Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

    Records 1 - 20 / 21

    • help
    • print

      Print search results

    • export

      Export search results

    Check title to add to marked list
    Correction to: Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein
    Keating, Samuel T. ; Groh, Laszlo ; Thiem, Kathrin ; Bekkering, Siroon ; Li, Yang ; Matzaraki, Vasiliki ; Heijden, Charlotte D.C.C. van der; Puffelen, Jelmer H. van; Lachmandas, Ekta ; Jansen, Trees ; Oosting, Marije ; Bree, L.C.J. de; Koeken, Valerie A.C.M. ; Moorlag, Simone J.C.F.M. ; Mourits, Vera P. ; Diepen, Janna van; Stienstra, Rinke ; Novakovic, Boris ; Stunnenberg, Hendrik G. ; Crevel, Reinout van; Joosten, Leo A.B. ; Netea, Mihai G. ; Riksen, Niels P. - \ 2020
    Journal of Molecular Medicine 98 (2020). - ISSN 0946-2716

    The correct name of the 17th Author is presented in this paper. In the paragraph “Metabolic analysis” of the Method section “an XFp Analyzer” should be changed to “an XFe96 Analyzer”.

    Rewiring of glucose metabolism defines trained immunity induced by oxidized low-density lipoprotein
    Keating, Samuel T. ; Groh, Laszlo ; Thiem, Kathrin ; Bekkering, Siroon ; Li, Yang ; Matzaraki, Vasiliki ; Heijden, Charlotte D.C.C. van der; Puffelen, Jelmer H. van; Lachmandas, Ekta ; Jansen, Trees ; Oosting, Marije ; Bree, L.C.J. de; Koeken, Valerie A.C.M. ; Moorlag, Simone J.C.F.M. ; Mourits, Vera P. ; Diepen, Janna van; Stienstra, Rinke ; Novakovic, Boris ; Stunnenberg, Hendrik G. ; Crevel, Reinout van; Joosten, Leo A.B. ; Netea, Mihai G. ; Riksen, Niels P. - \ 2020
    Journal of Molecular Medicine 98 (2020). - ISSN 0946-2716 - p. 819 - 831.
    Atherosclerosis - Cardiovascular disease - Diabetes complications - Glycolysis - Immunometabolism - Inflammation - Trained immunity

    Abstract: Stimulation of monocytes with microbial and non-microbial products, including oxidized low-density lipoprotein (oxLDL), induces a protracted pro-inflammatory, atherogenic phenotype sustained by metabolic and epigenetic reprogramming via a process called trained immunity. We investigated the intracellular metabolic mechanisms driving oxLDL-induced trained immunity in human primary monocytes and observed concomitant upregulation of glycolytic activity and oxygen consumption. In two separate cohorts of healthy volunteers, we assessed the impact of genetic variation in glycolytic genes on the training capacity of monocytes and found that variants mapped to glycolytic enzymes PFKFB3 and PFKP influenced trained immunity by oxLDL. Subsequent functional validation with inhibitors of glycolytic metabolism revealed dose-dependent inhibition of trained immunity in vitro. Furthermore, in vivo administration of the glucose metabolism modulator metformin abrogated the ability for human monocytes to mount a trained response to oxLDL. These findings underscore the importance of cellular metabolism for oxLDL-induced trained immunity and highlight potential immunomodulatory strategies for clinical management of atherosclerosis. Key messages: Brief stimulation of monocytes to oxLDL induces a prolonged inflammatory phenotype.This is due to upregulation of glycolytic metabolism.Genetic variation in glycolytic genes modulates oxLDL-induced trained immunity.Pharmacological inhibition of glycolysis prevents trained immunity.

    Trained Immunity: Linking Obesity and Cardiovascular Disease across the Life-Course?
    Bekkering, Siroon ; Saner, Christoph ; Riksen, Niels P. ; Netea, Mihai G. ; Sabin, Matthew A. ; Saffery, Richard ; Stienstra, Rinke ; Burgner, David P. - \ 2020
    Trends in Endocrinology & Metabolism 31 (2020)5. - ISSN 1043-2760 - p. 378 - 389.
    atherosclerosis - cardiovascular disease - inflammation - obesity - trained immunity

    Obesity, a chronic inflammatory disease, is the most prevalent modifiable risk factor for cardiovascular disease. The mechanisms underlying inflammation in obesity are incompletely understood. Recent developments have challenged the dogma of immunological memory occurring exclusively in the adaptive immune system and show that the innate immune system has potential to be reprogrammed. This innate immune memory (trained immunity) is characterized by epigenetic and metabolic reprogramming of myeloid cells following endogenous or exogenous stimulation, resulting in enhanced inflammation to subsequent stimuli. Trained immunity phenotypes have now been reported for other immune and non-immune cells. Here, we provide a novel perspective on the putative role of trained immunity in mediating the adverse cardiovascular effects of obesity and highlight potential translational pathways.

    Farm-scale bio-power-to-methane: Comparative analyses of economic and environmental feasibility
    Bekkering, Jan ; Zwart, Kor ; Martinus, Gerard ; Langerak, Jort ; Tideman, Jeroen ; Meij, Tineke van der; Alberts, Kees ; Steenis, Machiel van; Nap, Jan Peter - \ 2020
    International Journal of Energy Research 44 (2020)3. - ISSN 0363-907X - p. 2264 - 2277.
    bio-methanation - biogas - electrolysis - energy efficiency - greenhouse gas emission saving - supply chain optimisation

    Power-to-gas technologies are considered to be part of the future energy system, but their viability and applicability need to be assessed. Therefore, models for the viability of farm-scale bio-power-to-methane supply chains to produce green gas were analysed in terms of levelised cost of energy, energy efficiency and saving of greenhouse gas emission. In bio-power-to-methane, hydrogen from electrolysis driven by surplus renewable electricity and carbon dioxide from biogas are converted to methane by microbes in an ex situ trickle-bed reactor. Such bio-methanation could replace the current upgrading of biogas to green gas with membrane technology. Four scenarios were compared: a reference scenario without bio-methanation (A), bio-methanation (B), bio-methanation combined with membrane upgrading (C) and the latter with use of renewable energy only (all-green; D). The reference scenario (A) has the lowest costs for green gas production, but the bio-methanation scenarios (B-D) have higher energy efficiencies and environmental benefits. The higher costs of the bio-methanation scenarios are largely due to electrolysis, whereas the environmental benefits are due to the use of renewable electricity. Only the all-green scenario (D) meets the 2026 EU goal of 80% reduction of greenhouse gas emissions, but it would require a CO2 price of 200 € t−1 to achieve the levelised cost of energy of 65 €ct Nm−3 of the reference scenario. Inclusion of the intermittency of renewable energy in the scenarios substantially increases the costs. Further greening of the bio-methanation supply chain and how intermittency is best taken into account need further investigation.

    Op weg naar een inclusieve reisindustrie
    Duim, Rene van der - \ 2019
    ENose & NanopLESStic in finale Holland Chemistry Studentencompetitie
    Bekkering, Ezra ; Westert, Dorien ; Akkerman, Laura ; Scott, Elinor ; Smulders, Maarten ; Smet, Louis de - \ 2019
    Team NanopLESStic wins Holland Chemistry Student Competition 2019
    Akkerman, Laura ; Bekkering, Ezra ; Westert, Dorien ; Smet, Louis de; Smulders, Maarten ; Scott, Elinor - \ 2019
    Development of a nanoplastic filter by covalent modification of carbon surfaces
    Akkerman, Laura ; Bekkering, Ezra ; Westert, Dorien ; Smet, L.C.P.M. de; Scott, E.L. de; Scott, E.L. - \ 2019
    Effects of oral butyrate supplementation on inflammatory potential of circulating peripheral blood mononuclear cells in healthy and obese males
    Cleophas, Maartje C.P. ; Ratter, Jacqueline M. ; Bekkering, Siroon ; Quintin, Jessica ; Schraa, Kiki ; Stroes, Erik S. ; Netea, Mihai G. ; Joosten, Leo A.B. - \ 2019
    Scientific Reports 9 (2019). - ISSN 2045-2322

    Sodium butyrate is well-known for its immune-modulatory properties. Studies until now only focused on the in vitro effects of butyrate or assessed local effects in the gut upon butyrate administration. In this trial, we studied the systemic anti-inflammatory effects induced by sodium butyrate supplementation in humans. Nine healthy (Lean) and ten obese (metabolic syndrome group, MetSyn) males were given 4 grams sodium butyrate daily for 4 weeks. PBMCs were isolated before and after supplementation for direct stimulation experiments and induction of trained immunity by oxidized low-density lipoprotein (oxLDL), β-glucan, or Bacillus Calmette-Guérin vaccine (BCG). Butyrate supplementation moderately affected some of the cytokine responses in the MetSyn group. In the direct stimulation setup, effects of butyrate supplementation were limited. Interestingly, butyrate supplementation decreased oxLDL-induced trained immunity in the MetSyn group for LPS-induced IL-6 responses and Pam3CSK4-induced TNF-α responses. Induction of trained immunity by β-glucan was decreased by butyrate in the MetSyn group for Pam3CSK4-induced IL-10 production. In this study, while having only limited effects on the direct stimulation of cytokine production, butyrate supplementation significantly affected trained immunity in monocytes of obese individuals with metabolic complications. Therefore, oral butyrate supplementation may be beneficial in reducing the overall inflammatory status of circulating monocytes in patients with metabolic syndrome.

    Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
    Arts, Rob J.W. ; Novakovic, Boris ; Horst, Rob ter; Carvalho, Agostinho ; Bekkering, Siroon ; Lachmandas, Ekta ; Rodrigues, Fernando ; Silvestre, Ricardo ; Cheng, Shih Chin ; Wang, Shuang Yin ; Habibi, Ehsan ; Gonçalves, Luís G. ; Mesquita, Inês ; Cunha, Cristina ; Laarhoven, Arjan van; Veerdonk, Frank L. van de; Williams, David L. ; Meer, Jos W.M. van der; Logie, Colin ; O'Neill, Luke A. ; Dinarello, Charles A. ; Riksen, Niels P. ; Crevel, Reinout van; Clish, Clary ; Notebaart, Richard A. ; Joosten, Leo A.B. ; Stunnenberg, Hendrik G. ; Xavier, Ramnik J. ; Netea, Mihai G. - \ 2016
    Cell Metabolism 24 (2016)6. - ISSN 1550-4131 - p. 807 - 819.
    cholesterol metabolism - epigenetics - glutamine metabolism - glycolysis - trained immunity

    Induction of trained immunity (innate immune memory) is mediated by activation of immune and metabolic pathways that result in epigenetic rewiring of cellular functional programs. Through network-level integration of transcriptomics and metabolomics data, we identify glycolysis, glutaminolysis, and the cholesterol synthesis pathway as indispensable for the induction of trained immunity by β-glucan in monocytes. Accumulation of fumarate, due to glutamine replenishment of the TCA cycle, integrates immune and metabolic circuits to induce monocyte epigenetic reprogramming by inhibiting KDM5 histone demethylases. Furthermore, fumarate itself induced an epigenetic program similar to β-glucan-induced trained immunity. In line with this, inhibition of glutaminolysis and cholesterol synthesis in mice reduced the induction of trained immunity by β-glucan. Identification of the metabolic pathways leading to induction of trained immunity contributes to our understanding of innate immune memory and opens new therapeutic avenues.

    Noord4Bio: concrete kansen voor een biobased economy in Noord-Nederland
    Bos, H.L. ; Blaauw, R. ; Harmsen, P.F.H. ; Sanders, J.P.M. ; Euverink, G.J. ; Bekkering, E. - \ 2015
    Wageningen : Wageningen UR - Food & Biobased Research (Rapport / Wageningen UR Food & Biobased Research 1555) - ISBN 9789462575134 - 145
    regionale economie - regionale ontwikkeling - economische ontwikkeling - biobased economy - consultancy - noord-nederland - chemische industrie - regional economics - regional development - economic development - biobased economy - consultancy - north netherlands - chemical industry
    Noord-Nederland (de drie noordelijke provincies) kan een grootschalige producent en leverancier worden van hernieuwbare grondstoffen voor de regionale productie van ‘groene’ chemicaliën, kunststoffen en veevoeder eiwit. Voortbouwend op eerdere rapporten zoals het actieplan van de commissie Willems en de roadmap van de NOM, zijn in deze Noord4Bio-studie concrete kansen geïdentificeerd om de agrarische sector aan te laten sluiten op de chemie- en kunststoffensectoren van de regio, en zijn op basis van deze kansen aanbevelingen geformuleerd waarmee duurzame groei van de regio kan worden bewerkstelligd.
    Hospitality in hospitals in relatie tot FM. FMNactueel
    Mobach, Mark - \ 2014
    Workspace versus workplace
    Mobach, Mark - \ 2014
    Veiligheid is niet meer vanzelfsprekend
    Mobach, Mark ; Hartgers, Rene - \ 2014
    FM’er kan gezond gedrag medewerkers stimuleren
    Mobach, Mark - \ 2014
    A systematic review on micronutrient intake adequacy in adult minority populations residing in Europe: The need for action
    Ngo, J. ; Roman-Vinas, B. ; Ribas-Barba, L. ; Golsorkhi, M. ; Wharthon Medina, M. ; Bekkering, G.E. ; Cavelaars, A.J.E.M. ; Groot, C.P.G.M. de - \ 2014
    Journal of Immigrant and Minority Health 16 (2014)5. - ISSN 1557-1912 - p. 941 - 950.
    food-frequency questionnaires - vitamin-d deficiency - ethnic-groups - immigrant population - nutrient intake - african origin - dietary-intake - south-asians - risk-factors - east london
    This systematic review evaluated micronutrient intake inadequacy of ten micronutrients for adult ethnic minority populations residing in Europe. Pubmed was searched for studies, related references were checked and experts consulted. Ten studies were identified and six were included in the final analysis representing Albanian, Roma, Sub-Saharan African, South Asian and African-Caribbean minority groups. The Estimated Average Requirement cut point was applied to estimate inadequate intake. With the exception of a sub-Saharan African study, of seven micronutrients analysed, inadequate intakes were markedly elevated (>50 % of the population in most cases) in both genders for folate, vitamin B12, calcium and iron (the latter in females only). A pressing need exists for intake adequacy studies with sound methodologies addressing ethnic minority groups in Europe. These populations constitute a vulnerable population for inadequate intakes and results substantiate the need for further investigation, interventions and policy measures to reduce their nutritional risk
    Tackling the new materialities: Modern food and counter-movements in Ecuador
    Sherwood, S. ; Arce, A.M.G. ; Berti, P. ; Bekkering, E. - \ 2013
    Food Policy 41 (2013). - ISSN 0306-9192 - p. 1 - 10.
    pesticide use - obesity - health - farm - population - overweight - adolescents - transition - impacts
    Faced with rising non-communicable diseases (NCDs), the Ecuadorian Government has proposed a model health program targeting individual and environmental level determinants. Drawing on cosmopolitan social theory, the experiences of counter-movements and concerns over food policy, the authors explore how mass pesticide poisoning and obesity can be viewed as the product of the ‘success’ of the modernization policy as well as a specific range of global phenomena configuring civic activity and policy situations. Through the study of NCDs as an emergent social field, the authors examine historical developments and heterogeneity in peoples’ practices for insights on more practical and effective public policy responses. The rise of the consumer–citizen in counter-movements represents a paradoxical, but promising dynamic capable of reconstituting economies, culture, and society. In Ecuador, social action appears to be a largely neglected and under-utilized resource for tackling NCDs and perhaps other highly pressing and seemingly intractable food policy concerns
    Micronutrient intake and status in Central and Eastern Europe compared with other European countries, results from the EURRECA network
    Novakovic, R.N. ; Cavelaars, A.J.E.M. ; Bekkering, G.E. ; Roman-Vinas, B. ; Ngo, J. ; Gurinovic, M. ; Glibetic, M. ; Golesorkhi, M. ; Warthon-Medina, M. ; Satalic, Z. ; Geelen, A. ; Serra Majem, L. ; Veer, P. van 't; Groot, C.P.G.M. de - \ 2013
    Public Health Nutrition 16 (2013)5. - ISSN 1368-9800 - p. 824 - 840.
    dietary habits - folate status - iodine-deficiency - serum zinc - nutritional-status - thyroid volume - food-habits - schoolchildren - population - prevalence
    Objective: To compare micronutrient intakes and status in Central and Eastern Europe (CEE) with those in other European countries and with reference values. Design: Review of the micronutrient intake/status data from open access and grey literature source
    Making Sense of Epidemic Obesity in Ecuador: A Critical Social Perspective. Technical report for “Promising Agriculture and Food Policies and Innovations to Better Health and Nutrition in Latin America and the Caribbean”
    Sherwood, S.G. ; Arce, A.M.G. ; Berti, P. ; Borja, R. ; Oyarzun, P. ; Bekkering, E. - \ 2011
    Washington, D.C. : Pan-American Health Organization (PAHO) - 28 p.
    Data availability for assessing adequacy of micronutrient intake in potentially vulnerable groups in Europe
    Novakovic, R.N. ; Gurinovic, M. ; Bekkering, G.E. ; Ristic Medic, D. ; Kadvan, A. ; Ngo-de la, J. ; Roman, B. ; Serra-Majem, L. ; Golsorkhi, M. ; Warthon-Medina, M. ; Matthys, C. ; Groot, C.P.G.M. de - \ 2010
    In: 3rd European Public Health Conference, Amsterdam, The Netherlands, 10 - 13 November, 2010. - - p. 125 - 125.
    To collect the best data for assessing nutritional adequacy in intake for EURRECA (Network of Excellence – EURopean micronutrient RECommendations Aligned) prioritized micronutrients in vulnerable groups (vitamin C, folate, vitamin B12, vitamin D, calcium, iron, zinc, iodine, selenium and copper) in Europe. Methods: The literature search was targeted towards identifying the nutritional intake data in low income and immigrant populations, pregnant and lactating women as these populations were poorly represented by European Nutrition Health Report and the inventory made by Flynn et al. Structured Medline searches (plus Embase and Cochrane searches for ‘lactation’) were performed from inception applying ‘lactation’ and ‘pregnancy’ as MeSH terms and ‘low income’ and ‘immigrant’ as text words. Original studies were included if 1) performed in European Union after 1990; 2) representative populations and n > 100. 3) dietary assessment method should be based on at least 3 days of collection or validated FFQs (Food Frequency Questionnaires) for the specified micronutrients. Results: With respect to EURRECA inclusion criteria, 5 studies have been found on low income and immigrant population and only 7 on pregnant women, whereas no data has been found on lactating women. Conclusion: To provide general evidence on current nutritional situation in Europe, micronutrient intake of low income and immigrant populations, pregnant and lactating women needs more attention as the data for these potentially vulnerable groups is lacking. Acknowledgement: The studies reported herein have been carried out within the EURRECA Network of Excellence (, financially supported by the Commission of the European Communities, specific Research, Technology and Development (RTD) Programme Quality of Life and Management of Living Resources, within the Sixth Framework Programme, contract no. 036196.
    Check title to add to marked list
    << previous | next >>

    Show 20 50 100 records per page

    Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.