Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Service contract for markers for nitrofurazone and on semicarbazide analysis
    Mulder, P.P.J. ; Berendsen, B.J.A. ; Zuidema, T. ; Rhijn, J.A. van - \ 2006
    Wageningen : RIKILT (Rapport / RIKILT 2006.005) - 48
    vervalsing - nitrofuranen - merkers - metabolieten - adulteration - nitrofurans - markers - metabolites
    Adducten van nitrofuranen: metabolisme, uitscheidingskinetiek en analytiek
    Zuidema, T. - \ 2003
    Wageningen : RIKILT (Rapport / RIKILT 2003.022) - 56
    nitrofuranen - derivaten - vleeskuikens - blootstelling - metabolisme - furazolidon - in vitro - heterocyclische verbindingen - analytische scheikunde - nitrofurans - derivatives - broilers - exposure - metabolism - furazolidone - in vitro - heterocyclic compounds - analytical chemistry
    Absorption of a mutagenic metabolite released from protein-bound residues of furazolidone
    Hoogenboom, L.A.P. ; Bruchem, G.D. van; Sonne, K. ; Enninga, I.C. ; Rhijn, J.A. van; Heskamp, H. ; Huveneers-Oorsprong, M.B.M. ; Hoeven, J.C.M. van der; Kuiper, H.A. - \ 2002
    Environmental Toxicology and Pharmacology 11 (2002). - ISSN 1382-6689 - p. 273 - 287.
    furazolidone - bound residues - nitrofurans - MAO-inhibition
    The use of nitrofurans as veterinary drugs has been banned in the EU since 1993 due to doubts on the safety of the protein-bound residues of these drugs in edible products. Following treatment of pigs with the veterinary drug furazolidone free 3-amino-2-oxazolidinone (AOZ), the side-chain of the drug, could be detected in the blood in concentrations up to 0.3 g/ml. The identity of the free AOZ was confirmed by LC/MS. This shows that the side-chain can be released from the parent drug, most likely under the acidic conditions in the stomach. Free AOZ was also detected in the blood of rats fed pig liver with protein-bound residues of furazolidone. Incubation of isolated pig hepatocytes with radiolabeled AOZ, resulted in the formation of protein-bound metabolites, to a similar extent as observed with furazolidone itself. Much lower levels were formed in the presence of dimethylsulfoxide or 4-chlorobenzenesulfonamide, most likely due to inhibition of the enzyme involved in the metabolic activation of AOZ. These compounds also prevented the inhibition by AOZ of monoamine-oxidase (MAO) activity in pig hepatocytes. These data strongly indicate that the protein-bound metabolites of furazolidone in tissues of treated animals are derived following metabolic activation of furazolidone itself, but also of the free AOZ side-chain, following its release from the parent drug. In addition to the MAO-inhibition and formation of protein-adducts, AOZ gave a dose-related positive respons in the Salmonella/microsome mutagenicity test especially in the presence of rat liver S9-mix, in tester strains TA 1535 and TA 100. Furthermore, a positive response was obtained in the chromosome aberration test with human lymphocytes and in the bone marrow micronucleus test with mice treated intraperitoneally with AOZ. It is concluded that ingestion of protein-bound residues of furazolidone results in the release and absorption of AOZ, a compound with potential mutagenic properties. This is the first report showing that protein-bound residues of veterinary drugs can be of toxicological significance.
    Ontwikkeling van een FAST-LC methode voor een aantal nitrofuranen in ei
    Beek, W.M.J. ; Aerts, M.M.L. - \ 1986
    Wageningen : RIKILT (Rapport / RIKILT 86.73) - 5
    nitrofuranen - eieren - lc-ms - vloeistofchromatografie - nitrofurans - eggs - liquid chromatography-mass spectrometry - liquid chromatography
    Doel van dit onderzoek was: Het bepalen en/of screenen van de belangrijkste nitrofuranen in ei met behulp van FAST-LC op een meetniveau van 10 ppb. Er is een FAST-LC methode voor nitrofurantoine, nitrofurazon, furazolidon en furaltadon in ei ontwikkeld. Evenals bij vlees en melk worden door toepassing van het FAST-LC systeem monsters "on-line" automatisch geanalyseerd.
    Ontwikkeling van een FAST-LC methode voor een aantal nitrofuranen in vlees en melk
    Anonymous, - \ 1985
    Wageningen : RIKILT (Rapport / Afdeling Diergeneesmiddelen. Rijkskwaliteitsinstituut voor Land- en Tuinbouwprodukten no. 85.116)
    vlees - vleeswaren - melk testen - furanen - furfural - nitrofuranen - vloeistofchromatografie - hplc - meat - meat products - milk testing - furans - furfural - nitrofurans - liquid chromatography - hplc
    Door toepassing van het zogenaamde "FAST-LC systeem" kunnen monsters zonder veel manuele handelingen automatisch worden geanalyseerd op nitrofuranen, medicinale stoffen met een breed werkingsspectrum, toegepast tegen infectieziekten bij runderen, varkens en pluimvee. In de Verenigde Staten mogen geen residuen hiervan aantoonbaar in eieren, vlees, etc. aanwezig zijn
    Onderzoek naar residuen van antibiotica en chemotherapeutica bij slachtkippen
    Aerts, M.M.L. ; Nouws, J. ; Beek, W. - \ 1985
    Wageningen : RIKILT (Rapport / RIKILT 85.117) - 3
    pluimveevlees - kippenvlees - eendenvlees - vervalsing - besmetting - achteruitgang (deterioration) - chlooramfenicol - sulfonamiden - nitrofuranen - analyse - poultry meat - chicken meat - duck meat - adulteration - contamination - deterioration - chloramphenicol - sulfonamides - nitrofurans - analysis
    N.a.v. berichten als zou in Nederland, evenals in Belgie, ongeveer 4% van de slachtkippen antimicrobiele residuen bevatten zijn in de periode 1985-04-22 tot 1985-06-13 255 vleesmonsters microbiologisch gescreend op de aanwezigheid van antibiotica. Daarnaast werd met chemische methoden gekeken naar de aanwezigheid van chlooramfenicol, sulfonamiden en nitrofuranen.
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