Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Robotti: gewasmonitoring met camera's op een autonoom voertuig
    Veldhuisen, Bram - \ 2019
    Wageningen : Wageningen Plant Research
    Intensieve gewasmonitoring is noodzakelijk om de ecologie te begrijpen en dat kan nu automatisch gedaan worden door de cameratechnieken te combineren met een autonoom voertuig. De Robotti is een hoog technisch autonoom platform die ecologische processen ondersteunt en zo een brug vormt tussen technologie en ecologie.
    Adherence to a food group-based dietary guideline and incidence of prediabetes and type 2 diabetes
    Braver, Nicolette R. den; Rutters, Femke ; Kortlever - van der Spek, Andrea L.J. ; Ibi, Dorina ; Looman, Moniek ; Geelen, Anouk ; Elders, Petra ; Heijden, Amber A. van der; Brug, Johannes ; Lakerveld, Jeroen ; Soedamah-Muthu, Sabita S. ; Beulens, Joline W.J. - \ 2019
    European Journal of Nutrition (2019). - ISSN 1436-6207
    Dietary pattern - Dutch healthy diet index 2015 - Intermediate hyperglycemia - Prediabetes - Type 2 diabetes

    Purpose: In this study, we investigated the association between adherence to the Dutch Healthy Diet index 2015 (DHD15-index) and incidence of prediabetes (preT2D) and Type 2 Diabetes (T2D) in a representative sample for the general Dutch population. Methods: Two prospective cohort studies, The Hoorn and The New Hoorn Study, were used for data analyses. In total, data from 2951 participants without diabetes at baseline (mean age 56.5 ± 7.5 years; 49.6% male) were harmonized. Baseline dietary intake was assessed with validated Food Frequency Questionnaires and adherence to the DHD15-index was calculated (range 0–130). PreT2D and T2D were classified according to the WHO criteria 2011. Poisson regression was used to estimate prevalence ratios between participant scores on the DHD15-index and preT2D and T2D, adjusted for follow-up duration, energy intake, socio-demographic, and lifestyle factors. Change in fasting plasma glucose levels (mmol/L) over follow-up was analysed using linear regression analyses, additionally adjusted for baseline value. Results: During a mean follow-up of 6.3 ± 0.7 years, 837 participants developed preT2D and 321 participants developed T2D. The highest adherence to the DHD15-index was significantly associated with lower T2D incidence [model 3, PRT3vsT1: 0.70 (0.53; 0.92), ptrend = 0.01]. The highest adherence to the DHD15-index pointed towards a lower incidence of preT2D [PRT3vsT1: 0.87 (0.74; 1.03), ptrend = 0.11]. Higher adherence to the DHD15-index was not associated with change in fasting plasma glucose levels [β10point: − 0.012 (− 0.034; 0.009)mmol/L]. Conclusion: The present study showed that the highest compared to the lowest adherence to the DHD15-index was associated with a lower T2D incidence, and pointed towards a lower incidence of preT2D. These results support the benefits of adhering to the guidelines in T2D prevention.

    Participatieve monitoring in Lumbricus : Een brug tussen innovatie en implementatie
    Breman, B.C. ; Kuindersma, W. ; Meijerink, Sander ; Ellen, Gerald Jan ; Wassink, W. ; Brugmans, Bart ; Bolt, F.J.E. van der - \ 2019
    Water Governance (2019)1. - ISSN 2211-0224 - p. 46 - 49.
    Nederland staat voor een aantal grote uitdagingen op het gebied van het waterbeheer, dat heeft de zomer van 2018 nog maar eens extra duidelijk gemaakt. Omdat het klimaat verandert krijgen we vaker te maken met extreme neerslag en langdurige perioden van droogte. Dit heeft direct consequenties voor onder andere de waterkwaliteit en de waterkwantiteit. Op de hoger gelegen zandgronden in Nederland zijn deze consequenties zo mogelijk nog groter omdat hier de mogelijkheden om water tijdelijk te bergen of van elders aan te voeren vaak veel beperkter zijn.
    Buurtsportcoaches slaan brug tussen zorg en sport
    Wagemakers, A. ; Molleman, Gerard R.M. - \ 2019
    Mediator 33 (2019).
    Om het effect te onderzoeken van buurtsportcoaches, volgden onderzoekers van Wageningen University & Research en Radboudumc drie jaar lang de activiteiten van coaches in negen gemeenten. De buurtsportcoaches hebben de verbinding weten te leggen tussen zorg, sport en bewegen.
    Correlates of irregular family meal patterns among 11-year-old children from the pro children study
    Totland, Torunn Holm ; Knudsen, Markus Dines ; Paulsen, Mari Mohn ; Bjelland, Mona ; Van’T Veer, Pieter ; Brug, Johannes ; Klepp, Knut Inge ; Andersen, Lene Frost - \ 2017
    Food and Nutrition Research 61 (2017). - ISSN 1654-6628
    Children - Fruit and vegetable intake - Irregular family meals - Screen time - Social differences

    Background: The importance of family meals to the consumption of healthful food choices has been stated in recent reviews. However, little information is available on barriers that interfere with regular family meal patterns during childhood. Objective: Describe family meal patterns among 11-year-old children across Europe and identify correlates of irregular family breakfast and dinner consumption. Design: Cross-sectional survey involving samples of 13,305 children from nine European countries in 2003. Results: The proportions of children who regularly ate family breakfast and dinner were 62% and 90%, respectively. Correlates of irregular family breakfasts and dinners were less vegetable consumption, and irregular family breakfasts were associated with more television viewing. Social differences in the consumption of family breakfasts were observed. Discussion: Strengths of this study are the large sample size and validated research method. Limitations are the cross-sectional design and self-reported data. Conclusion: The majority of 11-year-old children regularly ate breakfast and dinner with their families. More television viewing and less vegetable consumption were associated with irregular family breakfasts and dinners, respectively. Social differences were observed in the regularity of family breakfasts. Promoting family meals across social class may lead to healthier eating and activity habits, sustainable at the population level.

    Duurzame landbouw nog een brug te ver
    Boer, I.J.M. de; Poppe, K.J. - \ 2017
    Bioraffinage, de brug tussen landbouw en de chemie
    Sanders, Johan - \ 2016
    The 2015 Dutch food-based dietary guidelines
    Kromhout, D. ; Spaaij, C.J.K. ; Goede, J. de; Weggemans, R.M. ; Brug, Johannes ; Geleijnse, Johanna M. ; Goudoever, Johannes B. van; Hoes, Arno W. ; Hopman, Maria T.E. ; Iestra, Jolein A. ; Mensink, Ronald P. ; Pijl, Hanno ; Romijn, Johannes A. ; Schols, Annemie M.W.J. ; Seidell, Jaap C. ; Veer, Pieter van 't; Visser, Marjolein ; Zwietering, Marcel H. - \ 2016
    European Journal of Clinical Nutrition 70 (2016)8. - ISSN 0954-3007 - p. 869 - 878.

    The objective of this study was to derive food-based dietary guidelines for the Dutch population. The dietary guidelines are based on 29 systematic reviews of English language meta-analyses in PubMed summarizing randomized controlled trials and prospective cohort studies on nutrients, foods and food patterns and the risk of 10 major chronic diseases: coronary heart disease, stroke, heart failure, diabetes, breast cancer, colorectal cancer, lung cancer, chronic obstructive pulmonary disease, dementia and depression. The committee also selected three causal risk factors for cardiovascular diseases or diabetes: systolic blood pressure, low-density lipoprotein cholesterol and body weight. Findings were categorized as strong or weak evidence, inconsistent effects, too little evidence or effect unlikely for experimental and observational data separately. Next, the committee selected only findings with a strong level of evidence for deriving the guidelines. Convincing evidence was based on strong evidence from the experimental data either or not in combination with strong evidence from prospective cohort studies. Plausible evidence was based on strong evidence from prospective cohort studies only. A general guideline to eat a more plant food-based dietary pattern and limit consumption of animal-based food and 15 specific guidelines have been formulated. There are 10 new guidelines on legumes, nuts, meat, dairy produce, cereal products, fats and oils, tea, coffee and sugar-containing beverages. Three guidelines on vegetables, fruits, fish and alcoholic beverages have been sharpened, and the 2006 guideline on salt stayed the same. A separate guideline has been formulated on nutrient supplements. Completely food-based dietary guidelines can be derived in a systematic and transparent way.

    A randomized controlled trial to examine the effect of 2-year vitamin B12 and folic acid supplementation on physical performance, strength, and falling: additional findings from the B-PROOF study
    Swart, K.M.A. ; Ham, A.C. ; Wijngaarden, J.P. van; Enneman, A.W. ; Dijk, S.C. van; Sohl, E. ; Brouwer, E.M. ; Zwaluw, N.L. van der; Zillikens, M.C. ; Dhonukshe-Rutten, R.A.M. ; Velde, N. van der; Brug, J. ; Uitterlinden, A.G. ; Groot, C.P.G.M. de; Lips, P. ; Schoor, N.M. van - \ 2016
    Calcified Tissue International 98 (2016)1. - ISSN 0171-967X - p. 18 - 27.
    Elevated homocysteine concentrations are associated with a decline in physical function in elderly persons. Homocysteine-lowering therapy may slow down this decline. This study aimed to examine the effect of a 2-year intervention of vitamin B12 and folic acid supplementation on physical performance, handgrip strength, and risk of falling in elderly subjects in a double-blind, randomized placebo-controlled trial. Participants aged ≥65 years with elevated plasma homocysteine concentrations [12–50 µmol/L (n = 2919)] were randomly assigned to daily supplementation of 500 µg vitamin B12, 400 µg folic acid, and 600 IU vitamin D3, or to placebo with 600 IU vitamin D3. Physical performance (range 0–12) and handgrip strength (kg) were measured at baseline and after 2 years. Falls were reported prospectively on a research calendar. Intention-to-treat (primary) and per-protocol (secondary) analyses were performed. Physical performance level and handgrip strength significantly decreased during the follow-up period, but this decline did not differ between groups. Moreover, time to first fall was not significantly different (HR: 1.0, 95 % CI 0.9–1.2). Secondary analyses on a per-protocol base identified an interaction effect with age on physical performance. In addition, the treatment was associated with higher follow-up scores on the walking test (cumulative OR: 1.3, 95 % CI 1.1–1.5). Two-year supplementation of vitamin B12 and folic acid was neither effective in reducing the age-related decline in physical performance and handgrip strength, nor in the prevention of falling in elderly persons. Despite the overall null-effect, the results provide indications for a positive effect of the intervention on gait, as well as on physical performance among compliant persons >80 years. These effects should be further tested in future studies
    Suske en Wiske. De beestige brug
    Wamelink, G.W.W. - \ 2015
    Vakblad Natuur Bos Landschap 12 (2015)120. - ISSN 1572-7610 - p. 30 - 30.
    Op zoek naar de 'Bricoleurs van Brabant' : Hans Horsten in gesprek met Joks Janssen
    Janssen, J. - \ 2015
    In: PON Jaarboek 2015 'Kom over de brug: transformeren leer je al doende’ / Blanken, M., Cox, S., den Hartog, J., Smulders, M., Tilburg : PON Kennis in uitvoering - ISBN 9789050495257 - p. 71 - 79.
    Schrijver van artikel: Hans Horsten
    Replacing Non-Active Video Gaming by Active Video Gaming to Prevent Excessive Weight Gain in Adolescents
    Simons, M. ; Brug, J. ; Chinapaw, M.J.M. ; Boer, M. de; Seidell, J. ; Vet, E. de - \ 2015
    PLoS ONE 10 (2015)7. - ISSN 1932-6203 - 21 p.
    randomized controlled-trial - physical-activity levels - sedentary behavior - health indicators - childhood obesity - screen time - children - games - overweight - questionnaire
    Objective - The aim of the current study was to evaluate the effects of and adherence to an active video game promotion intervention on anthropometrics, sedentary screen time and consumption of sugar-sweetened beverages and snacks among non-active video gaming adolescents who primarily were of healthy weight. Methods - We assigned 270 gaming (i.e. =2 hours/week non-active video game time) adolescents randomly to an intervention group (n = 140) (receiving active video games and encouragement to play) or a waiting-list control group (n = 130). BMI-SDS (SDS = adjusted for mean standard deviation score), waist circumference-SDS, hip circumference and sum of skinfolds were measured at baseline, at four and ten months follow-up (primary outcomes). Sedentary screen time, physical activity, consumption of sugar-sweetened beverages and snacks, and process measures (not at baseline) were assessed with self-reports at baseline, one, four and ten months follow-up. Multi-level-intention to treat-regression analyses were conducted. Results - The control group decreased significantly more than the intervention group on BMI-SDS (ß = 0.074, 95%CI: 0.008;0.14), and sum of skinfolds (ß = 3.22, 95%CI: 0.27;6.17) (overall effects). The intervention group had a significantly higher decrease in self-reported non-active video game time (ß = -1.76, 95%CI: -3.20;-0.32) and total sedentary screen time (Exp (ß = 0.81, 95%CI: 0.74;0.88) than the control group (overall effects). The process evaluation showed that 14% of the adolescents played the Move video games every week =1 hour/week during the whole intervention period. Conclusions - The active video game intervention did not result in lower values on anthropometrics in a group of ‘excessive’ non-active video gamers (mean ~ 14 hours/week) who primarily were of healthy weight compared to a control group throughout a ten-month-period. Even some effects in the unexpected direction were found, with the control group showing lower BMI-SDS and skin folds than the intervention group. The intervention did result in less self-reported sedentary screen time, although these results are likely biased by social desirability.
    Naar een groene ontmoetingsplek : reflectie op het initiëren van bewonersparticipatie door de vier Buurtstichtingen in Hoensbroek
    Eppink, H.J. ; Pfeiffer, L.H. ; Cremers, C. - \ 2015
    Wageningen : Wageningen UR, Wetenschapswinkel (Rapport / Wageningen UR, Wetenschapswinkel 306) - ISBN 9789461738776 - 42
    openbaar groen - burgers - gemeenten - publieke participatie - bewonersparticipatie - zuid-limburg - public green areas - citizens - municipalities - public participation - community participation - zuid-limburg
    Vier buurtstichtingen in Hoensbroek hebben interesse getoond om gedeeltelijk verantwoordelijkheid te nemen voor de openbare groene ruimte. De buurtstichtingen ziet de gemeente als brug tussen overheid en burgers. De inhoud van dit rapport is interessant voor andere buurtstichtingen om eigen initiatieven vorm te geven.
    5 jaar Wageningen Potato Centre (WPC)
    Brouwer, T.A. ; Tramper, M. ; Visser, R.G.F. - \ 2015
    Wageningen : Wageningen UR
    akkerbouw - aardappelen - wetenschappelijk onderzoek - landbouwbedrijven - proefbedrijven - kennisoverdracht - verbetering - arable farming - potatoes - scientific research - farms - pilot farms - knowledge transfer - improvement
    Het kennisplatform Wageningen Potato Centre (WPC) is een initiatief van Wageningen UR om een brug te slaan tussen wetenschap en bedrijfsleven. Strategisch en fundamenteel wordt toegankelijk én toepasbaar gemaakt voor de partners van WPC.
    Associations between active video gaming and other energy-balance related behaviours in adolescents: a 24-hour recall diary study
    Simons, M. ; Chinapaw, M.J.M. ; Brug, J. ; Seidell, J.C. ; Vet, E. de - \ 2015
    International journal of behavioral nutrition and physical activity 12 (2015). - ISSN 1479-5868
    Active video games may contribute to reducing time spent in sedentary activities, increasing physical activity and preventing excessive weight gain in adolescents. Active video gaming can, however, only be beneficial for weight management when it replaces sedentary activities and not other physical activity, and when it is not associated with a higher energy intake. The current study therefore examines the association between active video gaming and other energy-balance-related behaviours (EBRBs). Findings Adolescents (12–16 years) with access to an active video game and who reported to spend at least one hour per week in active video gaming were invited to participate in the study. They were asked to complete electronic 24-hour recall diaries on five randomly assigned weekdays and two randomly assigned weekend-days in a one-month period, reporting on time spent playing active and non-active video games and on other EBRBs. Findings indicated that adolescents who reported playing active video games on assessed days also reported spending more time playing non-active video games (Median¿=¿23.6, IQR¿=¿56.8 minutes per week) compared to adolescents who did not report playing active video games on assessed days (Median¿=¿10.0, IQR¿=¿51.3 minutes per week, P¿
    Kom over de brug! Op weg naar boer-burgercollectieven voor natuur- en landschapsbeheer. Tips voor agrarische natuurverenigingen en groene burgergroepen
    Westerink, J. ; Vogelzang, T.A. ; Rooij, S.A.M. van; Holster, H.C. ; Alebeek, F.A.N. van; Schrijver, R.A.M. - \ 2015
    Wageningen : Alterra, Wageningen-UR
    agrarisch natuurbeheer - financieren - landschap - ecosysteemdiensten - burgers - boeren - economische samenwerking - agri-environment schemes - financing - landscape - ecosystem services - citizens - farmers - economic cooperation
    Tot nu toe staat private financiering van agrarisch natuur- en landschapsbeheer nog in de kinderschoenen. Op kleine schaal zijn enkele gebiedsfondsen opgezet waar bedrijven en burgers aan meebetalen, soms ondersteund vanuit goede doelen, of vanuit initiatieven zoals Streekrekeningen. Wat is er nodig voor meer financiering van het landschap door ‘de buurt’? Agrarische natuur- en landschapsbeheerders en de Agrarische Natuurverenigingen (ANV’s) op zoek naar nieuwe verdienmodellen voor agrarisch natuur- en landschapsbeheer. In de zoektocht naar ‘verdienmodellen’ door partnerschap met ‘de buurt’ is snel succes niet te verwachten. Een combinatie van de uitdaging aangaan, lange adem, en weten dat het moeilijk wordt, is nodig voor deze zoektocht.
    Towards the integration and development of a cross-European research network and infrastructure: the DEterminants of DIet and Physical ACtivity (DEDIPAC) Knowledge Hub
    Lakerveld, J. ; Ploeg, H.P. van der; Kroeze, W. ; Ahrens, W. ; Allais, O. ; Andersen, L.F. ; Cardon, F. ; Capranica, L. ; Chastin, S. ; Donnelly, A. ; Ekelund, U. ; Finglas, P.M. ; Flechtner-Mors, M. ; Hebestreit, A. ; Hendriksen, I. ; Kubiak, T. ; Lanza, M. ; Loyen, A. ; MacDonncha, C. ; Mazzocchi, M. ; Monsivais, P. ; Murphy, M. ; Nöthlings, U. ; O’Gorman, D.J. ; Renner, B. ; Roos, G. ; Schuit, A.J. ; Schulze, M.B. ; Steinacker, J. ; Stronks, K. ; Volkert, D. ; Veer, P. van 't; Lien, N. ; Bourdeaudhuij, I. De; Brug, J. - \ 2014
    International journal of behavioral nutrition and physical activity 11 (2014). - ISSN 1479-5868 - 10 p.
    public-health - interventions - framework - obesity - science - design - food
    To address major societal challenges and enhance cooperation in research across Europe, the European Commission has initiated and facilitated ‘joint programming’. Joint programming is a process by which Member States engage in defining, developing and implementing a common strategic research agenda, based on a shared vision of how to address major societal challenges that no Member State is capable of resolving independently. Setting up a Joint Programming Initiative (JPI) should also contribute to avoiding unnecessary overlap and repetition of research, and enable and enhance the development and use of standardised research methods, procedures and data management. The Determinants of Diet and Physical Activity (DEDIPAC) Knowledge Hub (KH) is the first act of the European JPI ‘A Healthy Diet for a Healthy Life’. The objective of DEDIPAC is to contribute to improving understanding of the determinants of dietary, physical activity and sedentary behaviours. DEDIPAC KH is a multi-disciplinary consortium of 46 consortia and organisations supported by joint programming grants from 12 countries across Europe. The work is divided into three thematic areas: (I) assessment and harmonisation of methods for future research, surveillance and monitoring, and for evaluation of interventions and policies; (II) determinants of dietary, physical activity and sedentary behaviours across the life course and in vulnerable groups; and (III) evaluation and benchmarking of public health and policy interventions aimed at improving dietary, physical activity and sedentary behaviours. In the first three years, DEDIPAC KH will organise, develop, share and harmonise expertise, methods, measures, data and other infrastructure. This should further European research and improve the broad multi-disciplinary approach needed to study the interactions between multilevel determinants in influencing dietary, physical activity and sedentary behaviours. Insights will be translated into more effective interventions and policies for the promotion of healthier behaviours and more effective monitoring and evaluation of the impacts of such interventions
    Active video games as a tool to prevent excessive weight gain in adolescents: rationale, design and methods of a randomized controlled trial
    Simons, M. ; Chinapaw, M.J.M. ; Bovenkamp, M. van de; Boer, M.R. de; Seidell, J.C. ; Brug, J. ; Vet, E. de - \ 2014
    BMC Public Health 14 (2014). - ISSN 1471-2458 - 13 p.
    promote physical-activity - sedentary screen time - body-mass index - intrinsic motivation - self-determination - economic burden - obesity - children - overweight - youth
    Background Excessive body weight, low physical activity and excessive sedentary time in youth are major public health concerns. A new generation of video games, the ones that require physical activity to play the games –i.e. active games- may be a promising alternative to traditional non-active games to promote physical activity and reduce sedentary behaviors in youth. The aim of this manuscript is to describe the design of a study evaluating the effects of a family oriented active game intervention, incorporating several motivational elements, on anthropometrics and health behaviors in adolescents. Methods/Design The study is a randomized controlled trial (RCT), with non-active gaming adolescents aged 12 – 16 years old randomly allocated to a ten month intervention (receiving active games, as well as an encouragement to play) or a waiting-list control group (receiving active games after the intervention period). Primary outcomes are adolescents’ measured BMI-SDS (SDS =¿adjusted for mean standard deviation score), waist circumference-SDS, hip circumference and sum of skinfolds. Secondary outcomes are adolescents’ self-reported time spent playing active and non-active games, other sedentary activities and consumption of sugar-sweetened beverages. In addition, a process evaluation is conducted, assessing the sustainability of the active games, enjoyment, perceived competence, perceived barriers for active game play, game context, injuries from active game play, activity replacement and intention to continue playing the active games. Discussion This is the first adequately powered RCT including normal weight adolescents, evaluating a reasonably long period of provision of and exposure to active games. Next, strong elements are the incorporating motivational elements for active game play and a comprehensive process evaluation. This trial will provide evidence regarding the potential contribution of active games in prevention of excessive weight gain in adolescents.
    Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial
    Wijngaarden, J.P. van; Swart, K.M.A. ; Enneman, A.W. ; Dhonukshe-Rutten, R.A.M. ; Dijk, S.C. van; Ham, A.C. ; Brouwer, E.M. ; Zwaluw, N.L. van der; Sohl, E. ; Meurs, J.B.J. van; Zillikens, M.C. ; Schoor, N.M. van; Velde, N. van der; Brug, J. ; Uitterlinden, A.G. ; Lips, P. ; Groot, C.P.G.M. de - \ 2014
    American Journal of Clinical Nutrition 100 (2014)6. - ISSN 0002-9165 - p. 1578 - 1586.
    hip fracture - osteoporotic fractures - bone turnover - d deficiency - risk - metaanalysis - folate - level - women
    Background: Elevated plasma homocysteine concentrations are a risk factor for osteoporotic fractures. Lowering homocysteine with combined vitamin B-12 and folic acid supplementation may reduce fracture risk. Objective: This study [B-vitamins for the PRevention Of Osteoporotic Fractures (B-PROOF)] aimed to determine whether vitamin B-12 and folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic elderly individuals. Design: This was a double-blind, randomized, placebo-controlled trial in 2919 participants aged =65 y with elevated homocysteine concentrations (12–50 µmol/L). Participants were assigned to receive daily 500 µg vitamin B-12 plus 400 µg folic acid or placebo supplementation for 2 y. Both intervention and placebo tablets also contained 600 IU vitamin D3. The primary endpoint was time to first osteoporotic fracture. Exploratory prespecified subgroup analyses were performed in men and women and in individuals younger than and older than age 80 y. Data were analyzed according to intention-to-treat and per-protocol principles. Results: Osteoporotic fractures occurred in 61 persons (4.2%) in the intervention group and 75 persons (5.1%) in the placebo group. Osteoporotic fracture risk was not significantly different between groups in the intention-to-treat analyses (HR: 0.84; 95% CI: 0.58, 1.21) or per-protocol analyses (HR: 0.81; 95% CI: 0.54, 1.21). For persons >80 y, in per-protocol analyses, osteoporotic fracture risk was lower in the intervention group than in the placebo group (HR: 0.27; 95% CI: 0.10, 0.74). The total number of adverse events (including mortality) did not differ between groups. However, 63 and 42 participants in the intervention and placebo groups, respectively, reported incident cancer (HR: 1.56; 95% CI: 1.04, 2.31). Conclusions: These data show that combined vitamin B-12 and folic acid supplementation had no effect on osteoporotic fracture incidence in this elderly population. Exploratory subgroup analyses suggest a beneficial effect on osteoporotic fracture prevention in compliant persons aged >80 y. However, treatment was also associated with increased incidence of cancer, although the study was not designed for assessing cancer outcomes. Therefore, vitamin B-12 plus folic acid supplementation cannot be recommended at present for fracture prevention in elderly people. The B-PROOF study was registered with the Netherlands Trial Register (trialregister.nl) as NTR1333 and at clinicaltrials.gov as NCT00696414.
    Personal, social and game-related correlates of active and non-active video gaming among Dutch gaming adolescents
    Simons, M. ; Vet, E.W.M.L. de; Chinapaw, M. ; Boer, M.R. de; Seidell, J.C. ; Brug, J. - \ 2014
    JMIR Serious Games 2 (2014)1. - ISSN 2291-9279 - 13 p.
    Background: Playing video games contributes substantially to sedentary behavior in youth. A new generation of video games—active games—seems to be a promising alternative to sedentary games to promote physical activity and reduce sedentary behavior. At this time, little is known about correlates of active and non-active gaming among adolescents. Objective: The objective of this study was to examine potential personal, social, and game-related correlates of both active and non-active gaming in adolescents. Methods: A survey assessing game behavior and potential personal, social, and game-related correlates was conducted among adolescents (12-16 years, N=353) recruited via schools. Multivariable, multilevel logistic regression analyses, adjusted for demographics (age, sex and educational level of adolescents), were conducted to examine personal, social, and game-related correlates of active gaming =1 hour per week (h/wk) and non-active gaming >7 h/wk. Results: Active gaming =1 h/wk was significantly associated with a more positive attitude toward active gaming (OR 5.3, CI 2.4-11.8; P7 h/wk was significantly associated with a more positive attitude toward non-active gaming (OR 2.6, CI 1.1-6.3; P=.035), a stronger habit regarding gaming (OR 3.0, CI 1.7-5.3; P7 h/wk. Active gaming is most strongly (negatively) associated with attitude with respect to non-active games, followed by observed active game behavior of brothers and sisters and attitude with respect to active gaming (positive associations). On the other hand, non-active gaming is most strongly associated with observed non-active game behavior of friends, habit strength regarding gaming and attitude toward non-active gaming (positive associations). Habit strength was a correlate of both active and non-active gaming, indicating that both types of gaming are habitual behaviors. Although these results should be interpreted with caution because of the limitations of the study, they do provide preliminary insights into potential correlates of active and non-active gaming that can be used for further research as well as preliminary direction for the development of effective intervention strategies for replacing non-active gaming by active gaming among adolescents.
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