Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Satellite NO2 data improve national land use regression models for ambient NO2 in a small densely populated country
Hoek, G. ; Eeftens, M. ; Beelen, R. ; Fischer, P. ; Brunekreef, B. ; Boersma, K.F. ; Veefkind, P. - \ 2015
Atmospheric Environment 105 (2015). - ISSN 1352-2310 - p. 173 - 180.
Land use regression (LUR) modelling has increasingly been applied to model fine scale spatial variation of outdoor air pollutants including nitrogen dioxide (NO2). Satellite observations of tropospheric NO2 improved LUR model in very large study areas, including Canada, United States and Australia. The aim of our study was to assess the value of satellite observations of NO2 in modelling the spatial variation of annual average NO2 concentrations in a small densely populated country. We used surface level annual average NO2 concentration and geographic information system data from 144 monitoring sites spread over the Netherlands: 26 regional background, 78 urban background and 40 traffic sites for developing land use regression models. For the 144 monitoring sites we obtained the annual average tropospheric NO2 concentration for 2007 from the Ozone Monitoring Instrument (OMI) satellite sensor. These OMI data reflect a spatial scale of about 10 × 10 km. We calculated the correlation between satellite and surface level NO2 concentrations for all sites and for background sites only. We next evaluated whether adding satellite observations improved land use regression models. Annual average satellite observations of tropospheric NO2 correlated well spatially with annual average urban plus regional background (R = 0.74, n = 104 sites) and especially regional background NO2 concentrations (R = 0.88, n = 26). The correlation was moderate for all sites, including traffic locations (R = 0.51, n = 144). A LUR model including satellite NO2 observations performed better (overall R2 = 0.84) than LUR models including geographical coordinates or indicator variables (overall R2 65–74%) in modeling concentrations at the 104 background sites across the Netherlands. Satellite NO2 observations agreed well with measured surface concentrations at background locations and improved land use regression models, even in a small densely populated country.
Predicting the risk of newborn children to become overweight later in childhood: the PIAMA birth cohort study
Steur, M. ; Smit, H.A. ; Schipper, C.M.A. ; Scholtens, S. ; Kerkhof, M. van de; Jongste, J.C. de; Haveman-Nies, A. ; Brunekreef, B. ; Wijga, A.H. - \ 2011
International Journal of Pediatric Obesity 6 (2011)2-2. - ISSN 1747-7166 - p. e170 - e178.
self-reported height - regression-analysis - obesity - weight - prevention - validity - smoking - pregnancy - allergy - models
Objective. To develop a decision rule by which children with a high risk to develop overweight can be distinguished at birth from children at low risk. Design, setting and participants. Data of 1 687 Dutch children born in 1996/1997 who participated in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) longitudinal birth cohort study were analysed. Perinatal candidate predictors of overweight at 8 years of age were selected and a prediction model was developed using stepwise model selection based on the Akaike Information Criterion (AIC). The prediction model was internally validated using resampling techniques. Outcome measure. Overweight at the age of 8 years. Results. A total of 13.9% (n = 253) of the children were overweight at 8 years of age. Independent positive predictors of overweight were paternal and maternal body mass index, female gender, smoking in the parental house, birth weight and hospital delivery. From the model, a decision rule was derived by which an overweight score could be calculated. Of the children with an overweight score below 89.45, only 2.7% were overweight at the age of 8, whereas in children with an overweight score above 105.02 the prevalence of overweight was 35.4%. Conclusion. The risk of overweight at the age of 8 years can be predicted with six characteristics that are available at birth. The decision rule developed in this study may help to target early preventive measures against overweight in high-risk children
Predicting the risk of newborn children to become overweight later in childhood
Steur, M. ; Smit, H.A. ; Schipper, C.M.A. ; Scholtens, S. ; Kerkhof, M. van de; Jongste, J.C. de; Haveman-Nies, A. ; Brunekreef, B. ; Wijga, A.H. - \ 2010
In: 3rd European Public Health Conference, Amsterdam, The Netherlands, 10 - 13 November, 2010. - - p. 66 - 66.
To develop a decision rule by which children with a high risk to develop overweight can be distinguished at birth from children at low risk. Design, setting and participants. Data of 1 687 Dutch children born in 1996/1997 who participated in the Prevention and Incidence of Asthma and Mite Allergy (PIAMA) longitudinal birth cohort study were analysed. Perinatal candidate predictors of overweight at 8 years of age were selected and a prediction model was developed using stepwise model selection based on the Akaike Information Criterion (AIC). The prediction model was internally validated using resampling techniques. Outcome measure. Overweight at the age of 8 years. Results. A total of 13.9% (n = 253) of the children were overweight at 8 years of age. Independent positive predictors of overweight were paternal and maternal body mass index, female gender, smoking in the parental house, birth weight and hospital delivery. From the model, a decision rule was derived by which an overweight score could be calculated. Of the children with an overweight score below 89.45, only 2.7% were overweight at the age of 8, whereas in children with an overweight score above 105.02 the prevalence of overweight was 35.4%. Conclusion. The risk of overweight at the age of 8 years can be predicted with six characteristics that are available at birth. The decision rule developed in this study may help to target early preventive measures against overweight in high-risk children.
Eczeem in kinderen tot en met 8 jaar: de rol van borstvoeding en de eerste vaste hapjes
Laan, L.N. van der; Scholtens, S. ; Wijga, A.H. ; Haveman-Nies, A. ; Brunekreef, B. ; Postma, D.M. ; Kerkhof, M. van de; Smit, H.A. - \ 2008
In: Nederlands Congres Volksgezondheid (NCVGZ) 2008, 9 - 10 April, 2008, Groningen, the Netherlands. - - p. 81 - 81.
Increased serum IL-10/IL-12 ratio in wheezing infants
Koopman, L.P. ; Savelkoul, H.F.J. ; Benten, I.J. van; Gerritsen, J. ; Brunekreef, B. ; Neijens, H.J. - \ 2003
Pediatric Allergy and Immunology 14 (2003). - ISSN 0905-6157 - p. 112 - 119.
soluble e-selectin - atopic-dermatitis - interleukin-2 receptor - adhesion molecules - allergic diseases - il-10 production - t-cells - asthma - children - ige
To investigate the association between various serum markers and atopic symptoms in the first year of life, and to evaluate the prognostic value of these markers for the development of wheezing and skin rash in the second year of life. Data of 86 children on the development of wheezing and skin rash in the first 2 years of life were collected prospectively, making use of parental completed questionnaires, weekly symptom cards, structured interview and physical examination. Serum markers (IL-10, IL-12, IL-13, eotaxin, sE-selectin, sICAM-1, sIL-2R) and total and specific IgE were determined at age 1. Children who developed wheezing in the first year of life had lower serum levels of IL-12 than children without symptoms (median 40.3 pg/ml vs. 49.0 pg/ml, p = 0.01) and a higher serum IL-10/IL-12 ratio (0.41 vs. 0.31, p = 0.001) at age 1. The IL-10/IL-12 ratio increased with an increasing number of wheezing episodes. Levels of sE-selectin in children with wheezing and in children with itchy skin rash in the first year of life were higher than in symptom free children (6.1 ng/ml and 5.9 ng/ml vs. 4.9 ng/ml, p = 0.01 and p = 0.03, respectively). Children who developed wheezing in the second year of life already had increased sICAM-1 levels at age 1. Children who developed wheezing in the first year of life showed a serum cytokine response that is skewed towards a T-helper 2 profile, with lower IL-12 levels and an increased IL-10/IL-12 ratio. Children who developed wheezing in the second year of life had elevated sICAM-1 levels at age 1. Follow-up of the children is needed to evaluate the prognostic value of various serum markers for the development of allergic disease in later childhood.
A case-control study of plasma antioxidant (pro-)vitamins in relation to respiratory symptoms in non-smokers
Grievink, L. ; Smit, H.A. ; Veer, P. van 't; Brunekreef, B. ; Kromhout, D. - \ 2000
Epidemiology 11 (2000). - ISSN 1044-3983 - p. 59 - 63.
The aim of this study was to investigate the relations between plasma levels of antioxidants, [beta]-carotene and [alpha]-tocopherol, and chronic respiratory symptoms in Dutch adults who never smoked or were long-term former smokers. Cases (who reported one or more respiratory symptoms) and controls were selected from a population-based cross-sectional study. Plasma concentrations of antioxidants were determined in 491 cases and 496 controls. ORs for the presence of chronic respiratory symptoms were estimated for quintiles of plasma antioxidant concentration after adjustment for age, gender, and body mass index. The OR of respiratory symptoms in all but the highest quintile of plasma [beta]-carotene decreased and were slightly below one. We saw no meaningful relation with plasma [alpha]-tocopherol.
Influence of shift work and host factors on endotoxin-related acute peak flow changes
Zock, J.P. ; Heederik, D.J.J. ; Brunekreef, B. - \ 1999
American Journal of Respiratory and Critical Care Medicine 159 (1999). - ISSN 1073-449X - p. 137 - 142.
Acute effects of urban air pollution on respiratory health of children with and without chronic respiratory symptoms
Zee, S. van der; Hoek, G. ; Boezen, H.M. ; Schouten, J.P. ; Wijnen, J.H. van; Brunekreef, B. - \ 1999
Occupational and Environmental Medicine 56 (1999)12. - ISSN 1351-0711 - p. 802 - 812.
Acute effects of winter air pollution on respiratory health
Zee, S. van der - \ 1999
Agricultural University. Promotor(en): B. Brunekreef; D.S. Postma, co-promotor(en): G. Hoek. - S.l. : S.n. - ISBN 9789058081018 - 193
luchtverontreiniging - winter - nederland - ademhaling - fysiologie - air pollution - winter - netherlands - respiration - physiology

In this thesis, acute respiratory health effects of exposure to winter air pollution are investigated in panels of children (7-11 yr) and adults (50-70 yr) with and without chronic respiratory symptoms, living in urban and non-urban areas in the Netherlands. The study was performed during three consecutive winters starting in 1992/1993. Each winter, subjects performed twice daily measurements of Peak Expiratory Flow (PEF) and registered the occurrence of respiratory symptoms and medication use in a diary. Air pollution concentrations were measured daily in both areas.

The contrast in the concentrations of particulate air pollutants (PM 10 , Black Smoke and sulfate) between urban andnon-urban areas was small, but there was more contrast in the concentrations of the gaseous pollutants SO 2 and NO 2 .

In symptomatic children from both areas, significant associations were observed between PM 10 , Black Smoke (BS) and sulfate concentrations and the prevalence of lower respiratory symptoms (LRS) and PEF decrements. Particle concentrations were also associated with bronchodilator use in the urban areas, but not in the non-urban areas. However, differences in use of maintenace medication might be responsible for this. In non-symptomatic children, significant associations were observed between PM 10 and BS concentration and the prevalence of PEF decrements, but of smaller magnitude than for symptomatic children. No associations with respiratory symptoms were observed.

In symptomatic adults living in urban areas, PM 10 , BS, sulfate and SO 2 concentrations were associated with the prevalence of decrements in morning PEF, but not in evening PEF. Although especially BS was also associated with upper respiratory symptoms, particle concentrations were not associated with LRS or bronchodilator use. In symptomatic subjects living in non-urban areas, and in non-symptomatic adults from both urban and non-urban areas, no consistent associations between air pollution concentrations and indicators of respiratory health iwere found.

Separate analyses in children, based on the presence/absence of objective medical characteristics showed that PM 10 was most cocnsistently associated with respiratory health indicators in symptomatic children who had either high total serum IgE level or a positive skin prick test.

In conclusion, low levels of particulate air pollution were associated with adverse effects on respiratory health in 7-11 yr children, while in 50-70 year old symptomatic adults only a weak effect was found. Although there was a tendency of more consistent particle effects in the urban panels, the differences with the non-urban panels were small and might reflect differences in asthma medication use.

Traffic related air pollution in city districts near motorways
Roorda-Knape, M.C. ; Janssen, N.A.H. ; Hartog, J. de; Vliet, P.H.N. van; Harssema, H. ; Brunekreef, B. - \ 1999
Science of the Total Environment 235 (1999). - ISSN 0048-9697 - p. 339 - 341.
Inhomogeneity in response to air pollution in European children (PEACE project)
Roemer, W. ; Clench-Aas, J. ; Englert, N. ; Hoek, G. ; Katsouyanni, K. ; Pekkanen, J. ; Brunekreef, B. - \ 1999
Occupational and Environmental Medicine 56 (1999). - ISSN 1351-0711 - p. 86 - 92.
Personal exposure to fine particles in children correlates closely with ambient fine particles
Janssen, N.A.H. ; Hoek, G. ; Harssema, H. ; Brunekreef, B. - \ 1999
Archives of Environmental Health 56 (1999). - ISSN 0003-9896 - p. 482 - 487.
Mass concentration and elemental composition of PM10 in class rooms
Janssen, N.A.H. ; Hoek, G. ; Brunekreef, B. ; Harssema, H. - \ 1999
Occupational and Environmental Medicine 54 (1999)2. - ISSN 1351-0711 - p. 482 - 487.
Self-reporting versus parental reporting of acute respiratory symptoms of children and their relation to pulmonary function and air pollution
Hoek, G. ; Wypii, D. ; Brunekreef, B. - \ 1999
International Journal of Epidemiology 28 (1999). - ISSN 0300-5771 - p. 293 - 299.
Modulation of the acute respiratory effects of winter air pollution by serum and dietary antioxidants : a panel study
Grievink, L. ; Zee, S.C. van der; Hoek, G. ; Boezen, H.M. ; Veer, P. van 't; Brunekreef, B. - \ 1999
European Respiratory Journal 13 (1999). - ISSN 0903-1936 - p. 1439 - 1446.
Plasma concentrations of the antioxidants beta-carotene and alpha-tocopherol in relation to lung function
Grievink, L. ; Smit, H.A. ; Veer, P. van 't; Brunekreef, B. ; Kromhout, D. - \ 1999
European Journal of Clinical Nutrition 52 (1999). - ISSN 0954-3007 - p. 813 - 817.
Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements
Grievink, L. ; Zijlstra, A.G. ; Xiaodong, K. ; Brunekreef, B. - \ 1999
American Journal of Epidemiology 149 (1999). - ISSN 0002-9262 - p. 306 - 314.
Fungal extracellular polysaccharides in house dust as a marker for exposure to fungi : Relations with culturable fungi, reported home dampness and respiratory symptoms
Douwes, J. ; Sluis, B. van der; Doekes, G. ; Leusden, F. van; Wijnands, L. ; Strien, R. van; Verhoeff, A. ; Brunekreef, B. - \ 1999
Journal of Allergy and Clinical Immunology 103 (1999). - ISSN 0091-6749 - p. 494 - 500.
On eggs and chickens
Jongste, J.C. de; Brunekreef, B. - \ 1999
European Respiratory Journal 14 (1999). - ISSN 0903-1936 - p. 2 - 3.
Effects of house dust mite avoidance measures on Der p 1 concentrations and clinical conditions of mild adult housedustmite-allergic asthmatic patients, using no inhaled steroids
Cloosterman, S. ; Schermer, T. ; Bijl-Hofland, I. ; Heide, S. van der; Brunekreef, B. ; Elshout, F. van den; Herwaarden, C. ; Schayck, C.P. - \ 1999
Clinical and Experimental Allergy 29 (1999). - ISSN 0954-7894 - p. 1336 - 1346.
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