Review of the evidence regarding the use of antenatal multiple micronutrient supplementation in low- and middle-income countries
Bourassa, Megan W. ; Osendarp, Saskia J.M. ; Adu-Afarwuah, Seth ; Ahmed, Saima ; Ajello, Clayton ; Bergeron, Gilles ; Black, Robert ; Christian, Parul ; Cousens, Simon ; Pee, Saskia de; Dewey, Kathryn G. ; Arifeen, Shams El ; Engle-Stone, Reina ; Fleet, Alison ; Gernand, Alison D. ; Hoddinott, John ; Klemm, Rolf ; Kraemer, Klaus ; Kupka, Roland ; McLean, Erin ; Moore, Sophie E. ; Neufeld, Lynnette M. ; Persson, Lars Åke ; Rasmussen, Kathleen M. ; Shankar, Anuraj H. ; Smith, Emily ; Sudfeld, Christopher R. ; Udomkesmalee, Emorn ; Vosti, Stephen A. - \ 2019
Annals of the New York Academy Of Sciences 1444 (2019)1. - ISSN 0077-8923 - p. 6 - 21.
LMICs - micronutrient - pregnancy - supplements
Inadequate micronutrient intakes are relatively common in low- and middle-income countries (LMICs), especially among pregnant women, who have increased micronutrient requirements. This can lead to an increase in adverse pregnancy and birth outcomes. This review presents the conclusions of a task force that set out to assess the prevalence of inadequate micronutrient intakes and adverse birth outcomes in LMICs; the data from trials comparing multiple micronutrient supplements (MMS) that contain iron and folic acid (IFA) with IFA supplements alone; the risks of reaching the upper intake levels with MMS; and the cost-effectiveness of MMS compared with IFA. Recent meta-analyses demonstrate that MMS can reduce the risks of preterm birth, low birth weight, and small for gestational age in comparison with IFA alone. An individual-participant data meta-analysis also revealed even greater benefits for anemic and underweight women and female infants. Importantly, there was no increased risk of harm for the pregnant women or their infants with MMS. These data suggest that countries with inadequate micronutrient intakes should consider supplementing pregnant women with MMS as a cost-effective method to reduce the risk of adverse birth outcomes.
Dietary supplement for energy and reduced appetite containing the β-agonist isopropyloctopamine leads to heart problems and hospitalisations
Bovee, Toine F.H. ; Mol, Hans G.J. ; Bienenmann-Ploum, Monique E. ; Heskamp, Henri H. ; Bruchem, Gerard D. van; Ginkel, Leendert A. van; Kooijman, Martin ; Lasaroms, Johan J.P. ; Dam, Ruud van; Hoogenboom, Ron L.A.P. - \ 2016
Food Additives & Contaminants. Pt. A, Chemistry, Analysis, Control, Exposure & Risk Assessment 33 (2016)5. - ISSN 1944-0049 - p. 749 - 759.
Biosensor - enforcement - health risks - internet - supplements - web shops
In 2013 the Dutch authorities issued a warning against a dietary supplement that was linked to 11 reported adverse reactions, including heart problems and in one case even a cardiac arrest. In the UK a 20-year-old woman, said to have overdosed on this supplement, died. Since according to the label the product was a herbal mixture, initial LC-MS/MS analysis focused on the detection of plant toxins. Yohimbe alkaloids, which are not allowed to be present in herbal preparations according to Dutch legislation, were found at relatively high levels (400–900 mg kg–1). However, their presence did not explain the adverse health effects reported. Based on these effects the supplement was screened for the presence of a β-agonist, using three different biosensor assays, i.e. the validated competitive radioligand β2-adrenergic receptor binding assay, a validated β-agonists ELISA and a newly developed multiplex microsphere (bead)-based β-agonist assay with imaging detection (MAGPIX®). The high responses obtained in these three biosensors suggested strongly the presence of a β-agonist. Inspection of the label indicated the presence of N-isopropyloctopamine. A pure standard of this compound was bought and shown to have a strong activity in the three biosensor assays. Analysis by LC-full-scan high-resolution MS confirmed the presence of this ‘unknown known’ β3-agonist N-isopropyloctopamine, reported to lead to heart problems at high doses. A confirmatory quantitative analysis revealed that one dose of the preparation resulted in an intake of 40–60 mg, which is within the therapeutic range of this compound. The case shows the strength of combining bioassays with chemical analytical techniques for identification of illegal pharmacologically active substances in food supplements.
That’s why I take my ONS. Means-end chain as a novel approach to elucidate the personally relevant factors driving ONS consumption in nutritionally frail elderly users
Uijl, L.C. den; Kremer, S. ; Jager, G. ; Stelt, Annelies van der; Graaf, C. de; Gibson, P. ; Godfrey, J. ; Lawlor, J.B. - \ 2015
Appetite 89 (2015). - ISSN 0195-6663 - p. 33 - 40.
sensory attributes - supplements - care - malnutrition - perceptions - prevalence - interview - consumers - motives - drinks
Oral nutritional supplements (ONS) are a recommended form of nutritional intervention for older malnourished persons when a ‘food first’ approach and/or food fortification prove ineffective. The efficacy of ONS will depend on, amongst other factors, whether persons do, or do not, consume their prescribed amount. Factors influencing ONS consumption can be product, context, or person related. Whereas product and context have received some attention, little is known about the person factors driving ONS consumption. In addition, the relative importance of the product, context, and person factors to ONS consumption is not known. Using the means-end chain (MEC) method, the current study elucidated personally relevant factors (product, context, and person factors) related to ONS consumption in two groups of older nutritionally frail ONS users: community-dwelling persons and care home residents with mainly somatic disorders. To our knowledge, the current work is the first to apply the MEC method to study older nutritionally frail ONS users. Forty ONS users (n¿=¿20 per group) were recruited via healthcare professionals. The level of frailty was assessed using the FRAIL scale. Both groups were interviewed for 30 to 45 minutes using the soft laddering technique. The laddering data were analysed using LadderUX software™. The MEC method appeared to work well in both groups. The majority of the participants took ONS on their doctor's or dietician's prescription as they trusted their advice. The community-dwelling group took ONS to prolong their independence, whereas the care home group reported values that related more to small improvements in quality of life. In addition, care home residents perceived themselves as dependent on their caregiver for their ONS arrangements, whereas this dependence was not reported by community-dwelling persons. Key insights from this work will enable doctors and dieticians to customize their nutritional interventions to ONS users' personal needs and thus positively impact health outcomes
The effect of calcium on the composition and physical properties of whey protein particles prepared using emulsification
Westerik, N. ; Scholten, E. ; Corredig, M. - \ 2015
Food Chemistry 177 (2015). - ISSN 0308-8146 - p. 72 - 80.
beta-lactoglobulin - aggregation - gelation - supplements - droplets - chloride - gels
Protein microparticles were formed through emulsification of 25% (w/w) whey protein isolate (WPI) solutions containing various concentrations of calcium (0.0–400.0 mM) in an oil phase stabilized by polyglycerol polyricinoleate (PGPR). The emulsions were heated (at 80 °C) and the microparticles subsequently re-dispersed in an aqueous phase. Light microscopy and scanning electron microscopy (SEM) images revealed that control particles and those prepared with 7.4 mM calcium were spherical and smooth. Particles prepared with 15.0 mM calcium gained an irregular, cauliflower-like structure, and at concentrations larger than 30.0 mM, shells formed and the particles were no longer spherical. These results describe, for the first time, the potential of modulating the properties of dense whey protein particles by using calcium, and may be used as structuring agents for the design of functional food matrices with increased protein and calcium content.
Chemical analysis of estragole in fennel based teas and associated safety assessment using the Margin of Exposure (MOE) approach
Berg, S.J.P.L. van den; Alhusainy, W. ; Restani, P. ; Rietjens, I. - \ 2014
Food and Chemical Toxicology 65 (2014). - ISSN 0278-6915 - p. 147 - 154.
foeniculum-vulgare - essential oils - methyl eugenol - supplements - fruits - risk
This study describes the analysis of estragole in dry fennel preparations and in infusions prepared from them and an associated safety assessment. A wide range of estragole levels of 0.15–13.3 mg/g dry fennel preparation was found. The estragole content in infusions was considerably lower ranging between 0.4 and 133.4 µg/25 mL infusion prepared from 1 g dry material. Infusions prepared from whole fennel fruits contained about 3-fold less estragole compared to infusions prepared from fine cut fennel material. Safety assessment was performed using the Margin of Exposure (MOE) approach comparing available tumour data to the estimated daily estragole intakes from the consumption of 1–3 cups fennel tea. MOEs obtained for adults generally point at a low priority for risk management, especially when one cup of fennel tea is used daily during lifetime. MOEs for use of fennel teas by children were generally
Naktuinbouw experimenteert met nieuwe eiwitgewassen
Roza, C. ; Reith, J.H. - \ 2014
Buitenstebinnen : halfjaarlijkse uitgave van Naktuinbouw 2014 (2014)3. - p. 14 - 17.
nieuwe voedingsmiddelen - eiwitgehalte - nieuwe cultuurgewassen - wolffia - zeewieren - zeewierenteelt - algen - eetbare paddestoelen - voeding en gezondheid - voedingsstoffen - supplementen - biobased economy - novel foods - protein content - new crops - wolffia - seaweeds - seaweed culture - algae - edible fungi - nutrition and health - nutrients - supplements - biobased economy
In 2050 zijn er volgens de Verenigde Naties wereldwijd 9 miljard monden te voeden. De vraag naar vlees stijgt. Ondertussen verdwijnt er bruikbare landbouwgrond, vooral door klimaatverandering. De hamvraag: hoe voorzien we iedereen van voldoende eiwit in 2050? Antwoord: door niet alleen te mikken op dierlijk eiwit, bijvoorbeeld insecten kunnen ook een efficiënte vervanging zijn van vlees. Kroos, algen, wieren en paddenstoelen worden al geteeld om er eiwit uit te winnen. De veredeling staat nog in de kinderschoenen, maar Naktuinbouw is voor sommige gewassen al bezig met de voorbereidingen voor rassenonderzoek.
|Vitamine B12, D, foliumzuur en leeftijdgerelateerde aandoeningen
Brouwer, E.M. ; Wijngaarden, J.P. van - \ 2011
Voeding Nu 4 (2011)13. - ISSN 1389-7608 - p. 20 - 21.
ouderen - botbreuken - gezondheidsbescherming - ziektepreventie - vitaminen - supplementen - foliumzuur - vitamine b12 - vitamine d - deficiëntie - voeding en gezondheid - elderly - bone fractures - health protection - disease prevention - vitamins - supplements - folic acid - vitamin b12 - vitamin d - deficiency - nutrition and health
Dat vitaminen en mineralen een positieve invloed uit kunnen oefenen op specifieke lichaamsprocessen is bekend. Twee promovendi van Wageningen Universiteit richten zich op het mogelijke verband tussen vitamine B12, foliumzuur en vitamine D en verschillende leeftijdgerelateerde aandoeningen. De associatie tussen een verhoogd homocysteïnegehalte en een verhoogd risico op fracturen was aanleiding voor een groot trial onderzoek onder ouderen. Dit B-PROOF onderzoek loopt nog.
Investigation of urinary steroid metabolites in calf urine after oral and intramuscular administration of DHEA
Becue, I. ; Poucke, C. ; Rijk, J.C.W. ; Bovee, T.F.H. ; Nielen, M.W.F. ; Peteghem, C. van - \ 2010
Analytical and Bioanalytical Chemistry 396 (2010)2. - ISSN 1618-2642 - p. 799 - 808.
mass-spectrometry - androgen profile - dehydroepiandrosterone - gas - consequences - prohormones - supplements - bioassay - men
DHEA (3ß-hydroxy-androst-5-en-17-one) is a natural steroid prohormone. Despite a lack of information on the effect, DHEA and other prohormones are frequently used as a food supplement by body-builders. DHEA is suspected for growth promoting abuse in cattle as well. Considering the latter, urine samples from a previous exposure study in which calves were exposed to 1 g DHEA per day for 7 days, were used. The calves were divided in three groups: one orally treated, one intramuscularly injected, and a control group. The effect of this treatment on the urinary profile of several precursors and metabolites of DHEA was investigated. Urine samples were collected several days before and during the 7 days of administration and were submitted to a clean-up procedure consisting of a separation of the different conjugates (free, glucuronidated, and sulfated forms) of each compound on a SAX column (Varian). An LC-MS/MS method was developed for the detection and quantification of several metabolites of the pathway of DHEA including 17a- and 17ß-testosterone, 4-androstenedione, 5-androstenediol, pregnenolone, and hydroxypregnenolone. Elevated levels of DHEA, 5-androstenediol, and 17a-testosterone were observed in the free and sulfated fraction of the urine of the treated calves, thus indicating that the administered DHEA is metabolized mainly by the ¿5-pathway with 5-androstenediol as the intermediate. Sulfoconjugates of DHEA and its metabolites were found to constitute the largest proportion of the urinary metabolites. The free form was also present, but in a lesser extent than the sulfated form, while glucuronides were negligible.
|Retention of health beneficial components during hot- and cold-smoking of African catfish (Clarias gariepinus) fillets
Larsen, R. ; Mierke-Klemeyer, S. ; Maehre, H. ; Elvevoll, E.O. ; Bandarra, N.M. ; Cordiero, A.R. ; Nunes, M.L. ; Schram, E. ; Luten, J.B. ; Oehlenschlaeger, J. - \ 2010
Archiv für Lebensmittelhygiene 61 (2010)1. - ISSN 0003-925X - p. 31 - 35.
heart-disease mortality - 16 countries - fatty-acids - selenium - fish - metaanalysis - prevention - supplements - taurine
Changes in content of selenium and taurine, and the alteration of fatty acid profile have been studied in African catfish fillets subjected to a commercial cold- or hot smoking process. Selenium content and the fatty acid profile did not change significantly during neither of the smoking procedures. Losses of taurine were 32 and 19 % during cold-smoking and hot-smoking, respectively. Significantly more taurine was lost during cold-smoking (P <0.05), probably due to the prolonged brining and smoking procedure. The results support conclusions from other studies, showing that low molecular water soluble components are more susceptible to losses during processing of seafood.
|Stunting and zinc deficiency among primary school children in rural areas with low soil zinc concentrations in Jiangsu Province, China
Qin, Yu ; Boonstra, A. ; Zhao, J. ; Wu, M. ; Hu, X. ; Kok, F.J. - \ 2009
Asia Pacific Journal of Clinical Nutrition 18 (2009)1. - ISSN 0964-7058 - p. 15 - 21.
controlled-trial - supplements - population - indicators - overweight - nutrition - thailand - obesity - iron
OBJECTIVE: To assess stunting and zinc deficiency among primary school children in north rural area of Jiangsu Province with low soil zinc concentrations, eastern part of China. METHODS: Two data collection rounds were conducted. In the first data collection round, 2268 primary school children aged 6-9 years were included by cluster sampling from three counties with low soil zinc concentrations. Anthropometric measures were assessed and stunting was defined as a z-score of height-for-age (HAZ) below -2 according to the WHO new Growth Standards in 2006. For the second data collection round, the county with the highest prevalence of stunting was selected. From this county, 297 children aged 6-9 years were recruited by cluster sampling. Anthropometric measures, serum and hair zinc, and haemoglobin were measured at this stage. RESULTS: The total prevalence of stunting (HAZ <-2) and mild stunting (-2
Chemical composition, rumen degradability, protein utilization and lactation response to selected tree leaves as substitute of cottonseed cake in the diet of dairy goats
Khan, N.A. ; Habib, G. ; Ullah, G. - \ 2009
Animal Feed Science and Technology 154 (2009)3-4. - ISSN 0377-8401 - p. 160 - 168.
tannin-containing leaves - condensed tannins - hydrolyzable tannins - digestion - supplements - nutrition - sheep - forages - growth - straw
The aim of this study was to investigate the potential of leaves from Grewia oppositifolia (G. oppositifolia) and Ziziphus mauritiana (Z. mauritiana) as a crude protein (CP) supplements to low quality diets of goats in Pakistan. Chemical composition and CP degradability of the tree leaves were compared with cottonseed cake (CSC). The CP content of the supplements ranged from 141 to 269 g/kg dry matter (DM). Contents of total phenols and condensed tannins (CT) were higher (P
Eight-fold increased risk for congenital heart defects in children carrying the nicotinamide N-methyltransferase polymorphism and exposed to medicines and low nicotinamide
Driel, L.M.J.W. van; Smedts, H.P.M. ; Helbing, W.A. ; Isaacs, A. ; Lindemans, J. ; Uitterlinden, A.G. ; Duijn, C.M. van; Vries, J.H.M. de; Steegers, E.A.P. ; Steegers-Theunissen, R.P.M. - \ 2008
European Heart Journal 29 (2008)11. - ISSN 0195-668X - p. 1424 - 1431.
plasma homocysteine - gene - pregnancy - malformations - multivitamin - association - methylation - supplements - folate - bias
Aims: Congenital heart defects (CHDs) have a multifactorial origin, in which subtle genetic factors and peri-conception exposures interact. We hypothesize that derangements in the homocysteine and detoxification pathways, due to a polymorphism in the nicotinamide N-methyltransferase (NNMT) gene, low maternal dietary nicotinamide intake, and medicine use in the peri-conception period, affect CHD risk. Methods and results: In 292 case and 316 control families, maternal peri-conception medicine use and low dietary intake of nicotinamide (13.8 mg/day) were independently associated with CHD risk [odds ratio (95% confidence interval) 1.6 (1.1¿2.3) and 1.5 (1.03¿2.3), respectively]. No significant association was found for the NNMT AG/AA genotype in mothers [0.9 (0.7¿1.3)], fathers [1.1 (0.8¿1.6)], or children [1.1 (0.8¿1.6)]. However, the combination of peri-conception medicine use, low dietary nicotinamide intake, and the NNMT AG/AA genotype in mothers or children showed risk of 2.7 (1.02¿8.1) and 8.8 (2.4¿32.5), respectively. Conclusion: Children carrying the NNMT A allele face additional CHD risk in combination with peri-conception exposure to medicines and/or a low dietary nicotinamide intake. These findings provide a first set of data against which future studies with larger sample sizes can be compared with.
Metal supplementation to anaerobic granular sludge bed reactors: an environmental engineering approach
Gonzalez Fermoso, F. - \ 2008
Wageningen University. Promotor(en): Jules van Lier; Piet Lens. - S.l. : S.n. - ISBN 9789085048787 - 247
rioolslib - anaërobe omstandigheden - bioreactoren - metalen - supplementen - sewage sludge - anaerobic conditions - bioreactors - metals - supplements
The objective of this research is the optimization of essential metal dosing in upflow anaerobic sludge bed (UASB) reactors used for methanogenic wastewater treatment. Optimization of essential metal dosing in UASB reactors is a compromise between achieving the maximal biological activity of the biomass present in the reactor, while minimizing the costs of the supplied metal and the metal losses into the environment. The fate of metals in the anaerobic granular sludge is studied. The boundary conditions to keep a stable reactor operation are evaluated: Nutrient deficiency due to lack of essential metals versus toxicity in case of their excess. Finally, metal dosing strategies are evaluated. It is shown that the metal addition to UASB reactors and the methanogenic activity are related and, more important, this relation can be quantified
Physico-chemical characteristics and degradation rate of soluble protein obtained from the washout fraction of feeds
Gierus, M. ; Jonge, L.H. de; Meijer, G.A.L. - \ 2005
Livestock Production Science 97 (2005)2-3. - ISSN 0301-6226 - p. 219 - 229.
ruminal degradation - dairy-cows - in-situ - grass-silage - rumen - degradability - hay - digestibility - supplements - system
The (water)-soluble fraction of feeds is often assumed to be completely and immediately degraded in the rumen. The objective of this study was to separate the washout fraction (fraction A) obtained usually by difference after submitting the nylon bags to the machine-washing program, to investigate the nature and the degradation of the soluble crude protein in the washout fraction. The washout fraction obtained in vitro (filtrate) of 10 feeds was collected in water using nylon mesh as a filter. The feeds used in the study were: two grass silages, soybean meal, three corn gluten feeds, lupine meal, rapeseed meal, wet brewers grain silage and corn gluten feed silage. Average N losses during filtration and from machine-washed nylon bags ranged from 15% (rape seed meal) to 74% (grass silage) and were not different between procedures. N recovered in the filtrate ranged from 12% (soybean meal) to 60% (corn gluten feed silage) of sample N. The three fractions obtained from the filtrate were: soluble protein (TP), non-protein N (NPN) and fine particles (NS). The NS fraction was obtained after centrifugation of the filtrate and comprised 0% to 87% of N in the filtrate. Soluble protein (TP) in the supernatant was obtained after precipitation with trichloroacetic acid and N in the remaining supernatant was defined as non-protein N (NPN). Significant amounts of TP were found in soybean meal (58%), lupine meal (30%) and rapeseed meal (27%) as percent of total N in the filtrate. NPN ranged from 13% to 100% of N in the filtrate. The in vitro incubation of the protein N (NS + TP) showed that all fractions were not completely degraded, suggesting a potential participation as escape protein. Fine particles in the filtrate have similar degradation rates as the residue left in the filter. It is concluded that the washout fraction consisted of different crude protein fractions that were not always completely and immediately degraded in the rumen.
Low toenail chromium concentration and increased risk of nonfatal myocardial infarction
Guallar, E. ; Jimenez, J. ; Veer, P. van 't; Bode, P. ; Riemersma, R.A. ; Gomez-Aracena, J. ; Kark, J.D. ; Arab, L. ; Kok, F.J. ; Martin-Moreno, J.M. - \ 2005
American Journal of Epidemiology 162 (2005)2. - ISSN 0002-9262 - p. 157 - 164.
cardiovascular-disease - coronary-artery - dietary - metaanalysis - weight - atherosclerosis - supplements - picolinate - nutrition - glucose
Chromium intake may increase insulin sensitivity, glucose tolerance, and the ratio of high density lipoprotein cholesterol to low density lipoprotein cholesterol. However, the epidemiologic evidence on the association between chromium and cardiovascular disease is very limited. To determine whether low toenail chromium concentrations were associated with risk of nonfatal myocardial infarction, the authors conducted an incident, population-based, case-control study in eight European countries and Israel in 1991-1992. Cases (n = 684) were men with a first diagnosis of myocardial infarction recruited from the coronary units of participating hospitals. Controls (n = 724) were men selected randomly from population registers (five study centers) or through other sources, such as hospitalized patients (three centers), general practitioners' practices (one center), or relatives or friends of cases (one center). Toenail chromium concentration was assessed by neutron activation analysis. Average toenail chromium concentrations were 1.10 ¿g/g in cases (95% confidence interval: 1.01, 1.18) and 1.30 ¿g/g in controls (95% CI: 1.21, 1.40). Multivariate odds ratios for quintiles 2-5 were 0.82 (95% CI: 0.52, 1.31), 0.68 (95% CI: 0.43, 1.08), 0.60 (95% CI: 0.37, 0.97), and 0.59 (95% CI: 0.37, 0.95). Toenail chromium concentration was inversely associated with the risk of a first myocardial infarction in men. These results add to an increasing body of evidence that points to the importance of chromium for cardiovascular health
|Vitamine B12 en cognitieve functies
Eussen, S.J.P.M. ; Groot, C.P.G.M. de; Hoefnagels, W.H.L. ; Staveren, W.A. van - \ 2004
Voeding Nu 4 (2004)4. - ISSN 1389-7608 - p. 29 - 31.
ouderen - vitamine b12 - vitaminetekorten - voedingsstoffentekorten - voedingstoestand - deficiëntie - cognitieve ontwikkeling - mentale vaardigheid - supplementen - toevoegingen - wetenschappelijk onderzoek - elderly - vitamin b12 - vitamin deficiencies - nutrient deficiencies - nutritional state - deficiency - cognitive development - mental ability - supplements - additives - scientific research
Vitamine B12-deficiëntie is een relatief veel voorkomend probleem bij ouderen. Wageningen Universiteit onderzoekt wat de optimale hoeveelheid vitamine B12 in capsules zou moeten zijn om een vitamine B12-deficiëntie te behandelen en of deze hoeveelheid B12 gunstige effecten heeft op het cognitief functioneren bij ouderen met een vitamine B12-deficiëntie