Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Framework to determine the effectiveness of dietary exposure mitigation to chemical contaminants
    Fels, H.J. van der; Edwards, S. ; Kennedy, M. ; O'Hagan, A. ; O'Mahony, C. ; Scholz, G. ; Steinberg, P. ; Tennant, D. ; Chiodini, A. - \ 2014
    Food and Chemical Toxicology 74 (2014). - ISSN 0278-6915 - p. 360 - 371.
    chromatography-mass spectrometry - solid-phase microextraction - extraction-gas chromatography - single-laboratory validation - fusarium mycotoxin content - methyl mercury exposure - spme-gc-ms - risk-assessment - baby-food - fish consumption
    In order to ensure the food safety, risk managers may implement measures to reduce human exposure to contaminants via food consumption. The evaluation of the effect of a measure is often an overlooked step in risk analysis process. The aim of this study was to develop a systematic approach for determining the effectiveness of mitigation measures to reduce dietary exposure to chemical contaminants. Based on expert opinion, a general framework for evaluation of the effectiveness of measures to reduce human exposure to food contaminants was developed. The general outline was refined by application to three different cases: 1) methyl mercury in fish and fish products, 2) deoxynivalenol in cereal grains, and 3) furan in heated products. It was found that many uncertainties and natural variations exist, which make it difficult to assess the impact of the mitigation measure. Whenever possible, quantitative methods should be used to describe the current variation and uncertainty. Additional data should be collected to cover natural variability and reduce uncertainty. For the time being, it is always better for the risk manager to have access to all available information, including an assessment of uncertainty; however, the proposed methodology provides a conceptual framework for addressing these systematically.
    Developments in mycotoxin analysis: an update for 2010-2011
    Shephard, G.S. ; Berthiller, F. ; Burdaspal, P. ; Crews, C. ; Jonker, M.A. ; Krska, R. ; MacDonald, S. ; Malone, R.J. ; Maragos, C. ; Solfrizzo, M. ; Egmond, H.P. van; Whitaker, T.B. - \ 2012
    World Mycotoxin Journal 5 (2012)1. - ISSN 1875-0710 - p. 3 - 30.
    tandem mass-spectrometry - performance liquid-chromatography - traditional chinese medicines - immunoaffinity column cleanup - single-laboratory validation - aflatoxin m-1 contamination - thin-layer-chromatography - infected tall fescue - cereal-based foods - ht-2
    This review highlights developments in mycotoxin analysis and sampling over a period between mid-2010 and mid-2011. It covers the major mycotoxins: aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. Analytical methods for mycotoxins continue to be developed and published. Despite much interest in immunochemical methods and in the rapid development of LC-MS methodology, more conventional methods, sometimes linked to novel clean-up protocols, have also been the subject of research publications over the above period. Occurrence of mycotoxins falls outside the main focus of this review; however, where relevant to analytical method development, this has been mentioned.
    Surface Plasmon Resonance Biosensor Screening Method for Paralytic Shellfish Poisoning Toxins: A Pilot Interlaboratory Study
    Top, H. van den; Elliott, C.T. ; Haughey, S.A. ; Vilarino, N. ; Egmond, H.J. van; Botana, L.M. ; Campbell, K. - \ 2011
    Analytical Chemistry 83 (2011)11. - ISSN 0003-2700 - p. 4206 - 4213.
    single-laboratory validation - harmful algal blooms - saxitoxin
    A surface plasmon resonance (SPR) optical biosensor method was developed for the detection of paralytic shellfish poisoning (PSP) toxins in shellfish. This application was transferred in the form of a prototype kit to seven laboratories using Biacore Q SPR optical biosensor instrumentation for interlaboratory evaluation. Each laboratory received 20 shellfish samples across a range of species including blind duplicates for analysis. The samples consisted of 4 noncontaminated samples spiked in duplicate with a low level of PSP toxins (240 µg STXdiHCl equivalents/kg), a high level of saxitoxin (825 µg STXdiHCl/kg), 2 noncontaminated, and 14 naturally contaminated samples. All 7 participating laboratories completed the study, and HorRat values obtained were
    Developments in mycotoxin analysis: an update for 2009-2010
    Shephard, G.S. ; Berthiller, F. ; Burdaspal, P. ; Crews, C. ; Jonker, M.A. ; Krska, R. ; MacDonald, S. ; Malone, B. ; Maragos, C. ; Sabino, M. ; Solfrizzo, M. ; Egmond, H.P. van; Whitaker, T.B. - \ 2011
    World Mycotoxin Journal 4 (2011)1. - ISSN 1875-0710 - p. 3 - 28.
    tandem mass-spectrometry - performance liquid-chromatography - single-laboratory validation - lc-ms/ms method - traditional chinese medicines - immunoaffinity column cleanup - aflatoxin m-1 levels - ergot alkaloids - baby food - fluorescence detection
    This review highlights developments in mycotoxin analysis and sampling over a period between mid-2009 and mid-2010. It covers the major mycotoxins aflatoxins, Alternaria toxins, ergot alkaloids, fumonisins, ochratoxin, patulin, trichothecenes, and zearalenone. New and improved methods for mycotoxins continue to be published. Immunological-based method developments continue to be of wide interest in a broad range of formats. Multimycotoxin determination by LC-MS/MS is now being targeted at the specific ranges of mycotoxins and matrices of interest or concern to the individual laboratory. Although falling outside the main emphasis of the review, some aspects of natural occurrence have been mentioned, especially if linked to novel method developments
    Developments in mycotoxin analysis: an update for 2008-2009
    Shephard, G.S. ; Berthiller, F. ; Dorner, J. ; Krska, R. ; Lombaert, G.A. ; Malone, B. ; Maragos, C. ; Sabino, M. ; Solfrizzo, M. ; Trucksess, M.W. ; Egmond, H.P. van; Whitaker, T.B. - \ 2010
    World Mycotoxin Journal 3 (2010)1. - ISSN 1875-0710 - p. 3 - 23.
    performance liquid-chromatography - linked-immunosorbent-assay - tandem mass-spectrometry - corn-based food - immunoaffinity column cleanup - fluorescence detection method - single-laboratory validation - near-infrared spectroscopy - resorcylic acid lactones - afl
    This review highlights developments in mycotoxin analysis and sampling over a period between mid-2008 and mid-2009. It covers the major mycotoxins: aflatoxins, alternaria toxins, cyclopiazonic acid, fumonisins, ochratoxin, patulin, trichothecenes and zearalenone. Developments in mycotoxin analysis continue, with emphasis on novel immunological methods and further description of LC-MS and LC-MS/MS, particularly as multimycotoxin applications for different ranges of mycotoxins. Although falling outside the main emphasis of the review, some aspects of natural occurrence have been mentioned, especially if linked to novel method developments.
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