come to acknowledge the importance of an environment that makes the healthy choice the easy choice. All stakeholders including the target community are involved to achieve changes in legislation, in people's social and physical context, and in individual characteristics that support healthy diets and other lifestyles. Some early large-scale community-based heart health interventions showed promising results. The Stanford Five City Project, for example, showed net improvements in knowledge of coronary heart disease risk factors of approximately 12%. Net declines in smoking prevalence (14%), cholesterol (2%), and systolic (3%) and diastolic (5%) blood pressure were also observed. Most later studies did not replicate these findings and it was therefore suggested that community-based interventions, which require substantial commitment and resources, may be less effective than approaches targeting high-risk groups. We present the rationale and theories for community-based interventions, and then elaborate on the methodological challenges in the design and the outcome and process evaluation of community-based interventions. We provide an overview of some of the evidence on the effectiveness of community-based heart health interventions and conclude with the perspectives for community-based interventions in future research and practice.
Comparative analysis of the natriuretic peptide precursor gene cluster in vertebrates reveals loss of ANF and retention of CNP-3 in chicken
Houweling, A.C. ; Somi, S. ; Massink, M.P.G. ; Groenen, M.A.M. ; Moorman, A.F.M. ; Christoffels, V.M. - \ 2005
Developmental Dynamics 233 (2005)3. - ISSN 1058-8388 - p. 1076 - 1082.
cardiac chamber formation - sequence-analysis - differential expression - messenger-rna - porcine brain - atrial - cloning - heart - rat - mouse
We identified and characterized the chicken natriuretic peptide precursor gene cluster and found its organization to be highly conserved compared with the mammalian Nppb-Nppa cluster. However, phylogenetic analysis indicated that the putative chicken natriuretic peptide precursor genes are the homologues of CNP-3 and Nppb, respectively. Comparative expression analysis revealed that, in human, mouse, and rat hearts, Nppb is a novel marker for the differentiating working myocardium. Its expression pattern is strikingly similar to that of Nppa before birth, and diverges only after birth. In contrast, whereas the chicken Nppb gene expression profile resembled that of mammalian Nppb, the CNP-3 gene showed very limited expression in the heart, not resembling the pattern of either Nppa or Nppb. These results show that, in chicken, the Nppa gene has been lost from the natriuretic peptide precursor gene cluster, whereas the CNP-3 gene has been retained
Genetic mapping of quantitative trait loci affecting susceptibility in chicken to develop the Pulmonary Hypertension Syndrome (PHS)
Rabie, T.S.K.M. ; Crooijmans, R.P.M.A. ; Bovenhuis, H. ; Vereijken, A.L.J. ; Veenendaal, A. ; Poel, J.J. van der; Arendonk, J.A.M. van; Pakdel, A. ; Groenen, M.A.M. - \ 2005
Animal Genetics 36 (2005)6. - ISSN 0268-9146 - p. 468 - 476.
whole genome scan - right ventricular hypertrophy - broiler-chickens - ascites syndrome - high-altitude - linkage map - growth - heart - failure - poultry
Pulmonary hypertension syndrome (PHS), also referred to as ascites syndrome, is a growth-related disorder of chickens frequently observed in fast-growing broilers with insufficient pulmonary vascular capacity at low temperature and/or at high altitude. A cross between two genetically different broiler dam lines that originated from the White Plymouth Rock breed was used to produce a three-generation population. This population was used for the detection and localization of quantitative trait loci (QTL) affecting PHS-related traits. Ten full-sib families consisting of 456 G2 birds were typed with 420 microsatellite markers covering 24 autosomal chromosomes. Phenotypic observations were collected on 4202 G3 birds and a full-sib across family regression interval mapping approach was used to identify QTL. There was statistical evidence for QTL on chicken chromosome 2 (GGA2), GGA4 and GGA6. Suggestive QTL were found on chromosomes 5, 8, 10, 27 and 28. The most significant QTL were located on GGA2 for right and total ventricular weight as percentage of body weight (%RV and %TV respectively). A related trait, the ratio of right ventricular weight as percentage to total ventricular weight (RATIO), reached the suggestive threshold on this chromosome. All three QTL effects identified on GGA2 had their maximum test statistic in the region flanked by markers MCW0185 and MCW0245 (335-421 cM)
Mendelian randomization, 18 years onwards
Katan, M.B. - \ 2004
International Journal of Epidemiology 33 (2004)1. - ISSN 0300-5771 - p. 10 - 11.
disease - heart
Schatting van de lichamelijke aktiviteit door middel van kontinue registratie van de hartfrequentie
Baecke, J. - \ 1977
Nijmegen : G.V.O. - 28
hart - heart
Voorlopig verslag van een onderzoek naar de invloed van verschillende obstakels in een hindernisbaan op de hartslagfrequentie van varkens
Heuff, H.E. ; Jong, N. de; Elshof, W.J. - \ 1971
Zeist : I.V.O. (Rapport / Instituut voor veeteeltkundig onderzoek "Schoonoord", no. C 154) - 18
hart - varkens - diergeneeskunde - zoölogie - heart - pigs - veterinary science - zoology
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