Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study
Wijnands, J.M.A. ; Boonen, A. ; Dagnelie, P.C. ; Greevenbroek, M.M.J. van; Kallen, C.J.H. van der; Ferreira, I. ; Schalkwijk, C.G. ; Feskens, E.J.M. ; Stehouwer, C.D.A. ; Linden, S. van der; Arts, I.C.W. - \ 2014
RHEUMATOLOGY 53 (2014)11. - ISSN 1462-0324 - p. 2053 - 2062.
peripheral arterial-disease - c-reactive protein - type-2 diabetes-mellitus - nitric-oxide production - metabolic syndrome - carotid atherosclerosis - cardiovascular-disease - hypertensive patients - risk-factor - subclinical atherosclerosis
Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.
Hoge voedselprijzen wakkeren onrust aan
Ittersum, M.K. van; Boonen, J. - \ 2014
Telegraaf (2014). - 1 p.
A practical manual to assess and improve farm performances
Aarts, H.F.M. ; Grignard, A. ; Boonen, J. ; Haan, M. de; Hennart, S. ; Oenema, J. ; Lorinquer, E. ; Sylvain, F. ; Herrmann, K. ; Elsaesser, M. ; Castellan, E. ; Kohnen, H. - \ 2013
Wageningen : Plant Research International - 98
melkveehouderij - prestatieniveau - dairy farming - performance
The business of a dairy farmer is to supply society with dairy products in a way that provides him sufficient income and satisfaction. But he has to avoid farming practices hampering the rural area to deliver other valuable products, like clean drinking water, biodiversity, and attractive recreation facilities. The socio-economic objectives of farmers change, as do the wants of rural societies. The prices of land, feeds, fuels and fertilizers change while innovations to support farming become available. Consequently, a farmer has to adapt his farming practices to the changing reality. In this context, DAIRYMAN aims to strengthen rural communities in the regions of North Western Europe (NWE) where dairy farming is a main economic activity and a vital form of land use. DAIRYMAN will lead to a more competitive dairy sector, stronger regional economies, and an improved ecological performance of the rural area. DAIRYMAN is a project in the INTERREG IVB programme co-funded by the European Regional Development Fund. The project is working at three levels: regional, commercial dairy pilot farms, and knowledge transfer centres.
A discrete event modelling framework for simulation of long-term outcomes of sequential treatment strategies for ankylosing spondylitis
Tran-Duy, A. ; Boonen, A. ; Laar, M.A.F.J. ; Franke, A.C. ; Severens, J.L. - \ 2011
Annals of the Rheumatic Diseases 70 (2011)12. - ISSN 0003-4967 - p. 2111 - 2118.
tumor-necrosis-factor - nonsteroidal antiinflammatory drug - asas consensus statement - placebo-controlled trial - metrology index basmi - cost-effectiveness - rheumatoid-arthritis - infliximab remicade(r) - united-kingdom - clinical-trial
Objective To develop a modelling framework which can simulate long-term quality of life, societal costs and cost-effectiveness as affected by sequential drug treatment strategies for ankylosing spondylitis (AS). Methods Discrete event simulation paradigm was selected for model development. Drug efficacy was modelled as changes in disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)) and functional status (Bath Ankylosing Spondylitis Functional Index (BASFI)), which were linked to costs and health utility using statistical models fitted based on an observational AS cohort. Published clinical data were used to estimate drug efficacy and time to events. Two strategies were compared: (1) five available non-steroidal anti-inflammatory drugs (strategy 1) and (2) same as strategy 1 plus two tumour necrosis factor a inhibitors (strategy 2). 13 000 patients were followed up individually until death. For probability sensitivity analysis, Monte Carlo simulations were performed with 1000 sets of parameters sampled from the appropriate probability distributions. Results The models successfully generated valid data on treatments, BASDAI, BASFI, utility, quality-adjusted life years (QALYs) and costs at time points with intervals of 1–3 months during the simulation length of 70 years. Incremental cost per QALY gained in strategy 2 compared with strategy 1 was €35 186. At a willingness-to-pay threshold of €80 000, it was 99.9% certain that strategy 2 was cost-effective. Conclusions The modelling framework provides great flexibility to implement complex algorithms representing treatment selection, disease progression and changes in costs and utilities over time of patients with AS. Results obtained from the simulation are plausible
Cost-of-illness of rheumatoid arthritis and ankylosing spondylitis
Franke, A.C. ; Ament, A.J.H.A. ; Laar, M.A.F.J. ; Boonen, A. ; Severens, J.L. - \ 2009
Clinical and Experimental Rheumatology 27 (2009)55. - ISSN 0392-856X - p. S118 - S123.
step-down prednisolone - indirect medical costs - 3 european countries - psoriatic-arthritis - health-care - economic-evaluation - long-term - follow-up - burden - disease
Objective. To assess, quantify and summarise the cost of illness of rheumatoid arthritis (RA) and ankylosing spondylitis (AS) from the societal perspective Methods. Original studies reporting costs of RA or AS were searched systematically. Both cost-of-illness studies and economic evaluations of therapies were included. Studies were appraised for patient and study characteristics, type of costs and actual costs. Reported costs were aggregated by cost categories and overall mean costs were summarised by cost domain (healthcare, patient and family, and productivity costs). Results. Overall mean costs of RA ((sic)14.906 per year) were above that of AS ((sic)9,374 per Year), while the relative distribution (of costs over cost domains was approximately similar. For both diseases, productivity costs based on the human cost approach were 3 to 70 times higher than the friction costs and accounted for more than half the total costs of both diseases. Conclusion. Productivity costs constitute the largest part of the total cost-off-illness of RA and AS refleciing the high burden of the disease on work participation. Although total and direct costs of illness in RA were higher than tit AS, the average age of AS patients was 10 years lower and therefore, time costs associated with AS may actually be equal or higher.
Belevingswaarde van het landschap van Winterswijk bij een multifunctioneel gras- en bouwlandgebruik
Veltman, D. ; Lyklema, W.F. ; Boonen, A.G. ; Kooijman, W. ; Mosterman, E. ; Pollaert, M. ; Korevaar, H. ; Geerts, R.H.E.M. - \ 2003
Wageningen : Plant Research International (Rapport / Plant Research International 68) - 52
landschap - landschapsecologie - perceptie - taxatie - plattelandsplanning - karteringen - landschapsbescherming - nederland - cultuurlandschap - gelderland - achterhoek - landscape - landscape ecology - perception - valuation - rural planning - surveys - landscape conservation - netherlands - cultural landscape - gelderland - achterhoek
Zooming in and zooming out: the equimarginal theory and its role in integrated pest management.
Wossink, G.A.A. ; Rossing, W.A.H. ; Boonen, J.H.M. - \ 1997
In: Policy Measures to control environmental impacts from Agriculture, Concerted Action AIR3-CT93-1164, Workshop on Pesticides, Wageningen, The Netherlands / Oskam, A.J., Vijftigschild, R.A.N., - p. 250 - 269.
Zooming in and zooming out:the equimarginal theory and its role in integrated pest management.
Wossink, G.A.A. ; Rossing, W.A.H. ; Boonen, J.H.M. - \ 1995
In: Workshop on Pesticides - Policy measures to control environmental impacts from agriculture. Concerted action AIR3, Wageningen (1995)
Inkomsten- en uitgavenpatroon van middelbare scholieren; een secudaire analyse
Goossens, R.C. ; Jager, H.J. de; Kamsteeg, J. ; Scherhorn, E. ; Boonen, K. - \ 1983
Wageningen : Vakgroep Huishoudkunde - 120 p.
Onderzoek naar de mogelijkheden van eenmalig oogsten van augurken
Sweep, A.A.M. ; Boonen, P.H.G. - \ 1970
Naaldwijk : [s.n.] (Informatiereeks / Proefstation voor groenten- en fruitteelt onder glas te Naaldwijk no. 2) - 27
cucumis sativus - komkommers - cucumbers
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