Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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    Implementation of guidance on dossier evaluation for the registration of pest control products in Kenya
    Horst, Mechteld ter; Akinyi Aluoch, June ; Wanyonyi Barasa, Maurice ; Bosman-Hoefakker, Saskia ; Broeders, Jessica ; Etten, Jacobijn van; Jong, Esther de; Ngaruiya, Paul N. ; Steenbergh, Anne ; Valk, Harold van der; Wagate, Githaiga ; Muthoni Wambugu, Sarah ; Nekoye Waswa, Maureen ; Wipfler, Louise - \ 2019
    Wageningen : Wageningen Environmental Research (Wageningen Environmental Research report 2980) - ISBN 9789463952613 - 37
    This document describes suggestions for further steps that can be taken with regard to the evaluation of pest control products in Kenya. The document should be read together with the document describing proposed guidance on dossier evaluation for the registration of pest control products in Kenya and as such both contribute to a future complete pesticide evaluation manual for Kenya.Both documents were developed within the Pesticide management initiative East African Region: Kenya (PEAR -Kenya) project. The project ran in the period 2016 – 2019 and was sponsored and supported by the Dutch Ministry of Agriculture, Nature and Food Quality and the Embassy of the Netherlands in Nairobi.This document is intended to feed into discussions on further development of a complete pesticide evaluation manual for Kenya using the guidance mentioned as a starting point. Reflections on some of the methods proposed and also information on what is needed to implement the guidance developed in the project are provided. Additionally, suggestions for developing a framework for the risk assessment of aquatic organisms are given.
    Guidance on dossier evaluation for the registration of pest control products in Kenya
    Horst, Mechteld ter; Akinyi Aluoch, June ; Wanyonyi Barasa, Maurice ; Bosman-Hoefakker, Saskia ; Broeders, Jessica ; Etten, Jacobijn van; Jong, Esther de; Ngaruiya, Paul N. ; Steenbergh, Anne ; Valk, Harold van der; Wagate, Githaiga ; Muthoni Wambugu, Sarah ; Nekoye Waswa, Maureen ; Wipfler, Louise - \ 2019
    Wageningen : Wageningen Environmental Research (Wageningen Environmental Research report 2979) - ISBN 9789463952606 - 93
    This document describes guidance on dossier evaluation for the registration of pest control products in Kenya. The document provides guidance for the assessment of a limited number of aspects that are part of evaluation of a pest control product registration dossier. It should therefore not be considered as a complete pesticide evaluation manual, though it is intended to contribute to a future complete pest control product evaluation manual for Kenya. The guidance should be read together with an im plementation report which contains stepping stones for further development.The guidance was developed within the Pesticide management initiative East African Region: Kenya (PEAR -Kenya) project. The project ran in the period 2016 – 2019 and was sponsored and supported by the Dutch Ministry of Agriculture, Nature and Food Quality and the Embassy of the Netherlands in Nairobi.The guidance addresses various aspects of a pest control product evaluation covering low risk pest control products, microbial pest control product, chemical pest control products and equivalence determination. The evaluation procedures developed covers a fast-track pathway for low risk products. For microbial products the procedure focusses on identification, human pathology and infectiveness and hazard and risk assessments for metabolites of potential concern. For chemical products the procedure includes methods for human health and pollinator risk assessments. The evaluation process of new pest control products can be speeded up if the active ingredient or active agent of a new product proves to be equivalent to an already registered product.
    Sensible heating as a potential mechanism for enhanced cloud formation over temperate forest
    Bosman, Peter J.M. ; Heerwaarden, Chiel C. van; Teuling, Adriaan J. - \ 2019
    Quarterly Journal of the Royal Meteorological Society 145 (2019)719. - ISSN 0035-9009 - p. 450 - 468.
    cloud formation - flux partitioning - forest cloud cover - large-eddy simulation - sensible heat flux - sensible heating - surface heat fluxes

    It has been recently shown for two forests in France (Les Landes and Sologne) that summer cloud cover over the forest is increased relative to its surroundings. This study aims to contribute to the elucidation of the physical mechanisms responsible for this increased cloud cover, focusing on surface flux partitioning. This was done by performing a case study for a heatwave day on which enhanced cloud cover over the forest of Les Landes was observed. Two numerical experiments (large-eddy simulations) with a homogeneous forest cover were performed, one in which the sensible heat flux was increased by approximately 5% of the total available energy and another one in which the same amount of energy was added to the latent heat flux. The addition of energy to the sensible heat flux led to a stronger increase in cloud cover than the same addition to the latent heat flux. The mean relative humidity at the boundary layer top showed only small differences, indicating it was not a sufficient indicator for cloud formation in this case. Important information, which immediately underlines the need for large-eddy simulations, is contained in modifications of the shape of the probability density functions of temperature and humidity. With enhanced sensible heating, the higher peak values of relative humidity contribute to an increased cloud cover. A crucial reason for the differences in cloud cover between the experiments is conjectured to be a decrease in the required amount of energy for air parcels to reach the lifting condensation level, indirectly caused by the boundary layer and near-surface warming associated with the stronger sensible heat flux. As forests in the region do have a higher sensible heat flux than their surroundings, we highlight one potential mechanism for enhanced cloud cover.

    Leerlingen HPC Zetten beoordelen smaak en uiterlijk van vier nieuwe appelkruisingen
    Ravesloot, M.B.M. ; Heiden, Alma van der; Bosman, Anita ; Beekhuizen, Sandra - \ 2018
    Wageningen University & Research - 1 p.
    Miscanthus biochar had limited effects on soil physical properties, microbial biomass, and grain yield in a four-year field experiment in Norway
    O’toole, Adam ; Moni, Christophe ; Weldon, Simon ; Schols, Anne ; Carnol, Monique ; Bosman, Bernard ; Rasse, Daniel P. - \ 2018
    Agriculture 8 (2018)11. - ISSN 2077-0472
    Biochar - Miscanthus - Norway

    The application of biochar to soils is a promising technique for increasing soil organic C and offsetting GHG emissions. However, large-scale adoption by farmers will likely require the proof of its utility to improve plant growth and soil quality. In this context, we conducted a four-year field experiment between October 2010 to October 2014 on a fertile silty clay loam Albeluvisol in Norway to assess the impact of biochar on soil physical properties, soil microbial biomass, and oat and barley yield. The following treatments were included: Control (soil), miscanthus biochar 8 t C ha−1 (BC8), miscanthus straw feedstock 8 t C ha−1 (MC8), and miscanthus biochar 25 t C ha−1 (BC25). Average volumetric water content at field capacity was significantly higher in BC25 when compared to the control due to changes in BD and total porosity. The biochar amendment had no effect on soil aggregate (2–6 mm) stability, pore size distribution, penetration resistance, soil microbial biomass C and N, and basal respiration. Biochar did not alter crop yields of oat and barley during the four growing seasons. In order to realize biochar’s climate mitigation potential, we suggest future research and development efforts should focus on improving the agronomic utility of biochar in engineered fertilizer and soil amendment products.

    Delta Atelier : Hot spot Coast, Polders
    Rooij, L.L. de; Kort, de, R. ; Oliemans, W.J. ; Bosman, Maurits ; Rahman, Atiqur ; Slager, Kymo ; Rahman, Moshiur ; Ruhul Alam, Mollah - \ 2015
    Bangladesh Deltaplan 2100 - 71 p.
    De Knoflookpad in Nederland: ondergang of 'slechts' een bottleneck?
    Bosman, W. ; Struijk, R.P.J.H. ; Zekhuis, M. ; Ottburg, F.G.W.A. ; Crombaghs, B. ; Schut, D. ; Hoof, P. van - \ 2015
    De Levende Natuur 116 (2015)1. - ISSN 0024-1520 - p. 2 - 6.
    amphibia - padden - fauna - habitats - zoögeografie - oost-nederland - amphibia - toads - fauna - habitats - zoogeography - east netherlands
    In 2001 werd het landelijk Beschermingsplan Knoflookpad opgesteld. Wat is er sindsdien gedaan om de stand van de Knoflookpad te verbeteren en tot welke resultaten heeft dat geleid? Wat betekent dit voor de toekomst? Waar liggen de kansen voor de Knoflookpad? In een drietal artikelen komen achtereenvolgens aan bod: de historie van de Knoflookpad in Nederland, waarom en hoe in 2010 werd overgegaan tot bijplaatsing en herintroductie en tot slot welke scenario’s er zijn voor de toekomst van de Knoflookpad.
    Kan de Knoflookpad op termijn van de Intensive Care af?
    Ottburg, F.G.W.A. ; Crombaghs, B. ; Bosman, W. ; Zekhuis, M. ; Jansman, H.A.H. ; Snep, R.P.H. - \ 2015
    De Levende Natuur 116 (2015)1. - ISSN 0024-1520 - p. 15 - 20.
    amphibia - padden - fauna - habitats - beschermde soorten - natuurbeleid - amphibia - toads - fauna - habitats - protected species - nature conservation policy
    In 2001 werd het landelijk Beschermingsplan Knoflookpad opgesteld. Wat is er sindsdien gedaan om de stand van de Knoflookpad te verbeteren en tot welke resultaten heeft dat geleid? Wat betekent dit voor de toekomst? Waar liggen de kansen voor de Knoflookpad? In een drietal artikelen komen achtereenvolgens aan bod: de historie van de Knoflookpad in Nederland, waarom en hoe in 2010 werd overgegaan tot bijplaatsing en herintroductie en tot slot welke scenario’s er zijn voor de toekomst van de Knoflookpad.
    Antimicrobial resistance in commensal Escherichia coli in veal calves is associated with antimicrobial drug use
    Bosman, A.B. ; Wagenaar, J.A. ; Stegeman, J.A. ; Vernooij, J.C.M. ; Mevius, D.J. - \ 2014
    Epidemiology and Infection 142 (2014)9. - ISSN 0950-2688 - p. 1893 - 1904.
    to-finish farms - antibiotic-resistance - fecal samples - exposed herd - risk-factors - pigs - prevalence - coliforms - bacteria - ontario
    The aim of this study was to determine the association between farm management factors, including antimicrobial drug usage, and resistance in commensal Escherichia coli isolates from the faeces of white veal calves. Ninety E. coli isolates from one pooled sample per farm (n = 48) were tested for their phenotypical resistance against amoxicillin, tetracycline, cefotaxime, ciprofloxacin and trimethoprim/sulfamethoxazole (TMP/SMX). Logistic regression analysis revealed the following risk factors (P <0·05); farmer wearing the same work clothes for several days [ciprofloxacin, odds ratio (OR) 2·6; tetracycline, OR 2·4], administration of trimethoprim-sulfonamide combinations (TMP/SMX, OR 3·0; amoxicillin, OR 3·1; tetracycline, OR 2·6), ¿0·3 animal daily dosage per production cycle (ADD/pc), quinolones (ciprofloxacin, OR 2·8), ¿1·3 ADD/pc, penicillins (ciprofloxacin, OR 3·3; tetracycline, OR 3·4), 20-40 ADD/pc, tetracyclines (tetracycline, OR 3·2) and >40 ADD/pc, tetracyclines (tetracycline, OR 13·1; amoxicillin, OR 6·5). In this study antimicrobial resistance in commensal E. coli was mainly associated with antimicrobial drug use.
    Dissecting the genetic architecture of resistance to orsay virus infection in C. elegans
    Sterken, M.G. ; Wang, Y. ; Snoek, L.B. ; Volkers, R.J.M. ; Riksen, J.A.G. ; Bosman, K.J. ; Pijlman, G.P. ; Kammenga, J.E. - \ 2014
    In: Proceedings of Evolutionary Biology of Caenorhabditis and other Nematodes. - - p. 111 - 111.
    Host-pathogen interactions play a major role in evolutionary selection and in shaping natural genetic variation. Recent identification of viral infection in C. elegans has prompted research into understanding the underlying pathways of Orsay virus (OrV) infection in natural populations. Here we report the dissection of the genetic architecture of OrV infection. We found that wild type Hawaii CB4856 strain was more resistant to OrV than the canonical Bristol N2 strain. To gain insight into the genetic architecture of resistance, 52 fully sequenced recombinant inbred lines (CB4856 x N2 RILs) were exposed to OrV using our recently developed quantitative assay. This led to the identification of two distinct loci on chromosome IV associated with OrV resistance. These loci were both associated with a lower viral load in the CB4856 genotype. Strikingly, these loci do not harbour the recently found drh-1 locus, which encodes a RIG-I like helicase that plays an important role in antiviral RNAi. To verify our results and gain additional insight into the genetic architecture, a panel of 18 introgression lines (ILs) (together covering chromosome IV entirely) was exposed to OrV. Both loci could be verified by ILs, also showing more resistance against OrV infection with the CB4856 locus. Our results provide insight in the loci underlying the higher viral resistance in CB4856. They also form an important step toward identifying polymorphic genes underlying resistance to viral infection in C. elegans.
    Dissecting the genetic architecture of resistance to orsay virus infection in C. elegans
    Sterken, M.G. ; Wang, Y. ; Snoek, L.B. ; Volkers, R.J.M. ; Riksen, J.A.G. ; Bosman, K.J. ; Pijlman, G.P. ; Kammenga, J.E. - \ 2014
    In: Proceedings of PhD Spring School Host-Microbe Interactomics. - - p. 12 - 12.
    Host-pathogen interactions play a major role in evolutionary selection and in shaping natural genetic variation. Recent identification of viral infection in C. elegans has prompted research into understanding the underlying pathways of Orsay virus (OrV) infection in natural populations. Here we report the dissection of the genetic architecture of OrV infection. We found that wild type Hawaii CB4856 strain was more resistant to OrV than the canonical Bristol N2 strain. To gain insight into the genetic architecture of resistance, 52 fully sequenced recombinant inbred lines (CB4856 x N2 RILs) were exposed to OrV using our recently developed quantitative assay. This led to the identification of two distinct loci on chromosome IV associated with OrV resistance. These loci were both associated with a lower viral load in the CB4856 genotype. Strikingly, these loci do not harbour the recently found drh-1 locus, which encodes a RIG-I like helicase that plays an important role in antiviral RNAi. To verify our results and gain additional insight into the genetic architecture, a panel of 18 introgression lines (ILs) (together covering chromosome IV entirely) was exposed to OrV. Both loci could be verified by ILs, also showing more resistance against OrV infection with the CB4856 locus. Our results provide insight in the loci underlying the higher viral resistance in CB4856. They also form an important step toward identifying polymorphic genes underlying resistance to viral infection in C. elegans.
    The effects of development on gene expression in L4 Caenorhabditis elegans larvae
    Riksen, J.A.G. ; Snoek, L.B. ; Sterken, M.G. ; Volkers, R.J.M. ; Klatter, M. ; Bosman, K. ; Bevers, R.P.J. ; Smant, G. ; Cossins, A.R. ; Kammenga, J.E. - \ 2014
    In: Proceedings of the Berlin C. elegans Meeting. - - p. 215 - 215.
    Organismal development is the most dynamic period of the life cycle yet we have only a rough understanding of the dynamics of gene expression during this period. We explore how development affects gene expression, by a detailed map of the C. elegans transcriptome. We found that over 10,000 genes display changes in expression and explored the properties of genes with different dynamics. A time series experiment was conducted on synchronized populations of C. elegans Bristol N2. The worms were grown in three batches, covering the time points from 42-64 hours post bleaching leading to a dense time series with 1 hour intervals on average. A follow up experiment was conducted using N2 and seven wild-isolates, CB4856, JU1581, JU1921, JU1930, JU1932, JU1944 and JU 1949. These were grown on two different food sources to show the applicability of the generated data as a transcriptional determinant of age. It was found that more than 10,000 genes have a dynamic expression pattern during the L4 stage. We found up- and down-regulated genes and also genes with more specific patterns. One noticeable pattern was a group of genes that is specifically up-regulated around 50 hours. Signs of purifying selection in non-coding regions of string up-regulated genes were found. This is an indication that highly up-regulated genes during development are constrained on their regulatory properties. Using the time-series we show that genotype and environment affect the development and the applicability of transcriptomics data to measure age. Our data help in understanding the transition from larvae to adult worms and can be used te eliminate experimental artefacts due to differences in developmental timing between experiments.
    A heritable antiviral RNAi response limits Orsay virus infection in Caenorhabditis elegans N2
    Sterken, M.G. ; Snoek, L.B. ; Bosman, K.J. ; Daamen, J. ; Riksen, J.A.G. ; Bakker, J. ; Pijlman, G.P. ; Kammenga, J.E. - \ 2014
    PLoS ONE 9 (2014)2. - ISSN 1932-6203
    c. elegans - gene-expression - interference - requirements - inheritance - environment - diversity - pathways - genotype - immunity
    Orsay virus (OrV) is the first virus known to be able to complete a full infection cycle in the model nematode species Caenorhabditis elegans. OrV is transmitted horizontally and its infection is limited by antiviral RNA interference (RNAi). However, we have no insight into the kinetics of OrV replication in C. elegans. We developed an assay that infects worms in liquid, allowing precise monitoring of the infection. The assay revealed a dual role for the RNAi response in limiting Orsay virus infection in C. elegans. Firstly, it limits the progression of the initial infection at the step of recognition of dsRNA. Secondly, it provides an inherited protection against infection in the offspring. This establishes the heritable RNAi response as anti-viral mechanism during OrV infections in C. elegans. Our results further illustrate that the inheritance of the anti-viral response is important in controlling the infection in the canonical wild type Bristol N2. The OrV replication kinetics were established throughout the worm life-cycle, setting a standard for further quantitative assays with the OrV-C. elegans infection model.
    A rapid and massive gene expression shift marking adolescent transition in C. elegans
    Snoek, L.B. ; Sterken, M.G. ; Volkers, R.J.M. ; Klatter, M. ; Bosman, K.J. ; Bevers, R.P.J. ; Riksen, J.A.G. ; Smant, G. ; Cossins, A.R. ; Kammenga, J.E. - \ 2014
    Scientific Reports 4 (2014). - ISSN 2045-2322
    caenorhabditis-elegans - natural variation - genome - populations - robustness - diversity - profiles - genotype - project - age
    Organismal development is the most dynamic period of the life cycle, yet we have only a rough understanding of the dynamics of gene expression during adolescent transition. Here we show that adolescence in Caenorhabditis elegans is characterized by a spectacular expression shift of conserved and highly polymorphic genes. Using a high resolution time series we found that in adolescent worms over 10,000 genes changed their expression. These genes were clustered according to their expression patterns. One cluster involved in chromatin remodelling showed a brief up-regulation around 50 h post-hatch. At the same time a spectacular shift in expression was observed. Sequence comparisons for this cluster across many genotypes revealed diversifying selection. Strongly up-regulated genes showed signs of purifying selection in non-coding regions, indicating that adolescence-active genes are constrained on their regulatory properties. Our findings improve our understanding of adolescent transition and help to eliminate experimental artefacts due to incorrect developmental timing.
    Bulbillen: als seks niet nodig is (interview met C. Kik)
    Bosman, G. ; Kik, C. - \ 2013
    De Volkskrant (2013).
    Vitale medewerkers in vitale organisaties: de resultaten van de sectoranalyse binnen het WO.
    Vaandrager, L. ; Peeters, J.G.H. ; Bosman, A. ; Schouteten, R. ; Senden, T. - \ 2013
    Vitale medewerkers in vitale organisaties: De resultaten van de sectoranalyse binnen het WO Deel 1 van de Taskforce Vitaliteit
    Vaandrager, L. ; Peeters, J.G.H. ; Bosman, A. ; Schouteten, R. - \ 2013
    SoFoKleS
    Ontwerpdeel: Good Practice MyBalance 2.0. Deel 2 van de taskforce vitaliteit
    Peeters, J.G.H. ; Vaandrager, L. ; Bosman, A. ; Schouteten, R. - \ 2013
    SoFoKleS - 37 p.
    An innovative team-based stop smoking competition among Maori and Pacific Island smokers: rationale and method for the study and its evaluation
    Glover, M. ; Bosman, A. ; Wagemakers, A. ; Kira, A. ; Paton, C. ; Cowie, N. - \ 2013
    BMC Public Health 13 (2013). - ISSN 1471-2458 - 15 p.
    international quit - social support - win contest - new-zealand - cessation - intervention - community - campaign - population - efficacy
    Maori and Pacific Island people have significantly higher smoking rates compared to the rest of the New Zealand population. The main aim of this paper is to describe how knowledge of Indigenous people’s practices and principles can be combined with proven effective smoking cessation support into a cessation intervention appropriate for Indigenous people.
    Within-farm dynamics of ESBL/AmpC-producing Escherichia coli in veal calves: a longitudinal approach
    Hordijk, J. ; Mevius, D.J. ; Kant, A. ; Bos, M.E.H. ; Graveland, H. ; Bosman, A.B. ; Hartskeerl, M. ; Heederik, D.J.J. ; Wagenaar, J.A. - \ 2013
    Journal of Antimicrobial Chemotherapy 68 (2013)11. - ISSN 0305-7453 - p. 2468 - 2476.
    spectrum-beta-lactamase - food-producing animals - plasmids encoding ctx-m-14 - extended-spectrum - klebsiella-pneumoniae - antimicrobial agents - companion animals - fecal carriage - young calves - resistance
    OBJECTIVES: To assess the within-farm dynamics of extended-spectrum ß-lactamase (ESBL)/AmpC-producing Escherichia coli in veal calves. METHODS: Three veal-calf fattening farms were screened. Faecal samples from all calves within a compartment (109-150 per farm) were taken upon arrival on the farm (T0) and after 3, 6, 8 and 10 weeks (T3-T10). ESBL/AmpC genes were characterized by PCR and sequencing. Plasmids were characterized by transformation, PCR-based replicon typing and plasmid multilocus sequence typing (MLST). E. coli genotypes were analysed by MLST. RESULTS: At T0 the prevalence of ESBL/AmpC-producing E. coli ranged from 18% to 26%. These were predominantly isolates carrying blaCTX-M-1 and blaCTX-M-15 genes, located on various plasmids and E. coli sequence types (STs). Farm 1 was negative for ESBL/AmpC-producing E. coli after T0. Farm 2 showed an increase up to 37% at T3, which subsequently decreased gradually to 0% at T10. The presence from T3 to T10 on farm 2 was mainly caused by the clonal spread of a multiresistant E. coli ST57 harbouring blaCTX-M-14 on an IncF F2:A-:B- plasmid. Farm 3 showed a gradual decrease in prevalence to 1.4% at T10, with a relative increase of the identical clonal variant as shown for farm 2. A second clonal variant found in farm 3 was a multiresistant E. coli ST10 harbouring blaCTX-M-14 on an IncK plasmid. CONCLUSIONS: The prevalence of ESBL/AmpC-producing E. coli decreased over time. A clonal spread was observed on farm 2 and farm 3, illustrative of the complex dynamics probably associated with the use of antimicrobials.
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