Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Records 1 - 19 / 19

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    How the COVID-19 pandemic highlights the necessity of animal research
    Genzel, Lisa ; Adan, Roger ; Berns, Anton ; Beucken, Jeroen van den; Blokland, Arjan ; Boddeke, Erik H.W.G.M. ; Bogers, Willy M. ; Bontrop, Ronald ; Bulthuis, R. ; Bousema, Teun ; Clevers, Hans ; Coenen, Tineke C.J.J. ; Dam, Anne Marie van; Deen, Peter M.T. ; Dijk, K.W. van; Eggen, Bart J.L. ; Elgersma, Ype ; Erdogan, Izel ; Englitz, Bernard ; Fentener van Vlissingen, J.M. ; Fleur, Susanne la; Fouchier, Ron ; Fitzsimons, Carlos P. ; Frieling, Wilbert ; Haagmans, Bart ; Heesters, Balthasar A. ; Henckens, Marloes ; Herfst, Sander ; Hol, Elly ; Hove, Daniel van den; Jonge, Marien I. de; Jonkers, Jos ; Joosten, Leo A.B. ; Kalsbeek, Andries ; Kamermans, Maarten ; Kampinga, Harm H. ; Kas, Martien J. ; Keijer, J. ; Kersten, Sander ; Kiliaan, Amanda J. ; Kooij, Taco W.A. ; Kooijman, Sander ; Koopman, Werner J.H. ; Korosi, Aniko ; Krugers, Harm J. ; Kuiken, Thijs ; Kushner, Steven A. ; Langermans, Jan A.M. ; Lesscher, Heidi ; Lucassen, Paul J. ; Lutgens, Esther ; Netea, Mihai G. ; Noldus, Lucas P.J.J. ; Meer, Jos W.M. van der; Meye, Frank J. ; Mul, Joram D. ; Oers, Kees van; Olivier, Jocelien D.A. ; Pasterkamp, R.J. ; Philippens, Ingrid H.C.H.M. ; Prickaerts, Jos ; Pullox, Bart J.A. ; Rensen, Patrick C.N. ; Rheenen, Jacco van; Rij, Ronald P. van; Ritsma, Laila ; Rockx, Barry H.G. ; Roozendaal, Benno ; Schothorst, Evert M. van; Stittelaar, K. ; Stockhofe, Norbert ; Swaab, Dick F. ; Swart, Rik L. de; Vanderschuren, Louk J.M.J. ; Vries, Taco de; Vrij, Femke de; Wezel, Richard van; Wierenga, Corette J. ; Wiesmann, Maximilian ; Willuhn, Ingo ; Zeeuw, Chris I. de; Homberg, Judith R. - \ 2020
    Current Biology 30 (2020)18. - ISSN 0960-9822 - p. R1014 - R1018.
    Recently, a petition was offered to the European Commission calling for an immediate ban on animal testing. Although a Europe-wide moratorium on the use of animals in science is not yet possible, there has been a push by the non-scientific community and politicians for a rapid transition to animal-free innovations. Although there are benefits for both animal welfare and researchers, advances on alternative methods have not progressed enough to be able to replace animal research in the foreseeable future. This trend has led first and foremost to a substantial increase in the administrative burden and hurdles required to make timely advances in research and treatments for human and animal diseases. The current COVID-19 pandemic clearly highlights how much we actually rely on animal research. COVID-19 affects several organs and systems, and the various animal-free alternatives currently available do not come close to this complexity. In this Essay, we therefore argue that the use of animals is essential for the advancement of human and veterinary health. In this Essay, Genzel et al. make the case for animal research in light of the COVID-19 pandemic.
    Functionality of cryopreserved juvenile ovaries from mutant mice in different genetic background strains after allotransplantation
    Huang, K.Y. ; Groot, S.A. de; Woelders, H. ; Horst, G.T.J. van der; Themmen, A.P.N. ; Colenbrander, B. ; Fentener van Vlissingen, J.M. - \ 2010
    Cryobiology 60 (2010)2. - ISSN 0011-2240 - p. 129 - 137.
    in-vitro fertilization - adult-mouse ovaries - dna-repair enzyme - orthotopic transplantation - antral follicles - tissue - vitrification - oocytes - fertility - protein
    The rapid expansion of mutant mouse colonies for biomedical research has resulted in lack of space at laboratory animal facilities and increasing risks of losing precious lines. These challenges require cheap and effective methods in addition to freezing embryos and sperm to archive the expanding mutant mouse lines. Cryopreservation of mouse ovarian tissue has been reported, but the application in the diverse mutant lines and genetic backgrounds has not yet been studied. In this study, juvenile ovaries (10-day-old) collected from genetically modified mouse lines were cryopreserved using high concentrations of cryoprotectants (dimethyl sulfoxide (Me(2)SO) and ethylene glycol (EG)) and instrumented ultra-rapid freezing. The validation of the frozen ovary batches was assessed by orthotopically transplanting a thawed ovary into a nearly completely ovariectomized mature female (congenic with the ovary donor). After 2 weeks of recovery, the ovary recipient was continuously paired with a male (congenic with the ovary donor) to evaluate the fertility of the recipient and delivered offspring were genotyped to evaluate the continued functionality of the grafted ovary. The recipient females delivered genetically modified offspring starting 6 weeks after ovary transplantation and lasting up to 6 months. The presented cryopreservation and transplantation protocols enabled retrieval of the genetic modification in 20 (from 22) genetically modified mutant mouse models on a C57BL/6 (17), FVB (2), or BALB/c (1) background. The thawed ovaries functioned after successful orthotopic allotransplantation to congenic wild-type recipients and produced mutant offspring, which allowed recreation of the desired genotype as a heterozygote on the proper genetic background. The results indicate that cryopreservation of mouse ovaries is a promising method to preserve genetic modification of the increasing number of mutant mouse models and can be used as a model for ovary cryopreservation using a variety of mouse mutants.
    Jan Fentener van Vlissingen
    Ingenbleek, P.T.M. - \ 2009
    In: Nederlandse ondernemers 1850-1950, Noord-Brabant, Limburg, Zeeland, Rotterdam / Visser, Joop, Dicke, Matthijs, van der Zouwen, Annelies, Zutphen : Walburg Pers - ISBN 9789057306495 - p. 91 - 95.
    Cryopreservation of ovarian tissue - an efficient and thus ethically sound approach for archiving genetically modified mouse lines
    Huang, K.Y. ; Themmen, A.P.N. ; Kramer, P. ; Woelders, H. ; Horst, G.T.J. van der; Colenbrander, B. ; Fentener van Vlissingen, J.M. - \ 2008
    Effect of recombinant porcine somatotropin and monoclonal antibody directed to ovine somatotrophic hormone on nitrogen retention and immune parameters in pigs.
    Hel, W. van der; Parmentier, H.K. ; Hole, N.J.K. ; James, S. ; Brandsma, H.A. ; Fentener van Vlissingen, J.M. ; Nieuwland, M.G.B. ; Joling, P. - \ 1994
    Journal of Animal Science 72 (1994). - ISSN 0021-8812 - p. 2820 - 2827.
    Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats.
    Groten, J.P. ; Koeman, J.H. ; Nesselrooij, J.H.J. van; Luten, J.B. ; Fentener van Vlissingen, J.M. ; Stenhuis, W.S. ; Bladeren, P.J. van - \ 1994
    Fundamental and Applied Toxicology 23 (1994). - ISSN 0272-0590 - p. 544 - 552.
    Evaluation of a method to study protein digestion in the proximal digestive tract of young piglets.
    Makkink, C.A. ; Kemp, B. ; Fentener van Vlissingen, J.M. - \ 1991
    In: Proc. 5th Int. Symp. Digestive physiology in pigs, M.W.A. Verstegen et al. (eds.). EAAP publ. 54. Pudoc, Wageningen - p. 173 - 178.
    Effect of rPST administration and ambient temperature on metabolic rate and feed intake.
    Hel, W. van der; Verstegen, M.W.A. ; Kanis, E. ; Fentener van Vlissingen, M. ; Wal, P. van der - \ 1991
    In: Abstract 83rd ASAS Meeting Wyoming - p. 235 - 235.
    Effects of pST in nutrient requirements of pigs.
    Fentener van Vlissingen, M. ; Weerden, E.J. van; Verstegen, M.W.A. - \ 1991
    In: Proc. Int. Symp. Biotechnology for control and product quality in meat production: implications and acceptability, P. van der Wal et al. (eds.). Washington DC, 1990. Pudoc, Wageningen - p. 131 - 141.
    Effect of administration of rpST and OA15 on nitrogen balance and immune parameters in pigs.
    Hel, W. van der; Parmentier, H.K. ; Brandsma, H.A. ; Fentener van Vlissingen, J.M. ; Nieuwland, M.G.B. - \ 1991
    Unknown Publisher - 24 p.
    Effect of rpST administration and ambient temperature in growing pigs on metabolic rate and feed intake.
    Hel, W. van der; Verstegen, M.W.A. ; Kanis, E. ; Fentener van Vlissingen, J.M. ; Wal, P. van der - \ 1991
    Journal of Animal Science 69 (1991)suppl. 1. - ISSN 0021-8812 - p. 239 - 239.
    Effect of rPST treatment on N gain in pigs at various protein and energy intake levels.
    Weerden, E.J. van; Verstegen, M.W.A. ; Fentener van Vlissingen, J.M. ; Hel, W. van der; Kanis, E. ; Wal, P. van der - \ 1990
    Journal of Animal Science 68 (1990)suppl. 1. - ISSN 0021-8812 - p. 275 - 275.
    Effect of pST treatment on metabolic rate and daily pattern of activity.
    Hel, W. van der; Verstegen, M.W.A. ; Kanis, E. ; Fentener van Vlissingen, J.M. ; Wal, P. van der; Brandsma, H.A. - \ 1990
    Journal of Animal Science 68 (1990)suppl. 1. - ISSN 0021-8812 - p. 277 - 277.
    Effect of pST treatment on N-gain in pigs at various protein and energy intake levels.
    Weerden, E.J. van; Verstegen, M.W.A. ; Fentener van Vlissingen, J.M. ; Hel, W. van der; Kanis, E. ; Wal, P. van der - \ 1990
    In: ASAS 68 suppl. 1 - p. 275 - 275.
    Effect of PST treatment on N gain at various protein and energy intake levels.
    Weerden, E.J. van; Verstegen, M.W.A. ; Fentener van Vlissingen, J.M. ; Hel, W. van der; Kanis, E. ; Wal, P. van der - \ 1990
    Journal of Animal Science 68 (1990)suppl. 1. - ISSN 0021-8812 - p. 275 - 275.
    Effect of rPST administration regimen in growing pigs in relation to feeding level.
    Fentener van Vlissingen, J.M. ; Kanis, E. ; Weerden, E.J. van; Wal, P. van der - \ 1990
    Journal of Animal Science 68 (1990)suppl. 1. - ISSN 0021-8812 - p. 273 - 274.
    De benutting van non-starch polysaccharides (NSP's) bij het varken : verteringsfysiologische aspekten en dierlijke produktie
    Fentener van Vlissingen, J.M. ; Mulder, M.M. - \ 1988
    Lelystad : I.V.V.O. (IVVO rapport nr. 197) - 13
    cellulose - chemie - verteerbaarheid - voer - fysiologie - varkens - water - cellulose - chemistry - digestibility - feeds - physiology - pigs - water
    Interpretatie verteringsonderzoek varkens met behulp van nylon bag (mest) en in vitro technieken = The prediction of digestibility in the pig with mobile nylon bags and in vitro enzymatic digestion
    Fentener van Vlissingen, J.M. ; Leeuwen, P. van; Bakker, J.G.M. - \ 1988
    Lelystad : IVVO (Rapport IVVO no. 193) - 58
    dieren - verteerbaarheid - experimenten - voer - in vitro - varkens - planten - in vivo experimenten - animals - digestibility - experiments - feeds - in vitro - pigs - plants - in vivo experimentation
    Interpretatie verteringsonderzoek varkens met behulp van nylon bag (mest) en in vitro technieken.
    Fentener van Vlissingen, J.M. ; Leeuwen, P. van; Bakker, J.G.M. ; Huisman, J. ; Hartog, L.A. den - \ 1988
    Unknown Publisher - 66 p.
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