Flavonoids and heart health: Proceedings of the ILSI North America Flavonoids Workshop may 31-june 1, 2005, Washington DC
Erdman, J.W. ; Balentine, D. ; Arab, L. ; Beecher, G. ; Dwyer, J.T. ; Folts, J. ; Harnly, J. ; Hollman, P.C.H. ; Keen, C.L. ; Mazza, G. ; Messina, M. ; Scalbert, A. ; Vita, J. ; Williamson, G. ; Burrows, J. - \ 2007
The Journal of Nutrition 137 (2007)3. - ISSN 0022-3166 - p. 718s - 737s.
low-density-lipoprotein - coronary-artery-disease - potentially anticarcinogenic flavonoids - environmental estrogenic compounds - estradiol-induced tumorigenesis - improves endothelial function - liquid-chromatographic method - catechol o-methyltransferase - ran
This article provides an overview of current research on flavonoids as presented during a workshop entitled, "Flavonoids and Heart Health," held by the ILSI North America Project Committee on Flavonoids in Washington, DC, May 31 and June 1, 2005. Because a thorough knowledge and understanding about the science of flavonoids and their effects on health will aid in establishing dietary recommendations for bioactive components such as flavonoids, a systematic review of the science of select flavonoid classes (i.e., flavonols, flavones, flavanones, isoflavones, flavan-3-ols, anthocyanins, and proanthocyanidins) was presented. The objectives of the workshop were to 1) present and discuss current research on flavonoid intake and the relation between flavonoids and heart health; 2) develop information that could lead to expert consensus on the state-of-the-science of dietary intake of flavonoids on heart health; and 3) summarize and prioritize the research needed to establish the relations between specific flavonoids and heart health. Presentations included the basics of the biology of flavonoids, including the types and distribution in foods, analytical methodologies used to determine the amounts in foods, the bioavailability, the consumption patterns and potential biomarkers of intake, risk assessment and safety evaluation, structure/function claims, and the proposed mechanism(s) of the relation between certain flavonoids and heart health endpoints. Data presented support the concept that certain flavonoids in the diet can be associated with significant health benefits, including heart health. Research gaps were identified to help advance the science.
New simple spectrophotometric assay of total carotenes in margarines
Luterotti, S. ; Bicanic, D.D. ; Pozgaj, R. - \ 2006
Analytica Chimica Acta 573-574 (2006)1-2. - ISSN 0003-2670 - p. 466 - 473.
liquid-chromatographic method - beta-carotene - geometric isomers - vitamin-a - quantification - identification - tocopherols - separation - extracts - retinol
Direct and reliable spectrophotometric method for assaying total carotenes (TC) in margarines with the minimum of sample manipulation is proposed. For the first time saponification step used in determination of carotenes in margarines was omitted leading to a substantial cost saving and reduction of time needed to complete the analysis. The resulting analytical procedure is characterized in details in terms of the figures of merit. The method is sensitive, precise and accurate; for both, standard additions and calibration in soybean oil, recovery ranges between 98 and 102%. For the most accurate analyses the approach of standard additions is preferred but for quick routine analyses this latter can be replaced by the calibration in soybean oil. Limit of detection value (LOD = 3S.D.B/a, where S.D.B is the standard deviation of the blank, "a" is the slope of calibration line) as low as 12 g TC/100 g was achieved in soybean oil enabling the sensitive detection. Concentration of TC in margarines declared as being coloured with ß-carotene (carotene) ranges between 0.3 and 0.9 mg/100 g while in carrot extract-coloured margarine TC is 0.2 mg/100 g.