Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Kroonen-Backbier, Brigitte - \ 2020
    Minder afhankelijk gewasbescherming op zuidoostelijk zand
    Verstegen, Harry - \ 2020
    Bodemkwaliteit grasland essentieel
    Kroonen-Backbier, Brigitte - \ 2020
    Minder zwaar grond bewerken past telers
    Balen, Derk van; Hoekzema, Gerard - \ 2020
    Dutch national scientific research program on land subsidence: Living on soft soils subsidence and society
    Stouthamer, Esther ; Erkens, Gilles ; Cohen, Kim ; Hegger, Dries ; Driessen, Peter ; PeterWeikard, Hans ; Hefting, Mariet ; Hanssen, Ramon ; Fokker, Peter ; Akker, Jan Van Den; Groothuijse, Frank ; Rijswick, Marleen Van - \ 2020
    In: Proceedings of the International Association of Hydrological Sciences. - Copernicus Publications (Proceedings of the International Association of Hydrological Sciences ) - ISBN 9781907161308 - p. 815 - 819.

    In the Netherlands land subsidence is a continuously ongoing process. Consequently, an increasing number of people and economic assets are exposed to subsidence, damage costs are soaring, and flood risk and greenhouse gas emissions are increasing. In some areas tipping points have already been reached, where current land-use can no longer be maintained without considerable costs, underlining the urgency to take action. Together with a consortium consisting of universities, research institutes, governmental agencies, public and private partners we have developed a national, multidisciplinary research programme aiming to develop an integrative approach to achieve feasible, legitimate and sustainable solutions for managing the negative societal effects of land subsidence, connecting fundamental research on subsidence processes to socio-economic impact of subsidence and to governance and legal framework design. The program is designed to co-create insights that help to effectively mitigate and adapt to subsidence within the Netherlands by making major improvements in measuring and modeling the processes and consequences of subsidence, identifying, developing and critically evaluating control measures and designing governance and legal approaches that facilitate their implementation. Hereto we will develop (a) new satellite-based technology to measure, attribute and monitor subsidence, (b) solid understanding of the interacting multiple processes contributing to total subsidence, (c) sophisticated physical and economic numerical models to predict humaninduced subsidence rates and impacts, and (d) implementation strategies that go beyond technical measures, to strengthen governance and financing capacities as well as legal frameworks. This fully integrated approach deals with all impacts of land subsidence on society and the economy.

    Vroeg vanggewas zaaien best voor stikstof vasthouden maïs
    Kroonen-Backbier, Brigitte - \ 2020
    Onkruidbeheersing in bieten wordt maatwerk
    Kroonen, Marc - \ 2020
    Waterbeschikbaarheid en minder wateroverlast gaan samen
    Kroonen-Backbier, Brigitte - \ 2020
    Lifestyle-Intervention-Induced Reduction of Abdominal Fat Is Reflected by a Decreased Circulating Glycerol Level and an Increased HDL Diameter
    Beekman, Marian ; Schutte, Bianca A.M. ; Akker, Erik B. van den; Noordam, Raymond ; Dibbets-Schneider, Petra ; Geus-Oei, Lioe Fee de; Deelen, Joris ; Rest, Ondine van de; Heemst, Diana van; Feskens, Edith J.M. ; Slagboom, P.E. - \ 2020
    Molecular Nutrition & Food Research 64 (2020)10. - ISSN 1613-4125
    abdominal fat - biomarkers - lifestyle interventions - metabolomics

    Scope: Abdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease. Cardiometabolic disease risk and its associated high abdominal fat mass, cholesterol, and glucose concentrations can be reduced by a healthier lifestyle. Hence, the aim is to understand the relation between lifestyle-induced changes in body composition, and specifically abdominal fat, and accompanying changes in circulating metabolic biomarkers. Methods and results: Data from the Growing Old Together (GOTO) study was used, which is a single arm lifestyle intervention in which 164 older adults (mean age 63 years, BMI 23–35 kg/m2) changed their lifestyle during 13 weeks by 12.5% caloric restriction plus 12.5% increase in energy expenditure. It is shown here that levels of circulating metabolic biomarkers, even after adjustment for body mass index, specifically associate with abdominal fat mass. The applied lifestyle intervention mainly reduces abdominal fat mass (−2.6%, SD = 3.0) and this reduction, when adjusted for general weight loss, is highly associated with decreased circulating glycerol concentrations and increased HDL diameter. Conclusion: The lifestyle-induced reduction of abdominal fat mass is particularly associated, independent of body mass index or general weight loss, with decreased circulating glycerol concentrations and increased HDL diameter.

    Onderzoek naar een kennisbasis voor natuurgedreven landbouw
    Dijk, J. van; Veer, G. van der; Woestenburg, M. ; Stoop, J. ; Wijdeven, M. ; Veluw, K. van; Schrijver, R. ; Akker, J. van den; Woudenberg, E. van; Kerkhoven, D. ; Slot, M. - \ 2020
    WINK - 52
    Streep door verplichte drijfmestrijenbemesting in maïs
    Kroonen-Backbier, Brigitte ; Ickenroth, Peter ; Haperen, Adriën van - \ 2020
    Akker moet schuilplaats aan insect bieden
    Apeldoorn, Dirk van - \ 2020
    Design Features of Embodied Conversational Agents in eHealth : a Literature Review
    Stal, Silke ter; Kramer, Lean Leonie ; Tabak, Monique ; Akker, Harm op den; Hermens, Hermie - \ 2020
    International Journal of Human-Computer Studies 138 (2020). - ISSN 1071-5819
    design feature - eHealth - Embodied Conversational Agent - review

    Embodied conversational agents (ECAs) are gaining interest to elicit user engagement and stimulate actual use of eHealth applications. In this literature review, we identify the researched design features for ECAs in eHealth, the outcome variables that were used to measure the effect of these design features and what the found effects for each variable were. Searches were performed in Scopus, ACM Digital Library, PsychINFO, Pubmed and IEEE Xplore Digital Library, resulting in 1284 identified articles of which 33 articles were included. The agents speech and/or textual output and its facial and gaze expressions were the most common design features. Little research was performed on the agent's looks. The measured effect of these design features was often on the perception of the agent's and user's characteristics, relation with the agent, system usage, intention to use, usability and behaviour change. Results show that emotion and relational behaviour seem to positively affect the perception of the agents characteristics and that relational behaviour also seems to positively affect the relation with the agent, usability and intention to use. However, these design features do not necessarily lead to behaviour change. This review showed that consensus on design features of ECAs in eHealth is far from established. Follow-up research should include more research on the effects of all design features, especially research on the effects in a long-term, daily life setting, and replication of studies on the effects of design features performed in other contexts than eHealth.

    A data-driven methodology reveals novel myofiber clusters in older human muscles
    Raz, Yotam ; Akker, Erik B. van den; Roest, Tijmen ; Riaz, Muhammad ; Rest, Ondine van de; Suchiman, Eka D. ; Lakenberg, Nico ; Stassen, Stefanie A. ; Putten, Maaike van; Feskens, Edith J.M. ; Reinders, Marcel J.T. ; Goeman, Jelle ; Beekman, Marian ; Raz, Vered ; Slagboom, Pieternella Eline - \ 2020
    FASEB Journal 34 (2020)4. - ISSN 0892-6638 - p. 5525 - 5537.
    bioinformatics - clustering - fibertyping - human - muscle - muscle health - myofiber - myosin heavy chain - RNA-sequencing - sarcomere

    Skeletal muscles control posture, mobility and strength, and influence whole-body metabolism. Muscles are built of different types of myofibers, each having specific metabolic, molecular, and contractile properties. Fiber classification is, therefore, regarded the key for understanding muscle biology, (patho-) physiology. The expression of three myosin heavy chain (MyHC) isoforms, MyHC-1, MyHC-2A, and MyHC-2X, marks myofibers in humans. Typically, myofiber classification is performed by an eye-based histological analysis. This classical approach is insufficient to capture complex fiber classes, expressing more than one MyHC-isoform. We, therefore, developed a methodological procedure for high-throughput characterization of myofibers on the basis of multiple isoforms. The mean fluorescence intensity of the three most abundant MyHC isoforms was measured per myofiber in muscle biopsies of 56 healthy elderly adults, and myofiber classes were identified using computational biology tools. Unsupervised clustering revealed the existence of six distinct myofiber clusters. A comparison with the visual assessment of myofibers using the same images showed that some of these myofiber clusters could not be detected or were frequently misclassified. The presence of these six clusters was reinforced by RNA expressions levels of sarcomeric genes. In addition, one of the clusters, expressing all three MyHC isoforms, correlated with histological measures of muscle health. To conclude, this methodological procedure enables deep characterization of the complex muscle heterogeneity. This study opens opportunities to further investigate myofiber composition in comparative studies.

    'Kansen voor nieuw verdienmodel'
    Visser, Chris de - \ 2020
    Verspreiding fusarium via drijfmest risico
    Visser, Chris de - \ 2020
    Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
    Liu, Jun ; Lahousse, Lies ; Nivard, Michel G. ; Bot, Mariska ; Chen, Lianmin ; Klinken, Jan Bert van; Thesing, Carisha S. ; Beekman, Marian ; Akker, Erik Ben van den; Slieker, Roderick C. ; Waterham, Eveline ; Kallen, Carla J.H. van der; Boer, Irene de; Li-Gao, Ruifang ; Vojinovic, Dina ; Amin, Najaf ; Radjabzadeh, Djawad ; Kraaij, Robert ; Alferink, Louise J.M. ; Murad, Sarwa Darwish ; Uitterlinden, André G. ; Willemsen, Gonneke ; Pool, Rene ; Milaneschi, Yuri ; Heemst, Diana van; Suchiman, H.E. ; Rutters, Femke ; Elders, Petra J.M. ; Beulens, Joline W.J. ; Heijden, Amber A.W.A. van der; Greevenbroek, Marleen M.J. van; Arts, Ilja C.W. ; Onderwater, Gerrit L.J. ; Maagdenberg, Arn M.J.M. van den; Mook-Kanamori, Dennis O. ; Hankemeier, Thomas ; Terwindt, Gisela M. ; Stehouwer, Coen D.A. ; Geleijnse, Johanna M. ; ‘t Hart, Leen M. ; Slagboom, Eline P. ; Dijk, Ko Willems van; Zhernakova, Alexandra ; Fu, Jingyuan ; Penninx, Brenda W.J.H. ; Boomsma, Dorret I. ; Demirkan, Ayşe ; Stricker, Bruno H.C. ; Duijn, Cornelia M. van - \ 2020
    Nature Medicine 26 (2020)1. - ISSN 1078-8956 - p. 110 - 117.

    Progress in high-throughput metabolic profiling provides unprecedented opportunities to obtain insights into the effects of drugs on human metabolism. The Biobanking BioMolecular Research Infrastructure of the Netherlands has constructed an atlas of drug–metabolite associations for 87 commonly prescribed drugs and 150 clinically relevant plasma-based metabolites assessed by proton nuclear magnetic resonance. The atlas includes a meta-analysis of ten cohorts (18,873 persons) and uncovers 1,071 drug–metabolite associations after evaluation of confounders including co-treatment. We show that the effect estimates of statins on metabolites from the cross-sectional study are comparable to those from intervention and genetic observational studies. Further data integration links proton pump inhibitors to circulating metabolites, liver function, hepatic steatosis and the gut microbiome. Our atlas provides a tool for targeted experimental pharmaceutical research and clinical trials to improve drug efficacy, safety and repurposing. We provide a web-based resource for visualization of the atlas (

    The development of reed composite fiber boards using partially bio-based, formaldehyde- and monomeric isocyanate-free resins
    Keijsers, E.R.P. ; Oever, M.J.A. van den; Dam, J.E.G. van; Lansbergen, Aad ; Koning, Cor ; Akker, Harald van der - \ 2020
    Reinforced Plastics 64 (2020)4. - ISSN 0034-3617 - p. 195 - 203.
    The transition towards a bio-based economy increases the demand for wood biomass. The increasing use of wood as raw material for paper, building materials and energy production results in increasing prices. Other types of biomass, e.g. reed released in nature conservation practice, could provide an alternative for the use of wood in e.g. particle boards. Particle board production plants have a relatively small capacity compared to e.g. pulping facilities for paper production. Combined with the high transportation costs of alternative fiber sources, due to low bulk density, the use of locally available raw material for particle board production is economically essential. In several countries wheat straw-based particle board material is currently produced using MDI-glue. Because of the high price of wheat straw in the Netherlands, other raw materials are of interest. Reed is a possible alternative, as large amounts of reed can be made available through nature conservation practice. Currently the value of this reed is negative and burning in nature is no longer allowed.
    Natuurmonumenten together with DSM, intends to convert the biomass released in nature conservation practice (ca. 175.000 t/y reed, grass, straw and woody biomass) into high quality feedstock for the bioeconomy and to contribute in this way to an enhanced sustainability of The Netherlands. This project investigates the technical and economic feasibility of using reed and a new (partially) bio-based resin in the production of fiber composite boards.
    Perspectives on agriculturally used drained peat soils: Comparison of the socioeconomic and ecological business environments of six European regions
    Buschmann, Christoph ; Röder, Norbert ; Berglund, Kerstin ; Berglund, Örjan ; Lærke, Poul Erik ; Maddison, Martin ; Mander, Ülo ; Myllys, Merja ; Osterburg, Bernhard ; Akker, Jan J.H. van den - \ 2020
    Land Use Policy 90 (2020). - ISSN 0264-8377
    Climate mitigation - Peatland management - Social-ecological system framework

    In Northern, Eastern and Central European countries, peat soils drained for agriculture are a considerable source of greenhouse gas emissions. Since emissions from this source have high mitigation potential, they will likely be a focus of the European Union's future climate goals. We describe and compare the similarities and differences in the socioeconomic and ecological business environment that policy makers, planners and farmers are confronted with when developing tailored proposals for low emission land use alternatives on peat land. The analysis is based on interviews with 33 typical farmers cultivating organic soils and on expert group discussions held in six different Northern, Eastern and Central European regions. Based on the Social-Ecological System Framework we identify and cluster important variables. Our results show that mainly hard economic variables determine preferred land use alternatives: the productivity of resource systems, the economic value of land and market incentives. Other variables, such as the heterogeneity of users and conflicts among them, are more important with respect to the implementation of alternatives. We point out possibilities to transfer solutions between regions and discuss an institutional framework for European Union, national and regional levels for facilitating implementation potential.

    A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals
    Deelen, Joris ; Kettunen, Johannes ; Fischer, Krista ; Spek, Ashley van der; Trompet, Stella ; Kastenmüller, Gabi ; Boyd, Andy ; Zierer, Jonas ; Akker, Erik B. van den; Ala-Korpela, Mika ; Amin, Najaf ; Demirkan, Ayse ; Ghanbari, Mohsen ; Heemst, Diana van; Ikram, Arfan ; Klinken, Jan Bert van; Mooijaart, Simon P. ; Peters, Annette ; Salomaa, Veikko ; Sattar, Naveed ; Spector, Tim D. ; Tiemeier, Henning ; Verhoeven, Aswin ; Waldenberger, Melanie ; Würtz, Peter ; Davey Smith, George ; Metspalu, Andres ; Perola, Markus ; Menni, Cristina ; Geleijnse, Johanna M. ; Drenos, Fotios ; Beekman, Marian ; Jukema, Wouter ; Duijn, Cornelia M. van; Slagboom, Eline - \ 2019
    Nature Communications 10 (2019). - ISSN 2041-1723

    Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals (age at baseline 18–109), of whom 5512 died during follow-up. We apply a stepwise (forward-backward) procedure based on meta-analysis results and identify 14 circulating biomarkers independently associating with all-cause mortality. Overall, these associations are similar in men and women and across different age strata. We subsequently show that the prediction accuracy of 5- and 10-year mortality based on a model containing the identified biomarkers and sex (C-statistic = 0.837 and 0.830, respectively) is better than that of a model containing conventional risk factors for mortality (C-statistic = 0.772 and 0.790, respectively). The use of the identified metabolic profile as a predictor of mortality or surrogate endpoint in clinical studies needs further investigation.

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