Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Küpers, Leanne K. ; Monnereau, Claire ; Sharp, Gemma C. ; Yousefi, Paul ; Salas, Lucas A. ; Ghantous, Akram ; Page, Christian M. ; Reese, Sarah E. ; Wilcox, Allen J. ; Czamara, Darina ; Starling, Anne P. ; Novoloaca, Alexei ; Lent, Samantha ; Roy, Ritu ; Hoyo, Cathrine ; Breton, Carrie V. ; Allard, Catherine ; Just, Allan C. ; Bakulski, Kelly M. ; Holloway, John W. ; Everson, Todd M. ; Xu, Cheng Jian ; Huang, Rae Chi ; Plaat, Diana A. van der; Wielscher, Matthias ; Merid, Simon Kebede ; Ullemar, Vilhelmina ; Rezwan, Faisal I. ; Lahti, Jari ; Dongen, Jenny van; Langie, Sabine A.S. ; Richardson, Tom G. ; Magnus, Maria C. ; Nohr, Ellen A. ; Xu, Zongli ; Duijts, Liesbeth ; Zhao, Shanshan ; Zhang, Weiming ; Plusquin, Michelle ; DeMeo, Dawn L. ; Solomon, Olivia ; Heimovaara, Joosje H. ; Jima, Dereje D. ; Gao, Lu ; Bustamante, Mariona ; Perron, Patrice ; Wright, Robert O. ; Hertz-Picciotto, Irva ; Zhang, Hongmei ; Karagas, Margaret R. ; Gehring, Ulrike ; Marsit, Carmen J. ; Beilin, Lawrence J. ; Vonk, Judith M. ; Jarvelin, Marjo Riitta ; Bergström, Anna ; Örtqvist, Anne K. ; Ewart, Susan ; Villa, Pia M. ; Moore, Sophie E. ; Willemsen, Gonneke ; Standaert, Arnout R.L. ; Håberg, Siri E. ; Sørensen, Thorkild I.A. ; Taylor, Jack A. ; Räikkönen, Katri ; Yang, Ivana V. ; Kechris, Katerina ; Nawrot, Tim S. ; Silver, Matt J. ; Gong, Yun Yun ; Richiardi, Lorenzo ; Kogevinas, Manolis ; Litonjua, Augusto A. ; Eskenazi, Brenda ; Huen, Karen ; Mbarek, Hamdi ; Maguire, Rachel L. ; Dwyer, Terence ; Vrijheid, Martine ; Bouchard, Luigi ; Baccarelli, Andrea A. ; Croen, Lisa A. ; Karmaus, Wilfried ; Anderson, Denise ; Vries, Maaike de; Sebert, Sylvain ; Kere, Juha ; Karlsson, Robert ; Arshad, Syed Hasan ; Hämäläinen, Esa ; Routledge, Michael N. ; Boomsma, Dorret I. ; Feinberg, Andrew P. ; Newschaffer, Craig J. ; Govarts, Eva ; Moisse, Matthieu ; Fallin, M.D. ; Melén, Erik ; Prentice, Andrew M. ; Kajantie, Eero ; Almqvist, Catarina ; Oken, Emily ; Dabelea, Dana ; Boezen, H.M. ; Melton, Phillip E. ; Wright, Rosalind J. ; Koppelman, Gerard H. ; Trevisi, Letizia ; Hivert, Marie France ; Sunyer, Jordi ; Munthe-Kaas, Monica C. ; Murphy, Susan K. ; Corpeleijn, Eva ; Wiemels, Joseph ; Holland, Nina ; Herceg, Zdenko ; Binder, Elisabeth B. ; Davey Smith, George ; Jaddoe, Vincent W.V. ; Lie, Rolv T. ; Nystad, Wenche ; London, Stephanie J. ; Lawlor, Debbie A. ; Relton, Caroline L. ; Snieder, Harold ; Felix, Janine F. - \ 2019
Nature Communications 10 (2019)1. - ISSN 2041-1723
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from −183 to 178 grams per 10% increase in methylation (P Bonferroni < 1.06 x 10 −7 ). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10 −74 ) and BMI in pregnancy (3/914, p = 1.13x10 −3 ), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Comined effects of smoking and alcohol on metabolic syndrome: the lifelines cohort study
Slagter, S.N. ; Vliet-Ostaptchouk, J.V. ; Vonk, J.M. ; Boezen, H.M. ; Dullaart, R.P.F. ; Muller Kobold, A.C. ; Feskens, E.J.M. ; Beek, A.P. van; Klauw, M.M. van der; Wolffenbuttel, B.H.R. - \ 2014
PLoS ONE 9 (2014)4. - ISSN 1932-6203 - 9 p.
genome-wide association - nutrition examination survey - coronary-heart-disease - body-mass index - blood-pressure - waist circumference - cigarette-smoking - physical-activity - national-health - dietary-intake
Introduction - The development of metabolic syndrome (MetS) is influenced by environmental factors such as smoking and alcohol consumption. We determined the combined effects of smoking and alcohol on MetS and its individual components. Methods - 64,046 participants aged 18–80 years from the LifeLines Cohort study were categorized into three body mass index (BMI) classes (BMI1 drink/day) and tobacco showed higher triglycerides levels. Up to 2 drinks/day was associated with a smaller waist circumference in overweight and obese individuals. Consumption of >2 drinks/day increased blood pressure, with the strongest associations found for heavy smokers. The overall metabolic profile of wine drinkers was better than that of non-drinkers or drinkers of beer or spirits/mixed drinks. Conclusion - Light alcohol consumption may moderate the negative associations of smoking with MetS. Our results suggest that the lifestyle advice that emphasizes smoking cessation and the restriction of alcohol consumption to a maximum of 1 drink/day, is a good approach to reduce the prevalence of MetS. Figures
Associations between smoking, components of metabolic syndrome and lipoprotein particle size
Slagter, S.N. ; Vliet-Ostaptchouk, J.V. ; Vonk, J.M. ; Boezen, H.M. ; Dullaart, R.P.F. ; Muller Kobold, A.C. ; Feskens, E.J.M. ; Beek, A.P. van; Klauw, M.M. van der; Wolffenbuttel, B.H.R. - \ 2013
BMC Medicine 11 (2013). - ISSN 1741-7015
coronary-heart-disease - apparently healthy-men - body-fat distribution - apolipoprotein-a-i - cigarette-smoking - life-style - insulin-resistance - blood-pressure - risk-factors - myocardial-infarction
Background: The clustering of metabolic and cardiovascular risk factors is known as metabolic syndrome (MetS). The risk of having MetS is strongly associated with increased adiposity and can be further modified by smoking behavior. Apolipoproteins (apo) associated with low-density lipoprotein-cholesterol (LDL-C) and high-density lipoprotein-cholesterol (HDL-C) may be altered in MetS. This study aimed to examine the association between smoking and the following parameters: MetS and its components, levels of apolipoproteins and estimated lipoprotein particle size, separately for men and women, and in different body mass index (BMI) classes. Methods: We included 24,389 men and 35,078 women aged between 18 and 80 years who participated in the LifeLines Cohort Study between December 2006 and January 2012; 5,685 men and 6,989 women were current smokers. Participants were categorized into three different body mass index (BMI) classes (BMI = 30 kg/m(2)). MetS was defined according to the National Cholesterol Education Program's Adult Treatment Panel III (NCEP:ATPIII) criteria. Blood pressure, anthropometric and lipid measurements were rigorously standardized, and the large sample size enabled a powerful estimate of quantitative changes. The association between smoking and the individual MetS components, and apoA1 and apoB, was tested with linear regression. Logistic regression was used to examine the effect of smoking and daily tobacco smoked on risk of having MetS. All models were age adjusted and stratified by sex and BMI class. Results: Prevalence of MetS increased with higher BMI levels. A total of 64% of obese men and 42% of obese women had MetS. Current smoking was associated with a higher risk of MetS in both sexes and all BMI classes (odds ratio 1.7 to 2.4 for men, 1.8 to 2.3 for women, all P values
Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms
Zee, S. van der; Hoek, G. ; Boezen, H.M. ; Schouten, J.P. ; Wijnen, J.H. van; Brunekreef, B. - \ 1999
Occupational and Environmental Medicine 56 (1999)12. - ISSN 1351-0711 - p. 802 - 812.
Modulation of the acute respiratory effects of winter air pollution by serum and dietary antioxidants : a panel study
Grievink, L. ; Zee, S.C. van der; Hoek, G. ; Boezen, H.M. ; Veer, P. van 't; Brunekreef, B. - \ 1999
European Respiratory Journal 13 (1999). - ISSN 0903-1936 - p. 1439 - 1446.
Effects of ambient air pollution on upper and lower respiratory symptoms and peak expiratory flow in children
Boezen, H.M. ; Zee, S. van der; Postma, D.S. ; Vonk, J.M. ; Gerritsen, J. ; Hoek, G. ; Brunekreef, B. ; Rijcken, B. ; Schouten, J.P. - \ 1999
The Lancet 353 (1999). - ISSN 0140-6736 - p. 874 - 878.
|Air pollution and respiratory health of children: the PEACE study in Amsterdam, The Netherlands.
Zee, S. van der; Hoek, G. ; Boezen, M. ; Schouten, J.P. ; Wijnen, J. van; Brunekreef, B. - \ 1998
European Respiratory Review 52 (1998). - ISSN 0905-9180 - p. 44 - 52.
|Peak expiratory flow variability, bronchial responsiveness and susceptibility to ambient air pollution in adults.
Boezen, H.M. ; Schouten, J. ; Rijcken, B. ; Vonk, J. ; Gerritsen, J. ; Zee, S. van der; Hoek, G. ; Brunekreef, B. ; Postma, D. - \ 1998
American Journal of Respiratory and Critical Care Medicine 158 (1998). - ISSN 1073-449X - p. 1848 - 1854.
Zee, S. van der; Hoek, G. ; Roemer, W. ; Janssen, N. ; Harssema, H. ; Brunekreef, B. ; Boezen, M. ; Kerkhof, M. ; Vonk, J. ; Schouten, J. ; Postma, D. ; Gerritsen, J. - \ 1997
Unknown Publisher - 79 p.
|Acute effects of ambient air pollution on lower respiratory symptoms in allergic hyperresponsive children.
Boezen, H.M. ; Gerritsen, J. ; Vonk, J.M. ; Postma, D.S. ; Zee, S.C. van der; Rijcken, B. ; Schouten, J.P. - \ 1997
American Journal of Respiratory and Critical Care Medicine 155 (1997)suppl.. - ISSN 1073-449X - p. A421 - A421.
|Interim rapportage Blootstelling aan en effecten van wintersmog op de menselijke gezondheid in stedelijke gebieden in Nederland.
Zee, S. van der; Hoek, G. ; Roemer, W. ; Brunekreef, B. ; Janssen, N. ; Harssema, H. ; Boezen, M. ; Kerkhof, M. ; Boluyt, N. ; Schouten, J. - \ 1995
Unknown Publisher - 50 p.