Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Mining microbiota signatures in human intestinal tract metagenomes
    Tims, S. - \ 2016
    Wageningen University. Promotor(en): Michiel Kleerebezem; Willem de Vos, co-promotor(en): Erwin Zoetendal. - Wageningen : Wageningen University - ISBN 9789462576933 - 264
    gastrointestinal microbiota - intestines - genomes - man - hosts - host guest relations - dna microarrays - gastrointestinal diseases - inflammatory bowel diseases - irritable colon - prebiotics - body mass index - oligosaccharides - microbiota van het spijsverteringskanaal - darmen - genomen - mens - gastheren (dieren, mensen, planten) - relaties tussen gastheer en gast - dna microarrays - maagdarmziekten - chronische darmontstekingen - prikkelbaar colon - prebiotica - quetelet index - oligosacchariden
    An apple a day... : de rol van voeding in transmurale zorg
    Witteman, Ben J.M. - \ 2015
    Wageningen : Wageningen University - ISBN 9789462571990 - 32
    ziekenhuiszorg - voedsel - chronische darmontstekingen - darmziekten - prikkelbaar colon - coeliakie - narcose - ondervoeding - vasten - darmen - hospital care - food - inflammatory bowel diseases - intestinal diseases - irritable colon - coeliac syndrome - narcosis - undernutrition - fasting - intestines
    'De gemiddelde levensverwachting stijgt in Nederland. Nochtans worden we op jongere leeftijd met chronische aandoeningen geconfronteerd. De kans hierop neemt de komende jaren sterk toe: van 1 miljoen nu naar 1,5 miljoen in 2020. Hierdoor zullen we geconfronteerd worden met voedingsproblemen waarbij een chronische ziekte een rol speelt. Aangepaste voeding, op grond van de onderliggende pathofysiologie, kan naast preventie van progressie van ziekte ook leiden tot een eerder klinisch herstel. De darm als gate-keeper van het lichaam speelt hierbij een belangrijke rol. Voedingsonderzoek bij deze doelgroep, gericht op verbetering van de darmgezondheid kan de patiënt een beter welzijn geven en de gezondheidszorg mogelijk goedkoper maken.'
    Evaluatie van de voedingsstatus van Nederlandse patiënten met chronische inflammatoire darmziekten : een pilotonderzoek
    Berg, M.C. van den; Plas, M. ; Mares, W. ; Witteman, B.J.M. ; Klein Gunnewiek, J.M.T. ; Vries, J.H.M. de - \ 2014
    Nederlands Tijdschrift voor Voeding en Dietetiek 60 (2014)1. - ISSN 1875-9955 - p. S1 - S12.
    voedingstoestand - darmziekten - chronische darmontstekingen - ondervoeding - patiënten - voeding en gezondheid - nutritional state - intestinal diseases - inflammatory bowel diseases - undernutrition - patients - nutrition and health
    Introductie Het doel van deze pilotstudie was het verkrijgen van inzicht in de voedingsstatus van Nederlandse patiënten met chronische inflammatoire darmziekten (IBD). Methoden De voedingsstatus werd onderzocht op basis van MUST-score, handknijpkracht, micronutriëntstatus in het bloed en voedingsinname. Daarnaast werden leeftijd, geslacht, ziektebeeld, ziekteactiviteit, kwaliteit van leven en medicatiegebruik geïnventariseerd en gecorreleerd aan ziekteactiviteit. Resultaten 41 personen met IBD (17 mannen en 24 vrouwen, 19-74 jaar), onder wie 22 met colitis ulcerosa en 19 met de ziekte van Crohn, namen deel aan het onderzoek. 4 deelnemers hadden volgens de MUST-score een verhoogd risico op ondervoeding. Van 4 deelnemers was de handknijpkracht onder de referentiewaarde. 14 personen hadden een tekort aan vitamine D, 3 aan selenium, 3 aan foliumzuur, 1 aan vitamine B12 en 1 aan magnesium. De micronutriëntconcentraties verschilden niet tussen deelnemers met verschillende ziektebeelden, MUST-scores of handknijpkracht. Serum vitamine B1 verschilde als enige micronutriënt tussen mannen en vrouwen (p=0,047). Foliumzuurconcentraties waren hoger bij hogere ziekteactiviteit (p=0,022) en bij lagere kwaliteit van leven (p=0,030). Serumspiegels van vitamine D en vitamine E waren hoger voor deelnemers boven de leeftijdsmediaan dan voor deelnemers daaronder (50 jaar, respectievelijk: p
    Intestinal colonization: How key microbial players become established in this dynamic process: Microbial metabolic activities and the interplay between the host and microbes
    Aidy, S.F. El; Abbeele, P. van den; Wiele, T. van der; Louis, P. ; Kleerebezem, M. - \ 2013
    Bioessays 35 (2013)10. - ISSN 0265-9247 - p. 913 - 923.
    sulfate-reducing bacteria - butyrate-producing bacteria - chain fatty-acids - inflammatory bowel diseases - human gut microbiota - human colon - ulcerative-colitis - hydrogen-sulfide - immune-system - human feces
    In this review, we provide an overview of the dynamic changes within the microbiota and its metabolites that are implicated in establishing and maintaining gastrointestinal homeostasis during various stages of microbial colonization. The gradual conversion of the gut microbiota toward a mutualistic microbial community involves replacement of pioneer gut colonizers with bacterial taxa that are characteristic for the adult gut. An important microbial signature of homeostasis in the adult gut is the prevalence and activity of a diverse spectrum of bacterial species that produce beneficial metabolites through metabolic interactions between microbial groups. Deciphering these microbial signatures and their metabolites that govern short and long-term equilibrium, as well as imbalances in host-microbial relationships, may provide novel diagnostic tools and/or therapeutic targets for specific disorders associated with intestinal dysbiosis and loss of homeostasis.
    Protective effect of Clostridium tyrobutyricum in acute dextran sodium sulphate-induced colitis: differential regulation of tumour necrosis factor-a and interleukin-18 in BALB/c and severe combined immunodeficiency mice
    Hudcovic, T. ; Kolinska, J. ; Klepetar, J. ; Stepankova, R. ; Rezanka, T. ; Srutkova, D. ; Schwarzer, M. ; Erban, V. ; Du, Z. ; Wells, J. ; Hrncir, T. ; Tlaskalova-Hogenova, H. ; Kozakova, H. - \ 2012
    Clinical and Experimental Immunology 167 (2012)2. - ISSN 0009-9104 - p. 356 - 365.
    inflammatory bowel diseases - chain fatty-acids - ulcerative-colitis - tight junction - intestinal inflammation - epithelial barrier - butyrate enemas - colonic-mucosa - tnf-alpha - murine colitis
    One of the promising approaches in the therapy of ulcerative colitis is administration of butyrate, an energy source for colonocytes, into the lumen of the colon. This study investigates the effect of butyrate producing bacterium Clostridium tyrobutyricum on dextran sodium sulphate (DSS)-induced colitis in mice. Immunocompetent BALB/c and immunodeficient severe combined immunodeficiency (SCID) mice reared in specific-pathogen-free (SPF) conditions were treated intrarectally with C. tyrobutyricum 1 week prior to the induction of DSS colitis and during oral DSS treatment. Administration of DSS without C. tyrobutyricum treatment led to an appearance of clinical symptoms – bleeding, rectal prolapses and colitis-induced increase in the antigen CD11b, a marker of infiltrating inflammatory cells in the lamina propria. The severity of colitis was similar in BALB/c and SCID mice as judged by the histological damage score and colon shortening after 7 days of DSS treatment. Both strains of mice also showed a similar reduction in tight junction (TJ) protein zonula occludens (ZO)-1 expression and of MUC-2 mucin depression. Highly elevated levels of cytokine tumour necrosis factor (TNF)-a in the colon of SCID mice and of interleukin (IL)-18 in BALB/c mice were observed. Intrarectal administration of C. tyrobutyricum prevented appearance of clinical symptoms of DSS-colitis, restored normal MUC-2 production, unaltered expression of TJ protein ZO-1 and decreased levels of TNF-a and IL-18 in the descending colon of SCID and BALB/c mice, respectively. Some of these features can be ascribed to the increased production of butyrate in the lumen of the colon and its role in protection of barrier functions and regulation of IL-18 expression
    Altered Host-Microbe Interaction in HIV: A Target for Intervention with Pro- and Prebiotics
    Hummelen, R. ; Vos, A.P. ; Land, B. van 't; Norren, K. van; Reid, G. - \ 2010
    International Reviews of Immunology 29 (2010)5. - ISSN 0883-0185 - p. 485 - 513.
    human-immunodeficiency-virus - randomized controlled-trial - placebo-controlled trial - coli nissle 1917 - chain galacto-oligosaccharides - active antiretroviral therapy - inflammatory bowel diseases - intestinal epithelial-cells - lactobacillus-rhamnosus-gg - ele
    The intestinal immune system is severely affected by HIV and circulating microbial products from the intestinal tract that provide an ongoing source of systemic inflammation and concomitant viral replication. In addition, HIV-infected individuals can have a deregulated immune response that may hamper the anti-viral capacity of the host. Various probiotic organisms and prebiotic agents have been shown to enhance intestinal epithelial barrier functions, reduce inflammation, and support effective Th-1 responses. As these characteristics may benefit HIV patients, this review aims to provide a theoretical framework for the development of probiotic and prebiotic interventions specifically for this population.
    Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria
    Png, C.W. ; Linden, S.K. ; Gilshenan, K.S. ; Zoetendal, E.G. ; McSweeney, C.S. ; Sly, L.I. ; McGuckin, M.A. ; Florin, T.H. - \ 2010
    American Journal of Gastroenterology 105 (2010)11. - ISSN 0002-9270 - p. 2420 - 2428.
    human-colon ecosystems - inflammatory bowel diseases - polymerase-chain-reaction - genome-wide association - crohns-disease - akkermansia-muciniphila - sequence-analysis - mucus layer - susceptibility - degradation
    OBJECTIVES: Mucosa-associated bacteria are increased in inflammatory bowel disease (IBD), which suggests the possibility of an increased source of digestible endogenous mucus substrate. We hypothesized that mucolytic bacteria are increased in IBD, providing increased substrate to sustain nonmucolytic mucosa-associated bacteria. METHODS: Mucolytic bacteria were characterized by the ability to degrade human secretory mucin (MUC2) in pure and mixed anaerobic cultures. Real-time PCR was used to enumerate mucosa-associated mucolytic bacteria in 46 IBD and 20 control patients. Bacterial mucolytic activity was tested in vitro using purified human MUC2. RESULTS: We confirm increased total mucosa-associated bacteria 16S rRNA gene in macroscopically and histologically normal intestinal epithelium of both Crohn's disease (CD) (mean 1.9-fold) and ulcerative colitis (UC) (mean 1.3-fold). We found a disproportionate increase in some mucolytic bacteria. Mean Ruminococcus gnavus were increased >4-fold and Ruminococcus torques ~100-fold in macroscopically and histologically normal intestinal epithelium of both CD and UC. The most abundantly detected mucolytic bacterium in controls, Akkermansia muciniphila, was reduced many fold in CD and in UC. Coculture of A. muciniphila with MUC2 as the sole carbon source led to reduction in its abundance while it augmented growth of other bacteria. CONCLUSIONS: Mucolytic bacteria are present in healthy humans, where they are an integral part of the mucosa-associated bacterial consortium. The disproportionate increase in R. gnavus and R. torques could explain increased total mucosa-associated bacteria in IBD
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