Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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The relationship between fermented food intake and mortality risk in the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort
Praagman, J. ; Dalmeijer, G.W. ; Schouw, Y.T. van der; Soedamah-Muthu, S.S. ; Verschuren, W.M.M. ; Bueno-de Mesquita, H.B. ; Geleijnse, J.M. ; Beulens, J.W.J. - \ 2015
The British journal of nutrition 113 (2015). - ISSN 0007-1145 - p. 498 - 506.
coronary-heart-disease - lactic-acid bacteria - dairy-products - colorectal-cancer - consumption - stroke - metaanalysis - questionnaire - menaquinone - men
The objective of the present study was to investigate the relationship between total and subtypes of bacterial fermented food intake (dairy products, cheese, vegetables and meat) and mortality due to all causes, total cancer and CVD. From the European Prospective Investigation into Cancer and Nutrition-Netherlands cohort, 34 409 Dutch men and women, aged 20–70 years who were free from CVD or cancer at baseline, were included. Baseline intakes of total and subtypes of fermented foods were measured with a validated FFQ. Data on the incidence and causes of death were obtained from the national mortality register. Cox proportional hazards models were used to analyse mortality in relation to the quartiles of fermented food intake. After a mean follow-up of 15 (sd 2·5) years, 2436 deaths occurred (1216 from cancer and 727 from CVD). After adjustment for age, sex, total energy intake, physical activity, education level, hypertension, smoking habit, BMI, and intakes of fruit, vegetables and alcohol, total fermented food intake was not found to be associated with mortality due to all causes (hazard ratio upper v. lowest quartile (HRQ4 v. Q1) 1·00, 95 % CI 0·88, 1·13), cancer (HRQ4 v. Q1 1·02, 95 % CI 0·86, 1·21) or CVD (HRQ4 v. Q1 1·04, 95 % CI 0·83, 1·30). Bacterial fermented foods mainly consisted of fermented dairy foods (78 %) and cheese (16 %). None of the subtypes of fermented foods was consistently related to mortality, except for cheese which was moderately inversely associated with CVD mortality, and particularly stroke mortality (HRQ4 v. Q1 0·59, 95 % CI 0·38, 0·92, Ptrend= 0·046). In conclusion, the present study provides no strong evidence that intake of fermented foods, particularly fermented dairy foods, is associated with mortality.
High fat challenges with different fatty acids affect distinct atherogenic gene expression pathways in immune cells from lean and obese subjects
Esser, D. ; Dijk, S.J. van; Oosterink, E. ; Lopez, S. ; Muller, M.R. ; Afman, L.A. - \ 2015
Molecular Nutrition & Food Research 59 (2015)8. - ISSN 1613-4125 - p. 1563 - 1572.
triglyceride-rich lipoproteins - blood mononuclear-cells - men - atherosclerosis - inflammation - activation - receptors - adherence - profiles - alpha
Scope - Early perturbations in vascular health can be detected by imposing subjects to a high fat (HF) challenge and measure response capacity. Subtle responses can be determined by assessment of whole-genome transcriptional changes. We aimed to magnify differences in health by comparing gene-expression changes in peripheral blood mononuclear cells toward a high MUFA or saturated fatty acids (SFA) challenge between subjects with different cardiovascular disease risk profiles and to identify fatty acid specific gene-expression pathways. Methods and results -In a cross-over study, 17 lean and 15 obese men (50–70 years) received two 95 g fat shakes, high in SFAs or MUFAs. Peripheral blood mononuclear cell gene-expression profiles were assessed fasted and 4-h postprandially. Comparisons were made between groups and shakes. During fasting, 294 genes were significantly differently expressed between lean and obese. The challenge increased differences to 607 genes after SFA and 2516 genes after MUFA. In both groups, SFA decreased expression of cholesterol biosynthesis and uptake genes and increased cholesterol efflux genes. MUFA increased inflammatory genes and PPAR-a targets involved in ß-oxidation. Conclusion - Based upon gene-expression changes, we conclude that an HF challenge magnifies differences in health, especially after MUFA. Our findings also demonstrate how SFAs and MUFAs exert distinct effects on lipid handling pathways in immune cells.
Iron metabolism is prospectively associated with insulin resistance and glucose intolerance over a 7-year follow-up period: the CODAM study
Wlazlo, N. ; Greevenbroek, M.M.J. van; Ferreira, I. ; Jansen, E.H.J.M. ; Feskens, E.J.M. ; Kallen, C.J.H. van der; Schalkwijk, C.G. ; Bravenboer, B. ; Stehouwer, C.D.A. - \ 2015
Acta Diabetologica 52 (2015)2. - ISSN 0940-5429 - p. 337 - 348.
beta-cell function - serum ferritin - diabetes-mellitus - syndrome desir - fatty liver - risk - transferrin - stores - men - inflammation
Objectives Several markers of iron metabolism have been associated with insulin resistance (IR) and type 2 diabetes mellitus in cross-sectional studies. However, prospective data on these associations are scarce, and it is currently unclear in which tissues iron metabolism may contribute to IR. Therefore, we investigated whether markers of iron metabolism were associated with IR in muscle, liver, and adipocytes, and with glucose intolerance over a 7-year follow-up period. Design and methods Serum ferritin, transferrin, total iron, non-transferrin-bound iron, and transferrin saturation were determined at baseline of a prospective cohort study in 509 individuals (60 % men, age 59 ± 6.9 years, body mass index 28.5 ± 4.3). Both at baseline and after a 7-year follow-up (n = 386), measures of glucose, insulin (during glucose tolerance tests), and non-esterified fatty acids were obtained. Using generalized estimating equations, we investigated associations between baseline iron markers and indices of muscle, liver, and adipocyte insulin resistance (adipocyte IR), as well as glucose intolerance, over the 7-year period. Results Over a 7-year period, baseline serum ferritin (per 10 µg/L increase) was positively associated with homeostasis model assessment insulin resistance (HOMA2-IR) [ß = 0.77 % (95 % CI 0.50–1.03)], hepatic insulin resistance (hepatic IR) [ß = 0.39 % (0.23–0.55)], adipocyte IR [ß = 1.00 % (0.65–1.35)], and AUCglucose [ß = 0.32 % (0.18–0.46)] after adjustment for several covariates, including inflammatory markers (all p <0.001). Similarly, serum transferrin (per 0.1 g/L) was associated with HOMA2-IR [ß = 2.66 % (1.55–3.78)], hepatic IR [ß = 1.16 % (0.47–1.85)], adipocyte IR [ß = 3.75 % (2.27–5.25)], and AUCglucose [ß = 1.35 % (0.74–1.96)] over 7 years. Conclusions Iron metabolism and related factors may contribute to IR in muscle, liver, and adipocytes, eventually leading to impaired glucose metabolism and hyperglycaemia.
Work and Masculinity in Katanga's Artisanal Mines
Cuvelier, J.G.R. - \ 2014
Afrika Spectrum 49 (2014)2. - ISSN 0002-0397 - p. 3 - 26.
conflict sierra-leone - mining town - african - gold - men - diamonds - tanzania - identity - culture - economy
This article, based on 16 months of anthropological fieldwork between 2005 and 2012, examines the relationship between work and masculinity among ardsanal miners, or creuseurs, in Katanga, the southeastern province of the Democratic Republic of the Congo. It argues that men's involvement in ardsanal mining should be considered not only as an economic survival strategy but also as an attempt to experiment with new ways of being a man in a context of economic crisis and changing gender relations. Furthermore, the article criticizes the tendency to downplay or underestimate the complexity and diversity of processes of masculine identity construction in Africa's ardsanal-mining areas. In order to do justice to the intricacy of these processes, the article proposes using concepts and insights from the field of masculinity studies and distinguishing between a levelling and a differentiating trend in artisanal miners' masculinity practices.
Slow Food: Sustained Impact of Harder Foods on the Reduction in Energy Intake over the Course of the Day
Bolhuis, D.P. ; Forde, C.G. ; Cheng, Y.J. ; Xu, H.H. ; Martin, N. ; Graaf, C. de - \ 2014
PLoS ONE 9 (2014)4. - ISSN 1932-6203
bite size - young-adults - eating rate - weight - obesity - satiation - appetite - meal - men - viscosity
Background: Previous research has shown that oral processing characteristics like bite size and oral residence duration are related to the satiating efficiency of foods. Oral processing characteristics are influenced by food texture. Very little research has been done on the effect of food texture within solid foods on energy intake. Objectives: The first objective was to investigate the effect of hardness of food on energy intake at lunch, and to link this effect to differences in food oral processing characteristics. The second objective was to investigate whether the reduction in energy intake at lunch will be compensated for in the subsequent dinner. Design: Fifty subjects (11 male, BMI: 21 +/- 2 kg/m(2), age: 24 +/- 2 y) participated in a cross-over study in which they consumed ad libitum from a lunch with soft foods or hard foods on two separate days. Oral processing characteristics at lunch were assessed by coding video records. Later on the same days, subjects consumed dinner ad libitum. Results: Hard foods led to a similar to 13% lower energy intake at lunch compared to soft foods (P <0.001). Hard foods were consumed with smaller bites, longer oral duration per gram food, and more chewing per gram food compared to the soft foods (P <0.05). Energy intake at dinner did not differ after both lunches (P=0.16). Conclusions: Hard foods led to reduced energy intake compared to soft foods, and this reduction in energy intake was sustained over the next meal. We argue that the differences in oral processing characteristics produced by the hardness of the foods explain the effect on intake. The sustained reduction in energy intake suggests that changes in food texture can be a helpful tool in reducing the overall daily energy intake.
A systematic review and meta-analysis examining the effect of eating rate on energy intake and hunger
Robinson, E. ; Almiron-Roig, E. ; Rutters, F. ; Graaf, C. de; Forde, C.G. ; Smith, C.T. ; Nolan, S.J. ; Jebb, S.A. - \ 2014
American Journal of Clinical Nutrition 100 (2014)1. - ISSN 0002-9165 - p. 123 - 151.
libitum food-intake - particle-size - gut hormones - obese - meal - women - appetite - men - weight - consumption
Background: Reductions in eating rate are recommended to prevent and treat obesity; yet, the relation between eating rate and energy intake has not been systematically reviewed, with studies producing mixed results. Objective: Our main objective was to examine how experimentally manipulated differences in eating rate influence concurrent energy intake and subjective hunger ratings. Design: We systematically reviewed studies that experimentally manipulated eating rate and measured concurrent food intake, self-reported hunger, or both. We combined effect estimates from studies by using inverse variance meta-analysis, calculating the standardized mean difference (SMD) in food intake between fast and slow eating rate conditions. Results: Twenty-two studies were eligible for inclusion. Evidence indicated that a slower eating rate was associated with lower energy intake in comparison to a faster eating rate (random-effects SMD: 0.45; 95% CI: 0.25, 0.65; P <0.0001). Subgroup analysis indicated that the effect was consistent regardless of the type of manipulation used to alter eating rate, although there was a large amount of heterogeneity between studies. There was no significant relation between eating rate and hunger at the end of the meal or up to 3.5 h later. Conclusions: Evidence to date supports the notion that eating rate affects energy intake. Research is needed to identify effective interventions to reduce eating rate that can be adopted in everyday life to help limit excess consumption.
Adherence to dietary guidelines and cardiovascular disease risk in the EPIC-NL cohort
Struijk, E.A. ; May, A.M. ; Wezenbeek, N.L.W.J. ; Fransen, H. ; Soedamah-Muthu, S.S. ; Geelen, A. ; Boer, J. ; Schouw, Y.T. van der; Bueno de Mesquita, H.B. ; Beulens, J.W.J. - \ 2014
International Journal of Cardiology 176 (2014)2. - ISSN 0167-5273 - p. 354 - 359.
coronary-heart-disease - major chronic disease - systematic analysis - for-americans - global burden - style diet - 21 regions - women - men - questionnaire
Background Global and national dietary guidelines have been created to lower chronic disease risk. The aim of this study was to assess whether greater adherence to the WHO guidelines (Healthy Diet Indicator (HDI)); the Dutch guidelines for a healthy diet (Dutch Healthy Diet-index (DHD-index)); and the Dietary Approaches to Stop Hypertension (DASH) diet was associated with a lower risk of cardiovascular disease (CVD), coronary heart disease (CHD) or stroke. Methods A prospective cohort study was conducted among 33,671 healthy Dutch men and women aged 20–70 years recruited into the EPIC-NL study during 1993–1997. We used Cox regression adjusted for relevant confounders to estimate the hazard ratios per standard deviation increase in score and 95% confidence intervals (CI) of the associations between the dietary guidelines and CVD, CHD and stroke risk. Results After an average follow-up of 12.2 years, 2752 CVD cases were documented, including 1630 CHD cases and 527 stroke cases. We found no association between the HDI (0.98, 95% CI 0.94; 1.02) or DHD-index (0.96, 95% CI 0.92; 1.00) and CVD incidence. Similar results were found for these guidelines and CHD or stroke incidence. Higher adherence to the DASH diet was significantly associated with a lower CVD (0.92, 95% CI 0.89; 0.96), CHD (0.91, 95% CI 0.86; 0.95), and stroke (0.90, 95% CI 0.82; 0.99) risk. Conclusion The HDI and the DHD-index were not associated with CVD risk, while the DASH diet was significantly associated with a lower risk of developing CVD, CHD and stroke.
Diet quality and markers of endothelial function: The CARDIA study
Sijtsma, F.P.C. ; Meyer, K.A. ; Steffen, L.M. ; Horn, L. van; Shikany, J.M. ; Odegaard, A.O. ; Gross, M.D. ; Kromhout, D. ; Jacobs, D.R. - \ 2014
Nutrition, Metabolism & Cardiovascular Diseases 24 (2014)6. - ISSN 0939-4753 - p. 632 - 638.
cardiovascular-disease risk - plasma-concentrations - atherosclerosis mesa - young-adults - inflammation - patterns - dysfunction - biomarkers - men
Background and aim: Dietary patterns are associated cross-sectionally with cellular adhesion molecules (CAMs). We studied prospective associations of three dietary patterns with CAMs. Methods and results: In the Coronary Artery Risk Development in Young Adults (CARDIA) study, diet was assessed at years 0 (1985-86) and 7 (1992-93) examinations. Four circulating CAMs (E-selectin, P-selectin, soluble intercellular adhesion molecule 1 (sICAM-1), and vascular cellular adhesion molecule (VCAM)) were assayed at years 7 and 15 (2000-01). We created one index score "A Priori Diet Quality Score" and derived dietary patterns using principal components analysis (PCA). Multivariable linear regression models predicted year 15 CAMs from averaged (year 0/7) dietary patterns. The A Priori Diet Quality Score rated 46 food groups beneficial, neutral or adverse based on hypothesized health effects. We derived two PCA dietary patterns: "fruit and vegetables (FV)" (high intakes of fruit, vegetables, and whole grains) and "meat" (high intakes of red meat, refined grain, and butter). All dietary patterns were related to E-selectin and sICAM-1. P-selectin was not related to the FV dietary pattern. VCAM was only related to the A Priori Diet Quality Score. Strongest associations were for the meat dietary pattern with E-selectin (effect size 28% of an SD (+3.9/13.7 ng/mL)) and P-selectin (effect size 37% of an SD (+4.1/11.2 ng/mL)) and the A Priori Diet Quality Score with sICAM-1 (effect size 34% of an SD (-15.1/44.7 ng/mL)) and VCAM (effect size of 26% of an SD (-45.1/170.3 ng/mL)). Conclusion: This prospective analysis suggests that dietary patterns are associated with CAMs. (C) 2014 Elsevier B. V. All rights reserved.
Stability of dietary patterns assessed with reduced rank regression; the Zutphen Elderly Study
Jankovic, N. ; Streppel, M.T. ; Kampman, E. ; Groot, C.P.G.M. de; Boshuizen, H.C. ; Soedamah-Muthu, S.S. ; Kromhout, D. ; Feskens, E.J.M. - \ 2014
Nutrition Journal 13 (2014). - ISSN 1475-2891
coronary-heart-disease - nutrient intake - swedish women - risk-factors - food - mortality - cancer - reproducibility - index - men
Background Reduced rank regression (RRR) combines exploratory analysis with a-priori knowledge by including risk factors in the model. Dietary patterns, derived from RRR analysis, can be interpreted by the chosen risk factor profile and give an indication of positive or adverse health effects for a specific disease. Our aim was to assess the stability of dietary patterns derived by RRR over time. Methods We used data from 467 men, aged 64–85 years, participating in the 1985 and 1990 examination rounds of the Zutphen Elderly Study. Backwards regression on risk factors and food groups was applied prior to the RRR analysis to exclude food groups with low predictability (from 36 to 19 food groups) for the chosen risk factor profile. For the final RRR analysis, dietary intake data from 19 food groups as predictor variables and 6 established risk factors for cardiovascular diseases (body mass index, systolic and diastolic blood pressure, high density lipoprotein and total cholesterol levels, and uric acid) were used. Results Three RRR dietary patterns were derived for both examination years: a “(low in) cereal fibre pattern”, an “alcohol pattern” and an “inconsistent pattern”. The “(low in) cereal fibre pattern” was most stable over time, with a correlation coefficient of 0.47 (95% CI: 0.38-0.53) between 1985 and 1990 measurements. Conclusion Dietary patterns as measured by RRR, after backwards regression, are reasonably stable over a period of five years. Thus, RRR appears to be an attractive method to measure long-term dietary exposure for nutritional epidemiological studies, with one dietary measurement at baseline.
All-cause mortality risk of metabolically healthy abdominal obese individuals: The EPIC-MORGEN study
A, D.L. van der; Nooyens, A.J.C. ; Duijnhoven, F.J.B. van; Verschuren, M.W.W. ; Boer, J.M. - \ 2014
Obesity 22 (2014)2. - ISSN 1930-7381 - p. 557 - 564.
physical-activity questionnaire - food frequency questionnaire - relative validity - cardiovascular-disease - mho individuals - cohort profile - weight-loss - women - prevalence - men
Objective It appears that a certain proportion of obese individuals have a normal metabolic profile despite having excess weight. Whether these so-called “metabolically healthy” obese express lower disease and mortality risks than “metabolically unhealthy” obese is still unclear. The mortality risk of “metabolically healthy” abdominal obese (MHAO) individuals was investigated. Design and Methods Prospective cohort study (EPIC-MORGEN) among 22,654 individuals aged 20-59 years followed for an average of 13.4 years (SD 2.3). MHAO was assessed at baseline (1993-1997) and defined as abdominal obesity (waist circumference =102 cm/=88 cm (men/women)) with normal glucose, blood pressure, and plasma lipids. All-cause mortality risks adjusted for age and sex were estimated using Cox proportional hazards models. Results Individuals who were “metabolically healthy” nonabdominal obese (MHNAO) comprised the reference group. As compared to MHNAO, mortality risk for MHAO was around 40% higher (Hazard ratio (HR) 1.43; 95% confidence interval (CI): 1.00-2.04) and of the same magnitude as that for “metabolically unhealthy” nonabdominal obese (MUNAO) (HR 1.31; 95% CI: 1.08-1.59). The HR for MUAO was 1.99 (95% CI: 1.62-2.43). Conclusions Mortality risk of MHAO individuals was significantly higher than that of MHNAO individuals and lower than, but not statistically significantly different from, that of MUAO individuals.
No effect of n-3 fatty acids on high-sensitivity C-reactive protein after myocardial infarction: The Alpha Omega Trial
Hoogeveen, E.K. ; Geleijnse, J.M. ; Kromhout, D. ; Giltay, E.J. - \ 2014
European Journal of Preventive Cardiology 21 (2014)11. - ISSN 2047-4873 - p. 1429 - 1436.
soluble adhesion molecules - coronary-heart-disease - necrosis-factor-alpha - cardiovascular risk - fish-oil - docosahexaenoic acid - inflammatory markers - serum concentrations - supplementation - men
Background Persistent inflammation plays a role in the pathogenesis of atherosclerosis. n-3 Fatty acids may have anti-inflammatory effects. This study examined the effect of plant-derived alpha-linolenic acid (ALA) and marine n-3 fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on high-sensitivity C-reactive protein (hsCRP), a systemic marker of (low-grade) inflammation. Design/Methods A supplementary study in the Alpha Omega Trial: a multicenter, double-blind, randomized, placebo-controlled trial of low-dose n-3 fatty acids. Patients were enrolled from 2002 to 2006 and followed for 40 months. A total of 2425 patients, aged 60–80 years (79% men), with a history of myocardial infarction, were randomly assigned to margarines supplemented with a targeted additional intake of 400¿mg/day EPA and DHA, 2¿g/day ALA, EPA-DHA plus ALA, or placebo for 40 months. Results Patients consumed on average 19.8¿g margarine/day, providing an additional amount of 238¿mg/day EPA with 158¿mg/day DHA, 1.98¿g/day ALA, or both, in the active treatment groups. In the placebo group, the geometric mean hsCRP (95% confidence interval (CI)) was 1.84¿mg/l (95% CI: +1.70 to +2.00) at baseline and 1.98¿mg/l (95% CI: 1.82 to 2.15) after 40 months (p¿
A structural equation modelling approach to explore the role of B vitamins and immune markers in lung cancer risk
Baltar, V.T. ; Xun, W.W. ; Johansson, M. ; Bueno-de-Mesquita, B. ; Boshuizen, H.C. ; Gils, C.H. van; Onland-Moret, C.N. - \ 2013
European Journal of Epidemiology 28 (2013)8. - ISSN 0393-2990 - p. 677 - 688.
one-carbon metabolism - dna methylation - indoleamine 2,3-dioxygenase - colorectal-cancer - system activation - folate - infection - men - polymorphisms - neopterin
The one-carbon metabolism (OCM) is considered key in maintaining DNA integrity and regulating gene expression, and may be involved in the process of carcinogenesis. Several B-vitamins and amino acids have been implicated in lung cancer risk, via the OCM directly as well as immune system activation. However it is unclear whether these factors act independently or through complex mechanisms. The current study applies structural equations modelling (SEM) to further disentangle the mechanisms involved in lung carcinogenesis. SEM allows simultaneous estimation of linear relations where a variable can be the outcome in one equation and the predictor in another, as well as allowing estimation using latent variables (factors estimated by correlation matrix). A large number of biomarkers have been analysed from 891 lung cancer cases and 1,747 controls nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Four putative mechanisms in the OCM and immunity were investigated in relation to lung cancer risk: methionine-homocysteine metabolism, folate cycle, transsulfuration, and mechanisms involved in inflammation and immune activation, all adjusted for tobacco exposure. The hypothesized SEM model confirmed a direct and protective effect for factors representing methionine-homocysteine metabolism (p = 0.020) and immune activation (p = 0.021), and an indirect protective effect of folate cycle (p = 0.019), after adjustment for tobacco smoking. In conclusion, our results show that in the investigation of the involvement of the OCM, the folate cycle and immune system in lung carcinogenesis, it is important to consider complex pathways (by applying SEM) rather than the effects of single vitamins or nutrients (e.g. using traditional multiple regression). In our study SEM were able to suggest a greater role of the methionine-homocysteine metabolism and immune activation over other potential mechanisms.
Smoking and the risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition
Rohrmann, S. ; Linseisen, J. ; Allen, N. ; Bueno-de-Mesquita, H.B. ; Johnsen, N.F. ; Tjonneland, A. ; Overvad, K. ; Kaaks, R. ; Teucher, B. ; Boeing, H. ; Pischon, T. ; Lagiou, P. ; Trichopoulou, A. ; Trichopoulos, D. ; Palli, D. ; Krogh, V. ; Tunnino, R. ; Ricceri, F. ; Suarez, M.V.A. ; Agudo, A. ; Sanchez, M.J. ; Chirlaque, M.D. ; Barricarte, A. ; Larranaga, N. ; Boshuizen, H.C. ; Kranen, H.J. ; Stettin, P. ; Johansson, M. ; Bjartell, A. ; Ulmert, D. ; Khaw, K.T. ; Wareham, N.J. ; Ferrari, P. ; Romieux, I. ; Gunter, M.J.R. ; Riboli, E. ; Key, T.J. - \ 2013
British Journal of Cancer 108 (2013)3. - ISSN 0007-0920 - p. 708 - 714.
cigarette-smoking - follow-up - health-professionals - prospective us - tobacco use - cohort - men - recurrence - association - mortality
Background: Smoking is not associated with prostate cancer incidence in most studies, but associations between smoking and fatal prostate cancer have been reported. Methods: During 1992 and 2000, lifestyle information was assessed via questionnaires and personal interview in a cohort of 145112 European men. Until 2009, 4623 incident cases of prostate cancer were identified, including 1517 cases of low-grade, 396 cases of high grade, 1516 cases of localised, 808 cases of advanced disease, and 432 fatal cases. Multivariable Cox proportional hazards regression models were used to examine the association of smoking status, smoking intensity, and smoking duration with the risk of incident and fatal prostate cancer. Results: Compared with never smokers, current smokers had a reduced risk of prostate cancer (RR = 0.90, 95% CI: 0.83-0.97), which was statistically significant for localised and low-grade disease, but not for advanced or high-grade disease. In contrast, heavy smokers (25+ cigarettes per day) and men who had smoked for a long time (40+ years) had a higher risk of prostate cancer death (RR = 1.81, 95% CI: 1.11-2.93; RR = 1.38, 95% CI: 1.01-1.87, respectively). Conclusion: The observation of an increased prostate cancer mortality among heavy smokers confirms the results of previous prospective studies.
Fruit and Vegetable Consumption and Mortality: European Prospective Investigation Into Cancer and Nutrition
Leenders, M. ; Sluijs, I. van der; Ros, M.M. ; Boshuizen, H.C. ; Siersema, P.D. ; Ferrari, P. ; Weikert, C. ; Tjonneland, A. ; Olsen, A. ; Boutron-Ruault, M.C. ; Clavel-Chapelon, F. ; Nailler, L. ; Teucher, B. ; Li, K.R. ; Boeing, H. ; Bergmann, M.M. ; Trichopoulou, A. ; Lagiou, P. ; Trichopoulos, D. ; Palli, D. ; Pala, V. ; Panico, S. ; Tumino, R. ; Sacerdote, C. ; Peeters, P.H.M. ; Gils, C.H. van; Lund, E. ; Engeset, D. ; Redondo, M.L. ; Agudo, A. ; Sanchez, M.J. ; Navarro, C. ; Ardanaz, E. ; Sonestedt, E. ; Ericson, U. ; Nilsson, L.M. ; Khaw, K.T. ; Warcham, N.J. ; Key, T.J. ; Crowe, F.L. ; Romieu, I. ; Gunter, M.J. ; Gallo, V. ; Overvad, K. ; Riboli, E. ; Bueno-de-Mesquita, H.B. - \ 2013
American Journal of Epidemiology 178 (2013)4. - ISSN 0002-9262 - p. 590 - 602.
cardiovascular-disease - oxidative stress - heart-disease - dietary assessment - risk - population - impact - men - calibration - health
In this study, the relation between fruit and vegetable consumption and mortality was investigated within the European Prospective Investigation Into Cancer and Nutrition. Survival analyses were performed, including 451,151 participants from 10 European countries, recruited between 1992 and 2000 and followed until 2010. Hazard ratios, rate advancement periods, and preventable proportions to respectively compare risk of death between quartiles of consumption, to estimate the period by which the risk of death was postponed among high consumers, and to estimate proportions of deaths that could be prevented if all participants would shift their consumption 1 quartile upward. Consumption of fruits and vegetables was inversely associated with all-cause mortality (for the highest quartile, hazard ratio = 0.90, 95% confidence interval (CI): 0.86, 0.94), with a rate advancement period of 1.12 years (95% CI: 0.70, 1.54), and with a preventable proportion of 2.95%. This association was driven mainly by cardiovascular disease mortality (for the highest quartile, hazard ratio = 0.85, 95% CI: 0.77, 0.93). Stronger inverse associations were observed for participants with high alcohol consumption or high body mass index and suggested in smokers. Inverse associations were stronger for raw than for cooked vegetable consumption. These results support the evidence that fruit and vegetable consumption is associated with a lower risk of death.
Effect of Alpha Linolenic Acid Supplementation on Serum Prostate Specific Antigen (PSA): Results from the Alpha Omega Trial
Brouwer, I.A. ; Geleijnse, J.M. ; Klaasen, V.M. ; Smit, L.A. ; Giltay, E.J. ; Goede, J. de; Heijboer, A.C. ; Kromhout, D. ; Katan, M.B. - \ 2013
PLoS ONE 8 (2013)12. - ISSN 1932-6203
n-3 fatty-acids - cancer risk - dietary-fat - metaanalysis - men - disease
Background: Alpha linolenic acid (ALA) is the major omega-3 fatty acid in the diet. Evidence on health effects of ALA is not conclusive, but some observational studies found an increased risk of prostate cancer with higher intake of ALA. We examined the effect of ALA supplementation on serum concentrations of prostate-specific antigen (PSA), a biomarker for prostate cancer. Methods: The Alpha Omega Trial (ClinicalTrials.govIdentifier: NCT00127452) was a double-blind, placebo-controlled trial of ALA and the fish fatty acids eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) on the recurrence of cardiovascular disease, using a 262 factorial design. Blood was collected at the start and the end of the intervention period. The present analysis included 1622 patients with a history of a myocardial infarction, aged 60-80 years with an initial PSA concentration,4 ng/mL. They received either 2 g per day of ALA or placebo in margarine spreads for 40 months. T-tests and logistic regression were used to assess the effects of ALA supplementation on changes in serum PSA (both continuously and as a dichotomous outcome, cut-off point: >4 ng/mL). Findings: Mean serum PSA increased by 0.42 ng/mL on placebo (n = 815) and by 0.52 ng/mL on ALA (n = 807), a difference of 0.10 (95% confidence interval: 20.02 to 0.22) ng/mL (P = 0.12). The odds ratio for PSA rising above 4 ng/mL on ALA versus placebo was 1.15 (95% CI: 0.84-1.58). Interpretation: An additional amount of 2 g of ALA per day increased PSA by 0.10 ng/mL, but the confidence interval ranged from 20.02 to 0.22 ng/mL and included no effect. Therefore, more studies are needed to establish whether or not ALA intake has a clinically significant effect on PSA or prostate cancer.
Women's autonomy and husbands' involvement in maternal health care in Nepal
Thapa, D.K. ; Niehof, Anke - \ 2013
Social Science and Medicine 93 (2013). - ISSN 0277-9536 - p. 1 - 10.
reproductive health - decision-making - antenatal care - fertility - men - services - fathers - india - perspectives - household
Both increasing women’s autonomy and increasing husbands’ involvement in maternal health care are promising strategies to enhance maternal health care utilization. However, these two may be at odds with each other insofar as autonomouswomenmay not seek their husband’s involvement, and involved husbands may limit women’s autonomy. This study assessed the relationship between women’s autonomy and husbands’ involvement in maternal health care. Field work for this study was carried out during SeptembereNovember 2011 in the Kailali district of Nepal. In-depth interviews and focus group discussions were used to investigate the extent of husbands’ involvement in maternal health care. A survey was carried out among 341 randomly selectedwomenwho delivered a live baby within one year prior to the survey. The results showthat husbandswere involved in giving advice, supporting to reduce the householdwork burden, and makingfinancial and transportation arrangements for the delivery. After adjustment for other covariates, economic autonomy was associated with lower likelihood of discussion with husband during pregnancy, while domestic decision-making autonomy was associated with both lower likelihood of discussion with husband during pregnancy and the husband’s presence at antenatal care (ANC) visits. Movement autonomy was associated with lower likelihood of the husband’s presence at ANC visits. Intra-spousal communication was associated with higher likelihood of discussing health with the husband during pregnancy, birth preparedness, and the husbands’ presence at the health facility delivery. The magnitude and direction of association varied per autonomy dimension. These findings suggest that programs to improve the women’s autonomy and at the sametimeincrease the husband’s involvement should be carefully planned. Despite the traditional cultural beliefs that go against the involvement of husbands, Nepalese husbands are increasingly entering into the area of maternal health which was traditionally considered ‘women’s business’.
Twenty-four hour urinary urea excretion and 9-year risk of hypertension: the PREVEND study
Tielemans, S.M.A.J. ; Geleijnse, J.M. ; Baak, M.A. van; Engberink, M.F. ; Brink, E.J. ; Jong, P.E. ; Gansevoort, R.T. ; Bakker, S.J.A. - \ 2013
Journal of Hypertension 31 (2013)8. - ISSN 0263-6352 - p. 1564 - 1569.
blood-pressure - protein-intake - association - nutrients - nitrogen - cohort - trial - life - men
OBJECTIVES:: It is not yet clear whether dietary protein could help maintaining a healthy blood pressure (BP). We investigated the association between total protein intake, estimated from 24-h urinary urea excretion, and incident hypertension in Dutch men and women. METHODS:: We analyzed data of 3997 men and women (aged 28-75 years) who participated in the Prevention of Renal and Vascular Endstage Disease (PREVEND) study, a prospective cohort study. Urea excretion was assessed in two consecutive 24-h urine collections at baseline and approximately 4 years later, from which total protein intake was estimated using the Maroni method. Participants were followed for 9 years for hypertension incidence, defined as BP at least 140/90¿mmHg or initiation of antihypertensive medication. Hazard ratios (HR) were obtained in sex-specific quintiles of protein intake using time-dependent Cox regression, adjusted for age, sex, BMI, smoking, alcohol use, and 24-h urinary excretions of sodium and potassium. RESULTS:: Baseline BP was on average 119/70¿mmHg and 976 participants developed hypertension during follow-up. Mean protein intake (in g/kg ideal body weight) was 1.18¿±¿0.26 for men and 1.12¿±¿0.25 for women. Estimated protein intake was nonlinearly inversely associated with incident hypertension in the fully adjusted model, with nonsignificant HR of 0.77, 0.75, 0.82, and 0.83 in consecutive quintiles compared with the lowest quintile (P-trend: 0.52). CONCLUSION:: Protein intake, as assessed by urinary urea excretion, was not significantly associated with 9-year hypertension incidence in Dutch men and women.
Dairy product intake in relation to glucose regulation indices and risk of type 2 diabetes
Struijk, E.A. ; Heraclides, A. ; Witte, D.R. ; Soedamah-Muthu, S.S. ; Geleijnse, J.M. ; Toft, U. ; Lau, C.J. - \ 2013
Nutrition, Metabolism & Cardiovascular Diseases 23 (2013)9. - ISSN 0939-4753 - p. 822 - 828.
vitamin-k - consumption - mellitus - women - disease - men - phylloquinone - menaquinones - metaanalysis - association
Background and aim A high intake of dairy has been linked to lower risk of type 2 diabetes (T2D). The relationship between dairy intake and glucose metabolism is still not well understood. The aim of this study was to investigate the relation between the intake of total dairy and dairy subgroups and T2D and measures of glucose metabolism. Methods and results A total of 5953 Danish men and women aged 30–60 years without baseline diabetes or cardiovascular diseases were included in this prospective analysis. The dairy intake at baseline was categorised into low-fat dairy, full-fat dairy, milk and milk products, cheese and fermented dairy. Fasting plasma glucose (FPG), 2-h plasma glucose (2hPG), HbA1c, insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-B) were considered at 5-year follow-up. In the maximally-adjusted model (demographics, lifestyle factors, dietary factors and waist), cheese intake was inversely associated with 2hPG (ß = -0.048, 95% CI -0.095; -0.001). Fermented dairy intake was inversely associated with FPG (ß = -0.028, 95% CI -0.048; -0.008) and HbA1c (ß = -0.016, 95% CI -0.030; -0.001). Total dairy intake and the dairy subgroups were not related to HOMA-IR and HOMA-B in the maximally-adjusted model. Furthermore, there was no significant association between intake of total dairy or any of the dairy subgroups and incidence of T2D. Conclusion Our data suggest a modest beneficial effect of cheese and fermented dairy on glucose regulation measures; however, this did not translate into a significant association with incident T2D.
Associations between changes in anthropometric measures and mortality in old age: a role for mid-upper arm circumference?
Hollander, E.L. de; Bemelmans, W.J.E. ; Groot, C.P.G.M. de - \ 2013
Journal of the American Medical Directors Association 14 (2013)3. - ISSN 1525-8610 - p. 187 - 193.
body-mass index - waist circumference - weight change - cardiovascular events - muscle area - obesity - risk - health - adults - men
Objectives: In elderly individuals, little is known about changes in different anthropometric measures with respect to mortality. We examined the association between changes in eight anthropometric measures and mortality in an elderly population. Design: Longitudinal study including baseline measurements in 1988-1990 and repeated measures in 1993. Setting: European towns. Participants: A total of 1061 older adults born in 1913-1918 from the Survey in Europe on Nutrition and the Elderly, A Concerted Action study were included in this study. Measurements: Weight, body mass index, waist circumference, waist to hip ratio, waist to height ratio, mid-upper arm circumference (MUAC), triceps skinfold thickness, and corrected arm muscle area were taken during both measurements. Results: A Cox regression model was used to examine the association between anthropometric changes (divided into quintiles, smallest change - reference category) and all-cause and cardiovascular disease mortality over approximately 6 years of follow-up, adjusted for baseline measurement of application, age, sex, smoking, education, physical activity, and major chronic diseases. A decrease in weight (>= 3.2 kg), waist circumference (>= 3.1 cm), and MUAC (>= 1.6 cm and 0.6-1.6 cm) were (near) significantly associated with an all-cause mortality risk of 1.48 (95% CI: 0.99-2.20), 1.52 (95% CI: 1.01-2.31), 1.81 (95% CI: 1.17-2.79), and 1.66 (95% CI: 1.10-2.49), respectively. Also for MUAC, an increase (>= 1.3 cm) was significantly associated with an increased all-cause and cardiovascular disease mortality risk [hazard ratio, 1.52 (95% CI: 1.00-2.31) and 1.94 (95% CI: 1.00-3.75), respectively]. Conclusion: Associations were observed for decreases in only 3 of 8 anthropometric measures and all-cause mortality. Decreases in MUAC had the strongest association with mortality and was the only measure in which an increase also was associated with mortality. This suggests a role for MUAC in the prediction of mortality in elderly individuals. Published by Elsevier Inc. on behalf of the American Medical Directors Association, Inc.
Dietary amino acids and the risk of hypertension in a Dutch older population: the Rotterdam Study
Altorf-van der Kuil, W. ; Engberink, M.F. ; Neve, M. De; Rooij, F.J.A. van; Hofman, M.K. ; Veer, P. van 't; Witteman, J.C.M. ; Franco, O.H. ; Geleijnse, J.M. - \ 2013
American Journal of Clinical Nutrition 97 (2013)2. - ISSN 0002-9165 - p. 403 - 410.
food frequency questionnaire - blood-pressure - arginine intake - protein-intake - disease - trial - men - supplementation - association - intermap
Background: Inverse associations between dietary protein and hypertension have been reported, which may be attributed to specific amino acids. Objective: We examined whether the intake of glutamic acid, arginine, cysteine, lysine, or tyrosine was associated with blood pressure (BP) levels (n = 3086) and incident hypertension (n = 1810) in the Rotterdam Study. Design: We calculated BP levels in quartiles of amino acid intake as a percentage of total protein intake (% of protein) with adjustment for age, sex, BMI, smoking, alcohol intake, education, and dietary factors. Subsequently, we used Cox proportional models that included the same confounders to evaluate the associations between specific amino acid intake and hypertension incidence. Results: Glutamic acid contributed most to protein intake (21% of protein), whereas lysine provided 7%, arginine 5%, tyrosine 4%, and cysteine 1.5%. A higher intake of tyrosine (~0.3% of protein) was significantly related to a 2.4 mm Hg lower systolic BP (P-trend = 0.05) but not to diastolic BP (P = 0.35). The other amino acids were not significantly associated with BP levels in a cross-sectional analysis. During 6 y of follow-up (7292 person-years), 873 cases of hypertension developed. None of the amino acids were significantly associated with incident hypertension (HR: 0.81–1.18; P-trend > 0.2). Conclusion: Our data do not suggest a major role for glutamic acid, arginine, lysine, tyrosine, or cysteine intake (as % of of protein intake) in determining population BP or risk of hypertension.
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