Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Beneficial effect of personalized lifestyle advice compared to generic advice on wellbeing among Dutch seniors – An explorative study
Doets, Esmée L. ; Hoogh, Iris M. de; Holthuysen, Nancy ; Wopereis, Suzan ; Verain, Muriel C.D. ; Puttelaar, Jos van den; Hogenelst, Koen ; Boorsma, André ; Bouwman, Emily P. ; Timmer, Marielle ; Pasman, Wilrike J. ; Erk, Marjan van; Reinders, Machiel J. - \ 2019
Physiology and Behavior 210 (2019). - ISSN 0031-9384
Lifestyle behavior - Muscle health - Older adults - Personalized nutrition - Web-based feedback - Wellbeing

The aim of this explorative study is to evaluate whether personalized compared to generic lifestyle advice improves wellbeing in a senior population. We conducted a nine-week single-blind randomized controlled trial including 59 participants (age 67.7 ± 4.8 years) from Wageningen and its surrounding areas in the Netherlands. Three times during the intervention period, participants received either personalized advice (PA), or generic advice (GA) to improve lifestyle behavior. Personalization was based on metabolic health measures and dietary intake resulting in an advice that highlighted food groups and physical activity types for which behavior change was most urgent. Before and after the intervention period self-perceived health was evaluated as parameter of wellbeing using a self-perceived health score (single-item) and two questionnaires (Vita-16 and Short Form-12). Additionally, anthropometry and physical functioning (short physical performance battery, SPPB) were assessed. Overall scores for self-perceived health did not change over time in any group. Resilience and motivation (Vita-16) slightly improved only in the PA group, whilst mental health (SF-12) and energy (Vita-16) showed slight improvement only in the GA group. SPPB scores improved over time in both the PA and GA group. PA participants also showed a reduction in body fat percentage and hip circumference, whereas these parameters increased in the GA group Our findings suggest that although no clear effects on wellbeing were found, still, at least on the short term, personalized advice may evoke health benefits in a population of seniors as compared to generic advice.

Cattle affect regeneration of the palm species Attalea princeps in a Bolivian forest–savanna mosaic
Hordijk, Iris ; Meijer, Fabian ; Nissen, Esther ; Boorsma, Tjalle ; Poorter, Lourens - \ 2019
Biotropica 51 (2019)1. - ISSN 0006-3606 - p. 28 - 38.
Beni savanna - Bolivia - landscape mosaic - Llanos de Moxos - Motacú palm

Attalea princeps is an important palm species that shapes the forest–savanna mosaic in Beni, Bolivia, as it dominates the two principal forest landscape elements (forest islands and gallery forest), and provides a vital microhabitat, food, and nesting source for numerous plant and animal species. The forest–savanna mosaic is used for extensive grazing, and the palm population is declining on the forest islands due to a low regeneration rate, which threatens the maintenance of this landscape. We therefore examined the (a)biotic factors that influence the population structure of Attalea in the centers and edges of forest islands and gallery forests. Ninety-one 0.1-ha plots were established, and 500 palm adults and 3,700 juveniles were measured for their size, health condition, and fire damage. For each plot, habitat characteristics, such as landscape position, grazing pressure, and soil conditions, were measured. Attalea population density was significantly lower on the forest islands than in the gallery forests, especially in the juvenile life stage. A structural equation model showed that juvenile density is positively related to the health condition of juveniles and amount of fruits present, where the amount of fruits is positively affected by the condition of adults. Juvenile density is negatively influenced by grazing, affecting the health condition of the juvenile, as well as organic matter and phosphate availability in the soil. Therefore, it is recommended to decrease the grazing pressure by decreasing livestock densities, fencing off vulnerable forest islands, or by rotating cattle.Abstract in Spanish is available with online material.

Data from: Cattle affect regeneration of the palm species Attalea princeps in a Bolivian forest-savanna mosaic
Hordijk, Iris ; Meijer, Fabian ; Nissen, Esther ; Boorsma, Tjalle ; Poorter, L. - \ 2018
Wageningen University & Research
landscape mosaic - Motacú palm - Attalea princeps
Attalea princeps is an important palm species that shapes the forest-savanna mosaic in Beni, Bolivia, because it dominates and shapes the two principal forest landscape elements (forest islands and gallery forest), and it provides a vital microhabitat, food and nesting source for numerous plant and animal species. The forest-savanna mosaic is used for extensive grazing, and the palm population is declining on the forest islands due to a low regeneration rate, which threatens the maintenance of this landscape. We therefore examined the (a)biotic factors that influence the population structure of Attalea in the centers and edges of forest islands and gallery forests. Ninety-one 0.1 ha plots were established and 500 palm adults and 3700 juveniles were measured for their size, health condition and fire damage. For each plot habitat characteristics, such as landscape position, grazing pressure, and soil conditions were measured. Attalea population density was significantly lower on the forest islands than in the gallery forests, especially in the juvenile life stage. A structural equation model showed that juvenile density is positively related to the health condition of the juveniles and amount of fruits present, where the amount of fruits is positively affected by the condition of the adults. Juvenile density is negatively influenced by grazing, affecting the health condition of the juvenile, as well as organic matter and phosphate availability in the soil. Therefore, it is recommended to decrease the grazing pressure by decreasing livestock densities, fencing off vulnerable forest islands, or by rotating cattle.
Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
Schmeits, P.C.J. ; Schaap, M.M. ; Luijten, M. ; Someren, E. van; Boorsma, A. ; Loveren, H. van; Peijnenburg, A.A.C.M. ; Hendriksen, P.J.M. - \ 2015
Archives of Toxicology 89 (2015)12. - ISSN 0340-5761 - p. 2325 - 2337.
Transcriptomics in combination with in vitro cell systems is a powerful approach to unravel modes of action of toxicants. An important question is to which extent the modes of action as revealed by transcriptomics depend on cell type, species and study type (in vitro or in vivo). To acquire more insight into this, we assessed the transcriptomic effects of the immunosuppressive drug cyclosporine A (CsA) upon 6 h of exposure of the mouse cytotoxic T cell line CTLL-2, the thymoma EL-4 and primary splenocytes and compared these to the effects in spleens of mice orally treated with CsA for 7 days. EL-4 and CTLL-2 cells showed the highest similarities in response. CsA affected many genes in primary splenocytes that were not affected in EL-4 or CTLL-2. Pathway analysis demonstrated that CsA upregulated the unfolded protein response, endoplasmic reticulum stress and NRF2 activation in EL-4 cells, CTLL-2 cells and primary mouse splenocytes but not in mouse spleen in vivo. As expected, CsA downregulated cell cycle and immune response in splenocytes in vitro, spleens in vivo as well as CTLL-2 in vitro. Genes up- and downregulated in human Jurkat, HepG2 and renal proximal tubular cells were similarly affected in CTLL-2, EL-4 and primary splenocytes in vitro. In conclusion, of the models tested in this study, the known mechanism of immunotoxicity of CsA is best represented in the mouse cytotoxic T cell line CTLL-2. This is likely due to the fact that this cell line is cultured in the presence of a T cell activation stimulant (IL-2) making it more suitable to detect inhibitory effects on T cell activation.
Assuring safety without animal testing concept (ASAT). Integration of human disease data with in vitro data to improve toxicology testing
Stierum, R. ; Aarts, J.M.M.J.G. ; Boorsma, J. ; Bosgra, S. ; Caiment, F. ; Ezendam, J. ; Greuping, R. ; Hendriksen, P. ; Soeteman-Hernandez, L.G. ; Jennen, D. ; Kleinjans, J. ; Kroese, D. ; Kuper, F. ; Loveren, H. van; Monshouwer, M. ; Russel, F. ; Someren, E. van; Tsamou, M. ; Groothuis, G. - \ 2014
Toxicology Letters 229 (2014)suppl.10. - ISSN 0378-4274 - p. S4 - S21.
According to the Assuring Safety Without Animal Testing (ASAT) principle, risk assessment may ultimately become possible without the use of animals (Fentem et al., (2004). Altern. Lab. Anim. 32, 617–623). The ASAT concept takes human disease mechanisms as starting point and tries to define if activation of these mechanisms by chemical exposure in in vitro models can be used for toxicological risk assessment. The goal of the present research was to study if integration of public data, from human diseases and in vitro toxicology, is possible at the data level. Two human diseases, associated with chemical exposure, were included: human hepatocellular carcinoma and allergic contact dermatitis (ACD). Data were retrieved from expert knowledge and different online sources (e.g. GEO, ArrayExpress) and a Knowledge Base for storage and modelling of the data was established. Using the Knowledge Base for ACD, it was possible to discern sensitizing from non-sensitizing compounds, as defined by enrichment of clinically defined disease gene sets in in vitro genomics datasets. In addition, the strongest sensitizers most profoundly activated these gene sets. During the presentation, the Knowledge Base will be shown. In addition, the ongoing incorporation of (reverse) kinetic modelling to judge the relevance of in vitro concentrations, in relation to realistic in vivo exposure scenarios, will be illustrated. Finally, the expansion towards the development of data models for other disease areas (cholestasis) will be discussed.
Next-generation text-mining mediated generation of chemical response-specific gene sets for interpretation of gene expression data
Hettne, K.M. ; Boorsma, A. ; Dartel, D.A.M. van; Goeman, J.J. ; Jong, E. de; Piersma, A.H. ; Stierum, R.H. ; Kleinjans, J.C. ; Kors, J.A. - \ 2013
BMC Medical Genomics 6 (2013). - ISSN 1755-8794 - 17 p.
stem-cell test - developmental toxicity - global test - disease - tool
Background: Availability of chemical response-specific lists of genes (gene sets) for pharmacological and/or toxic effect prediction for compounds is limited. We hypothesize that more gene sets can be created by next-generation text mining (next-gen TM), and that these can be used with gene set analysis (GSA) methods for chemical treatment identification, for pharmacological mechanism elucidation, and for comparing compound toxicity profiles. Methods: We created 30,211 chemical response-specific gene sets for human and mouse by next-gen TM, and derived 1,189 (human) and 588 (mouse) gene sets from the Comparative Toxicogenomics Database (CTD). We tested for significant differential expression (SDE) (false discovery rate -corrected p-values <0.05) of the next-gen TM-derived gene sets and the CTD-derived gene sets in gene expression (GE) data sets of five chemicals (from experimental models). We tested for SDE of gene sets for six fibrates in a peroxisome proliferator-activated receptor alpha (PPARA) knock-out GE dataset and compared to results from the Connectivity Map. We tested for SDE of 319 next-gen TM-derived gene sets for environmental toxicants in three GE data sets of triazoles, and tested for SDE of 442 gene sets associated with embryonic structures. We compared the gene sets to triazole effects seen in the Whole Embryo Culture (WEC), and used principal component analysis (PCA) to discriminate triazoles from other chemicals. Results: Next-gen TM-derived gene sets matching the chemical treatment were significantly altered in three GE data sets, and the corresponding CTD-derived gene sets were significantly altered in five GE data sets. Six next-gen TM-derived and four CTD-derived fibrate gene sets were significantly altered in the PPARA knock-out GE dataset. None of the fibrate signatures in cMap scored significant against the PPARA GE signature. 33 environmental toxicant gene sets were significantly altered in the triazole GE data sets. 21 of these toxicants had a similar toxicity pattern as the triazoles. We confirmed embryotoxic effects, and discriminated triazoles from other chemicals. Conclusions: Gene set analysis with next-gen TM-derived chemical response-specific gene sets is a scalable method for identifying similarities in gene responses to other chemicals, from which one may infer potential mode of action and/or toxic effect.
Comparative Analysis of Transcriptome and Fitness Profiles Reveals General and Condition-Specific Cellular Functions Involved in Adaptation to Environmental Change in Saccharomyces cerevisiae
Zakrzewska, A. ; Boorsma, A. ; Beek, A. van; Hageman, J.A. ; Westerhuis, J.A. ; Hellingwerf, K.J. ; Brul, S. ; Klis, F.M. ; Smits, J. - \ 2010
OMICS - A Journal of Integrative Biology 14 (2010)5. - ISSN 1536-2310 - p. 603 - 614.
perturbing compound chitosan - translational responses - regulatory elements - genetic interaction - genomic expression - candida-albicans - global analysis - multiple levels - growth-rate - yeast
The transcriptional responses of yeast cells to a wide variety of stress conditions have been studied extensively. In addition, deletion mutant collections have been widely used to measure the combined effect of gene loss and stress on growth (fitness). Here we present a comparative analysis of 1,095 publicly available transcription and genome-wide fitness profiles in yeast, from different laboratories and experimental platforms. We analyzed these data, using T-profiler, to describe the correlation in behavior of a priori defined functional groups. Two-mode clustering analysis of the fitness T-profiles revealed that functional groups involved in regulating ribosome biogenesis and translation offer general stress resistance. These groups are closely related to growth rate and nutrient availability. General stress sensitivity was found in deletion mutant groups functioning in intracellular vesicular transport, actin cytoskeleton organization, and cell polarity, indicating that they play an key role in maintaining yeast adaptability. Analysis of the phenotypic and transcriptional variability of our a priori defined functional groups showed that the quantitative effect on fitness of both resistant and sensitive groups is highly condition-dependent. Finally, we discuss the implications of our results for combinatorial drug design
Tussensprint naar 2015. Advies over de financiering van de primaire waterkeringen voor de bescherming van Nederland tegen overstroming
Vellinga, P. ; Stive, M.J.F. ; Vrijling, J.K. ; Boorsma, P.B. ; Verschuuren, J.M. ; Ierland, E.C. van - \ 2006
Amsterdam : Klimaatcentrum Vrije Universiteit - 69 p.
The university: a regional booster? Economic impacts of academic knowledge infrastructure.
Florax, R.J.G.M. - \ 1992
University of Twente. Promotor(en): P.B. Boorsma; H. Folmer. - Ashgate : Aldershot - 330 p.
Evaluatie wegenplan Driebruggen : beproeving van een nieuwe methode
Boorsma, S. - \ 1988
Wageningen : ICW (ICW nota 1857) - 62
kostenanalyse - bedrijfswegen - ruilverkaveling - landgebruik - ruimtelijke ordening - plattelandswegen - nederland - zuid-holland - cost analysis - farm roads - land consolidation - land use - physical planning - rural roads - netherlands
Beschrijving van enige cassavecultivars
Marrewijk, G.A.M. van; Boorsma, P.A. ; Hofstede, G.W. ; Sakiman, J.K.S. - \ 1972
Paramaribo : Centrum voor Landbouwkundig Onderzoek in Suriname (Celos rapporten no. 67) - 48
cassave - cultivars - landbouwkundig onderzoek - suriname - plantenontwikkeling - plantenmorfologie - cassava - agricultural research - plant development - plant morphology
Dit verslag behelst een morfologische beschrijving van de cassaveklonen in de CELOS-collectie alsmede de neerslag van een aantal waarnemingen omtrent groei, ontwikkeling en productie onder de omstandigheden van de jonge kustvlakte. Alle waarnemingen werden verricht op het terrein van het Centrum voor Landbouwkundig Onderzoek in Suriname aan jaarlijks vernieuwde aanplantingen in de periode mei 1969 t/m februari 1972.
Voortgezette onderzoekingen naar de overerving van zaadhuidkleur en zaadhuidpatroon bij Vigna unguiculata (L.) walp
Boorsma, P.A. - \ 1972
Wageningen : [s.n.] (Celos rapporten no. 65) - 34
plantkunde - vignabonen - peulvruchten - suriname - vigna - botany - cowpeas - grain legumes
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