Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Stekende insecten Griendtsveen 2017 : notitie
    Verdonschot, Piet F.M. ; Dekkers, T.B.M. - \ 2018
    Wageningen : Zoetwaterecosystemen, Wageningen Environmental Research - ISBN 9789463432924 - 58
    De inventarisatie van steekmuglarven leverde in 2016 4 kleinere gebiedsdelen op met hoge aantallen steekmuglarven (de zogenaamde ‘hotspots’). In april-mei 2017 is de larveninventarisatie herhaald. Hieruit bleek dat de larven van de moerassteekmug A. cinereus over het gehele gebied verspreid zijn met op de ‘hotspots’ opnieuw hoogste aantallen. In de periode daarna vielen de meeste locaties droog. Het jaar 2017 was een droog jaar waarbij al vroeg in het voorjaar, mogelijk zelfs in de winter, veel potentiële tijdelijke wateren al droog stonden. Het patroon van ontwikkeling van volwassen steekmuggen liet over 2017 een ‘klassiek’ beeld van een moerassteekmuggenpopulatie zien met hoge aantallen in het voorjaar die daarna snel uitdoven. Alleen in juni trad additioneel een kleine populatie van plantenboorsteekmuggen op. Dit beeld is een gevolg van het opdrogen van tijdelijke wateren in het gebied in het voorjaar. De in totaal lagere aantallen in het gehele gebied en de beperking van deze aantallen tot de maand mei hebben ertoe geleid dat in het dorp Griendtsveen in 2017 geen overlast is ervaren. De verdeling van de aantallen over de jaren 2015, 2016 en 2017 naar zone rondom en in het dorp laat zien dat er ieder jaar een afname van de aantallen optreedt richting de dorpskern. In de periode 2015-2017 is het aantallen verzamelde knutten toegenomen met een factor 3. Dit kan samenhangen met nattere weilanden aan de zuidzijde, in het dorp en aan de westzijde. De adviezen voor maatregelen om de ‘hotspots’ aan te pakken zijn in 2017 in gang gezet en ten dele uitgevoerd
    DNA methylation as a mediator of the association between prenatal adversity and risk factors for metabolic disease in adulthood
    Tobi, Elmar W. ; Slieker, Roderick C. ; Luijk, René ; Dekkers, Koen F. ; Stein, Aryeh D. ; Xu, Kate M. ; Slagboom, P.E. ; Zwet, Erik W. Van; Lumey, L.H. ; Heijmans, Bastiaan T. ; T'Hoen, Peter A. ; Pool, René ; Greevenbroek, Marleen M. Van; Stehouwer, Coen D. ; Kallen, Carla J. Van Der; Schalkwijk, Casper G. ; Wijmenga, Cisca ; Zhernakova, Sasha ; Tigchelaar, Ettje F. ; Beekman, Marian ; Deelen, Joris ; Heemst, Diana Van; Veldink, Jan H. ; Berg, Leonard H. Van Den; Duijn, Cornelia M. Van; Hofman, Albert ; Uitterlinden, André G. ; Jhamai, P.M. ; Verbiest, Michael ; Verkerk, Marijn ; Breggen, Ruud Van Der; Rooij, Jeroen Van; Lakenberg, Nico ; Mei, Hailiang ; Bot, Jan ; Zhernakova, Dasha V. ; Hof, Peter Van 't; Deelen, Patrick ; Nooren, Irene ; Moed, Matthijs ; Vermaat, Martijn ; Jan Bonder, Marc ; Dijk, Freerk Van; Arindrarto, Wibowo ; Kielbasa, Szymon M. ; Swertz, Morris A. ; Isaacs, Aaron ; Franke, Lude - \ 2018
    Science Advances 4 (2018)1. - ISSN 2375-2548
    Although it is assumed that epigenetic mechanisms, such as changes in DNA methylation (DNAm), underlie the relationship between adverse intrauterine conditions and adult metabolic health, evidence from human studies remains scarce. Therefore, we evaluated whether DNAm in whole blood mediated the association between prenatal famine exposure and metabolic health in 422 individuals exposed to famine in utero and 463 (sibling) controls. We implemented a two-step analysis, namely, a genome-wide exploration across 342, 596 cytosine-phosphate-guanine dinucleotides (CpGs) for potential mediators of the association between prenatal famine exposure and adult body mass index (BMI), serum triglycerides (TG), or glucose concentrations, which was followed by formalmediation analysis.DNAm mediated the association of prenatal famine exposure with adult BMI and TG but not with glucose. DNAm at PIM3 (cg09349128), a gene involved in energy metabolism, mediated 13.4% [95% confidence interval (CI), 5 to 28%] of the association between famine exposure and BMI. DNAm at six CpGs, including TXNIP (cg19693031), influencing b cell function, and ABCG1 (cg07397296), affecting lipid metabolism, together mediated 80% (95% CI, 38.5 to 100%) of the association between famine exposure and TG. Analyses restricted to those exposed to famine during early gestation identified additional CpGs mediating the relationship with TG near PFKFB3 (glycolysis) and METTL8 (adipogenesis). DNAm at the CpGs involved was associated with gene expression in an external data set and correlated with DNAm levels in fat depots in additional postmortem data. Our data are consistent with the hypothesis that epigenetic mechanisms mediate the influence of transient adverse environmental factors in early life on long-termmetabolic health. The specific mechanism awaits elucidation.
    Viscoelastic properties of soy protein isolate - pectin blends: Richer than those of a simple composite material
    Dekkers, B.L. ; Boom, R.M. ; Goot, A.J. van der - \ 2018
    Food Research International 107 (2018). - ISSN 0963-9969 - p. 281 - 288.
    Concentrated soy protein isolate (SPI) – pectin blends acquire fibrous textures by shear-induced structuring while heating. The objective of this study was to determine the viscoelastic properties of concentrated SPI-pectin blends under similar conditions as during shear-induced structuring, and after cooling. A closed cavity rheometer was used to measure these properties under these conditions. At 140 °C, SPI and pectin had both a lower G* than the blend of the two and also showed a different behavior in time. Hence, the viscoelastic properties of the blend are richer than those of a simple composite material with stable physical phase properties. In addition, the G′pectin was much lower compared with the G′SPI and G′SPI-pectin upon cooling, confirming that pectin formed a weak dispersed phase. The results can be explained by considering that the viscoelastic properties of the blend are influenced by thermal degradation of the pectin phase. This degradation leads to: i) release of galacturonic acid, ii) lowering of the pH, and iii) water redistribution from the SPI towards the pectin phase. The relative importance of those effects are evaluated.
    Metabolic imaging of fatty kidney in diabesity : Validation and dietary intervention
    Jonker, Jacqueline T. ; Heer, Paul De; Engelse, Marten A. ; Rossenberg, Evelien H. Van; Klessens, Celine Q.F. ; Baelde, Hans J. ; Bajema, Ingeborg M. ; Koopmans, Sietse Jan ; Coelho, Paulo G. ; Streefland, Trea C.M. ; Webb, Andrew G. ; Dekkers, Ilona A. ; Rabelink, Ton J. ; Rensen, Patrick C.N. ; Lamb, Hildo J. ; Vries, Aiko P.J. De - \ 2018
    Nephrology Dialysis Transplantation 33 (2018)2. - ISSN 0931-0509 - p. 224 - 230.
    chronic kidney disease - fatty kidney - proton magnetic - renal triglyceride content - resonance spectroscopy - type 2 diabetes mellitus
    Background Obesity and type 2 diabetes have not only been linked to fatty liver, but also to fatty kidney and chronic kidney disease. Since non-invasive tools are lacking to study fatty kidney in clinical studies, we explored agreement between proton magnetic resonance spectroscopy (1 H-MRS) and enzymatic assessment of renal triglyceride content (without and with dietary intervention). We further studied the correlation between fatty kidney and fatty liver. Methods Triglyceride content in the renal cortex was measured by 1 H-MRS on a 7-Tesla scanner in 27 pigs, among which 15 minipigs had been randomized to a 7-month control diet, cafeteria diet (CAF) or CAF with low-dose streptozocin (CAF-S) to induce insulin-independent diabetes. Renal biopsies were taken from corresponding MRS-voxel locations. Additionally, liver biopsies were taken and triglyceride content in all biopsies was measured by enzymatic assay. Results Renal triglyceride content measured by 1 H-MRS and enzymatic assay correlated positively (r = 0.86, P < 0.0001). Compared with control diet-fed minipigs, renal triglyceride content was higher in CAF-S-fed minipigs (137 ± 51 nmol/mg protein, mean ± standard error of the mean, P < 0.05), but not in CAF-fed minipigs (60 ± 10 nmol/mg protein) compared with controls (40 ± 6 nmol/mg protein). Triglyceride contents in liver and kidney biopsies were strongly correlated (r = 0.97, P < 0.001). Conclusions Non-invasive measurement of renal triglyceride content by 1 H-MRS closely predicts triglyceride content as measured enzymatically in biopsies, and fatty kidney appears to develop parallel to fatty liver. 1 H-MRS may be a valuable tool to explore the role of fatty kidney in obesity and type 2 diabetic nephropathy in humans in vivo.
    Novel processing concepts for making fibrous food products
    Dekkers, B.L. ; Goot, A.J. van der - \ 2018
    In: Intensification of Biobased Processes / Górak, Andrzej, Stankiewicz, Andrzej, Royal Society of Chemistry (RSC Green Chemistry 55) - ISBN 9781782628552 - p. 462 - 477.
    A route to make Western diets more sustainable is through reduction of the consumption of animal-derived products. The simplest route to achieve this is to replace animal-derived products with vegetables, beans or pulses. However, modern consumers highly appreciate the texture and juiciness of meat. That is why scientists and food engineers aim to mimic the structure of meat using plant-derived ingredients. In this book chapter, we describe the need to reduce meat consumption in more detail and outline current processes to make today's meat analog products. However, the current products do not satisfy all consumer demands with respect to taste, texture and/or price. That is why we present novel routes and processing concepts currently being studied to make meat analogs. Those routes include concepts that aim to rebuild structures using molecular orientation, cellular imitation and methods that aim to alter naturally present structures in plant materials. The chapter ends by reviewing possible raw materials to be used in those applications and the importance of understanding the effect on functional properties when preparing the ingredients.
    The phase properties of soy protein and wheat gluten in a blend for fibrous structure formation
    Dekkers, B.L. ; Azad Emin, M. ; Boom, R.M. ; Goot, A.J. van der - \ 2018
    Food Hydrocolloids 79 (2018). - ISSN 0268-005X - p. 273 - 281.
    Fibrous macrostructures can be obtained from among others soy protein isolate (SPI) - wheat gluten (WG) blends, when deformed with simple shear flow while heating. This SPI-WG blend consists of two phases, which are separated on a micrometer scale. The properties, especially the rheological properties, of SPI- andWG-phases determine the structure formation process largely. The objective of this study was to determine the properties of the phases present in SPI-WG blends using conditions relevant for fibrous structure formation. Since, the rheological properties are dependent on the concentration of each protein
    in its respective phase, we determined the water content in the two phases with a methodology based on time-domain nuclear magnetic resonance. The spatial distribution of the two phases was studied with confocal scanning laser microscopy, and the rheological properties were measured with three types of
    oscillatory rheology. The experiments showed that the SPI-phase absorbed more water than the WGphase, which resulted in a larger volume fraction than mass fraction of the SPI-phase and vice versa for WG. The absorption of more water by SPI resulted in a lower concentration of SPI in that phase, remarkably leading to a G0-value for SPI that was similar to the rheological properties of WG. Similarities
    in rheological properties seem to be required to strongly deform and align the dispersed phase and form fibrous macrostructures.
    Aqueous fractionation processes of soy protein for fibrous structure formation
    Geerts, Marlies E.J. ; Dekkers, Birgit L. ; Padt, Albert van der; Goot, Atze Jan van der - \ 2018
    Innovative Food Science and Emerging Technologies 45 (2018). - ISSN 1466-8564 - p. 313 - 319.
    Desired properties of ingredients differ for various applications. Here, we use a reverse engineering approach to obtain soy protein fractions targeted for the application of meat analogs. Aqueous fractionation was used to produce these soy protein fractions, which were structured with simple shear flow deformation while heating. The water holding capacity (WHC), nitrogen solubility index (NSI), enthalpy of transition, and viscoelastic properties were determined. We found that a soy protein fraction/full fat flour blend resulted in distinct fibrous structures but only when the soy protein fraction was toasted at 150 °C. At this optimum toasting temperature (150 °C), the protein fractions had a high WHC, intermediate NSI and its viscoelastic property was characterized as G* between 1 and 10 kPa. These functional properties were shown to be key for fibrous structure formation, whereas, the influence of the state of the proteins was limited. Industrial relevance The market for meat analogs is growing. Nowadays, most of the meat analogs are produced with soy protein concentrates and isolates. These concentrates and isolates are obtained with conventional fractionation processes that involve organic solvents to extract the oil first. As a result, the application of these ingredients is limited, e.g. the product cannot be classified as organic. In this study, we therefore investigated aqueous fractionation of soy to obtain a soy protein fraction with desired functionality that can be used for the application of meat analogs and satisfy the values of consumers.
    Understanding fiber formation in a concentrated soy protein isolate - Pectin blend
    Dekkers, Birgit L. ; Hamoen, Remco ; Boom, Remko M. ; Goot, Atze Jan van der - \ 2018
    Journal of Food Engineering 222 (2018). - ISSN 0260-8774 - p. 84 - 92.
    Droplet breakup - Droplet coalescence - Mechanical properties - Microstructure - Shear-induced deformation - Water-in-water emulsion
    Concentrated blends of pectin in soy protein, subjected to simple shear flow while heated form solid, fibrous materials that are a basis for meat analogues. The commonly accepted ‘rule of mixing’ based on the cross-sectional area of a weak dispersed phase was used to predict mechanical anisotropy of the material. Experimentally, two different dispersed phases were observed in the continuous soy protein matrix; air and pectin. An optimum in shape anisotropy of the air and pectin droplets, and mechanical anisotropy was found for a shear rate of 39 s−1. At higher shear rates, air was expelled and break-up of pectin droplets was found, resulting in materials with hardly any mechanical anisotropy. There was discrepancy between the modeled and experimental data when using the same mass fraction and volume fraction of pectin, whereas the model fitted better when assuming that the pectin phase absorbs more water relatively to the soy phase.
    The phase behaviour of soy protein and wheat gluten blends used for fibrous structure formation
    Dekkers, Birgit - \ 2017
    Klimaatverandering in de Grote Polder en Polder Groenendijk : Workshopverslag
    Goosen, H. ; Rooij, L.L. de; Steingröver, E.G. ; Opdam, P.F.M. ; Haan, E. de; Dekkers, F. - \ 2017
    Wageningen : Wageningen Environmental Research (Wageningen Environmental Research rapport ) - 18
    Het klimaat verandert en dat merken we langzaam maar zeker. Maar wat zijn hiervan de gevolgen op lokaal niveau? Om hier een beeld van te vormen is informatie over klimaatverandering en (land)gebruik samengebracht voor de Grote Polder en Polder Groenendijk. Kunnen we een eerste beeld vormen van wat klimaatverandering betekent voor het bedrijfsleven op het bedrijvenpark, voor de Heineken-brouwerij, voor de gemeente Zoeterwoude, voor het Hoogheemraadschap van Rijnland, voor de boeren, voor de natuur, en voor de mensen die er wonen en recreëren? Tijdens een bijeenkomst op 28 september 2017, georganiseerd door het Hoogheemraadschap van Rijnland in het kader van de Groene Thema Cirkel Water, is met diverse partijen uit het gebied het beeld besproken en zijn een aantal verhaallijnen afgeleid. Deze verhaallijnen worden verder verwerkt in de ‘story maps’ van de klimaateffectatlas Zuid Holland.
    De kracht van sport in de wijk voor: Kwetsbare jongeren
    Goor, Roel van; Super, Sabina ; Holman, Marije - \ 2017
    In: Kracht van Sport in de Wijk / Vervoorn, Cees, Deutekom, Marije, Dekkers, Vera, - p. 29 - 46.
    Lezingenreeks 2017: Kracht van Sport in de Wijk

    Biedt sport kwetsbare jongeren meer structuur in hun dagelijkse leven? Voelt een vluchteling zich eerder welkom door sportdeelname? Leert sport mensen met psychiatrische problemen beter om te gaan met tegenslag? In de vijfdelige lezingreeks ‘Kracht van Sport’ stond in 2017 de problematiek en inzet van sport bij diverse doelgroepen in de wijk centraal.

    In de lezingenreeks Kracht van Sport in de Wijk gingen experts op zoek naar manieren waarop welzijnswerkers, zorgverleners en professionals sport gezamenlijk als middel kunnen inzetten om de leefkwaliteit van wijkbewoners te verhogen.
    De kracht van sport in de wijk voor: Mensen met een beperking
    Kampen, Thomas ; Leenaars, Karlijn ; Weidemann, Kim - \ 2017
    In: Kracht van Sport in de Wijk / Vervoorn, Cees, Deutekom, Marije, Dekkers, Vera, - p. 13 - 28.
    Lezingenreeks 2017: Kracht van Sport in de Wijk

    Biedt sport kwetsbare jongeren meer structuur in hun dagelijkse leven? Voelt een vluchteling zich eerder welkom door sportdeelname? Leert sport mensen met psychiatrische problemen beter om te gaan met tegenslag? In de vijfdelige lezingreeks ‘Kracht van Sport’ stond in 2017 de problematiek en inzet van sport bij diverse doelgroepen in de wijk centraal.

    In de lezingenreeks Kracht van Sport in de Wijk gingen experts op zoek naar manieren waarop welzijnswerkers, zorgverleners en professionals sport gezamenlijk als middel kunnen inzetten om de leefkwaliteit van wijkbewoners te verhogen.
    Genome-wide analysis of bacterial determinants of plant growth promotion and induced systemic resistance by Pseudomonas fluorescens
    Cheng, X. ; Etalo, Desalegn W. ; Mortel, J.E. van de; Dekkers, E. ; Nguyen, Linh ; Medema, M.H. ; Raaijmakers, J.M. - \ 2017
    Environmental Microbiology 19 (2017)11. - ISSN 1462-2912 - p. 4638 - 4656.
    Pseudomonas fluorescens strain SS101 (Pf.SS101) promotes growth of Arabidopsis thaliana, enhances greening and lateral root formation, and induces systemic resistance (ISR) against the bacterial pathogen Pseudomonas syringae pv. tomato (Pst). Here, targeted and untargeted approaches were adopted to identify bacterial determinants and underlying mechanisms involved in plant growth promotion and ISR by Pf.SS101. Based on targeted analyses, no evidence was found for volatiles, lipopeptides and siderophores in plant growth promotion by Pf.SS101. Untargeted, genome-wide analyses of 7488 random transposon mutants of Pf.SS101 led to the identification of 21 mutants defective in both plant growth promotion and ISR. Many of these mutants, however, were auxotrophic and impaired in root colonization. Genetic analysis of three mutants followed by site-directed mutagenesis, genetic complementation and plant bioassays revealed the involvement of the phosphogluconate dehydratase gene edd, the response regulator gene colR and the adenylsulfate reductase gene cysH in both plant growth promotion and ISR. Subsequent comparative plant transcriptomics analyses strongly suggest that modulation of sulfur assimilation, auxin biosynthesis and transport, steroid biosynthesis and carbohydrate metabolism in Arabidopsis are key mechanisms linked to growth promotion and ISR by Pf.SS101.
    The genetic and biological basis of feed efficiency in mid-lactation Holstein dairy cows
    Hardie, L.C. ; VandeHaar, M.J. ; Tempelman, R.J. ; Weigel, K.A. ; Armentano, L.E. ; Wiggans, G.R. ; Veerkamp, R.F. ; Haas, Y. de; Coffey, M.P. ; Connor, E.E. ; Hanigan, M.D. ; Staples, C.R. ; Wang, Z. ; Dekkers, J.C.M. ; Spurlock, D.M. - \ 2017
    Journal of Dairy Science 100 (2017)11. - ISSN 0022-0302 - p. 9061 - 9075.
    Dairy - Feed efficiency - Genome-wide association study - Residual feed intake

    The objective of this study was to identify genomic regions and candidate genes associated with feed efficiency in lactating Holstein cows. In total, 4,916 cows with actual or imputed genotypes for 60,671 single nucleotide polymorphisms having individual feed intake, milk yield, milk composition, and body weight records were used in this study. Cows were from research herds located in the United States, Canada, the Netherlands, and the United Kingdom. Feed efficiency, defined as residual feed intake (RFI), was calculated within location as the residual of the regression of dry matter intake (DMI) on milk energy (MilkE), metabolic body weight (MBW), change in body weight, and systematic effects. For RFI, DMI, MilkE, and MBW, bivariate analyses were performed considering each trait as a separate trait within parity group to estimate variance components and genetic correlations between them. Animal relationships were established using a genomic relationship matrix. Genome-wide association studies were performed separately by parity group for RFI, DMI, MilkE, and MBW using the Bayes B method with a prior assumption that 1% of single nucleotide polymorphisms have a nonzero effect. One-megabase windows with greatest percentage of the total genetic variation explained by the markers (TGVM) were identified, and adjacent windows with large proportion of the TGVM were combined and reanalyzed. Heritability estimates for RFI were 0.14 (±0.03; ±SE) in primiparous cows and 0.13 (±0.03) in multiparous cows. Genetic correlations between primiparous and multiparous cows were 0.76 for RFI, 0.78 for DMI, 0.92 for MBW, and 0.61 for MilkE. No single 1-Mb window explained a significant proportion of the TGVM for RFI; however, after combining windows, significance was met on Bos taurus autosome 27 in primiparous cows, and nearly reached on Bos taurus autosome 4 in multiparous cows. Among other genes, these regions contain β-3 adrenergic receptor and the physiological candidate gene, leptin, respectively. Between the 2 parity groups, 3 of the 10 windows with the largest effects on DMI neighbored windows affecting RFI, but were not in the top 10 regions for MilkE or MBW. This result suggests a genetic basis for feed intake that is unrelated to energy consumption required for milk production or expected maintenance as determined by MBW. In conclusion, feed efficiency measured as RFI is a polygenic trait exhibiting a dynamic genetic basis and genetic variation distinct from that underlying expected maintenance requirements and milk energy output.

    Zinc absorption from milk is affected by dilution but not by thermal processing, and milk enhances absorption of Zinc from high-phytate rice in young dutch women
    Talsma, Elise F. ; Moretti, Diego ; Ly, Sou Chheng ; Dekkers, Renske ; Heuvel, Ellen G.H.M. van den; Fitri, Aditia ; Boelsma, Esther ; Stomph, Tjeerd Jan ; Zeder, Christophe ; Melse-Boonstra, Alida - \ 2017
    The Journal of Nutrition 147 (2017)6. - ISSN 0022-3166 - p. 1086 - 1093.
    Absorption - Food processing - Human - Isotope dilution - Milk - Phytate - Rice - Thermal processing - Zinc

    Background: Milk has been suggested to increase zinc absorption. The effect of processing and the ability of milk to enhance zinc absorption from other foods has not been measured directly in humans. Objective: We aimed to assess zinc absorption from 1) milk undergoing various processing and preparatory steps and 2) from intrinsically labeled high-phytate rice consumed with milk or water. Methods: Two randomized crossover studies were conducted in healthy young women [age:18-25 y; body mass index (in kg/m2): 20-25]: 1) a milk study (n = 19) comparing the consumption of 800 mL full-fat ultra-high temperature (UHT) milk [heat-treated milk (HTM)], full-fat UHT milk diluted 1:1 with water [heat-treated milk and water (MW)], water, or unprocessed (raw) milk (UM), each extrinsically labeled with 67Zn, and 2) a rice study (n = 18) comparing the consumption of 90 g intrinsically 67Zn-labeled rice with 600 mL of water [rice and water (RW)] or fullfat UHT milk [rice and milk (RM)]. The fractional absorption of zinc (FAZ) was measured with the double-isotope tracer ratio method. In vitro, we assessed zinc extraction from rice blended into water, UM, or HTM with or without phytate. Results: FAZ from HTM was 25.5% (95% CI: 21.6%, 29.4%) and was not different from UM (27.8%; 95% CI: 24.2%, 31.4%). FAZ from water was higher (72.3%; 95% CI: 68.7%, 75.9%), whereas FAZ fromMWwas lower (19.7%; 95% CI: 17.5%, 21.9%) than HTM and UM (both P < 0.01). FAZ from RM (20.7%; 95% CI: 18.8%, 22.7%) was significantly higher than from RW (12.8%; 95% CI: 10.8%, 14.6%; P < 0.01). In vitro, HTM and UM showed several orders of magnitude higher extraction of zinc from rice with HTM than from rice with water at various phytate concentrations. Conclusions: Milk enhanced human FAZ from high-phytate rice by 62% compared with water. Diluting milk with water decreases its absorption-enhancing proprieties, whereas UHT processing does not.

    Use of multi-trait and random regression models to identify genetic variation in tolerance to porcine reproductive and respiratory syndrome virus
    Lough, Graham ; Rashidi, Hamed ; Kyriazakis, Ilias ; Dekkers, Jack C.M. ; Hess, Andrew ; Hess, Melanie ; Deeb, Nader ; Kause, Antti ; Lunney, Joan K. ; Rowland, Raymond R.R. ; Mulder, Herman ; Doeschl-Wilson, Andrea - \ 2017
    Genetics, Selection, Evolution 49 (2017)1. - ISSN 0999-193X - p. 1 - 15.

    Background: A host can adopt two response strategies to infection: resistance (reduce pathogen load) and tolerance (minimize impact of infection on performance). Both strategies may be under genetic control and could thus be targeted for genetic improvement. Although there is evidence that supports a genetic basis for resistance to porcine reproductive and respiratory syndrome (PRRS), it is not known whether pigs also differ genetically in tolerance. We determined to what extent pigs that have been shown to vary genetically in resistance to PRRS also exhibit genetic variation in tolerance. Multi-trait linear mixed models and random regression sire models were fitted to PRRS Host Genetics Consortium data from 1320 weaned pigs (offspring of 54 sires) that were experimentally infected with a virulent strain of PRRS virus to obtain genetic parameter estimates for resistance and tolerance. Resistance was defined as the inverse of within-host viral load (VL) from 0 to 21 (VL21) or 0 to 42 (VL42) days post-infection and tolerance as the slope of the reaction-norm of average daily gain (ADG21, ADG42) on VL21 or VL42. Results: Multi-trait analysis of ADG associated with either low or high VL was not indicative of genetic variation in tolerance. Similarly, random regression models for ADG21 and ADG42 with a tolerance slope fitted for each sire did not result in a better fit to the data than a model without genetic variation in tolerance. However, the distribution of data around average VL suggested possible confounding between level and slope estimates of the regression lines. Augmenting the data with simulated growth rates of non-infected half-sibs (ADG0) helped resolve this statistical confounding and indicated that genetic variation in tolerance to PRRS may exist if genetic correlations between ADG0 and ADG21 or ADG42 are low to moderate. Conclusions: Evidence for genetic variation in tolerance of pigs to PRRS was weak when based on data from infected piglets only. However, simulations indicated that genetic variance in tolerance may exist and could be detected if comparable data on uninfected relatives were available. In conclusion, of the two defense strategies, genetics of tolerance is more difficult to elucidate than genetics of resistance.

    Semi-quantitative proteomics of mammalian cells upon short-term exposure to nonionizing electromagnetic fields
    Kuzniar, Arnold ; Laffeber, Charlie ; Eppink, Berina ; Bezstarosti, Karel ; Dekkers, Dick ; Woelders, Henri ; Zwamborn, A.P.M. ; Demmers, Jeroen ; Lebbink, Joyce H.G. ; Kanaar, Roland - \ 2017
    PLoS ONE 12 (2017)2. - ISSN 1932-6203

    The potential effects of non-ionizing electromagnetic fields (EMFs), such as those emitted by power-lines (in extremely low frequency range), mobile cellular systems and wireless networking devices (in radio frequency range) on human health have been intensively researched and debated. However, how exposure to these EMFs may lead to biological changes underlying possible health effects is still unclear. To reveal EMF-induced molecular changes, unbiased experiments (without a priori focusing on specific biological processes) with sensitive readouts are required. We present the first proteome-wide semi-quantitative mass spectrometry analysis of human fibroblasts, osteosarcomas and mouse embryonic stem cells exposed to three types of non-ionizing EMFs (ELF 50 Hz, UMTS 2.1 GHz and WiFi 5.8 GHz). We performed controlled in vitro EMF exposures of metabolically labeled mammalian cells followed by reliable statistical analyses of differential protein-and pathway-level regulations using an array of established bioinformatics methods. Our results indicate that less than 1% of the quantitated human or mouse proteome responds to the EMFs by small changes in protein abundance. Further network-based analysis of the differentially regulated proteins did not detect significantly perturbed cellular processes or pathways in human and mouse cells in response to ELF, UMTS or WiFi exposure. In conclusion, our extensive bioinformatics analyses of semi-quantitative mass spectrometry data do not support the notion that the short-time exposures to non-ionizing EMFs have a consistent biologically significant bearing on mammalian cells in culture.

    Stekende insecten rondom de Groote Peel : nulmeting 2016
    Verdonschot, Piet F.M. ; Dekkers, Dorine D. - \ 2017
    Wageningen : Wageningen Environmental Research (Alterra), Zoetwatersystemen (Notitie / Zoetwaterecosystemen, Wageningen Environmental Research ) - ISBN 9789463431231 - 40
    culicidae - steken (activiteit) - insecten - hoogveengebieden - moerassen - noord-brabant - culicidae - stinging - insects - moorlands - marshes - noord-brabant
    Het doel van het project ‘Stekende insecten rondom de Groote Peel’ is tweeledig: a) Het verrichten van een Quick-scan risico-analyse van het gebied Groote Peel en met name de mogelijke effecten van de voorgenomen maatregelen in het project LIFE+ op eventuele overlast veroorzaakt door steekmuggen en knutten. b) Het in 2016 rondom de Groote Peel uitvoeren van een nulmeting om inzicht te krijgen in en het vastleggen van het voorkomen van steekmuggen en knutten rondom de lokaal aanwezige bebouwing en nabij natte randzones.
    Stekende insecten Griendtsveen 2016
    Verdonschot, Piet F.M. ; Dekkers, Dorine D. - \ 2017
    Wageningen : Wageningen Environmental Research (Alterra), Zoetwatersystemen (Notitie / Zoetwaterecosystemen, Wageningen Environmental Research ) - ISBN 9789463431248 - 81
    insecten - steken (activiteit) - culicidae - moerassen - hoogveengebieden - noord-brabant - insects - stinging - culicidae - marshes - moorlands - noord-brabant
    Het doel van het project is het terugdringen van de steekmuggenoverlast in Griendtsveen door: 1) Het in het maatregelenpakket van LIFE+ in de Mariapeel opnemen van een aangepast peilbeheer om de ontwikkeling van langdurig tijdelijke wateren tegen te gaan en de isolatie van langdurig tijdelijke wateren op te heffen. Hiervoor dienen de langdurig tijdelijke wateren die functioneren als broedplaats voor moerassteekmuggen te worden gekarteerd en dient de gebiedshydrologie en –morfologie te worden vastgelegd om doelgerichte maatregelen te kunnen formuleren. 2) Het instellen van een monitoringsmeetnet om de overlast van stekende insecten in en rondom het dorp Griendtsveen te kunnen volgen in de tijd. 3) Eventueel de verbindingszone waarlangs moerassteekmuggen migreren van het natuurgebied naar het dorp zo in te richten dat deze dient als barrière voor stekende insecten.
    Monitoring effecten zandsuppletie Leuvenumse beek 2016
    Verdonschot, Ralf ; Dekkers, Dorine ; Verdonschot, Piet - \ 2017
    Wageningen : Wageningen Environmental Research - ISBN 9789463431170 - 34
    waterlopen - herstel - ecologisch herstel - zandsuppletie - macrofauna - gelderland - streams - rehabilitation - ecological restoration - sand suppletion - macrofauna - gelderland
    In de Leuvenumse beek wordt vanaf 2014 het suppleren van zand als beekherstelmaatregel toegepast door Waterschap Vallei en Veluwe en Natuurmonumenten. Omdat over deze relatief nieuwe maatregel nog niet veel kennis voorhanden is, worden sindsdien de hydromorfologische en biologische ontwikkelingen gevolgd. In 2016 zijn in een aantal suppletietrajecten metingen verricht aan het profiel van de beekbodem, zijn substraatschattingen en metingen aan stroomsnelheid en diepte van de beek verricht en is de samenstelling van de macrofaunalevensgemeenschap onderzocht met behulp van een quickscan-techniek. De macrofauna- en substraatmetingen zijn een herhaling van metingen in 2014, zodat de ontwikkeling in de tijd is vastgelegd.
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