Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

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    Assessment of the genetic and clinical determinants of fracture risk : Genome wide association and mendelian randomisation study
    Trajanoska, Katerina ; Morris, John A. ; Oei, Ling ; Zheng, Hou Feng ; Evans, David M. ; Kiel, Douglas P. ; Ohlsson, Claes ; Richards, J.B. ; Rivadeneira, Fernando ; Forgett, V. ; Leong, A. ; Ahmad, O.S. ; Laurin, C. ; Mokry, L.E. ; Ross, S. ; Elks, C.E. ; Bowden, J. ; Warrington, N.M. ; Kleinman, A. ; Willems, S.M. ; Wright, D. ; Day, F.R. ; Murray, A. ; Ruth, K.S. ; Tsilidis, K.K. ; Ackert-Bicknell, C.L. ; Bassett, J.H.D. ; Eerden, B.C.J. van der; Gautvik, K. ; Reppe, S. ; Williams, G.R. ; Medina-Gómez, C. ; Estrada, K. ; Amin, N. ; Enneman, A.W. ; Li, G. ; Liu, C.T. ; Liu, Y. ; Xiao, S.M. ; Lee, S.H. ; Koh, J.M. ; Tang, N.L.S. ; Cummings, S.R. ; Brown, M. ; Groot, L. de; Jukema, J.W. ; Lips, P. ; Meurs, J.B.J. van; Smith, A.V. ; Tian, S. - \ 2018
    BMJ: British Medical Journal 362 (2018). - ISSN 0959-8146

    Objectives To identify the genetic determinants of fracture risk and assess the role of 15 clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide association studies (GWAS) and a two-sample mendelian randomisation approach. Setting 25 cohorts from Europe, United States, east Asia, and Australia with genome wide genotyping and fracture data. Participants A discovery set of 37 857 fracture cases and 227 116 controls; with replication in up to 147 200 fracture cases and 150 085 controls. Fracture cases were defined as individuals (>18 years old) who had fractures at any skeletal site confirmed by medical, radiological, or questionnaire reports. Instrumental variable analyses were performed to estimate effects of 15 selected clinical risk factors for fracture in a two-sample mendelian randomisation framework, using the largest previously published GWAS meta-analysis of each risk factor. Results Of 15 fracture associated loci identified, all were also associated with bone mineral density and mapped to genes clustering in pathways known to be critical to bone biology (eg, SOST, WNT16, and ESR1) or novel pathways (FAM210A, GRB10, and ETS2). Mendelian randomisation analyses showed a clear effect of bone mineral density on fracture risk. One standard deviation decrease in genetically determined bone mineral density of the femoral neck was associated with a 55% increase in fracture risk (odds ratio 1.55 (95% confidence interval 1.48 to 1.63; P=1.5×10'68). Hand grip strength was inversely associated with fracture risk, but this result was not significant after multiple testing correction. The remaining clinical risk factors (including vitamin D levels) showed no evidence for an effect on fracture. Conclusions This large scale GWAS meta-analysis for fracture identified 15 genetic determinants of fracture, all of which also influenced bone mineral density. Among the clinical risk factors for fracture assessed, only bone mineral density showed a major causal effect on fracture. Genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy sources were not associated with fracture risk.

    Feeding in the transitional period
    Eerden, Ellen van - \ 2018
    New poultry nutrition
    Eerden, Ellen van - \ 2018
    Poultry health: the role of nutrition in controlling and enhancing intestinal integrity
    Eerden, Ellen van - \ 2018
    Development of the microbial balance in the intestinal tract to explain gut health
    Eerden, Ellen van - \ 2018
    Superior Stability of Au/SiO2 Compared to Au/TiO2 Catalysts for the Selective Hydrogenation of Butadiene
    Masoud, Nazila ; Delannoy, Laurent ; Schaink, Herrick ; Eerden, Ad van der; Rijk, Jan Willem de; Silva, Tiago A.G. ; Banerjee, Dipanjan ; Meeldijk, Johannes D. ; Jong, Krijn P. de; Louis, Catherine ; Jongh, Petra E. de - \ 2017
    ACS Catalysis 7 (2017)9. - ISSN 2155-5435 - p. 5594 - 5603.
    butadiene - catalyst - gold - selective hydrogenation - stability - supported nanoparticles

    Supported gold nanoparticles are highly selective catalysts for a range of both liquid-phase and gas-phase hydrogenation reactions. However, little is known about their stability during gas-phase catalysis and the influence of the support thereon. We report on the activity, selectivity, and stability of 2-4 nm Au nanoparticulate catalysts, supported on either TiO2 or SiO2, for the hydrogenation of 0.3% butadiene in the presence of 30% propene. Direct comparison of the stability of the Au catalysts was possible as they were prepared via the same method but on different supports. At full conversion of butadiene, only 0.1% of the propene was converted for both supported catalysts, demonstrating their high selectivity. The TiO2-supported catalysts showed a steady loss of activity, which was recovered by heating in air. We demonstrated that the deactivation was not caused by significant metal particle growth or strong metal-support interaction, but rather, it is related to the deposition of carbonaceous species under reaction conditions. In contrast, all the SiO2-supported catalysts were highly stable, with very limited formation of carbonaceous deposits. It shows that SiO2-supported catalysts, despite their 2-3 times lower initial activities, clearly outperform TiO2-supported catalysts within a day of run time. (Graph Presented).

    Occurrence of virus-induced COPD exacerbations during four seasons
    Djamin, Remco S. ; Uzun, Sevim ; Snelders, Eveline ; Kluytmans, Jan J.W. ; Hoogsteden, Henk C. ; Aerts, Joachim G.J.V. ; Eerden, Menno M. Van Der - \ 2015
    Bmc Infectious Diseases 47 (2015)2. - ISSN 2374-4235 - p. 96 - 100.
    Chronic obstructive pulmonary disease - Exacerbations - Seasonal patterns - Virus

    In this study, we investigated the occurrence of viral infections in acute exacerbations of chronic obstructive pulmonary disease (COPD) during four seasons. Viral infections were detected by the use of real-time reverse transcriptase polymerase chain reaction on pharyngeal swabs. During a 12-month period pharyngeal swabs were obtained in 136 exacerbations of 63 patients. In 35 exacerbations (25.7%) a viral infection was detected. Most viral infections occurred in the winter ( n = 14, 40.0%), followed by summer ( n = 9, 25.7%), autumn ( n = 6, 17.1%), and spring ( n = 6, 17.1%). Rhinovirus was the most frequently isolated virus ( n = 19, 51.4%), followed by respiratory syncytial virus ( n = 6, 16.2%), human metapneumovirus ( n = 5, 13.5%), influenza A ( n = 4, 10.8%), parainfluenza 4 ( n = 2, 5.4%), and parainfluenza 3 ( n = 1, 2.7%). This study showed that virus-induced COPD exacerbations occur in all four seasons with a peak in the winter months. However, the distribution of rhinovirus infections showed a different pattern, with most infections occurring in July.

    Effects of inclusion of hydrolyzed yeast on the immune response and performance of piglets after weaning
    Molist, F. ; Eerden, E. van; Parmentier, H.K. ; Vuorenmaa, J. - \ 2014
    Animal Feed Science and Technology 195 (2014). - ISSN 0377-8401 - p. 136 - 141.
    growth-performance - saccharomyces-cerevisiae - natural antibodies - weanling pigs - nutrient digestibility - weaned piglets - supplementation - polysaccharides - challenge - chickens
    The aim of this study was to examine whether yeast derivative (YD) based on brewery yeast hydrolyzate added to a post-weaning diet affected performance and immune responses in weaning pigs. One hundred and twenty pigs were allocated to 20 pens, taking initial body weight into account, and were distributed into two groups as follows: a negative control diet and the same diet supplemented with 2 g YD/kg. The YD used was Progut® (Hankkija Oy/Suomen Rehu, Hyvinkää, Finland). At days 7 and 21 of the experiment, half of the piglets per group were challenged intramuscularly with 1 mL of a solution of 20% sheep red blood cells (SRBC) in sterile phosphate buffered saline (PBS). At days 0, 14, 21 and 28 of the experiment, blood samples from the challenged piglets were obtained and acute-phase proteins (Pig-MAP), natural antibodies of the IgM- and IgG-isotype binding to keyhole limpet hemocyanin (KLH), and agglutinating antibody titers to SRBC were measured. Yeast derivative inclusion improved feed conversion ratio (P=0.025) for the overall period, tended to increase IgG (P=0.087) and IgM (P=0.061) antibodies in serum-binding KLH, and increased (P=0.037) SRBC agglutination titers. Collectively, these data suggest that YD supplementation as 2 g Progut®/kg to weanling pigs triggered the immune system to a more responsive state without penalizing the animal performance which could potentially be beneficial for overcoming disease challenges. Piglets fed with 2 g Progut®/kg for 28 days after weaning also showed an improvement in feed conversion ratio.
    Differences in fluorescence of doxycycline in chicken bone depending on dosage and treatment time
    Groot, M.J. ; Ossenkoppele, J.S. ; Bruchem, G.D. van; Eerden, E. van; Klis, J.D. van der; Nielen, M.W.F. - \ 2014
    Effects of herbal products in vitro and in vivo
    Groot, M.J. ; Pikkemaat, M.G. ; Driessen-van Lankveld, W.D.M. ; Eerden, M.E. van; Klis, J.D. van der - \ 2013
    diervoeding - geneeskrachtige kruiden - voedertoevoegingen - antimicrobe-eigenschappen - anti-infectieuze middelen - diergezondheid - animal nutrition - herbal drugs - feed additives - antimicrobial properties - antiinfective agents - animal health
    The aim of the study was to examine the antimicrobial action of herbal feed additives and the relation between this antimicrobial action and performance data in vivo and gut histology (villus/crypt ratio) as parameter for gut health.
    Effecten van kruidenproducten in vitro en in vivo
    Groot, M.J. ; Pikkemaat, M.G. ; Driessen, J.J.M. ; Eerden, E. van; Klis, J.D. van der - \ 2013
    Nederlands Tijdschrift voor Fytotherapie 4 (2013). - ISSN 1384-8925 - p. 16 - 20.
    Specific serum antibody responses following a Toxoplasma gondii and Trichinella spiralis co-infection in swine
    Bokken, G. ; Eerden, E. van; Opsteegh, M. ; Augustijn, M. ; Graat, E.A.M. ; Franssen, F. ; Görlich, K. ; Buschtöns, S. ; Tenter, A.M. ; Giessen, J.W.B. van der; Bergwerff, A.A. ; Knapen, F. van - \ 2012
    Veterinary Parasitology 184 (2012)2-4. - ISSN 0304-4017 - p. 126 - 132.
    tissue cysts - pigs - infections - mice - netherlands - diagnosis - britovi - pork
    The aim of this study was to examine the dynamics of parasite specific antibody development in Trichinella spiralis and Toxoplasma gondii co-infections in pigs and to compare these with antibody dynamics in T. spiralis and T. gondii single infections. In this experiment, fiftyfour pigs were divided into five inoculated groups of ten animals, and one control group of four animals. Two groups were inoculated with a single dose of either T. gondii tissue cysts or T. spiralis muscle larvae, one group was inoculated simultaneously with both parasites and two groups were successively inoculated at an interval of four weeks. Specific IgG responses to the parasites were measured by ELISA. T. gondii burden was determined by MC-PCR carried out on heart muscle and T. spiralis burden by artificial digestion of diaphragm samples. Specific IgG responses to T. gondii and T. spiralis in single and simultaneously inoculated animals showed a respective T. gondii and T. spiralis inoculation effect but no significant interaction of these parasites to the development of specific antibodies with the serum dilutions used. Moreover, our data showed that the specific IgG response levels in groups of animals successively or simultaneously co-infected were independent of a respective previous or simultaneous infection with the other parasite. Additionally, no differences in parasite burden were found within groups inoculated with T. gondii and within groups inoculated with T. spiralis. Conclusively, for the infection doses tested in this experiment, the dynamics of specific antibody development does not differ between single and simultaneous or successive infection with T. gondii and T. spiralis. However, lower parasitic doses and other ratios of doses, like low-low, low-high and high-low of T. gondii and T. spiralis in co-infection, in combination with other time intervals between successive infections may have different outcomes and should therefore be studied in further detail.
    The need for future wetland bird studies: scales of habitat use as input for ecological restoration and spatial water management
    Platteeuw, M. ; Foppen, R.P.B. ; Eerden, M.R. van - \ 2010
    Ardea 98 (2010)3. - ISSN 0373-2266 - p. 403 - 416.
    phalacrocorax-carbo-sinensis - european harriers circus - purple heron - netherlands - population - information - landscape - corridors - drought - climate
    All over Europe, wetlands have decreased in size, lost their original dynamics and became fragmented as the consequence of an ever increasing human land use. These processes have resulted in losses of nature values, among which declines in marshland bird populations. Ecological restoration of wetland systems follows from initiatives like EU Bird and Habitat Directives and Water Framework Directive, but may be, in itself, too costly to be widely applied. More promising perspectives to reinforce the wetland part of the ecological network Natura 2000 might come into focus when combined with spatial water management which is primarily aimed at more sustainable safety against flooding. In this way, the wetland network may acquire a wider public and political support. Knowledge on scale-related habitat use of wetland birds can play a role in the process of spatial planning. We illustrate this point by distinguishing four levels of spatial and temporal habitat use by wetland birds, and giving examples for each. The four levels are: (1) birds on stopover sites during migration, (2) territorial breeding birds, (3) colonial breeding birds, and (4) staging birds on wintering sites. This asks for ecological coherence on different scales, e.g. on the international level of migration flyways, on the regional level of landscapes and on the local level of individual wetlands. It is advocated that wetland ecologists dedicate themselves more specifically to quantifying the relevant data on habitat use of birds on each of these scale levels. Meanwhile, spatial planners should try to incorporate them into their efforts in realising combinations of ecological restoration or rehabilitation of wetlands and solutions for sustainable water management. These combinations might turn the tide for some seriously threatened species of marshland and wetland birds.
    Residual feed intake in young chickens : effects on energy partitioning and immunity
    Eerden, E. van - \ 2007
    Wageningen University. Promotor(en): Bas Kemp; Mart de Jong, co-promotor(en): Henry van den Brand. - [S.l.] : S.n. - ISBN 9789085045939 - 168
    jonge kippen - voeropname - efficiëntie - middelentoewijzing - energiegebruik - experimentele infectie - immuniteitsreactie - immuniteit - pullets - feed intake - efficiency - resource allocation - energy consumption - experimental infection - immune response - immunity
    Keywords: chicken, residual feed intake, resource allocation, immune response, Salmonella Enteritidis, energy partitioning.

    The continuous selection in farm animals for efficient production and high production levels may have led to animals that are "programmed" to put a lot of resources in production processes, at the expense of resources for maintenance processes, among which the immune system. When efficiently and non-efficiently producing animals in a population are discriminated, it is hypothesized that non-efficient animals are better able to reallocate resources from production processes to maintenance processes than efficient animals. Non-efficient animals may, thus, be better off than efficient animals when maintenance processes are under pressure.

    Residual feed intake is used as a trait to discriminate efficient and non-efficient animals. It is defined as the difference between observed feed intake and expected feed intake; in this thesis, expected feed intake is based on metabolic body weight and growth. Animals that eat more than expected have a high residual feed intake and are considered non-efficient, whereas animals that eat less than expected have a low residual feed intake and are considered efficient.

    The research described in this thesis was carried out with pullets. Pullets are young, growing female chickens that do not produce eggs yet. Pullets were rated from high to low residual feed intake as a phenotypic trait; animals with the highest and lowest values for residual feed intake were selected for further research. Immune responses to non-replicating antigens and to live Salmonella Enteritidis bacteria were investigated.

    The results showed that non-efficient pullets had a higher feed intake than efficient pullets, but body weight and growth were equal in efficient and non-efficient pullets. Energy partitioning trials showed that non-efficient pullets spent more energy on maintenance processes than efficient pullets. However, an infection with Salmonella Enteritidis did not lead to repartitioning of energy from production processes to maintenance processes. It was concluded that a Salmonella Enteritidis infection is not energetically costly. Efficient pullets had a lower immune status than non-efficient pullets in situations where the animals were not infected with Salmonella Enteritidis, whereas during a Salmonella Enteritidis infection the efficient pullets had higher immune responses than non-efficient pullets. It is suggested that efficient and non-efficient pullets, as measured by residual feed intake, may have different "immune coping styles".
    Profits and losses of dietary efficiency with respect to immune reactivity
    Eerden, E. van; Brand, H. van den; Kemp, B. - \ 2006
    Dietary efficiency: waste not, want not?
    Eerden, E. van; Brand, H. van den; Kemp, B. - \ 2006
    Energy Partitioning and Thyroid Hormone Levels During Salmonella enteritidis Infections in Pullets with High or Low Residual Feed Intake
    Eerden, E. van; Brand, H. van den; Heetkamp, M.J.W. ; Decuypere, M.P. ; Kemp, B. - \ 2006
    Poultry Science 85 (2006)10. - ISSN 0032-5791 - p. 1775 - 1783.
    growing layer hens - laying hens - food-consumption - divergent selection - growth-hormone - egg-production - body-weight - efficiency - chicken - lines
    This experiment was conducted to investigate whether feed efficiency, as measured by residual feed intake as a phenotypic trait, affects energy partitioning in pullets that have received Salmonella inoculation as an immune challenge. In each of 8 trials, energy partitioning was measured during 5 wk in 15-wk-old efficient (R¿) and nonefficient (R+) pullets, which were housed per efficiency group in 2 identical climate respiration chambers. After 1 wk of adaptation, the pullets in 4 trials were orally inoculated with 108 cfu of Salmonella enteritidis; pullets in the remaining trials were not inoculated and served as controls. Heat production was calculated from continuous recordings of O2 consumption and CO2 production. Energy and N partitioning were recorded on a weekly basis. Blood samples for analyses on thyroid hormones were taken at 16, 17, and 19 wk of age. There were no interactions between efficiency type and Salmonella treatment or Salmonella treatment effects in energy partitioning, except for a short-term increase in heat production in inoculated pullets. Nonefficient pullets had higher gross energy and ME intake, higher estimated ME for maintenance, lower ME:gross energy ratio, and higher total heat production and nonactivity-related heat production compared with R¿ pullets. Triiodothyronine levels in R+ pullets were higher at 16 and 17 wk but were lower at 19 wk of age compared with R¿ pullets. Thyroxine levels were higher in R¿ at 16 wk and showed interactions between efficiency type and Salmonella treatment at 17 and 19 wk of age. Body weights and spleen weights did not differ between efficiency groups. Nonefficient pullets had higher heart, liver, and ovary weights and more large yellow follicles than R¿ pullets. There were no Salmonella effects on body and organ weights. We conclude that R+ pullets have a faster running energy metabolism and that they put more resources into organ development than R¿ pullets. Inoculation with Salmonella has a short-term effect on nonactivity-related heat production but does not affect energy partitioning, regardless of efficiency type
    Detection of egg yolk antibodies reflecting Salmonella enteritidis infections using a surface plasmon resonance biosensor
    Thomas, M.E. ; Bouma, A. ; Eerden, E. van; Landman, W.J.M. ; Knapen, F. van; Stegeman, J.A. ; Bergwerff, A.A. - \ 2006
    Journal of Immunological Methods 315 (2006)1-2. - ISSN 0022-1759 - p. 68 - 74.
    laying hens - typhimurium - chickens - elisa - assay - immunosensor - netherlands - antigens - serum
    A surface plasmon resonance (SPR) biosensor assay was developed on the basis of a lipopolysaccharide antigen of Salmonella enterica serovar enteritidis (S. enterica serovar enteritidis) to detect egg yolk antibodies against S. enterica serovar enteritidis. This biosensor assay was compared to two commercial ELISA kits based on LPS antigen and flagellar antigen. A number of 163 egg yolk and combined egg white and yolk samples from chickens experimentally infected with S. enterica serovar enteritidis and 90 egg yolk and combined egg white and yolk samples from uninfected chickens were analyzed. Receiver operating characteristic analysis of the data calculated a diagnostic sensitivity of 82% and a diagnostic specificity of 100%. The within-day coefficient of variation of a positive internal-control egg yolk was 1%. The SPR biosensor assay was able to detect antibodies in a significantly higher percentage of known positive samples than the commercial ELISA's. The anticipated use of the SPR biosensor assay is to determine the S. enterica serovar enteritidis serostatus of non-vaccinated layer hens
    Een analyse van de mogelijke gevolgen van de aanleg van IJburg tweede fase voor watervogels in de SBZ IJmeer
    Schekkerman, H. ; Eerden, M.E. van; Rijn, S. van; Roos, M. - \ 2006
    Wageningen : Alterra (Alterra-rapport 1363) - 95
    vogels - milieueffect - wildbescherming - stedelijke planning - nederland - amsterdam - birds - environmental impact - wildlife conservation - urban planning - netherlands - amsterdam
    De gemeente Amsterdam heeft vergevorderde plannen om in het IJmeer, grenzend aan het Vogelrichtlijngebied (SBZ, Natura 2000 gebied) IJmeer, de tweede fase van de wijk IJburg te realiseren. In dit rapport wordt (1) beschreven welke specifieke waarden van het IJmeer volgens de Vogelrichtlijn dienen te worden beschermd, (2) verkend welke invloed IJburg II op deze waarden zal hebben en of daarbij sprake is van significante gevolgen in het kader van de Vogelrichtlijn, en (3) aangegeven welke mitigerende maatregelen de verstorende effecten van IJburg II kunnen voorkomen. Het rapport zal mede de basis vormen onder een nieuwe versie van het bestemmingsplan voor IJburg II, die vervolgens aan een `passende beoordeling¿ in het kader van de NB-wet 1998 zal worden onderworpen
    Salmonella Challenge Affects the Antibody Isotype Profile of Bile in Hens Differing in Metabolic Efficiency
    Cotter, P.F. ; Eerden, E. van - \ 2006
    Poultry Science 85 (2006)5. - ISSN 0032-5791 - p. 861 - 865.
    residual feed-intake - growing layer hens - enteritidis infection - immune-responses - chicken bile - iga - lectin - selection - subclass - jacalin
    Gel precipitation reactions determined antibody isotypes in bile from hens differing in dietary efficiency. Ouchterlony double diffusion employing ¿-chain specific goat-anti-chicken IgA, rabbit anti-chicken IgG, goat anti-chicken IgM, black turtle bean (BTB), and Jacalin lectins as precipitating reagents detected bile IgA, IgG, and IgM from Salmonella exposed and nonexposed hens. The IgA was present in 1 of 3 forms designated by reagent and frequency: IgAB (precipitated by BTB lectin) 100%; IgAA (precipitated by anti-¿ chain antibody) 98%, and IgAJ (precipitated by Jacalin) 97%. That both BTB and Jacalin precipitates contain IgA was confirmed by immuno-dot blots using affinity purified ¿-chain specific antibody, establishing each as IgA glycoforms. Three measurements of Ouchterlony precipitates were made; d1 and d2 indicate diffusion from sample or reagent wells, ? indicates arc length. Mean values for ?, estimating quantity, were IgAA (11.3 mm) and IgAB (11.6 mm) and IgAJ (8.3 mm). The crescent shape IgAJ arc and its slower diffusion (d1) suggested its molecular weight is greater than either IgAA or IgAB. Arc lengths of individual samples were not significantly correlated suggesting that these are independent components of bile. Oral Salmonella enteritidis challenge resulted in a highly significant difference in bile IgA profiles. The IgAJ arc lengths (?) in R¿ hens increased by 20% over those in nonchallenged R¿ hens. Conversely S. enteritidis challenge was associated with a decrease of 10% in IgAJ arc lengths in nonefficient (R+) hens. Salmonella enteritidis challenge was not associated with arc length differences in either IgAA or IgAB. The IgG was present in all specimens, and in 9 of 59 (15%) 2 forms were detected. The IgG quantity was unaffected by either efficiency type or S. enteritidis challenge. The IgM was detected in only 2 of 59 (3.4%) specimens. Our observations suggest IgA of bile is composed of multiple forms influenced both by diet efficiency status and S. enteritidis exposure. It appears that the latter resulted in an increased quantity of IgAJ in R¿ hens, and suggests the existence of functional differences among the various IgA types.
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