Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Records 1 - 3 / 3

  • help
  • print

    Print search results

  • export

    Export search results

  • alert
    We will mail you new results for this query: q=Brites
Check title to add to marked list
Genome-wide association study for kernel composition and flour pasting behavior in wholemeal maize flour
Alves, Mara Lisa ; Carbas, Bruna ; Gaspar, Daniel ; Paulo, Manuel ; Brites, Cláudia ; Mendes-Moreira, Pedro ; Brites, Carla Moita ; Malosetti, Marcos ; Eeuwijk, Fred Van; Vaz Patto, Maria Carlota - \ 2019
BMC Plant Biology 19 (2019)1. - ISSN 1471-2229
Bread - Candidate genes - Nutritional quality - Pasting behavior - Plant breeding - Portuguese maize germplasm - Zea mays L.

Background: Maize is a crop in high demand for food purposes and consumers worldwide are increasingly concerned with food quality. However, breeding for improved quality is a complex task and therefore developing tools to select for better quality products is of great importance. Kernel composition, flour pasting behavior, and flour particle size have been previously identified as crucial for maize-based food quality. In this work we carried out a genome-wide association study to identify genomic regions controlling compositional and pasting properties of maize wholemeal flour. Results: A collection of 132 diverse inbred lines, with a considerable representation of the food used Portuguese unique germplasm, was trialed during two seasons, and harvested samples characterized for main compositional traits, flour pasting parameters and mean particle size. The collection was genotyped with the MaizeSNP50 array. SNP-trait associations were tested using a mixed linear model accounting for genetic relatedness. Fifty-seven genomic regions were identified, associated with the 11 different quality-related traits evaluated. Regions controlling multiple traits were detected and potential candidate genes identified. As an example, for two viscosity parameters that reflect the capacity of the starch to absorb water and swell, the strongest common associated region was located near the dull endosperm 1 gene that encodes a starch synthase and is determinant on the starch endosperm structure in maize. Conclusions: This study allowed for identifying relevant regions on the maize genome affecting maize kernel composition and flour pasting behavior, candidate genes for the majority of the quality-associated genomic regions, or the most promising target regions to develop molecular tools to increase efficacy and efficiency of quality traits selection (such as "breadability") within maize breeding programs.

Blood–brain barrier transport and neuroprotective potential of blackberry-digested polyphenols : an in vitro study
Figueira, Inês ; Tavares, Lucélia ; Jardim, Carolina ; Costa, Inês ; Terrasso, Ana P. ; Almeida, Andreia F. ; Govers, Coen ; Mes, Jurriaan J. ; Gardner, Rui ; Becker, Jörg D. ; McDougall, Gordon J. ; Stewart, Derek ; Filipe, Augusto ; Kim, Kwang S. ; Brites, Dora ; Brito, Catarina ; Brito, M.A. ; Santos, Cláudia N. - \ 2017
European Journal of Nutrition (2017). - ISSN 1436-6207 - p. 1 - 18.
Blackberry - Brain endothelial cells - In vitro digestion - Microarrays - Neuronal cells
Purpose: Epidemiological and intervention studies have attempted to link the health effects of a diet rich in fruits and vegetables with the consumption of polyphenols and their impact in neurodegenerative diseases. Studies have shown that polyphenols can cross the intestinal barrier and reach concentrations in the bloodstream able to exert effects in vivo. However, the effective uptake of polyphenols into the brain is still regarded with some reservations. Here we describe a combination of approaches to examine the putative transport of blackberry-digested polyphenols (BDP) across the blood–brain barrier (BBB) and ultimate evaluation of their neuroprotective effects. Methods: BDP was obtained by in vitro digestion of blackberry extract and BDP major aglycones (hBDP) were obtained by enzymatic hydrolysis. Chemical characterization and BBB transport of extracts were evaluated by LC–MSn. BBB transport and cytoprotection of both extracts was assessed in HBMEC monolayers. Neuroprotective potential of BDP was assessed in NT2-derived 3D co-cultures of neurons and astrocytes and in primary mouse cerebellar granule cells. BDP-modulated genes were evaluated by microarray analysis. Results: Components from BDP and hBDP were shown to be transported across the BBB. Physiologically relevant concentrations of both extracts were cytoprotective at endothelial level and BDP was neuroprotective in primary neurons and in an advanced 3D cell model. The major canonical pathways involved in the neuroprotective effect of BDP were unveiled, including mTOR signaling and the unfolded protein response pathway. Genes such as ASNS and ATF5 emerged as novel BDP-modulated targets. Conclusions: BBB transport of BDP and hBDP components reinforces the health benefits of a diet rich in polyphenols in neurodegenerative disorders. Our results suggest some novel pathways and genes that may be involved in the neuroprotective mechanism of the BDP polyphenol components.
Diversity of Global Rice Markets and the Science Required for Consumer-Targeted Rice Breeding
Calingacion, M.N. ; Laborte, A.G. ; Nelson, A. ; Resurreccion, A. ; Chrystal Concepcion, J. ; Dara Daygon, V. ; Mumm, R. ; Reinke, R. ; Dipti, S. ; Zaczuk Bassinello, P. ; Manful, J. ; Sophany, S. ; Cordero Lara, K. ; Bao, J. ; Xie, L. ; Loaiza, K. ; El-hissewy, A. ; Gayin, J. ; Sharma, N. ; Rajeswari, S. ; Manonmani, S. ; Shobha Rani, N. ; Kota, S. ; Dewi Indrasari, S. ; Habibi, F. ; Hosseini, M. ; Tavasoli, F. ; Suzuki, K. ; Umemoto, T. ; Boualaphanh, C. ; Hong Lee, H. ; Pang Hung, Y. ; Ramli, A. ; Pa Aung, P. ; Ahmad, R. ; Iqbal Wattoo, J. ; Bandonill, E. ; Romero, M. ; Moita Brites, C. ; Hafeel, R. ; Sheng Lur, H. ; Cheaupun, K. ; Jongdee, S. ; Blanco, P. ; Bryant, R. ; Thi Lang, N. ; Hall, R.D. - \ 2014
PLoS ONE 9 (2014)1. - ISSN 1932-6203 - 12 p.
single-nucleotide polymorphisms - oryza-sativa l. - starch-synthase-iia - grain length - gelatinization temperature - gel consistency - eating quality - gene - gs3 - association
With the ever-increasing global demand for high quality rice in both local production regions and with Western consumers, we have a strong desire to understand better the importance of the different traits that make up the quality of the rice grain and obtain a full picture of rice quality demographics. Rice is by no means a ‘one size fits all’ crop. Regional preferences are not only striking, they drive the market and hence are of major economic importance in any rice breeding / improvement strategy. In this analysis, we have engaged local experts across the world to perform a full assessment of all the major rice quality trait characteristics and importantly, to determine how these are combined in the most preferred varieties for each of their regions. Physical as well as biochemical characteristics have been monitored and this has resulted in the identification of no less than 18 quality trait combinations. This complexity immediately reveals the extent of the specificity of consumer preference. Nevertheless, further assessment of these combinations at the variety level reveals that several groups still comprise varieties which consumers can readily identify as being different. This emphasises the shortcomings in the current tools we have available to assess rice quality and raises the issue of how we might correct for this in the future. Only with additional tools and research will we be able to define directed strategies for rice breeding which are able to combine important agronomic features with the demands of local consumers for specific quality attributes and hence, design new, improved crop varieties which will be awarded success in the global market.
Check title to add to marked list

Show 20 50 100 records per page

Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.