Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Effects of exchanging lactose for fat in milk replacer on ad libitum feed intake and growth performance in dairy calves
    Berends, H. ; Laar, H. van; Leal, L.N. ; Gerrits, W.J.J. ; Martín-Tereso, J. - \ 2020
    Journal of Dairy Science 103 (2020). - ISSN 0022-0302 - p. 4275 - 4287.
    calf - fat - growth - lactose - milk replacer

    The recent trend in the dairy industry toward ad libitum feeding of young calves merits reconsideration of calf milk replacer (CMR) formulations. Additionally, feed intake regulation in young calves provided with ad libitum milk and solid feeds is insufficiently understood. This study was designed to determine the effect of exchanging lactose for fat in CMR on voluntary feed intake and growth performance. Lactose was exchanged for fat on a weight/weight basis, resulting in different energy contents per kilogram of CMR. Thirty-two male calves (1.7 ± 0.12 d of age, 47.6 ± 0.83 kg of body weight) were assigned to 1 of 16 blocks based on arrival date. Within each block, calves were randomly assigned to 1 of 2 treatments. The experimental period was divided into 4 periods. In period 1, until 14 ± 1.7 d of age, calves were individually housed, restricted-fed their assigned CMR treatments at 2.5 to 3 L twice daily, and provided with unlimited access to water, chopped straw, and starter. In period 2, calves were group-housed with 8 calves per pen and received ad libitum access to their assigned CMR treatments, starter feed, chopped wheat straw, and water. During period 3, from 43 until 63 d of age, calves were weaned by restricting CMR allowance in 2 steps, maintaining access to all other feeds. All calves were completely weaned at d 64 of age and were monitored until 77 d of age (period 4). Measurements included the intake of all dietary components, body weight gain, and a selection of blood traits. Increasing fat content at the expense of lactose decreased CMR intake by 10%, whereas total calculated metabolizable energy intake and growth remained equal between treatments. Total solid feed (starter and straw) consumption was not affected by CMR composition. These data indicate that calves fed ad libitum regulate their CMR intake based on energy content. High-fat CMR increased plasma phosphate, nonesterified fatty acids, triglycerides, and bilirubin, whereas plasma glucose remained unchanged. Despite the limited animal numbers in the present experiment, there was a significant decrease in the total number of health events (mainly respiratory) requiring therapeutic intervention and in the total number of therapeutic interventions in calves fed high-fat CMR. Calves appeared to consume CMR based on energy content, with a difference in ad libitum intake proportional to the difference in energy content of the CMR, maintaining equal body weight gain and solid feed intake.

    The True Story on Deficiencies After Sleeve Gastrectomy: Results of a Double-Blind RCT
    Heusschen, Laura ; Schijns, Wendy ; Ploeger, Nadine ; Deden, Laura N. ; Hazebroek, Eric J. ; Berends, Frits J. ; Aarts, Edo O. - \ 2020
    Obesity Surgery 30 (2020). - ISSN 0960-8923 - p. 1280 - 1290.
    Bariatric surgery - Deficiencies, micronutrients, vitamins, minerals - Morbid obesity - SG - Sleeve gastrectomy

    Background: Since a few years, the laparoscopic sleeve gastrectomy (SG) has become the most performed bariatric operation worldwide. However, as with all bariatric procedures, SG also leads to vitamin and mineral deficiencies post-operatively and standard multivitamin supplements are probably not sufficient. Objective: The present study evaluates the effectiveness of a specialized multivitamin supplement for SG patients (WLS Optimum 1.0, FitForMe, Rotterdam, the Netherlands), compared to a standard multivitamin supplement (sMVS). Design: A double-blind randomized controlled trial was performed. For 12 months, patients in the intervention group received WLS Optimum, containing elevated doses of multiple vitamins and minerals. Patients in the control group were provided with sMVS, containing 100% of the recommended dietary allowance. Results: In total, 139 patients were available for analysis (WLS Optimum, n = 69; sMVS, n = 70). Intention-to-treat analyses revealed more folic acid deficiencies and higher serum vitamin B1 levels in the WLS Optimum group. Per protocol analyses showed that in patients using WLS Optimum, serum folic acid and vitamin B1 levels were higher, serum PTH levels were lower, and only one patient (2.6%) was anemic compared to 11 patients (17.5%) using a sMVS (p < 0.05 for all). No differences were found in prevalence of deficiencies for iron, vitamin B12, vitamin D, and other vitamins and minerals. Conclusions: This optimized multivitamin supplement only affected serum levels of folic acid, PTH and vitamin B1, and anemia rates compared to a sMVS. There is a clear need to further optimize multivitamin supplementation for SG patients. Besides, non-compliance with multivitamin supplements remains an important issue that should be dealt with. Clinical Trial Registry: The study protocol was registered at the clinical trials registry of the National Institutes of Health (ClinicalTrials.gov; identifier NCT01609387).

    Preweaning nutrient supply alters mammary gland transcriptome expression relating to morphology, lipid accumulation, DNA synthesis and RNA expression in Holstein heifer calves
    Hare, K.S. ; Leal, Leonel N. ; Romao, Josue M. ; Hooiveld, G.J.E.J. ; Soberon, F. ; Berends, H. ; Amburgh, Michael E. Van; Martín-Tereso, Javier ; Steele, Michael A. - \ 2019
    Wageningen University & Research
    Bos taurus - GSE121715 - PRJNA498213
    The objective of this study was to analyze the mammary gland transcriptome to determine how preweaning nutrient supply alters the molecular mechanisms that regulate preweaning mammary development. Holstein heifers were fed via milk replacer either an elevated level of nutrient intake (ELE; on average, 5.9 ± 0.2 Mcal ME in 8.4 L of milk replacer (MR)/d, n = 6) or a restricted amount of nutrients (RES; 2.8 ± 0.2 Mcal ME in 4L MR/day, n = 5) for 54 d postnatal, at which point they were slaughtered and samples of mammary parenchyma tissue were obtained. Parenchymal mRNA was analyzed and the fold changes (FC) of 18,111 genes (ELE relative to RES) were uploaded to Ingenuity Pathway Analysis (IPA) software for transcriptomic analysis. Using a threshold of P < 0.05, IPA identified that the FC of 1,931 of 18,811 differentially expressed genes (DEG) could be utilized for the analysis. A total 18 molecular and cellular functions were relevant (P < 0.05) to DE genes arising from the treatments, with Cell Death and Survival, Cellular Movement, Cellular Development, Cellular Growth and Proliferation, and Lipid Metabolism being the 5 most associated functions with DEG. Based on the directional FC of DEG, the mammary gland of ELE heifers was predicted to have increased Epithelial-Mesenchymal Transition (Z = 2.685) and Accumulation of Lipid (Z = 2.322), while the Synthesis of DNA (Z = -2.137), Transactivation of RNA (Z = -2.254), Expression of RNA (Z = -2.405), Transcription (Z = -2.482) and Transactivation (Z = -2.611) were all predicted to be decreased. Additionally, IPA predicted the activation status of 13 upstream regulators with direct influence on DEG as affected by ELE feeding that were either ligand-dependent nuclear receptors (n = 2), enzyme (n = 1), or transcription regulators (n = 10). Of these, 6 were activated (Z > 2) and 7 were inhibited (Z < -2). In summary, feeding ELE preweaning altered the mammary transcriptome of Holstein heifers affecting cell functions involved in the morphological and physiological development of the mammary gland
    Quantifying calf mortality on dairy farms: Challenges and solutions
    Santman-Berends, I.M.G.A. ; Schukken, Y.H. ; Schaik, G. van - \ 2019
    Journal of Dairy Science 102 (2019)7. - ISSN 0022-0302 - p. 6404 - 6417.
    census data - dairy calves - monitoring - mortality

    In the Netherlands, the mortality rate of ear-tagged calves <1 yr is one of the indicators that is continuously monitored in census data and is defined as the number of deceased calves relative to the number of calf-days-at-risk. In 2017, yearly calf mortality rates were published in the lay press and resulted in discussions about the calculation of this parameter among stakeholders because the same parameter appeared to be calculated in many different ways by different organizations. These diverse definitions of calf mortality answered different aims such as early detection of deviations, monitoring trends, or providing insight into herd-specific results, but were difficult to understand by stakeholders. The aim of this study was to evaluate several definitions of calf mortality for scientific validity, usefulness for policymakers, and comprehensibility by farmers. Based on expert consultations, 10 definitions for calf mortality were evaluated that assessed different age categories, time periods, and denominators. Differences in definitions appeared to have a large effect on the magnitude of mortality. For example, with the original mortality parameter, the mortality rate was 16.5% per year. When the first year of life was subdivided into 3 age categories, the mortality rate was 3.3, 4.5, and 3.1% for postnatal calves (≤14 d), preweaned calves (15–55 d), and weaned calves (56 d–1 yr), respectively. Although it was logical that these mortality rates were lower than the original, the sum of the 3 separate mortality rates was also lower than the original mortality rate. The reason was that the number of calves present in a herd and the risk of mortality are not randomly distributed over a calf's first year of life and the conditional nature of mortality rates when calculated for different age categories. Ultimately, 4 parameters to monitor calf mortality in Dutch dairy herds were chosen based on scientific value, usefulness for monitoring of trends, and comprehensibility by farmers: perinatal calf mortality risk (i.e., mortality before, during, or shortly after the moment of birth up to the moment of ear-tagging), postnatal calf mortality risk (≤14 d), preweaned calf mortality rate (15–55 d), and weaned calf mortality rate (56 d–1 yr). Slight differences in definitions of parameters can have a major effect on results, and many factors have to be taken into account when defining an important health indicator such as mortality. Our evaluation resulted in a more thorough understanding of the definitions of the selected parameters and agreement by the stakeholders to use these key indicators to monitor calf mortality.

    Effect of energy source in calf milk replacer on performance, digestibility, and gut permeability in rearing calves
    Amado, L. ; Berends, H. ; Leal, L.N. ; Wilms, J. ; Laar, H. Van; Gerrits, W.J.J. ; Martín-Tereso, J. - \ 2019
    Journal of Dairy Science 102 (2019)5. - ISSN 0022-0302 - p. 3994 - 4001.
    calf milk replacer - fat - gut permeability - lactose

    Current calf milk replacer (CMR) compositions significantly differ from whole milk in their levels of energy, protein, and minerals. Energy source is one of the major differences, as CMR contains high levels of lactose, whereas whole milk contains higher levels of fat. The aim of this study was to determine the effect of partially exchanging lactose for fat on performance, digestibility, and gut permeability in calves fed twice daily on a high feeding plane. Lactose and fat were exchanged in the CMR formulation on a weight–weight basis. The CMR were isonitrogenous but not isoenergetic. A total of 60 male Holstein-Friesian calves were assigned to 1 of 30 blocks based on serum IgG, body weight, and date of collection after birth. Within each block, calves were randomly assigned to 1 of 2 treatments: high fat and high lactose. The CMR was provided twice daily until 49 d of age, followed by a gradual weaning period of 14 d. Starter, straw, and water were available ad libitum throughout the complete study. Exchanging lactose for fat did not affect growth; intakes of starter, straw, water, crude protein, or total energy; or apparent total-tract digestibility of nutrients. Gastrointestinal permeability was assessed by measuring the recovery of lactulose and Cr in 24-h urine and the Cr concentration and lactulose:D-mannitol ratio in serum following an oral pulse dose. Urinary recoveries of Cr and lactulose were generally low in both treatments but were higher in calves fed the high-fat CMR. Accordingly, the serum lactulose:D-mannitol ratio and serum Cr concentrations were higher in calves fed the high-fat CMR. In wk 1 and during the weaning transition, calves fed the high-fat CMR had significantly fewer abnormal fecal scores. In conclusion, exchanging lactose for fat in the CMR did not affect growth performance, total feed intake, or nutrient digestibility. The high-fat CMR was associated with an increase in permeability markers but positively influenced fecal scores in calves.

    Preweaning nutrient supply alters mammary gland transcriptome expression relating to morphology, lipid accumulation, DNA synthesis, and RNA expression in Holstein heifer calves
    Hare, K.S. ; Leal, L.N. ; Romao, J.M. ; Hooiveld, G.J. ; Soberon, F. ; Berends, H. ; Amburgh, M.E. Van; Martín-Tereso, J. ; Steele, M.A. - \ 2019
    Journal of Dairy Science 102 (2019)3. - ISSN 0022-0302 - p. 2618 - 2630.
    Holstein - mammary parenchyma - metabolizable energy - preweaning - transcriptome

    The objective of this study was to analyze the mammary gland transcriptome to determine how preweaning nutrient supply alters the molecular mechanisms that regulate preweaning mammary development. Holstein heifers were fed via milk replacer (MR) either an elevated level of nutrient intake (ELE; on average, 5.9 ± 0.2 Mcal of ME in 8.4 L of MR/d, n = 6) or a restricted amount of nutrients (RES; 2.8 ± 0.2 Mcal of ME in 4 L of MR/d, n = 5) for 54 d after birth, at which point they were slaughtered and samples of mammary parenchyma tissue were obtained. Parenchymal mRNA was analyzed, and the fold change (FC) of 18,111 genes (ELE relative to RES) was uploaded to Ingenuity Pathway Analysis (IPA) software (Qiagen Bioinformatics, Redwood City, CA) for transcriptomic analysis. Using a threshold of P < 0.05, IPA identified that the FC of 1,931 of 18,811 differentially expressed genes (DEG) could be used for the analysis. A total of 18 molecular and cellular functions were relevant to DEG arising from the treatments; the 5 functions most associated with DEG were cell death and survival, cellular movement, cellular development, cellular growth and proliferation, and lipid metabolism. Based on the directional FC of DEG, the mammary gland of ELE heifers was predicted to have increased epithelial-mesenchymal transition (Z = 2.685) and accumulation of lipid (Z = 2.322), whereas the synthesis of DNA (Z = −2.137), transactivation of RNA (Z = −2.254), expression of RNA (Z = −2.405), transcription (Z = −2.482), and transactivation (Z = −2.611) were all predicted to be decreased. Additionally, IPA predicted the activation status of 13 upstream regulators with direct influence on DEG as affected by ELE feeding that were ligand-dependent nuclear receptors (n = 2), enzymes (n = 1), or transcription regulators (n = 10). Of these, 6 were activated (Z > 2) and 7 were inhibited (Z < −2). In summary, feeding ELE preweaning altered the mammary transcriptome of Holstein heifers, affecting cell functions involved in the morphological and physiological development of the mammary gland.

    Dit zijn de problemen die Wageningen oplost
    Marcelis, Leo - \ 2018

    Dit ziet Leo Marcelis als hij honderd jaar vooruit probeert te kijken: grote, hoge gebouwen rondom steden als Shanghai, New York of New Delhi waarin in twintig of dertig lagen groentes worden geteeld. De voedselflat. In een volledig gesloten systeem, zonder invloed van wind, zon of regen. Alles op maat leverbaar, in grote hoeveelheden. "Met heel weinig grond kun je gigantisch veel produceren", zegt Marcelis, hoogleraar Tuinbouw en Productfysiologie.

    Usefulness of storylines to increase the accessibility and transparency of RiverCare knowledge
    Sools, A. ; Cortes Arevalo, V.J. ; Verbrugge, L.N.H. ; Brugnach, M. ; Denderen, R.P. van; Candel, J.H.J. ; Gemert-Pijnen, J.E.W.C. van; Hulscher, S.J.M.H. - \ 2018
    In: The future river. - NCR (NCR 42-2018) - p. 64 - 65.
    Decreasing lateral migration and increasing planform complexity of the Dommel River during the Holocene
    Candel, J.H.J. ; Makaske, A. ; Kijm, Niels ; Storms, J.E.A. ; Wallinga, J. - \ 2018
    In: The future river. - NCR (NCR 42-2018) - p. 32 - 33.
    Nutrient supply alters transcriptome regulation in adipose tissue of pre-weaning Holstein calves
    Leal, Leonel N. ; Romao, Josue M. ; Hooiveld, Guido J. ; Soberon, Fernando ; Berends, Harma ; Boekschoten, Mark V. ; Amburgh, Michael E. Van; Martín-Tereso, Javier ; Steele, Michael A. - \ 2018
    PLoS ONE 13 (2018)8. - ISSN 1932-6203

    Performance of dairy cows can be influenced by early life nutrient supply. Adipose tissue is diet sensitive and an important component in that process as it is involved in the regulation of energetic, reproductive and immunological functions. However, it is not clear how early life nutrition alters the molecular regulation of adipose tissue in calves and potentially adult individuals. This study aimed at determining how differences in pre-weaning nutrient supply alter gene expression profiles and physiology in omental adipose tissue. A total of 12 female Holstein calves were fed two levels of milk replacer supply: a restricted amount of 11.72 MJ of metabolizable energy (ME) intake per day (n = 6) or an enhanced amount of 1.26 MJ ME intake per kg of metabolic body weight (BW0.75), resulting in supply from 17.58 to 35.17 MJ ME intake per day (n = 6). All calves had ad libitum access to a commercial calf starter and water. Analysis of the transcriptome profiles at 54 ± 2 days of age revealed that a total of 396 out of 19,968 genes were differentially expressed (DE) between groups (p < 0.001, FDR < 0.1). The directional expression of DE genes through Ingenuity Pathway Analysis showed that an enhanced nutrient supply alters adipose tissue physiology of pre-weaned calves. Several biological functions were increased (Z-score > +2), including Lipid Metabolism (Fatty Acid Metabolism), Cell Cycle (Entry into Interphase, Interphase, Mitosis and Cell Cycle Progression), Cellular Assembly and Organization (Cytoskeleton Formation and Cytoplasm Development) and Molecular Transport (Transport of Carboxylic Acid). These changes were potentially orchestrated by the activation/inhibition of 17 upstream regulators genes. Our findings indicate that adipose tissue of calves under an enhanced nutrient supply is physiologically distinct from restricted calves due to an increased development/expansion rate and also a higher metabolic activity through increased fatty acid metabolism.

    Efficacy of oral compared with intramuscular Vitamin B-12 supplementation after Roux-en-Y gastric bypass : A randomized controlled trial
    Schijns, Wendy ; Homan, Jens ; Meer, Leah van der; Janssen, Ignace M. ; Laarhoven, Cees J. van; Berends, Frits J. ; Aarts, Edo O. - \ 2018
    American Journal of Clinical Nutrition 108 (2018)1. - ISSN 0002-9165 - p. 6 - 12.
    cobalamin - deficiencies - Roux-en-Y gastric bypass - RYGB - supplementation - Vitamin B-12

    Background After Roux-en-Y gastric bypass (RYGB), patients often develop a vitamin B-12 deficiency. Objective Our objective was to investigate whether oral supplementation increases and normalizes low vitamin B-12 concentrations (vitamin B-12 > 200 pmol/L) in RYGB patients as compared to intramuscular injections. Design A randomized controlled trial in RYGB patients with subnormal serum B-12 concentrations was performed. One group (IM B-12) received bimonthly intramuscular hydroxocobalamin injections (2000 μg as loading dose and 1000 μg at follow-up) for 6 mo. The second group (oral B-12) received daily doses of oral methylcobalamin (1000 μg). Serum vitamin B-12 was determined at baseline (T0) and at 2 (T1), 4 (T2), and 6 mo (T3) after start of treatment. Concentrations of the secondary markers methylmalonic acid (MMA) and homocysteine (Hcy) were measured at T0 and T3. Results Fifty patients were included and randomized, 27 in IM B-12 and 23 in oral B-12. The median vitamin B-12 concentration at T0 was 175 pmol/L (range: 114-196 pmol/L) for IM B-12 and 167 pmol/L (range: 129-199 pmol/L) for oral B-12. Vitamin B-12 normalized in all individuals, and there was no significant difference in vitamin B-12 between the two groups. MMA and Hcy concentrations decreased significantly after 6 mo within each group (P < 0.001 and P < 0.001 for MMA and P = 0.03 and P = 0.045 for Hcy, respectively). There was no significant difference between the groups at 6 mo for both MMA and Hcy (P = 0.53 and P = 0.79). Conclusion The efficacy of oral vitamin B-12 supplementation was similar to that of hydroxocobalamin injections in the present study. Oral supplementation can be used as an alternative to hydroxocobalamin injections to treat RYGB patients with low values of serum vitamin B-12. This trial was registered at clinicaltrials.gov as NCT02270749.

    Dit zijn de problemen die Wageningen oplost
    Marcelis, Leo ; Goot, Atze Jan van der; Kampman, Ellen ; Schaminee, Joop - \ 2018
    Do specialized bariatric multivitamins lower deficiencies after RYGB?
    Schijns, Wendy ; Schuurman, Lisanne T. ; Melse-Boonstra, Alida ; Laarhoven, Cees J.H.M. van; Berends, Frits J. ; Aarts, Edo O. - \ 2018
    Surgery for Obesity and Related Diseases 14 (2018)7. - ISSN 1550-7289 - p. 1005 - 1012.
    Bariatric surgery - Deficiency - Mineral - Multivitamin - Obesity - Roux-en-Y gastric bypass - Specialized - Vitamin
    Background: One of the side effects of bariatric surgery is the risk of vitamin and mineral deficiencies. Vitamin B12, vitamin D, folate, and iron deficiencies are especially common among Roux-en-Y gastric bypass patients. Objective: To examine the effectiveness of a specialized multivitamin supplement for Roux-en-Y gastric bypass patients on deficiencies the first 3 years postoperatively, retrospectively in a large, prospectively collected cohort. Setting: Large specialized bariatric hospital. Results: One thousand one hundred sixty patients were included, 883 users and 258 who were nonusers of the specialized multivitamin. Patient characteristics and total weight were comparable. Higher serum concentrations of ferritin (124.7 ± 96.2 µg/L versus 106.0 ± 83.0 µg/L, P =.016), vitamin B12 (347.3 ± 145.1 pmol/L versus 276.8 ± 131.4 pmol/L, P<.001), folic acid (34.9 ± 9.6 nmol/L versus 25.4 ± 10.7 nmol/L, P<.001), and vitamin D (98.4 ± 28.7 nmol/L versus 90.0 ± 34.5 nmol/L, P =.002) were observed in users compared with nonusers after 1 year. Less new deficiencies were found for ferritin (1% versus 4%, P =.029), vitamin B12 (9% versus 23%, P<.001), and vitamin D (0% versus 4%, P<.001) in users compared with nonusers. Two and 3 years after the surgery these findings remained almost identical. Conclusions: The use of specialized multivitamin supplements resulted in less deficiencies of vitamin B12, vitamin D, folic acid, and ferritin. The study showed that Roux-en-Y gastric bypass patients benefited from the specialized multivitamin supplements and it should be advised to this patient group.
    Samenvatting ESBL-Attributieanalyse (ESBLAT) : Op zoek naar de bronnen van antibioticaresistentie bij de mens
    Mevius, Dik ; Heederik, Dick ; Duijkeren, Engeline ; Veldman, Kees ; Essen, Alieda van; Kant, Arie ; Liakopoulos, Apostolos ; Geurts, Yvon ; Pelt, Wilfrid van; Mughini Gras, Lapo ; Schmitt, Heike ; Dierikx, Cindy ; Hoek, Angela van; Evers, Eric ; Roda Husman, Annemaria de; Blaak, Hetty ; Dissel, Jaap van; Smid, Joost ; Dohmen, Wietske ; Dorado-Garcia, Alejandro ; Havelaar, Arie ; Hordijk, Joost ; Wagenaar, Jaap ; Fluit, Ad ; Bunt, Gerrita van den; Bonten, Marc ; Velthuis, Annet ; Heuvelink, Annet ; Buter, Rianne ; Gonggrijp, Maaike ; Santman-Berends, Inge ; Lam, Theo ; Urlings, Bert ; Heres, Lourens ; Bouwknecht, Martijn ; Groot, Jacques de - \ 2018
    Netherlands : De Stichting TKI Agri&Food (TKI) - 11 p.
    Rapport ESBL-Attributieanalyse (ESBLAT) : Op zoek naar de bronnen van antibioticaresistentie bij de mens
    Mevius, Dik ; Heederik, Dick ; Duijkeren, Engeline ; Veldman, Kees ; Essen, Alieda van; Kant, Arie ; Liakopoulos, Apostolos ; Geurts, Yvon ; Pelt, Wilfrid van; Mughini Gras, Lapo ; Schmitt, Heike ; Dierikx, Cindy ; Hoek, Angela van; Evers, Eric ; Roda Husman, Annemaria de; Blaak, Hetty ; Dissel, Jaap van; Smid, Joost ; Dohmen, Wietske ; Dorado-Garcia, Alejandro ; Havelaar, Arie ; Hordijk, Joost ; Wagenaar, Jaap ; Fluit, Ad ; Bunt, Gerrita van den; Bonten, Marc ; Velthuis, Annet ; Heuvelink, Annet ; Buter, Rianne ; Gonggrijp, Maaike ; Santman-Berends, Inge ; Lam, Theo ; Urlings, Bert ; Heres, Lourens ; Bouwknecht, Martijn ; Groot, Jacques de - \ 2018
    Netherlands : De Stichting TKI Agri&Food (TKI) - 73
    Small percentage of anaphylactic reactions treated with epinephrine during food challenges in Dutch children
    Valk, Johanna P.M. van der; Berends, Irene ; Wijk, Roy Gerth van; Arends, Nicolette J.T. ; Maaren, Maurits S. van; Groot, Hans de; Wichers, Harry J. ; Emons, Joyce A.M. ; Dubois, Anthony E.J. ; Jong, Nicolette W. de - \ 2018
    Annals of Allergy, Asthma and Immunology 120 (2018)3. - ISSN 1081-1206 - p. 300 - 303.
    Background: Severe allergic reactions, including anaphylaxis, occur during oral food challenges (OFCs) and the first-line treatment of anaphylaxis is epinephrine. Objective: To evaluate the percentage of anaphylactic reactions treated with epinephrine during OFCs and to identify associated factors for the administration of epinephrine. Methods: Children who underwent an OFC with peanut, hazelnut, cow's milk, hen's egg, or cashew nut from 2005 through 2015 in the Netherlands were evaluated. Children with reactions meeting the criteria for anaphylaxis according to the European Academy of Allergy and Clinical Immunology guidelines for food allergy and anaphylaxis were included. Children with an anaphylactic reaction treated with vs without epinephrine were compared. Possible factors associated with the administration of epinephrine, such as age, sex, symptoms consistent with asthma, history of an allergic reaction to the tested allergen, and symptom types during the anaphylactic reaction, were evaluated using logistic regression analysis. Results: Eighty-three children in clinical and research settings (43% boys; median age, 7 years; range, 1-17) who met the criteria for anaphylaxis were included in this study. Thirty-two of 83 children (39%) with anaphylaxis were treated with epinephrine. Respiratory symptoms during the OFC were treated significantly more often with epinephrine than gastrointestinal symptoms (P = .01). Conclusion: Only 39% of children with anaphylaxis, according to the guideline criteria, were treated with epinephrine during the OFC and most of these children had respiratory symptoms. There is need for an easy-to-use international guideline for the treatment of allergic symptoms during OFCs.
    Het celgetal en andere mastitisindicatoren
    Lam, T. ; Sandman-Berends, I. ; Kamphuis, C. ; Schukken, Y. ; Vliegher, S. de - \ 2017
    In: Handboek Uiergezondheid Rund / Lam, Theo, De Vliegher, Sarne, Nijmegen : Communication In Practice - ISBN 9789082232127 - p. 71 - 86.
    Neonatal nutrient supply affects pancreatic development in Holstein calves
    Neto Leal, Leonel ; Hooiveld, Guido ; Soberon, F. ; Berends, H. ; Boekschoten, M.V. ; Steele, M.A. ; Amburgh, M.E. van; Martin-Tereso, J. - \ 2017
    In: Book of Abstracts of the 68th Annual Meeting of the European Federation of Animal Science. - Wageningen : Wageningen Academic Publishers (Book of abstracts 23) - ISBN 9789086863129 - p. 387 - 387.
    Pre-weaning nutrient supply affects gene expression profiles in bone marrow and muscle in calves
    Neto Leal, Leonel ; Hooiveld, G.J.E.J. ; Soberon, F. ; Berends, H. ; Boekschoten, M.V. ; Steele, M.A. ; Amburgh, M.E. van; Martin-Tereso, J. - \ 2017
    In: Book of Abstracts of the 68th Annual Meeting of the European Federation of Animal Science. - Wageningen : Wageningen Academic Publishers (Book of abstracts 23) - ISBN 9789086863129 - p. 447 - 447.
    De meerwaarde van watersportactiviteiten voor mensen met een beperking
    Nieuwenhuizen, Jeroen van den; Jonge, F.H. de; Berends, Eva ; Horst, Milou van der; jong, Nynke de; Jonkers, Ilonka ; Liem, Windy Mulia ; Nimwegen, Judith van; Agro, Prince Pascal ; Peters, Saskia ; Pol, Ellen van der; Schmitz, Paulina ; Sluimer, Nienke ; Wagenaar, Marlijn - \ 2017
    Wageningen : Wageningen University & Research, Wetenschapswinkel (Wetenschapswinkel rapport 337) - ISBN 9789463432139 - 28
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