Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling
Sághy, Tibor ; Köröskényi, Krisztina ; Hegedűs, Krisztina ; Antal, Miklós ; Bankó, Csaba ; Bacsó, Zsolt ; Papp, Attila ; Stienstra, Rinke ; Szondy, Zsuzsa - \ 2019
Cell Death & Disease 10 (2019)6. - ISSN 2041-4889

Transglutaminase 2 (TG2) is a multifunctional protein that promotes clearance of apoptotic cells (efferocytosis) acting as integrin β3 coreceptor. Accumulating evidence indicates that defective efferocytosis contributes to the development of chronic inflammatory diseases. Obesity is characterized by the accumulation of dead adipocytes and inflammatory macrophages in the adipose tissue leading to obesity-related metabolic syndrome. Here, we report that loss of TG2 from bone marrow-derived cells sensitizes for high fat diet (HFD)-induced pathologies. We find that metabolically activated TG2 null macrophages express more phospho-Src and integrin β3, unexpectedly clear dying adipocytes more efficiently via lysosomal exocytosis, but produce more pro-inflammatory cytokines than the wild type ones. Anti-inflammatory treatment with an LXR agonist reverts the HFD-induced phenotype in mice lacking TG2 in bone marrow-derived cells with less hepatic steatosis than in wild type mice proving enhanced lipid clearance. Thus it is interesting to speculate whether LXR agonist treatment together with enhancing lysosomal exocytosis could be a beneficial therapeutic strategy in obesity.

Process the Existing Technical Reports on the Mapping of Green Linear Features (GLF) from two Feasibility studies (ESA, GIO) and Scientific Literature towards Detailed Call for Tender Technical Specifications : Contract No 3436/B2015/RO-COPERNICUS/EEA.56195
Hazeu, G.W. ; Mücher, C.A. ; Banko, G. ; Grillmayer, R. - \ 2015
Copenhagen : European Environment Agency
The EAGLE Concept: A Paradigm Shift in Land Monitoring
Arnold, S. ; Smith, G. ; Hazeu, G.W. ; Kosztra, B. ; Perger, C.H. ; Banko, G. ; Soukup, T. ; Strand, G.H. ; Valcarcel Sanz, N. ; Bock, M. - \ 2015
In: Land Use and Land Cover Semantics. Principles, Best Practices, and Prospects / Ahlqvist, Ola, Varanka, Dalia, Fritz, Steffen, Janowicz, Krzysztof, CRC Press - ISBN 9781482237399 - p. 107 - 144.
Generalization and aggregation rules set (report Task 3-2). Assistance to the EEA in the production of the new CORINE Land Cover (CLC) inventory including the support to the harmonisation of national monitoring for integration at pan- European level
Mathiesen, H. ; Hazeu, G.W. ; Delgado, J. ; Kosztra, B. ; Strand, G.H. ; Teiniranta, R. ; Banko, G. ; Hatunen, S. ; Heggem, E. ; Milenov, P. ; Radkov, R. ; Smith, G. ; Pataki, R. ; Tsvetkova, N. - \ 2015
Copenhagen : EEA - European Environment Agency
Geometric Test Case (report Task 4-1). Assistance to the EEA in the production of the new CORINE Land Cover (CLC) inventory including the support to the harmonisation of national monitoring for integration at pan- European level
Delgado, J. ; Valcarcel Sanz, N. ; Hazeu, G.W. ; Schuiling, C. ; Kosztra, B. ; Maucha, G. ; Lehoczki, R. ; Pataki, R. ; Soukup, T. ; Milenov, P. ; Radkov, R. ; Smith, G. ; Arnold, S. ; Hallin-Pihlatie, L. ; Martinez, C. ; Banko, G. ; Grillmayer, R. ; Caetano, M. ; Törmä, M. ; Marcelino, F. - \ 2015
Copenhagen : EEA - European Environment Agency
Developing Conceptual Framework for Ecosystem Mapping
Banko, G. ; Weiss, M. ; Moser, D. ; Ubach, R. ; Abdul Malak, D. ; Halada, L. ; Roerink, G.J. ; Hazeu, G.W. ; Mucher, C.A. ; Hennekens, S.M. ; Schaminee, J.H.J. ; Brodsky, L. - \ 2013
Kopenhagen : EEA - European Environment Agency
Comparison of HNV distribution patterns between CLC 2000 and CLC 2006 versions of HNV farmland (HNV farmland change layer)
Schwaiger, E. ; Banko, G. ; Doorn, A.M. van; Gergely, M. - \ 2013
Kopenhagen : European Environment Agency
The EAGLE concept - A vision of a future European Land Monitoring Framework
Arnold, S. ; Kosztra, B. ; Banko, G. ; Smith, G. ; Hazeu, G.W. ; Bock, M. ; Valcarcel Sanz, N. - \ 2013
Ecosystem services and Green Infrastructure. Regional policies implementation
Kleeschulte, S. ; Bouwma, I.M. ; Hazeu, G.W. ; Banko, G. ; Nichersu, I. - \ 2012
Malaga : ETC-SIA (European Environment Agency technical report )
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