Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Addendum: The FAIR Guiding Principles for scientific data management and stewardship
Wilkinson, Mark D. ; Dumontier, Michel ; Aalbersberg, Ijsbrand Jan ; Appleton, Gabrielle ; Axton, Myles ; Baak, Arie ; Blomberg, Niklas ; Boiten, Jan Willem ; Silva Santos, Luiz Bonino Da; Bourne, Philip E. ; Bouwman, Jildau ; Brookes, Anthony J. ; Clark, Tim ; Crosas, Mercè ; Dillo, Ingrid ; Dumon, Olivier ; Edmunds, Scott ; Evelo, Chris T. ; Finkers, Richard ; Gonzalez-Beltran, Alejandra ; Gray, Alasdair J.G. ; Groth, Paul ; Goble, Carole ; Grethe, Jeffrey S. ; Heringa, Jaap ; Hoen, Peter A.C. 't; Hooft, Rob ; Kuhn, Tobias ; Kok, Ruben ; Kok, Joost ; Lusher, Scott J. ; Martone, Maryann E. ; Mons, Albert ; Packer, Abel L. ; Persson, Bengt ; Rocca-Serra, Philippe ; Roos, Marco ; Schaik, Rene van; Sansone, Susanna Assunta ; Schultes, Erik ; Sengstag, Thierry ; Slater, Ted ; Strawn, George ; Swertz, Morris A. ; Thompson, Mark ; Lei, Johan van der; Mulligen, Erik van; Velterop, Jan ; Waagmeester, Andra ; Wittenburg, Peter ; Wolstencroft, Katherine ; Zhao, Jun ; Mons, Barend - \ 2019
Scientific Data 6 (2019). - ISSN 2052-4463

Advancing food, nutrition, and health research in Europe by connecting and building research infrastructures in a DISH-RI : Results of the EuroDISH project
Snoek, Harriëtte M. ; Eijssen, Lars M.T. ; Geurts, Marjolein ; Vors, Cecile ; Brown, Kerry A. ; Bogaardt, Marc Jeroen ; Dhonukshe-Rutten, Rosalie A.M. ; Evelo, Chris T. ; Fezeu, Leopold K. ; Finglas, Paul M. ; Laville, Martine ; Ocké, Marga ; Perozzi, Giuditta ; Poppe, Krijn ; Slimani, Nadia ; Tetens, Inge ; Timotijevic, Lada ; Zimmermann, Karin ; ’t Veer, Pieter van - \ 2018
Trends in Food Science and Technology 73 (2018). - ISSN 0924-2244 - p. 58 - 66.
Governance - Nutrition - Policy - Public health - Research infrastructures - Roadmap
Background: Research infrastructures (RIs) are essential to advance research on the relationship between food, nutrition, and health. RIs will facilitate innovation and allow insights at the systems level which are required to design (public health) strategies that will address societal challenges more effectively. Approach: In the EuroDISH project we mapped existing RIs in the food and health area in Europe, identified outstanding needs, and synthesised this into a conceptual design of a pan-European DISH-RI. The DISH model was used to describe and structure the research area: Determinants of food choice, Intake of foods and nutrients, Status and functional markers of nutritional health, and Health and disease risk. Key findings: The need to develop RIs in the food and health domain clearly emerged from the EuroDISH project. It showed the necessity for a unique interdisciplinary and multi-stakeholder RI that overarches the research domains. A DISH-RI should bring services to the research community that facilitate network and community building and provide access to standardised, interoperable, and innovative data and tools. It should fulfil the scientific needs to connect within and between research domains and make use of current initiatives. Added value can also be created by providing services to policy makers and industry, unlocking data and enabling valorisation of research insights in practice through public-private partnerships. The governance of these services (e.g. ownership) and the centralised and distributed activities of the RI itself (e.g. flexibility, innovation) needs to be organised and aligned with the different interests of public and private partners.
The FAIR Guiding Principles for scientific data management and stewardship : Comment
Wilkinson, Mark D. ; Dumontier, Michel ; Aalbersberg, Ijsbrand Jan ; Appleton, Gabrielle ; Axton, Myles ; Baak, Arie ; Blomberg, Niklas ; Boiten, Jan Willem ; Silva Santos, Luiz Bonino Da; Bourne, Philip E. ; Bouwman, Jildau ; Brookes, Anthony J. ; Clark, Tim ; Crosas, Mercè ; Dillo, Ingrid ; Dumon, Olivier ; Edmunds, Scott ; Evelo, Chris T. ; Finkers, Richard ; Gonzalez-Beltran, Alejandra ; Gray, Alasdair J.G. ; Groth, Paul ; Goble, Carole ; Grethe, Jeffrey S. ; Heringa, Jaap ; Hoen, Peter A.C. 't; Hooft, Rob ; Kuhn, Tobias ; Kok, Ruben ; Kok, Joost ; Lusher, Scott J. ; Martone, Maryann E. ; Mons, Albert ; Packer, Abel L. ; Persson, Bengt ; Rocca-Serra, Philippe ; Roos, Marco ; Schaik, Rene van; Sansone, Susanna Assunta ; Schultes, Erik ; Sengstag, Thierry ; Slater, Ted ; Strawn, George ; Swertz, Morris A. ; Thompson, Mark ; Lei, Johan van der; Mulligen, Erik van; Velterop, Jan ; Waagmeester, Andra ; Wittenburg, Peter ; Wolstencroft, Katherine ; Zhao, Jun ; Mons, Barend - \ 2016
Scientific Data 3 (2016). - ISSN 2052-4463

There is an urgent need to improve the infrastructure supporting the reuse of scholarly data. A diverse set of stakeholders-representing academia, industry, funding agencies, and scholarly publishers-have come together to design and jointly endorse a concise and measureable set of principles that we refer to as the FAIR Data Principles. The intent is that these may act as a guideline for those wishing to enhance the reusability of their data holdings. Distinct from peer initiatives that focus on the human scholar, the FAIR Principles put specific emphasis on enhancing the ability of machines to automatically find and use the data, in addition to supporting its reuse by individuals. This Comment is the first formal publication of the FAIR Principles, and includes the rationale behind them, and some exemplar implementations in the community.

Consensus statement understanding health and malnutrition through a systems approach: the ENOUGH program for early life.
Kaput, J. ; Ommen, B. van; Kremer, B. ; Priami, C. ; Pontes Monteiro, J. ; Morine, M. ; Pepping, F. ; Diaz, Z. ; Fenech, M. ; He, Y. ; Albers, R. ; Drevon, C.A. ; Evelo, C.T. ; Hancock, R.E.W. ; Ijsselmuiden, C. ; Lumey, L.H. ; Minihane, A.M. ; Muller, M.R. ; Murgia, C. ; Radonjic, M. ; Sobral, B.W.S. ; West Jr., K.P. - \ 2014
Genes & Nutrition 9 (2014)9. - ISSN 1555-8932 - 9 p.
birth-weight infants - developing-countries - global health - environmental enteropathy - participatory research - grand challenges - innate immunity - trace-elements - biology - nutrition
Nutrition research, like most biomedical disciplines, adopted and often uses experimental approaches based on Beadle and Tatum’s one gene—one polypeptide hypothesis, thereby reducing biological processes to single reactions or pathways. Systems thinking is needed to understand the complexity of health and disease processes requiring measurements of physiological processes, as well as environmental and social factors, which may alter the expression of genetic information. Analysis of physiological processes with omics technologies to assess systems’ responses has only become available over the past decade and remains costly. Studies of environmental and social conditions known to alter health are often not connected to biomedical research. While these facts are widely accepted, developing and conducting comprehensive research programs for health are often beyond financial and human resources of single research groups. We propose a new research program on essential nutrients for optimal underpinning of growth and health (ENOUGH) that will use systems approaches with more comprehensive measurements and biostatistical analysis of the many biological and environmental factors that influence undernutrition. Creating a knowledge base for nutrition and health is a necessary first step toward developing solutions targeted to different populations in diverse social and physical environments for the two billion undernourished people in developed and developing economies.
User-friendly solutions for microarray quality control and pre-processing on ArrayAnalysis.org
Eijssen, L.M. ; Jaillard, M. ; Adriaens, M.E. ; Gaj, S. ; Groot, P.J. de; Müller, M.R. ; Evelo, C.T. - \ 2013
Nucleic acids research 41 (2013)W1. - ISSN 0305-1048 - p. W71 - W76.
affymetrix-genechip data - expression analysis - probe level - bioconductor - interface - database - package - biology - biomart - update
Quality control (QC) is crucial for any scientific method producing data. Applying adequate QC introduces new challenges in the genomics field where large amounts of data are produced with complex technologies. For DNA microarrays, specific algorithms for QC and pre-processing including normalization have been developed by the scientific community, especially for expression chips of the Affymetrix platform. Many of these have been implemented in the statistical scripting language R and are available from the Bioconductor repository. However, application is hampered by lack of integrative tools that can be used by users of any experience level. To fill this gap, we developed a freely available tool for QC and pre-processing of Affymetrix gene expression results, extending, integrating and harmonizing functionality of Bioconductor packages. The tool can be easily accessed through a wizard-like web portal at http://www.arrayanalysis.org or downloaded for local use in R. The portal provides extensive documentation, including user guides, interpretation help with real output illustrations and detailed technical documentation. It assists newcomers to the field in performing state-of-the-art QC and pre-processing while offering data analysts an integral open-source package. Providing the scientific community with this easily accessible tool will allow improving data quality and reuse and adoption of standards.
Marginal selenium deficiency down-regulates inflammation-related genes in splenic leukocytes of the mouse
Kipp, A.P. ; Banning, A. ; Schothorst, E.M. van; Meplan, C. ; Coort, S.L. ; Evelo, C. ; Keijer, J. ; Hesketh, J. ; Brigelius, R. - \ 2012
Journal of Nutritional Biochemistry 23 (2012)9. - ISSN 0955-2863 - p. 1170 - 1177.
kappa-b activation - smooth-muscle-cells - response syndrome - immune-response - glutathione-peroxidase - protein-biosynthesis - t-cell - expression - selenoproteins - macrophages
Moderate selenium deficiency may lead to an impaired capacity to cope with health challenges. Functional effects of suboptimal selenium intake are not fully known, and biomarkers for an insufficient selenium supply are inadequate. We therefore fed mice diets of moderately deficient or adequate selenium intake for 6 weeks. Changes in global gene expression were monitored by microarray analysis in splenic leukocytes. Genes for four selenoproteins, Sepw1, Gpx1, Selh and Sep15, were the most significantly down-regulated in moderate selenium deficiency, and this was confirmed by quantitative polymerase chain reaction (qPCR). Classification of significantly affected genes revealed that processes related to inflammation, heme biosynthesis, DNA replication and transcription, cell cycle and transport were affected by selenium restriction. Down-regulation by moderate selenium deficiency of specific genes involved in inflammation and heme biosynthesis was confirmed by qPCR. Myeloperoxidase and lysozyme activities were decreased in selenium-restricted leukocytes, providing evidence for functional consequences. Genes for 31 nuclear factor (NF)-¿B targets were down-regulated in moderate selenium deficiency, indicating an impaired NF-¿B signaling. Together, the observed changes point to a disturbance in inflammatory response. The selenoproteins found here to be sensitive to selenium intake in murine leukocytes might also be useful as biomarkers for a moderate selenium deficiency in humans.
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention
Rubio-Aliaga, I. ; Roos, B. ; Sailer, M. ; McLoughlin, G. ; Schothorst, E.M. van; Erk, M.J. van; Keijer, J. ; Müller, M.R. ; Boekschoten, M.V. ; Bachmair, E.M. ; Coort, S.L. ; Evelo, C. ; Gibney, M.J. ; Daniel, H. ; Muller, M. ; Kleemann, R. ; Brennan, L. - \ 2011
Physiological genomics 43 (2011)8. - ISSN 1094-8341 - p. 408 - 416.
homocysteine s-methyltransferase - induced insulin-resistance - oxidative stress - deficient mice - ikk-beta - plasma - choline - liver - disease - obesity
Obesity frequently leads to insulin resistance and the development of hepatic steatosis. To characterize the molecular changes that promote hepatic steatosis, transcriptomics, proteomics, and metabolomics technologies were applied to liver samples from C57BL/6J mice obtained from two independent intervention trials. After 12 wk of high-fat feeding the animals became obese, hyperglycemic, and insulin resistant, had elevated levels of blood cholesterol and VLDL, and developed hepatic steatosis. Nutrigenomic analysis revealed alterations of key metabolites and enzyme transcript levels of hepatic one-carbon metabolism and related pathways. The hepatic oxidative capacity and the lipid milieu were significantly altered, which may play a key role in the development of insulin resistance. Additionally, high choline levels were observed after the high-fat diet. Previous studies have linked choline levels with insulin resistance and hepatic steatosis in conjunction with changes of certain metabolites and enzyme levels of one-carbon metabolism. The present results suggest that the coupling of high levels of choline and low levels of methionine plays an important role in the development of insulin resistance and liver steatosis. In conclusion, the complexities of the alterations induced by high-fat feeding are multifactorial, indicating that the interplay between several metabolic pathways is responsible for the pathological consequences.
Challenges of molecular nutrition research 6: the nutritional phenotype database to store, share and evaluate nutritional systems biology studies
Ommen, B. van; Bouwman, J.H. ; Dragsted, L.O. ; Drevon, C.A. ; Elliott, R. ; Groot, P.J. de; Kaput, J. ; Mathers, J.C. ; Müller, M.R. ; Pepping, F. ; Saito, J. ; Scalbert, A. ; Radonjic, M. ; Rocca-Serra, P. ; Travis, A. ; Wopereis, S. ; Evelo, C. - \ 2010
Genes & Nutrition 5 (2010)3. - ISSN 1555-8932 - p. 189 - 203.
gene-expression - metabolic phenotypes - association - framework - services - network - complex - health - diet
The challenge of modern nutrition and health research is to identify food-based strategies promoting life-long optimal health and well-being. This research is complex because it exploits a multitude of bioactive compounds acting on an extensive network of interacting processes. Whereas nutrition research can profit enormously from the revolution in ‘omics’ technologies, it has discipline-specific requirements for analytical and bioinformatic procedures. In addition to measurements of the parameters of interest (measures of health), extensive description of the subjects of study and foods or diets consumed is central for describing the nutritional phenotype. We propose and pursue an infrastructural activity of constructing the “Nutritional Phenotype database” (dbNP). When fully developed, dbNP will be a research and collaboration tool and a publicly available data and knowledge repository. Creation and implementation of the dbNP will maximize benefits to the research community by enabling integration and interrogation of data from multiple studies, from different research groups, different countries and different-omics levels. The dbNP is designed to facilitate storage of biologically relevant, pre-processed-omics data, as well as study descriptive and study participant phenotype data. It is also important to enable the combination of this information at different levels (e.g. to facilitate linkage of data describing participant phenotype, genotype and food intake with information on study design and-omics measurements, and to combine all of this with existing knowledge). The biological information stored in the database (i.e. genetics, transcriptomics, proteomics, biomarkers, metabolomics, functional assays, food intake and food composition) is tailored to nutrition research and embedded in an environment of standard procedures and protocols, annotations, modular data-basing, networking and integrated bioinformatics. The dbNP is an evolving enterprise, which is only sustainable if it is accepted and adopted by the wider nutrition and health research community as an open source, pre-competitive and publicly available resource where many partners both can contribute and profit from its developments. We introduce the Nutrigenomics Organisation (NuGO, http://www.nugo.org) as a membership association responsible for establishing and curating the dbNP. Within NuGO, all efforts related to dbNP (i.e. usage, coordination, integration, facilitation and maintenance) will be directed towards a sustainable and federated infrastructure
A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences
Caesar, R. ; Manieri, M. ; Kelder, T. ; Boekschoten, M.V. ; Evelo, C. ; Müller, M.R. ; Kooistra, T. ; Cinti, S. ; Kleemann, R. ; Drevon, C.A. - \ 2010
PLoS ONE 5 (2010)7. - ISSN 1932-6203 - 14 p.
element-binding protein - messenger-rna expression - fatty-acid-composition - gene-expression - lymphoid-cells - insulin sensitivity - human preadipocytes - glucose-metabolism - obese subjects - in-vitro
Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and site-specific functions. EWAT was found to exhibit physiological zonation. De novo lipogenesis in fat proximal to epididymis was stably low, whereas de novo lipogenesis distal to epididymis and at other locations was down-regulated in response to high-fat diet. The contents of linoleic acid and a-linolenic acid in EWAT were increased compared to other depots. Expression of the androgen receptor (Ar) was higher in EWAT than in MWAT and SWAT. We suggest that Ar may mediate depot-dependent differences in de novo lipogenesis rate and propose that accumulation of linoleic acid and a-linolenic acid in EWAT is favored by testosterone-mediated inhibition of de novo lipogenesis and may promote further elongation and desaturation of these polyunsaturated fatty acids during spermatogenesis
Four selenoproteins, protein biosynthesis, and Wnt signalling are particularly sensitive to selenium intake in mice colon
Kipp, A. ; Banning, A. ; Schothorst, E.M. van; Meplan, C. ; Schomburg, L. ; Evelo, C. ; Coort, S.L. ; Gaj, S. ; Keijer, J. ; Hesketh, J. ; Brigelius, R. - \ 2009
Molecular Nutrition & Food Research 53 (2009)12. - ISSN 1613-4125 - p. 1561 - 1572.
messenger-rna stability - thioredoxin-like family - glutathione-peroxidase - gene-expression - microarray data - colorectal adenoma - cancer prevention - molecular targets - oxidative stress - selenocysteine
Selenium is an essential micronutrient. Its recommended daily allowance is not attained by a significant proportion of the population in many countries and its intake has been suggested to affect colorectal carcinogenesis. Therefore, microarrays were used to determine how both selenoprotein and global gene expression patterns in the mouse colon were affected by marginal selenium deficiency comparable to variations in human dietary intakes. Two groups of 12 mice each were fed a selenium-deficient (0.086 mg Se/kg) or a selenium-adequate (0.15 mg Se/kg) diet. After 6 wk, plasma selenium level, liver, and colon glutathione peroxidase (GPx) activity in the deficient group was 12, 34, and 50%, respectively, of that of the adequate group. Differential gene expression was analysed with mouse 44K whole genome microarrays. Pathway analysis by GenMAPP identified the protein biosynthesis pathway as most significantly affected, followed by inflammation, Delta-Notch and Wnt pathways. Selected gene expression changes were confirmed by quantitative real-time PCR. GPx1 and the selenoproteins W, H, and M, responded significantly to selenium intake making them candidates as biomarkers for selenium status. Thus, feeding a marginal selenium-deficient diet resulted in distinct changes in global gene expression in the mouse colon. Modulation of cancer-related pathways may contribute to the higher susceptibility to colon carcinogenesis in low selenium status
Reduction of colonic inflammation in HLA-B27 transgenic rats by feeding Marie Ménard apples, rich in polyphenols
Castagnini, C. ; Luceri, C. ; Toti, S. ; Bigagli, E. ; Caderni, G. ; Femia, A.P. ; Giovannelli, L. ; Lodovici, M. ; Pitozzi, V. ; Salvadori, M. ; Messerini, L. ; Martin, R. ; Zoetendal, E.G. ; Gaj, S. ; Eijssen, L. ; Evelo, C. ; Renard, C.M. ; Baron, A. ; Dolara, P. - \ 2009
The British journal of nutrition 102 (2009)11. - ISSN 0007-1145 - p. 1620 - 1628.
nf-kappa-b - gradient gel-electrophoresis - 16s ribosomal-rna - polymerase-chain-reaction - gene-expression profiles - bowel-disease - dna-damage - gastrointestinal-tract - bacteroides-vulgatus - ulcerative-colitis
Inflammatory bowel diseases (IBD) are immunomediated ailments affecting millions of individuals. Although diet is regarded as an important factor influencing IBD, there are no accepted dietary recommendations presently available. We administered 7.6 % lyophilised apples obtained from two cultivars (Golden Delicious and Marie Ménard, low and high in polyphenols, respectively) to HLA-B27 transgenic rats which develop spontaneous IBD. After 3 months feeding, rats fed Marie Ménard apples had reduced myeloperoxidase activity (3.6 (sem 0.3) v. 2.2 (sem 0.2) U/g tissue; P <0.05) and reduced cyclo-oxygenase-2 (P <0.05) and inducible NO synthase gene expression (P <0.01) in the colon mucosa and significantly less diarrhoea (P <0.05), compared with control rats. Cell proliferation in the colon mucosa was reduced significantly by feeding Golden Delicious apples, with a borderline effect of Marie Ménard apples. Gene expression profiling of the colon mucosa, analysed using the Whole Rat Genome 4 x 44 K Agilent Arrays, revealed a down-regulation of the pathways of PG synthesis, mitogen-activated protein kinase (MAPK) signalling and TNFalpha-NF-kappaB in Marie Ménard-fed rats. In the stools of the animals of this group we also measured a significant reduction of bacteria of the Bacteriodes fragilis group. In conclusion, the administration of Marie Ménard apples, rich in polyphenols and used at present only in the manufacturing of cider, ameliorates colon inflammation in transgenic rats developing spontaneous intestinal inflammation, suggesting the possible use of these and other apple varieties to control inflammation in IBD patients
The NuGO proof of principle study package: a collaborative research effort of the European Nutrigenomics Oganisation
Baccini, M. ; Bachmaier, E.M. ; Biggeri, A. ; Boekschoten, M.V. ; Bouwman, F.G. ; Brennan, L. ; Caesar, R. ; Cinti, S. ; Coort, S.L. ; Crosley, K. ; Daniel, H. ; Drevon, C.A. ; Duthie, S. ; Eijssen, L. ; Elliott, R. ; Erk, M.J. van; Evelo, C. ; Gibney, M.J. ; Heim, C. ; Horgan, G. ; Johnson, I.T. ; Kelder, T. ; Kleemann, R. ; Kooistra, T. ; Iersel, M.P. van; Mariman, E.C.M. ; Mayer, C. ; McLoughlin, G. ; Müller, M.R. ; Mulholland, F. ; Ommen, B. van; Polley, A.C. ; Pujos-Guillot, E. ; Rubio-Aliaga, I. ; Roche, H. ; Roos, B. de; Sailer, M. ; Tonini, G. ; Williams, L.M. ; Wit, N.J.W. de - \ 2008
Genes & Nutrition 3 (2008)3. - ISSN 1555-8932 - p. 147 - 151.
immune-system
Genetic variation in thioredoxin interacting protein (TXNIP) is associated with hypertriglyceridaemia and blood pressure in diabetes mellitus
Greevenbroek, M.M.J. van; Vermeulen, V. ; Feskens, E.J.M. ; Evelo, V.T. ; Kruijshoop, M. ; Hoebee, B. ; Kallen, C.J.H. van der; Bruin, T.W.A. de - \ 2007
Diabetic medicine 24 (2007)5. - ISSN 0742-3071 - p. 498 - 504.
familial combined hyperlipidemia - endothelial growth-factor - cardiovascular risk-factors - glucose-intolerance - fatty liver - population - identification - expression - microalbuminuria - hypertension
Aims Thioredoxin interacting protein (TXNIP) is an attractive candidate gene for diabetes or diabetic dyslipidaemia, since TXNIP is the strongest glucose-responsive gene in pancreatic B-cells, TXNIP deficiency in a mouse model is associated with hyperlipidaemia and TXNIP is located in the 1q21-1q23 chromosomal Type 2 diabetes mellitus (DM) locus. We set out to investigate whether metabolic effects of TXNIP that were previously reported in a murine model are also relevant in human Type 2 DM. Methods The frequency distribution of a 3' UTR single nucleotide polymorphism (SNP) in TXNIP was investigated in subjects with normal glucose tolerance (NGT; n = 379), impaired glucose tolerance (IGT; n = 228) and Type 2 DM (n = 230). Metabolic data were used to determine the effect of this SNP on parameters associated with lipid and glucose metabolism. Results The frequency of the TXNIP variation did not differ between groups, but within the group of diabetic subjects, carriers of the TXNIP-T variant had 1.6-fold higher triglyceride concentrations (P = 0.015; n = 136) and a 5.5-mmHg higher diastolic blood pressure (P = 0.02; n = 212) than homozygous carriers of the common C-allele, whereas in non-diabetic subjects fasting glucose was 0.26 mmol/l lower (P = 0.002; n = 478) in carriers of the T-allele. Moreover, a significant interaction between plasma glucose concentrations and TXNIP polymorphism on plasma triglycerides was observed (P = 0.012; n = 544). Conclusion This is the first report to implicate TXNIP in a human disorder of energy metabolism, Type 2 diabetes. The effect of TXNIP on triglycerides is influenced by plasma glucose concentrations, suggesting that the biological relevance of TXNIP variations may be particularly relevant in recurrent episodes of hyperglycaemia.
Less Botrytis in supply chain by apropriate packaging
Sman, R.G.M. van der; Evelo, R.G. - \ 1998
Vakblad voor de Bloemisterij 1 (1998). - ISSN 0042-2223 - p. 37 - 37.
A dynamic and generic model of gas exchange of respiring produce: the effects of oxygen, carbon dioxide and temperature
Hertog, M.L.A.T.M. ; Peppelenbos, H.W. ; Evelo, R.G. ; Tijskens, L.M.M. - \ 1998
Postharvest Biology and Technology 14 (1998). - ISSN 0925-5214 - p. 335 - 349.
A ready for use MAP-model dynamic in time and temperature with incorporated models for respiration and keeping quality
Hertog, M.L.A.T.M. ; Peppelenbos, H.W. ; Tijskens, L.M.M. ; Evelo, R.G. - \ 1998
In: CIPA International Congress for plastics in agriculture - p. 521 - 535.
Kwaliteitsverloop en houdbaarheid van MA-verpakte broccoli : onderzoek als onderdeel van het AKK project GF-95.001 "toegevoegde waarde strategie project Frugifera"
Polderdijk, J.J. ; Boogaard, G.J.P.M. ; Boerrigter, H.A.M. ; Stappers, S. ; Evelo, R.G. - \ 1997
Wageningen : Instituut voor Agrotechnologisch Onderzoekinstituut, Dienst Landbouwkundig Onderzoek (ATO-DLO) (ATO-rapport B257) - 17
Modified atmosphere packaging: Optimisation through simulation
Hertog, M.L.A.T.M. ; Peppelenbos, H.W. ; Tijskens, L.M.M. ; Evelo, R.G. - \ 1997
In: proceedings 7th International Controlled Atmosphere Research Conference, 13-16 July, Davis, USA, Vol. 5 Fresh-cut fruits and vegetables and MAP Ed. J.R. Gorny - p. 83 - 88.
Verlenging van de bewaarduur van onbewortelde chrysantenstekken met behulp van MA-verpakkingen
Peppelenbos, H.W. ; Boogaard, Gérard van den; Robat, S. ; Evelo, R.G. ; Oosterhaven, J. - \ 1996
Wageningen : Agrotechnologisch Onderzoek Instituut (ATO-DLO) - 24
Onderzoek te behoeve van optimalisatie van een MA-kleinverpakking en kwaliteitsvoorspellingen voor panklare geschoonde spruiten
Polderdijk, J.J. ; Boerrigter, H.A.M. ; Boogaard, G.J.P.M. van den; Robat, S. ; Peppelenbos, H.W. ; Stappers, S. ; Oosterhaven, J. ; Evelo, R.G. - \ 1996
Wageningen : Agrotechnologisch Onderzoek Instituut (ATO-DLO) (Rapport / Instituut voor Agrotechnologisch Onderzoek, Dienst Landbouwkundig Onderzoek (ATO-DLO) B202) - 32
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