Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    The Maastricht-FFQ: Development and Validation of a Comprehensive Food Frequency Questionnaire for The Maastricht Study
    Dongen, Martien C.J.M. van; Wijckmans-Duysens, Nicole E.G. ; Biggelaar, Louise J.C.J. den; Ock, Marga C. ; Meijboom, S. ; Brants, H.A.M. ; Vries, J.H.M. de; Feskens, E.J.M. ; Bueno-de-Mesquita, H.B. ; Geelen, M.M.E.E. ; Stehouwer, C.D.A. ; Dagnelie, Pieter C. ; Eussen, Simone J.P.M. - \ 2019
    Nutrition 62 (2019). - ISSN 0899-9007
    Objective: To develop and validate a comprehensive food frequency questionnaire (FFQ) for The Maastricht Study, a population-based prospective cohort study in Maastricht, The Netherlands. Research Methods & Procedures: Item selection for the FFQ was based on explained variation and contribution to intake of energy and 24 nutrients. For validation, the FFQ was filled out by 135 participants (25-70 years) of the Nutrition Questionnaires plus study. Per person, on average 2.8 (range 1 to 5) telephone-based 24h dietary recalls (24hRs), two 24h urinary samples and one blood sample were available. Validity of 54 nutrients and 22 food groups was assessed by ranking agreement, correlation coefficients, attenuation factors, and ultimately de-attenuated correlation coefficients (validity coefficients). Results: Median correlation coefficients for energy and macronutrients, micronutrients and food groups were 0.45, 0.36 and 0.38, respectively. Median de-attenuated correlation coefficients were 0.53 for energy and macronutrients, 0.45 for micronutrients and 0.64 for food groups, being >0.50 for 18 out of 22 macronutrients and 16 out of 30 micronutrients, and >0.50 for 17 out of 22 food groups. The FFQ underestimated protein and potassium intake compared to 24h urinary nitrogen and potassium excretion by -18% and -2%, respectively. Correlation coefficients ranged from 0.50 and 0.55 for (fatty) fish intake and plasma EPA and DHA, and from 0.26-0.42 between fruit and vegetable intake and plasma carotenoids. Conclusion: Overall, the validity of the 253-item Maastricht-FFQ is good. The comprehensiveness of this FFQ make it well-suited for use in The Maastricht Study and similar populations.
    Gut Microbiota and Body Weight in School-Aged Children : The KOALA Birth Cohort Study
    Mbakwa, Catherine A. ; Hermes, Gerben D.A. ; Penders, John ; Savelkoul, Paul H.M. ; Thijs, Carel ; Dagnelie, Pieter C. ; Mommers, Monique ; Zoetendal, Erwin G. ; Smidt, Hauke ; Arts, Ilja C.W. - \ 2018
    Obesity 26 (2018)11. - ISSN 1930-7381 - p. 1767 - 1776.

    Objective: This study aimed to examine the intestinal microbiota composition of school-aged children in association with (over)weight. Methods: The fecal microbiota composition of 295 children was analyzed using the Human Intestinal Tract Chip. Anthropometric outcomes (overweight [BMI ≥ 85th percentile], age- and sex-standardized BMI and weight z scores) were measured at 6 to 7 years of age, and elastic net was used to select genus-like bacterial groups related to all anthropometric outcomes. Subsequently, multiple linear and logistic regression models were used to model associations between selected bacterial groups and anthropometric measures while controlling for confounders. Results: Prevotella melaninogenica, Prevotella oralis, Dialister, and uncultured Clostridiales II (UCII) accounted for 26.1% of the variation in microbiota composition. Several bacterial groups were inversely associated with the anthropometric outcomes: Sutterella wadsworthensis, Marvinbryantia formatexigens, Prevotella melanogenica, P oralis, Burkholderia, uncultured Clostridiales II, and Akkermansia, while Streptococcus bovis was positively associated with overweight. Microbial diversity and richness, and Bacteroidetes to Firmicutes ratio, were not significantly associated with any of the outcomes. Conclusions: In the largest population-based study on childhood gut microbiota and body weight so far, both new and previously identified bacterial groups were found to be associated with overweight. Further research should elucidate their role in energy metabolism.

    A national FFQ for the Netherlands (the FFQ-NL1.0): development and compatibility with existing Dutch FFQs
    Eussen, Simone ; Dongen, M.C.J.M. van; Wijckmans, N.E. ; Meijboom, S. ; Brants, H.A.M. ; Vries, J.H.M. de; Bueno-de-Mesquita, H.B. ; Geelen, M.M.E.E. ; Sluik, D. ; Feskens, E.J.M. ; Ocke, M.C. ; Dagnelie, P.C. - \ 2018
    Public Health Nutrition 21 (2018)12. - ISSN 1368-9800 - p. 2221 - 2229.
    Objective In the Netherlands, various FFQs have been administered in large cohort studies, which hampers comparison and pooling of dietary data. The present study aimed to describe the development of a standardized Dutch FFQ, FFQ-NL1.0, and assess its compatibility with existing Dutch FFQs. Design Dutch FFQTOOLTM was used to develop the FFQ-NL1.0 by selecting food items with the largest contributions to total intake and explained variance in intake of energy and thirty-nine nutrients in adults aged 25–69 years from the Dutch National Food Consumption Survey (DNFCS) 2007–2010. Compatibility with the Maastricht-FFQ, Wageningen-FFQ and EPICNL-FFQ was assessed by comparing the number of food items, the covered energy and nutrient intake, and the covered variance in intake. Results FFQ-NL1.0 comprised 160 food items, v. 253, 183 and 154 food items for the Maastricht-FFQ, Wageningen-FFQ and EPICNL-FFQ, respectively. FFQ-NL1.0 covered ≥85 % of energy and all nutrients reported in the DNFCS. Covered variance in intake ranged from 57 to 99 % for energy and macronutrients, and from 45 to 93 % for micronutrients. Differences between FFQ-NL1.0 and the other FFQs in covered nutrient intake and covered variance in intake were <5 % for energy and all macronutrients. For micronutrients, differences between FFQ-NL and other FFQs in covered level of intake were <15 %, but differences in covered variance were much larger, the maximum difference being 36 %. Conclusions The FFQ-NL1.0 was compatible with other FFQs regarding energy and macronutrient intake. However, compatibility for covered variance of intake was limited for some of the micronutrients. If implemented in existing cohorts, it is advised to administer the old and the new FFQ in combination to derive calibration factors.
    A systematic review of methods to assess intake of fruits and vegetables among healthy European adults and children : a DEDIPAC (DEterminants of DIet and Physical Activity) study
    Riordan, Fiona ; Ryan, Kathleen ; Perry, Ivan J. ; Schulze, Matthias B. ; Andersen, Lene Frost ; Geelen, Anouk ; van’t Veer, Pieter ; Eussen, Simone ; Dagnelie, Pieter ; Wijckmans-Duysens, Nicole ; Harrington, Janas M. - \ 2017
    Public Health Nutrition 20 (2017)3. - ISSN 1368-9800 - p. 417 - 448.
    DEDIPAC - Dietary assessment - Europe - Fruits and vegetables

    Objective: Evidence suggests that health benefits are associated with consuming recommended amounts of fruits and vegetables (F&V), yet standardised assessment methods to measure F&V intake are lacking. The current review aims to identify methods to assess F&V intake among children and adults in pan-European studies and inform the development of the DEDIPAC (DEterminants of DIet and Physical Activity) toolbox of methods suitable for use in future European studies. Design: A literature search was conducted using three electronic databases and by hand-searching reference lists. English-language studies of any design which assessed F&V intake were included in the review. Setting: Studies involving two or more European countries were included in the review. Subjects: Healthy, free-living children or adults. Results: The review identified fifty-one pan-European studies which assessed F&V intake. The FFQ was the most commonly used (n 42), followed by 24 h recall (n 11) and diet records/diet history (n 7). Differences existed between the identified methods; for example, the number of F&V items on the FFQ and whether potatoes/legumes were classified as vegetables. In total, eight validated instruments were identified which assessed F&V intake among adults, adolescents or children. Conclusions: The current review indicates that an agreed classification of F&V is needed in order to standardise intake data more effectively between European countries. Validated methods used in pan-European populations encompassing a range of European regions were identified. These methods should be considered for use by future studies focused on evaluating intake of F&V.

    The cross-sectional association between uric acid and atherosclerosis and the role of low-grade inflammation: the CODAM study
    Wijnands, J.M.A. ; Boonen, A. ; Dagnelie, P.C. ; Greevenbroek, M.M.J. van; Kallen, C.J.H. van der; Ferreira, I. ; Schalkwijk, C.G. ; Feskens, E.J.M. ; Stehouwer, C.D.A. ; Linden, S. van der; Arts, I.C.W. - \ 2014
    RHEUMATOLOGY 53 (2014)11. - ISSN 1462-0324 - p. 2053 - 2062.
    peripheral arterial-disease - c-reactive protein - type-2 diabetes-mellitus - nitric-oxide production - metabolic syndrome - carotid atherosclerosis - cardiovascular-disease - hypertensive patients - risk-factor - subclinical atherosclerosis
    Objectives. The aims of this study were to investigate (i) associations between uric acid and prevalent cardiovascular disease (CVD), ankle-arm blood pressure index (AAIx) and carotid intima-media thickness (CIMT) in the total population and in predefined subgroups according to glucose metabolism status and (ii) the extent to which these associations are explained by low-grade inflammation. Methods. Cross-sectional analyses were conducted among 530 individuals [60.6% men, mean age 58.9 years (S. D. 6.9), 52.6% normal glucose metabolism (NGM)] at increased risk of CVD from the Cohort of Diabetes and Atherosclerosis Maastricht study. A low-grade inflammation score was computed by averaging the z-scores of eight inflammation markers [CRP, TNF-alpha, IL-6, IL-8, serum amyloid A, intercellular adhesion molecule 1 (ICAM-1), ceruloplasmin and haptoglobin]. Results. After adjustment for traditional CVD risk factors, plasma uric acid (per S. D. of 81 mu mol/l) was associated with CVD in individuals with NGM [odds ratio (OR) = 1.66, 95% CI 1.06, 2.58] but not with disturbed glucose metabolism (DGM) (OR = 0.81, 95% CI 0.55, 1.19, P interaction = 0.165). Uric acid was associated with CIMT in the total population (beta = 0.024, 95% CI 0.007, 0.042) and slightly more strongly in individuals with NGM (beta = 0.030, 95% CI 0.006, 0.054) than DGM (beta = 0.018, 95% CI -0.009, 0.044, P interaction = 0.443). There was no association between uric acid and AAIx in any group (P interaction = 0.058). Uric acid was associated with low-grade inflammation in the total population (beta = 0.074, 95% CI 0.013, 0.134, P interaction = 0.737). Adding low-grade inflammation to the models did not attenuate any of the associations. Conclusion. The associations for uric acid with CIMT, and with CVD in NGM only, were not explained by low-grade inflammation. A difference in the strength of the associations between individuals with NGM and DGM was suggested.
    Complement C3 is inversely associated with habitual intake of provitamin A but not with dietary fat, fatty acids, or vitamin E in Middle-aged to older white adults and positively associated with intake of retinol in middle-aged to older white women
    Greevenbroek, M.M. ; Arts, I.C.W. ; Kallen, C.J.H. van der; Dagnelie, P.C. ; Ferreira, I. ; Jansen, G.H.E. ; Schalkwijk, C.G. ; Feskens, E.J.M. ; Stehouwer, C.D.A. - \ 2014
    The Journal of Nutrition 144 (2014)1. - ISSN 0022-3166 - p. 61 - 67.
    population-based cohort - myocardial-infarction - a supplementation - serum c3 - insulin-resistance - relative validity - immune-system - disease - risk - protein
    Complement factor 3 (C3) has been identified as a novel risk factor for obesity-associated cardiometabolic diseases. Data in the literature suggest that C3 concentrations may be influenced by diet. Therefore, we investigated the associations of intake of total fat, specific fatty acids, and fat-soluble vitamin E (and individual tocopherols) and vitamin A (and its dietary precursors) with circulating C3. In a white cohort [Cohort on Diabetes and Atherosclerosis Maastricht (CODAM)]; n = 501; 59.4 ± 7.1 y; 61% men], associations of habitual nutrient intake (assessed by a food-frequency questionnaire) with circulating C3 were evaluated by using cross-sectional multiple linear regression analyses. Adjustments were first performed for age, sex, glucose metabolism status (i.e., impaired glucose metabolism or type 2 diabetes), and energy intake and subsequently for BMI, waist circumference, alcohol intake, smoking behavior, and season of blood collection. No associations with C3 were observed for total dietary fat intake or intake of specific fatty acids [saturated, monounsaturated, polyunsaturated, n–6 (¿6), and n–3 (¿3) fatty acids], vitamin E, or individual tocopherols. We observed an inverse association with intake of provitamin A carotenoids a-carotene (in µg/d; regression coefficient ß = -0.075; 95% CI: -0.140, -0.010; P = 0.025) and ß-carotene (in µg/d; ß = -0.021; 95% CI: -0.044, 0.002; P = 0.068) with C3 (in mg/L). In contrast, and only in women, dietary retinol intake (in µg/d) was positively associated with C3 (ß = 0.116; 95% CI: 0.014, 0.218; P = 0.026; n = 196). In conclusion, these data suggest that fasting concentrations of C3 may, in a complex manner, be modifiable by variation in dietary provitamin A carotenoids and/or retinol content of the usual diet but most likely not by variations in fat composition and vitamin E content.
    Adenosine 5 '-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans
    Arts, I.C.W. ; Coolen, E.J.C.M. ; Bours, M.J.L. ; Huyghebaert, N. ; Cohen Stuart, M.A. ; Bast, A. ; Dagnelie, P.C. - \ 2012
    Journal of the International Society of Sports Nutrition 9 (2012). - ISSN 1550-2783
    low-back-pain - uric-acid - nucleoside transporters - cancer-patients - small-intestine - crohns-disease - nucleotide - triphosphate - transit - urate
    Background: Nutritional supplements designed to increase adenosine 5'-triphosphate (ATP) concentrations are commonly used by athletes as ergogenic aids. ATP is the primary source of energy for the cells, and supplementation may enhance the ability to maintain high ATP turnover during high-intensity exercise. Oral ATP supplements have beneficial effects in some but not all studies examining physical performance. One of the remaining questions is whether orally administered ATP is bioavailable. We investigated whether acute supplementation with oral ATP administered as enteric-coated pellets led to increased concentrations of ATP or its metabolites in the circulation. Methods: Eight healthy volunteers participated in a cross-over study. Participants were given in random order single doses of 5000 mg ATP or placebo. To prevent degradation of ATP in the acidic environment of the stomach, the supplement was administered via two types of pH-sensitive, enteric-coated pellets (targeted at release in the proximal or distal small intestine), or via a naso-duodenal tube. Blood ATP and metabolite concentrations were monitored by HPLC for 4.5 h (naso-duodenal tube) or 7 h (pellets) post-administration. Areas under the concentration vs. time curve were calculated and compared by paired-samples t-tests. Results: ATP concentrations in blood did not increase after ATP supplementation via enteric-coated pellets or naso-duodenal tube. In contrast, concentrations of the final catabolic product of ATP, uric acid, were significantly increased compared to placebo by similar to 50% after administration via proximal-release pellets (P = 0.003) and naso-duodenal tube (P = 0.001), but not after administration via distal-release pellets. Conclusions: A single dose of orally administered ATP is not bioavailable, and this may explain why several studies did not find ergogenic effects of oral ATP supplementation. On the other hand, increases in uric acid after release of ATP in the proximal part of the small intestine suggest that ATP or one of its metabolites is absorbed and metabolized. Uric acid itself may have ergogenic effects, but this needs further study. Also, more studies are needed to determine whether chronic administration of ATP will enhance its oral bioavailability.
    Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils
    Bartholomé, R. ; Haenen, G. ; Hollman, P.C.H. ; Bast, A. ; Dagnelie, P.C. ; Roos, D. ; Keijer, J. ; Kroon, P.A. ; Needs, P.W. ; Arts, I.C.W. - \ 2010
    Drug Metabolism and Pharmacokinetics 25 (2010)4. - ISSN 1347-4367 - p. 379 - 387.
    quercetin glucuronides - grain dust - inflammation - dietary - ph - tissue - cells - fluid - quercetin-4'-glucoside - quercetin-3-glucoside
    Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides. We have studied deconjugation kinetics and pH optimum for four sources of ß-glucuronidase (human neutrophil, human recombinant, myeloid PLB-985 cells, Helix pomatia) with five flavonoid glucuronides (quercetin-3-glucuronide, quercetin-3'-glucuronide, quercetin-4'-glucuronide, quercetin-7-glucuronide, 3'-methylquercetin-3-glucuronide), 4-methylumbelliferyl-ß-D-glucuronide, and para-nitrophenol-glucuronide. All substrate-enzyme combinations tested exhibited first order kinetics. The optimum pH for hydrolysis was between 3.5-5, with appreciable hydrolysis activities up to pH 5.5. At pH 4, the Km ranged 44-fold from 22 µM for quercetin-4'-glucuronide with Helix pomatia ß-glucuronidase, to 981 µM for para-nitrophenol-glucuronide with recombinant ß-glucuronidase. Vmax (range: 0.735-24.012 µmol·min-1·unit-1 [1 unit is defined as the release of 1 µM 4-methylumbelliferyl-ß-D-glucuronide per min]) and the reaction rate constants at low substrate concentrations (k) (range: 0.002-0.062 min-1·(unit/L)-1 were similar for all substrates-enzyme combinations tested. In conclusion, we show that ß-glucuronidase from four different sources, including human neutrophils, is able to deconjugate flavonoid glucuronides and non-flavonoid substrates at fairly similar kinetic rates. At inflammatory sites in vivo the pH, neutrophil and flavonoid glucuronide concentrations seem favorable for deconjugation. However, it remains to be confirmed whether this is actually the case.
    Selecting informative food items for compiling food-frequency questionnaires: comparison of procedures
    Molag, M.L. ; Vries, J.H.M. de; Duif, N. ; Ocke, M.C. ; Dagnelie, P.C. ; Goldbohm, R.A. ; Veer, P. van 't - \ 2010
    The British journal of nutrition 104 (2010)3. - ISSN 0007-1145 - p. 446 - 456.
    validation - health - diet - consumption - validity
    The authors automated the selection of foods in a computer system that compiles and processes tailored FFQ. For the selection of food items, several methods are available. The aim of the present study was to compare food lists made by MOM2, which identifies food items with highest between-person variance in intake of the nutrients of interest without taking other items into account, with food lists made by forward regression. The name MOM2 refers to the variance, which is the second moment of the nutrient intake distribution. Food items were selected for the nutrients of interest from 2 d of recorded intake in 3524 adults aged 25–65 years. Food lists by 80 % MOM2 were compared to those by 80 % explained variance for regression on differences between the number and type of food items, and were evaluated on (1) the percentage of explained variance and (2) percentage contribution to population intake computed for the selected items on the food list. MOM2 selected the same food items for Ca, a few more for fat and vitamin C, and a few less for carbohydrates and dietary fibre than forward regression. Food lists by MOM2 based on 80 % of variance in intake covered 75–87 % of explained variance for different nutrients by regression and contributed 53–75 % to total population intake. Concluding, for developing food lists of FFQ, it appears sufficient to select food items based on the contribution to variance in nutrient intake without taking covariance into account
    Simultaneous determination of adenosine triphosphate and its metabolites in human whole blood by RP-HPLC and UV detection
    Coolen, E.J.C.M. ; Arts, I.C.W. ; Swennen, E.L.R. ; Bast, A. ; Cohen Stuart, M.A. ; Dagnelie, P.C. - \ 2008
    Journal of Chromatography. B, Analytical technologies in the biomedical and life sciences 864 (2008)1-2. - ISSN 1570-0232 - p. 43 - 51.
    performance liquid-chromatography - myocardial adenine-nucleotides - reversed-phase - xanthine-oxidase - in-vitro - degradation products - creatine-phosphate - human-erythrocytes - purine metabolism - extracellular atp
    To obtain insight in mechanisms of action of extracellular adenosine triphosphate (ATP) and adenosine, a simple HPLC method has been optimized and applied to investigate ATP metabolism in human whole blood ex vivo. This method provided good chromatographic resolution and peak shape for all eight compounds within a 19 min run time. The baseline was clean, the lower limit of quantification was below 0.3 micromol/L for all adenine nucleotides and the method demonstrated good linearity. Within-day precision ranged from 0.7 to 5.9% and between-days from 2.6 to 15.3%. Simplicity and simultaneous detection of ATP and its metabolites make this method suitable for clinical pharmacokinetic studies.
    Design characteristics of food frequency questionnaires in relation to their validity
    Molag, M.L. ; Vries, J.H.M. de; Ocke, M.C. ; Dagnelie, P.C. ; Brandt, P.A. van den; Jansen, M.C.J.F. ; Staveren, W.A. van; Veer, P. van 't - \ 2007
    In: WEON 2007: Methodologische uitdagingen in cohortonderzoek, Maastricht, The Netehrlands, 21 - 22 June, 2007. - - p. 104 - 104.
    Design Characteristics of Food Frequency Questionnaires in Relation to Their Validity
    Molag, M.L. ; Vries, J.H.M. de; Ocke, M.C. ; Dagnelie, P.C. ; Brandt, P.A. van den; Jansen, S.C. ; Staveren, W.A. van; Veer, P. van 't - \ 2007
    American Journal of Epidemiology 166 (2007)12. - ISSN 0002-9262 - p. 1468 - 1478.
    dietary assessment methods - doubly-labeled water - energy-intake - nutrient intake - assessment instruments - history questionnaire - biochemical markers - urinary nitrogen - weighed records - womens health
    The authors investigated the role of food frequency questionnaire (FFQ) design, including length, use of portion-size questions, and FFQ origin, in ranking subjects according to their nutrient intake. They also studied the ability of the FFQ to detect differences in energy intake between subgroups and to assess energy and protein intake. In a meta-analysis of 40 validation studies, FFQs with longer food lists (200 items) were better than shorter FFQs at ranking subjects for most nutrients; results were statistically significant for protein, energy-adjusted total fat, and energy-adjusted vitamin C. The authors found that FFQs that included standard portions had higher correlation coefficients for energy-adjusted vitamin C (0.80 vs. 0.60, p <0.0001) and protein (0.69 vs. 0.61, p = 0.03) than FFQs with portion-size questions. However, it remained difficult from this review to analyze the effects of using portion-size questions. FFQs slightly underestimated gender differences in energy intake, although level of energy intake was underreported by 23% and level of protein intake by 17%. The authors concluded that FFQs with more items are better able to rank people according to their intake and that they are able to distinguish between subpopulations, even though they underestimated the magnitude of these differences.
    Effect of increase vegetable and fruit consumption on plasma folate and homocysteine concentrations
    Bogers, R.P. ; Dagnelie, P.C. ; Bast, A. ; Leeuwen, M. van; Klaveren, J.D. van; Brandt, P.A. van den - \ 2007
    Nutrition 23 (2007)2. - ISSN 0899-9007 - p. 97 - 102.
    folic-acid - controlled-trial - dietary-folate - heart-disease - metaanalysis - humans - bioavailability - questionnaire - carotenoids - validity
    OBJECTIVE: We assessed the effects of an intervention aimed at increasing the consumption of fruits and vegetables on plasma folate and homocysteine concentrations. METHODS: Seventy-one healthy non-smoking women (mean +/- SD 41 +/- 4 y of age) were randomized to an intervention or a control group. Participants in the intervention group (n = 36) received weekly packets containing fruits and vegetables free of charge and were asked to consume a daily amount of >/=200 g of vegetables and two pieces of fruit (the Dutch recommended intake level) over a period of 1 mo. Control subjects did not receive any intervention. RESULTS: Compared with the control group, reported fruit and vegetable intakes in the intervention group increased by 133 g/d (95% confidence interval [CI] 87-179, P <0.001) for fruits and juice and 64 g/d (95% CI 37-91, P <0.001) for vegetables and estimated folate intake from fruits and vegetables increased by 40 mug/d (95% CI 22-58, P <0.001). However, no effect was observed on plasma folate concentrations (intervention effect 0.3 nmol/L, 95% CI -1.8 to 2.8, P = 0.77) or homocysteine concentrations (intervention effect 0.26 mumol/L, 95% CI -0.34 to 0.87, P = 0.39). CONCLUSION: The results suggest that 4 wk of increased fruit and vegetable consumption to the recommended amounts may be insufficient to change plasma folate and homocysteine concentrations.
    Fruit consumption of boys (8-11 years) is related to preferences for sour taste
    Liem, D.G. ; Bogers, R.P. ; Dagnelie, P.C. ; Graaf, C. de - \ 2006
    Appetite 46 (2006)1. - ISSN 0195-6663 - p. 93 - 96.
    food preferences - vegetable intake - young-children - mothers - predictors - behavior - sweet
    The present study investigated whether the most preferred balance between sweet and sour taste of children (n = 50, 9.2 +/- 0.9 yrs of age) are related to their consumption of fruit. Taste preferences were measured with a rank-by-elimination procedure with seven sweet orangeades that differed in added citric acid (i.e. 0.009-0.065 M). Fruit consumption was assessed with a questionnaire that was completed by the children's parents. Results showed that boys' but not girls' most preferred balance between sweet and sour taste was positively correlated with their consumption of fruit: that is, the more added citric acid was preferred the more fruit was consumed. We conclude that preference for high concentrations of citric acid in a sweet context may be associated with the consumption of fruit in boys. In girls, the optimal balance between sweet and sour taste seems to be of less importance; their consumption of fruit may be more influenced by their parents, availability and health related motives. (c) 2005 Published by Elsevier Ltd.
    The influence of design characteristics of food frequency questionnaires in their validity to assess energy intake
    Molag, M.L. ; Vries, J.H.M. de; Veer, P. van 't; Brandt, P.A. van den; Dagnelie, P. ; Ocke, M.C. ; Jansen, M.C.J.F. ; Staveren, W.A. van - \ 2006
    European Journal of Epidemiology 21 (2006)suppl. 13. - ISSN 0393-2990 - p. 91 - 91.
    Using a correction factor to correct for overreporting in a food-frequency questionnaire does not improve biomarker-assessed validity of estimates for fruit and vegetable consumption
    Bogers, R.P. ; Dagnelie, P.C. ; Westerterp, K.R. ; Kester, A.D.M. ; Klaveren, J.D. van; Bast, A. ; Brandt, P.A. van den - \ 2003
    The Journal of Nutrition 133 (2003)4. - ISSN 0022-3166 - p. 1213 - 1219.
    plasma carotenoid concentrations - performance liquid-chromatography - dietary-intake - cardiovascular-disease - composition database - prospective cohort - cancer prevention - beta-carotene - breast-cancer - womens health
    To correct for overreporting of fruit and vegetable (FV) consumption in a food-frequency questionnaire, summary questions about consumption of main FV groups are often used to calculate correction factors. This study compared the ability to rank people according to their FV intake of those summary questions and the sum of questions on individual FV items within categories, and of corrected or uncorrected estimates of specific sorts of FV. Healthy middle-age women (n = 161) completed a food-frequency questionnaire about FV consumption during the previous month and gave a single fasting blood sample. Correction factors were calculated as the reported frequency on a summary question divided by the summed frequencies of all items in a category. Plasma carotenoids and vitamin C served as biomarkers of FV consumption. Significant correlations between FV consumption and biomarkers were observed (e.g., Spearman's correlation coefficient r with total carotenoids/vitamin C: 0.32/0.34 for vegetables, 0.30/0.25 for fruits). Summary estimates of cooked, raw and total vegetable consumption correlated higher with biomarkers than sum estimates. For fruits no differences in correlations between sum and summary estimates were observed. Applying a correction factor on the consumption of carrots and total cabbage resulted in lower correlations with relevant biomarkers. For broccoli/cauliflower, Brussels sprouts and citrus fruits, correlations with biomarkers did not change after correction. We conclude that summary questions may suffice to rank individuals according to their intake of main FV categories, and that correction for overreporting of individual FV items is probably not advisable when ranking individuals according to intake of these items.
    Alternative Foods
    Staveren, W.A. van; Dagnelie, P.C. - \ 1999
    In: International food safety handbook New York : Marcel Dekker - p. 203 - 212.
    Balancieren zwischen zuviel und zuwenig: Nahrstoffmangel und Aufholwachstum bei vegetarisch ernahrten Kindern.
    Dagnelie, P.C. ; Dusseldorp, M. van - \ 1998
    Erfahrungsheilkunde Acta Medica Empirica 8 (1998). - p. 477 - 484.
    Diet and growth in young vegetarians.
    Dusseldorp, M. van; Dagnelie, P.C. ; Staveren, W.A. van - \ 1996
    In: 'Feeding from toddlers to adolescence' / Ballabriga, A., - p. 209 - 220.
    Growth and nutritional status of macrobiotically fed children until 10 years of age.
    Jong, N. de; Dusseldorp, M. van; Bergsma, J.S. ; Arts, I.C.W. ; Dagnelie, P.C. ; Staveren, W.A. van - \ 1996
    Aktuelle Ernährungsmedizin 21 (1996)1. - ISSN 0341-0501 - p. 14 - 15.
    This is a review of a cross-sectional study and of a follow-up on food consumption, growth and development of Dutch children fed a macrobiotic diet. Anthropometric measurements and food frequency data were collected in 1985 and again in 1987. The children were at the time of data collection: 0-8 years and 2-10 years of age, respectively. Growth retardation was observed from the age of 6 months onwards. Five to six months before the follow-up took place, it was recommended to consume more dairy products, fish and fat. No catch-up growth was observed in the follow-up study, except for those who mean-while increased their consumption of dairy products and fish. In 1993 a second follow-up was performed.
    Catch-up growth in children fed a macrobiotic diet in early childhood.
    Dusseldorp, M. van; Arts, I.C.W. ; Bergsma, J.S. ; Jong, N. de; Dagnelie, P.C. ; Staveren, W.A. van - \ 1996
    The Journal of Nutrition 126 (1996)12. - ISSN 0022-3166 - p. 2977 - 2983.
    Macrobiotic nutrition and child health: results of a population-based, mixed-longitudinal cohort study in The Netherlands.
    Dagnelie, P.C. ; Staveren, W.A. van - \ 1994
    American Journal of Clinical Nutrition 59 (1994). - ISSN 0002-9165 - p. 1187S - 1196S.
    Effects of macrobiotic diets on linear growth in infants and children until 10 years of age.
    Dagnelie, P.C. ; Dusseldorp, M. van; Staveren, W.A. van; Hautvast, J.G.A.J. - \ 1994
    European Journal of Clinical Nutrition 48 (1994)suppl.1. - ISSN 0954-3007 - p. S103 - S112.
    Methylmalonic acid and homocysteine in plasma as indicators of functional cobalamin deficiency in infants on macrobiotic diets.
    Schneede, J. ; Dagnelie, P.C. ; Staveren, W.A. van; Vollset, S.E. ; Refsum, H. ; Ueland, P.M. - \ 1994
    Pediatric Research 36 (1994). - ISSN 0031-3998 - p. 194 - 201.
    Acceptatie van voedingsadviezen door Nederlandse macrobiotische gezinnen en groeisnelheid van macrobiotisch gevoede kinderen tot en met 9 jaar.
    Smeets, F.W.M. ; Dagnelie, P.C. ; Staveren, W.A. van; Kuik, M.J.J.A. ; Matze, M. ; Schlatmann, A.M. - \ 1992
    Tijdschrift voor sociale gezondheidszorg 70 (1992). - ISSN 0920-0517 - p. 227 - 233.
    Nutrition and mental development of 4-5-year old children on macrobiotic diets.
    Herens, M.C. ; Dagnelie, P.C. ; Kleber, R.J. ; Mol, M.C. ; Staveren, W.A. van - \ 1992
    Journal of Human Nutrition and Dietetics 5 (1992)1. - ISSN 0952-3871 - p. 1 - 9.
    Mental development of 4–5-year old children on macrobiotic diets (almost devoid of animal foods and fat) with long-term growth deficits, was studied using the Snijders-Oomen Non-verbal Intelligence (SON) scale. In addition, food consumption and behavioural style of the children, and family and parent characteristics were assessed. Parents were highly educated: 69% of the fathers and 47% of the mothers had completed college or university education. The children's energy intake was only 70% and calcium intake 40% of that reported for children of similar age on conventional diets. Fifteen out of 44 children (33%) did not complete the SON-test, mainly due to difficulties in concentration. The non-completers tended to score lower on parts of the SON-test and the educational level of their fathers was slightly lower: no other differences were observed. Intelligence quotients (IQ) of the children who completed the test were high (IQ=126) compared to the reference population (IQ= 100 by definition). No significant relationship between IQ's and educational level of parents was observed, possibly due to lack of varation in educational level within the study population. Family size was inversely related with IQ. It was concluded that long-standing mild to moderate malnutrition may not affect mental development in pre-school children if the children grow up in a stimulating social environment.
    Nutrients and contaminants in human milk from mothers on macrobiotic and omnivorous diets.
    Dagnelie, P.C. ; Staveren, W.A. van; Roos, A.H. ; Tuinstra, L.G.M.Th. ; Burema, J. - \ 1992
    European Journal of Clinical Nutrition 45 (1992). - ISSN 0954-3007 - p. 355 - 366.
    Stunting and nutrient deficiences in children on alternative diets.
    Dagnelie, P.C. ; Staveren, W.A. van; Hautvast, J.G.A.J. - \ 1991
    Acta pædiatrica Scandinavica 347 (1991). - p. 111 - 118.
    Vitamin B-12 from algae appears not to be bioavailable.
    Dagnelie, P.C. ; Staveren, W.A. van; Berg, H. van den - \ 1991
    American Journal of Clinical Nutrition 53 (1991)3. - ISSN 0002-9165 - p. 695 - 697.
    High prevalence of rickets in infants on macrobiotic diets.
    Dagnelie, P.C. ; Vergote, F.J.V.R.A. ; Staveren, W.A. van; Berg, H. van den; Dingjan, P.G. ; Hautvast, J.G.A.J. - \ 1990
    American Journal of Clinical Nutrition 51 (1990)2. - ISSN 0002-9165 - p. 202 - 208.
    Voedingsinterventie en follow-up-onderzoek bij macrobiotisch gevoede kinderen van 1 tot 2 jaar
    Dagnelie, P.C. ; Staveren, W.A. van; Vergote, F.J.V.R.A. ; Hautvast, J.G.A.J. - \ 1990
    Nederlands Tijdschrift voor Geneeskunde 134 (1990). - ISSN 0028-2162 - p. 341 - 345.
    Makrobiotische Kinderernährung.
    Dagnelie, P.C. - \ 1990
    Ernährungs-Umschau 37 (1990). - ISSN 0174-0008 - p. 194 - 201.
    Hematologische status van macrobiotisch en gangbaar gevoede kinderen van 10-20 maanden.
    Dagnelie, P.C. ; Staveren, W.A. van - \ 1989
    Voeding 49 (1989). - ISSN 0042-7926 - p. 158 - 159.
    Voedingstoestand en groei van macrobiotisch gevoede kinderen.
    Dagnelie, P.C. - \ 1989
    Tijdschrift voor Jeugdgezondheidszorg 21 (1989). - p. 42 - 44.
    Michio Kushi gooit roer om na onderzoek Wageningen.
    Dagnelie, P.C. - \ 1989
    Onkruid 60 (1989). - p. 57 - 61.
    Macrobiotische kindervoeding: op weg naar verandering.
    Dagnelie, P.C. - \ 1989
    Leven en Laten Leven 92 (1989). - p. 4 - 8.
    Macrobiotische kindervoeding. Helemaal zonder vet en dierlijke produkten kan het niet.
    Dagnelie, P.C. - \ 1989
    Medisch Contact 44 (1989)24. - ISSN 0025-8245 - p. 821 - 824.
    Macrobiotische kinderen micro?
    Dagnelie, P.C. - \ 1989
    Alternatieve Consumentengids 8 (1989). - p. 2 - 6.
    Ist die makrobiotische Ernährung kindergerecht?
    Dagnelie, P.C. - \ 1989
    Schrot und Kan 5 (1989). - p. 6 - 8.
    Nutritional status of infants aged 4 to 18 months on macrobiotic diets and matched omnivorous control infants: a population-based mixed longitudinal study. I. Weaning pattern, energy and nutrient intake.
    Dagnelie, P.C. ; Staveren, W.A. van; Verschuren, S.A.J.M. ; Hautvast, J.G.A.J. - \ 1989
    European Journal of Clinical Nutrition 43 (1989). - ISSN 0954-3007 - p. 311 - 323.
    Increased risk of vitamin B-12 and iron deficiency in infants on macrobiotic diets.
    Dagnelie, P.C. ; Staveren, W.A. van; Vergote, F.J.V.R.A. ; Dingjan, P.G. ; Berg, H. van den; Hautvast, J.G.A.J. - \ 1989
    American Journal of Clinical Nutrition 50 (1989)4. - ISSN 0002-9165 - p. 818 - 824.
    Nutritional status of infants aged 4 to 18 months on macrobiotic diets and matched omnivorous control infants: a population-based mixed-longitudinal study. II. Growth and psychomotor development.
    Dagnelie, P.C. ; Staveren, W.A. van; Vergote, F.J.V.R.A. ; Burema, J. ; Hof, M.A. van 't; Klaveren, J.D. van; Hautvast, J.G.A.J. - \ 1989
    European Journal of Clinical Nutrition 43 (1989). - ISSN 0954-3007 - p. 325 - 338.
    Do children on macrobiotic diets show catch-up growth? A population-based cross-sectional study in children aged 0-8 years.
    Dagnelie, P.C. ; Staveren, W.A. van; Klaveren, J.D. van; Burema, J. - \ 1988
    European Journal of Clinical Nutrition 42 (1988). - ISSN 0954-3007 - p. 1007 - 1016.
    Vitamin B12 and seaweed.
    Berg, H. van den; Dagnelie, P.C. ; Staveren, W.A. van - \ 1988
    The Lancet (1988). - ISSN 0140-6736 - p. 242 - 243.
    Food consumption, growth, and development of Dutch children fed on alternative diets.
    Staveren, W.A. van; Dagnelie, P.C. - \ 1988
    American Journal of Clinical Nutrition 48 (1988)3. - ISSN 0002-9165 - p. 819 - 821.
    Nutritional status and growth of children on macrobiotic diets : a population-based study
    Dagnelie, P.C. - \ 1988
    Agricultural University. Promotor(en): J.G.A.J. Hautvast; W.A. van Staveren. - S.l. : Dagnelie - 144
    kindervoeding - zuigelingenvoeding - biologische voedingsmiddelen - kinderen - zuigelingen - child nutrition - infant nutrition - organic foods - children - infants

    This thesis reports on the relationship between diet, growth, blood chemistry, psychomotor development, and clinical findings in the Dutch population of children on macrobiotic diets.- The macrobiotic diet mainly consisted of cereals, pulses and vegetables with small additions of seaweeds, fermented foods, nuts and seeds. meat and dairy products were avoided, whereas fish was occasionally being eaten but not by young children. The total Dutch macrobiotic population was invited to join the study; the refusal rate was below 5 per cent. A cross- sectional anthropometric study in macrobiotic children between birth and 8 years of age (n = 243) revealed that the age curves declined from the P50 of the Dutch standard mainly between 6 and 18 months of age. A partial return towards the P50 was observed after 2 years of age for weight and arm circumference, but not for height. A subsequent mixedlongitudinal study in macrobiotic infants aged 4 - 18 months and a matched omnivorous control group showed that growth of the macrobiotic infants was slowest between 8 and 14 months. This was attributed to a lack of both energy and protein in the macrobiotic weaning diet. The observed growth retardation was associated with retardation in gross motor and language development. For calcium, vitamin D, vitamin B12 and riboflavin, a low intake in combination with biochemical evidence of deficiency was found. Rickets was present in 28 per cent of macrobiotic infants in summer and 55 per cent in winter. AS a favourable aspect, lower levels of contaminants were found in the breast-milk of macrobiotic mothers. It is concluded that nutritional deficiencies are present in a high proportion of macrobiotic infants. Continued marginal deficiencies in older macrobiotic children seem to prevent catch-up growth in height. It is advised to adapt the macrobiotic diet as to include fatty fish (100 - 150 g/week), oil (20 - 25 g/day) and dairy products (one serving per day).

    Nutrition and mental development in macrobiotic children.
    Herens, M.C. ; Mol, M.C.J. ; Dagnelie, P.C. ; Kleber, R.J. ; Staveren, W.A. van - \ 1987
    In: Conf. Abstracts. Federation Eur. Nutrition Societies, Warschaw
    Groei en mentale ontwikkeling van macrobiotisch gevoede kinderen.
    Dagnelie, P.C. ; Staveren, W.A. van; Hautvast, J.G.A.J. ; Kleber, R.J. - \ 1987
    Tijdschrift voor sociale gezondheidszorg 65 (1987). - ISSN 0920-0517 - p. 190 - 190.
    Nutritional status of Dutch vegetarian children.
    Staveren, W.A. van; Dagnelie, P.C. - \ 1987
    In: Abstract Proc. First Int. Congr. Vegetarian Nutrition, Washington (1987)
    Nutrition and growth of macrobiotic children 4-18 months of age, a mixed longitudinal study.
    Dagnelie, P.C. ; Staveren, W.A. van; Hautvast, J.G.A.J. - \ 1987
    In: Fifth Eur. Nutrition Conf.: Nutrition sciences for human health, Abstracts, Warsaw - p. 124 - 124.
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