Very long-chain n-3 polyunsaturated fatty acids: a head start to win some years between the ears?
Dullemeijer, C. - \ 2009
Wageningen University. Promotor(en): Frans Kok; R.J. Brummer, co-promotor(en): I.A. Brouwer. - [S.l.] : S.n. - ISBN 9789085853770 - 136
vetzuren met een lange keten - hersenen - cognitieve ontwikkeling - mentale vaardigheid - visoliën - ouderen - vaatziekten - omega-3 vetzuren - kenvermogen - long chain fatty acids - brain - cognitive development - mental ability - fish oils - elderly - vascular diseases - omega-3 fatty acids - cognition
Very long-chain n-3 (or omega-3) polyunsaturated fatty acids have attracted considerable public interest during the past few years for their potential beneficial role in cognitive performance. The proposed benefits stretch from advantages in developing brains of infants and children to preventing cognitive decline at old age.
In this thesis, we first examined the role of very long-chain n-3 PUFA at the beginning of the lifespan. We investigated the effects of dietary very long-chain n-3 PUFA on the fatty acid composition of the several brain lobes in juvenile pigs, and showed that a diet enriched with fish oil resulted in higher proportions of DHA in the frontal, parietal and occipital brain lobes compared with the temporal brain lobe. These findings suggest a region-specific incorporation of DHA in the developing brain, which may guide future research into the mechanism by which very long-chain n-3 PUFA may in involved in brain development and function.
Subsequently, we investigated the role of very long-chain n-3 PUFA near the end of the lifespan. In a population of older adults, we investigated the association between very long-chain n-3 PUFA and cognitive decline over three years in multiple cognitive domains. We demonstrated that higher plasma proportions of very long-chain n-3 PUFA were associated with less decline in the cognitive domains sensorimotor speed and complex speed, but not in memory, information-processing speed and word fluency, compared with lower plasma proportions of very long-chain n-3 PUFA. These results suggest a beneficial role of very long-chain n-3 PUFA in the speed-related cognitive domains, which justifies future research in this area with sensitive cognitive outcome measurements that provide domain-specific information.
Finally, we touched upon the role of very long-chain n-3 PUFA in the macrovascular and the microvascular blood supply in the head region. We showed that plasma very long-chain n-3 PUFA were not associated with changes in carotid intima-media thickness and common carotid distension in a healthy older adult population. This may suggest that the role of very long-chain n-3 PUFA in a healthy population extends in particular to the smaller blood vessels. The role of very long-chain n-3 PUFA in the microcirculation of the brain could therefore be an interesting future direction of research. Although we did not directly investigate the role of very long-chain n-3 PUFA in the brain microcirculation, we did investigate whether plasma very long-chain n-3 PUFA were associated with age-related hearing loss over a period of three years in older adults. Since microvascular disease may decrease the blood supply to the highly vascularised cochlea, this may result in age-related hearing loss. We showed that higher plasma proportions of very long-chain n-3 PUFA were indeed associated with less age-related hearing loss compared with lower plasma proportions of very long-chain n-3 PUFA which implies that the hypothesis of improved microcirculation, if proven correct, may have far-reaching consequences.
In summary, this thesis showed that very long-chain n-3 PUFA have region-specific effects on the developing brain and that higher plasma proportions of very long-chain n-3 PUFA were associated with less decline in the speed-related cognitive domains and less age-related hearing loss. Further research is required to establish the role of very long-chain n-3 PUFA in the developing as well as the aging brain and to investigate the underlying mechanisms.
“Very long-chain n-3 polyunsaturated fatty acids: a head start to win some years between the ears?” PhD-thesis by Carla Dullemeijer, Top Institute Food and Nutrition and Division of Human Nutrition, Wageningen University, Wageningen, the Netherlands, May 15, 2009
Genome-wide scan for short and medium chain milk fatty acids
Stoop, W.M. ; Schennink, A. ; Visker, M.H.P.W. ; Mullaart, E. ; Arendonk, J.A.M. van; Bovenhuis, H. - \ 2008
melkvee - zwartbont - melkvet - vetzuren met een lange keten - loci voor kwantitatief kenmerk - merkers - genotyping - genexpressieanalyse - dairy cattle - holstein-friesian - milk fat - long chain fatty acids - quantitative trait loci - markers - genotyping - genomics
Aim of this research was to identify Quantitative Trait Loci (QTL) for long chain milk fatty acids. Therefore 1905 Dutch Holstein Friesian heifers were phenotyped. One of the conclusions was that the identification of QTL for long chain fatty acids, and in particular for C18:1trans fatty acids, strongly supports the hypothesis of a genetic component for these fatty acids
Anaerobic microbial LCFA degradation in bioreactors
Sousa, D.Z. ; Pereira, M.A. ; Alves, J.I. ; Smidt, H. ; Stams, A.J.M. ; Alves, M.M. - \ 2008
Water Science and Technology 57 (2008)3. - ISSN 0273-1223 - p. 439 - 444.
afvalwater - industrieel afval - vetzuren met een lange keten - voedselindustrie - anaërobe afbraak - bioreactoren - clostridiaceae - methanobacterium - palmitaten - waste water - industrial wastes - long chain fatty acids - food industry - anaerobic digestion - bioreactors - clostridiaceae - methanobacterium - palmitates - chain fatty-acids - sludge - nov. - methanogenesis - inhibition - bacterium - digestion - coculture - acetate
This paper reviews recent results obtained on long-chain fatty acids (LCFA) anaerobic degradation. Two LCFA were used as model substrates: oleate, a mono-unsaturated LCFA, and palmitate, a saturated LCFA, both abundant in LCFA-rich wastewaters. 16S rRNA gene analysis of sludge samples submitted to continuous oleate- and palmitate-feeding followed by batch degradation of the accumulated LCFA demonstrated that bacterial communities were dominated by members of the Clostridiaceae and Syntrophomonadaceae families. Archaeal populations were mainly comprised of hydrogen-consuming microorganisms belonging to the genus Methanobacterium, and acetate-utilizers from the genera Methanosaeta and Methanosarcina. Enrichment cultures growing on oleate and palmitate, in the absence or presence of sulfate, gave more insight into the major players involved in the degradation of unsaturated and saturated LCFA. Syntrophomonas-related species were identified as predominant microorganisms in all the enrichment cultures. Microorganisms clustering within the family Syntrophobacteraceae were identified in the methanogenic and sulfate-reducing enrichments growing on palmitate. Distinct bacterial consortia were developed in oleate and palmitate enrichments, and observed differences might be related to the different degrees of saturation of these two LCFA. A new obligately syntrophic bacterium, Syntrophomonas zehnderi, was isolated from an oleate-degrading culture and its presence in oleate-degrading sludges detected by 16S rRNA gene cloning and sequencing
Docosahexaenoic acid production by the marine algae Crypthecodinium cohnii
Swaaf, M.E. de - \ 2003
Delft University of Technology. Promotor(en): J.T. Pronk. - Delft[S.l.] : Delft University Press - ISBN 9789040724008 - 127
vetzuren met een lange keten - meervoudig onverzadigde vetzuren - algen - algenteelt - biomassa productie - biosynthese - long chain fatty acids - polyenoic fatty acids - algae - algae culture - biomass production - biosynthesis