Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Vitamin D-related genes, blood vitamin D levels and colorectal cancer risk in western european populations
Fedirko, Veronika ; Mandle, Hannah B. ; Zhu, Wanzhe ; Hughes, David J. ; Siddiq, Afshan ; Ferrari, Pietro ; Romieu, Isabelle ; Riboli, Elio ; Bueno-de-Mesquita, Bas ; Duijnhoven, Fränzel J.B. Van; Siersema, Peter D. ; Tjønneland, Anne ; Olsen, Anja ; Perduca, Vittorio ; Carbonnel, Franck ; Boutron-Ruault, Marie Christine ; Kühn, Tilman ; Johnson, Theron ; Krasimira, Aleksandrova ; Trichopoulou, Antonia ; Makrythanasis, Periklis ; Thanos, Dimitris ; Panico, Salvatore ; Krogh, Vittorio ; Sacerdote, Carlotta ; Skeie, Guri ; Weiderpass, Elisabete ; Colorado-Yohar, Sandra ; Sala, Núria ; Barricarte, Aurelio ; Sanchez, Maria Jose ; Quirós, Ramón ; Amiano, Pilar ; Gylling, Björn ; Harlid, Sophia ; Perez-Cornago, Aurora ; Heath, Alicia K. ; Tsilidis, Konstantinos K. ; Aune, Dagfinn ; Freisling, Heinz ; Murphy, Neil ; Gunter, Marc J. ; Jenab, Mazda - \ 2019
Nutrients 11 (2019)8. - ISSN 2072-6643
Colorectal neoplasms - Incidence - Single nucleotide polymorphism (SNP) - Vitamin D

Higher circulating 25-hydroxyvitamin D levels (25(OH)D) have been found to be associated with lower risk for colorectal cancer (CRC) in prospective studies. Whether this association is modified by genetic variation in genes related to vitamin D metabolism and action has not been well studied in humans. We investigated 1307 functional and tagging single-nucleotide polymorphisms (SNPs; individually, and by gene/pathway) in 86 vitamin D-related genes in 1420 incident CRC cases matched to controls from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. We also evaluated the association between these SNPs and circulating 25(OH)D in a subset of controls. We confirmed previously reported CRC risk associations between SNPs in the VDR, GC, and CYP27B1 genes. We also identified additional associations with 25(OH)D, as well as CRC risk, and several potentially novel SNPs in genes related to vitamin D transport and action (LRP2, CUBN, NCOA7, and HDAC9). However, none of these SNPs were statistically significant after Benjamini-Hochberg (BH) multiple testing correction. When assessed by a priori defined functional pathways, tumor growth factor β(TGFβ) signaling was associated with CRC risk (P ≤ 0.001), with most statistically significant genes being SMAD7 (PBH = 0.008) and SMAD3 (PBH = 0.008), and 18 SNPs in the vitamin D receptor (VDR) binding sites (P = 0.036). The 25(OH)D-gene pathway analysis suggested that genetic variants in the genes related to VDR complex formation and transcriptional activity are associated with CRC depending on 25(OH)D levels (interaction P = 0.041). Additional studies in large populations and consortia, especially with measured circulating 25(OH)D, are needed to confirm our findings.

Scientific manuscript on overall case study outcomes and future framework : deliverable D9.3
Roe, Mark ; Berry, Rachel ; Koroušić Seljak, Barbara ; Eftimov, Tome ; Bucher, Tamara ; Nazare, Julie-Anne ; Laville, Martine ; Mantur-Vierendeel, Angelika ; Ginchev, Todor ; Costa-Requena, Jose ; Hieke, Sophie ; Freisling, Heinz ; Finglas, Paul ; Zimmermann, K.L. ; Veer, P. van 't - \ 2018
EU - 38 p.
Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations
Duijnhoven, Fränzel J.B. van; Jenab, Mazda ; Hveem, Kristian ; Siersema, Peter D. ; Fedirko, Veronika ; Duell, Eric J. ; Kampman, Ellen ; Halfweeg, Anouk ; Kranen, Henk J. van; Ouweland, Jody M.W. van den; Weiderpass, Elisabete ; Murphy, Neil ; Langhammer, Arnulf ; Ness-Jensen, Eivind ; Olsen, Anja ; Tjønneland, Anne ; Overvad, Kim ; Cadeau, Claire ; Kvaskoff, Marina ; Boutron-Ruault, Marie Christine ; Katzke, Verena A. ; Kühn, Tilman ; Boeing, Heiner ; Trichopoulou, Antonia ; Kotanidou, Anastasia ; Kritikou, Maria ; Palli, Domenico ; Agnoli, Claudia ; Tumino, Rosario ; Panico, Salvatore ; Matullo, Giuseppe ; Peeters, Petra ; Brustad, Magritt ; Olsen, Karina Standahl ; Lasheras, Cristina ; Obón-Santacana, Mireia ; Sánchez, María José ; Dorronsoro, Miren ; Chirlaque, Maria Dolores ; Barricarte, Aurelio ; Manjer, Jonas ; Almquist, Martin ; Renström, Frida ; Ye, Weimin ; Wareham, Nick ; Khaw, Kay Tee ; Bradbury, Kathryn E. ; Freisling, Heinz ; Aune, Dagfinn ; Norat, Teresa ; Riboli, Elio ; Bueno-de-Mesquita, H.B. - \ 2018
International Journal of Cancer 142 (2018)6. - ISSN 0020-7136 - p. 1189 - 1201.
Cancer epidemiology - Nested case-control study - Pancreatic cancer - Vitamin D
Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n=626; HUNT2 n=112; median follow-up=6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend=0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend=0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.
Comparison of meal patterns across five European countries using standardized 24-h recall (GloboDiet) data from the EFCOVAL project
Park, Min Kyung ; Freisling, Heinz ; Huseinovic, Ena ; Winkvist, Anna ; Huybrechts, Inge ; Crispim, Sandra Patricia ; Vries, Jeanne H.M. de; Geelen, Anouk ; Niekerk, Maryse ; Rossum, Caroline van; Slimani, Nadia - \ 2018
European Journal of Nutrition 57 (2018)3. - ISSN 1436-6207 - p. 1045 - 1057.
Eating frequency - EFCOVAL - Food consumption - GloboDiet/EPIC-Soft - Meal/snack pattern - Snacking
Purpose: To examine meal patterns in terms of frequency and circadian timing of eating in five European countries participating in the EFCOVAL project. Methods: In this cross-sectional study, 559 men and women, aged 44–65 years, were recruited in Belgium, the Czech Republic, France (Southern part), The Netherlands, and Norway. Dietary data were collected by trained interviewers using standardized computerised 24-h recalls (GloboDiet). Means ± SE of (1) eating frequency, (2) overnight fasting, and (3) time between eating occasions were estimated by country using means from 2 days of 24-h recalls. We also estimated the frequency of eating occasions per hour by country as well as the proportional energy intake of meals/snacks by country compared to the mean energy intake of all countries. Results: Mean eating frequency ranged from 4.3 times/day in France to 7.1 times/day in The Netherlands (p <0.05). Mean overnight fasting was shortest in the Netherlands (9.2 h) and longest in Czech Republic (10.9 h) (p <0.05). Mean time between single eating occasions was shortest in The Netherlands (2.4 h) and longest in France (4.3 h) (p <0.05). Different patterns of energy intake by meals and snacks throughout the day were observed across the five countries. Conclusions: We observed distinct differences in meal patterns across the five European countries included in the current study in terms of frequency and circadian timing of eating, and the proportion of energy intake from eating occasions.
Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk : Meta-analysis of individual participant data of seven prospective cohorts in Europe
Freisling, Heinz ; Arnold, Melina ; Soerjomataram, Isabelle ; O'Doherty, Mark George ; Ordóñez-Mena, José Manuel ; Bamia, Christina ; Kampman, Ellen ; Leitzmann, Michael ; Romieu, Isabelle ; Kee, Frank - \ 2017
British Journal of Cancer 116 (2017)11. - ISSN 0007-0920 - p. 1486 - 1497.
Ageing - Body fat distribution - Cancer - CHANCES consortium - Cohort - Obesity - Prevention

Background:We evaluated the associations of anthropometric indicators of general obesity (body mass index, BMI), an established risk factor of various cancer, and body fat distribution (waist circumference, WC; hip circumference, HC; and waist-to-hip ratio, WHR), which may better reflect metabolic complications of obesity, with total obesity-related and site-specific (colorectal and postmenopausal breast) cancer incidence.Methods:This is a meta-analysis of seven prospective cohort studies participating in the CHANCES consortium including 18 668 men and 24 751 women with a mean age of 62 and 63 years, respectively. Harmonised individual participant data from all seven cohorts were analysed separately and alternatively for each anthropometric indicator using multivariable Cox proportional hazards models.Results:After a median follow-up period of 12 years, 1656 first-incident obesity-related cancers (defined as postmenopausal female breast, colorectum, lower oesophagus, cardia stomach, liver, gallbladder, pancreas, endometrium, ovary, and kidney) had occurred in men and women. In the meta-analysis of all studies, associations between indicators of adiposity, per s.d. increment, and risk for all obesity-related cancers combined yielded the following summary hazard ratios: 1.11 (95% CI 1.02-1.21) for BMI, 1.13 (95% CI 1.04-1.23) for WC, 1.09 (95% CI 0.98-1.21) for HC, and 1.15 (95% CI 1.00-1.32) for WHR. Increases in risk for colorectal cancer were 16%, 21%, 15%, and 20%, respectively per s.d. of BMI, WC, HC, and WHR. Effect modification by hormone therapy (HT) use was observed for postmenopausal breast cancer (Pinteraction <0.001), where never HT users showed an ∼20% increased risk per s.d. of BMI, WC, and HC compared to ever users.Conclusions:BMI, WC, HC, and WHR show comparable positive associations with obesity-related cancers combined and with colorectal cancer in older adults. For postmenopausal breast cancer we report evidence for effect modification by HT use.

Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition
Ward, Heather A. ; Norat, Teresa ; Overvad, Kim ; Dahm, Christina C. ; Bueno-de-Mesquita, H.B. ; Jenab, Mazda ; Fedirko, Veronika ; Duijnhoven, Fränzel J.B. Van; Skeie, Guri ; Romaguera-Bosch, Dora ; Tjonneland, Anne ; Olsen, Anja ; Carbonnel, Franck ; Affret, Aurélie ; Boutron-Ruault, Marie Christine ; Katzke, Verena ; Kühn, Tilman ; Aleksandrova, Krassimira ; Boeing, Heiner ; Trichopoulou, Antonia ; Lagiou, Pagona ; Bamia, Christina ; Palli, Domenico ; Sieri, Sabina ; Tumino, Rosario ; Naccarati, Alessio ; Mattiello, Amalia ; Peeters, Petra H. ; Weiderpass, Elisabete ; Åsli, Lene Angell ; Jakszyn, Paula ; Ramón Quirós, J. ; Sánchez, María José ; Dorronsoro, Miren ; Huerta, José María ; Barricarte, Aurelio ; Jirström, Karin ; Ericson, Ulrika ; Johansson, Ingegerd ; Gylling, Björn ; Bradbury, Kathryn E. ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Stepien, Magdalena ; Freisling, Heinz ; Murphy, Neil ; Cross, Amanda J. ; Riboli, Elio - \ 2016
The British journal of nutrition 116 (2016)2. - ISSN 0007-1145 - p. 316 - 325.
Cancer survival - Cohorts - Colorectal cancers - Diets - European Prospective Investigation into Cancer and Nutrition
Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival after CRC diagnosis. Among 3789 CRC cases in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, pre-diagnostic consumption of red meat, processed meat, poultry and dietary fibre was examined in relation to CRC-specific mortality (n 1008) and all-cause mortality (n 1262) using multivariable Cox regression models, adjusted for CRC risk factors. Pre-diagnostic red meat, processed meat or fibre intakes (defined as quartiles and continuous grams per day) were not associated with CRC-specific or all-cause mortality among CRC survivors; however, a marginal trend across quartiles of processed meat in relation to CRC mortality was detected (P 0·053). Pre-diagnostic poultry intake was inversely associated with all-cause mortality among women (hazard ratio (HR)/20 g/d 0·92; 95 % CI 0·84, 1·00), but not among men (HR 1·00; 95 % CI 0·91, 1·09) (P for heterogeneity=0·10). Pre-diagnostic intake of red meat or fibre is not associated with CRC survival in the EPIC cohort. There is suggestive evidence of an association between poultry intake and all-cause mortality among female CRC survivors and between processed meat intake and CRC-specific mortality; however, further research using post-diagnostic dietary data is required to confirm this relationship.
Overweight duration in older adults and cancer risk: a study of cohorts in Europe and the United States
Arnold, Melina ; Freisling, Heinz ; Stolzenberg-Solomon, R. ; Kee, F. ; Feskens, E.J.M. - \ 2016
European Journal of Epidemiology 31 (2016)9. - ISSN 0393-2990 - p. 893 - 904.
Recent studies have shown that cancer risk related to overweight and obesity is mediated by time and might be better approximated by using life years lived with excess weight. In this study we aimed to assess the impact of overweight duration and intensity in older adults on the risk of developing different forms of cancer. Study participants from seven European and one US cohort study with two or more weight assessments during follow-up were included (n = 329,576). Trajectories of body mass index (BMI) across ages were estimated using a quadratic growth model; overweight duration (BMI ≥ 25) and cumulative weighted overweight years were calculated. In multivariate Cox models and random effects analyses, a longer duration of overweight was significantly associated with the incidence of obesity-related cancer [overall hazard ratio (HR) per 10-year increment: 1.36; 95 % CI 1.12–1.60], but also increased the risk of postmenopausal breast and colorectal cancer. Additionally accounting for the degree of overweight further increased the risk of obesity-related cancer. Risks associated with a longer overweight duration were higher in men than in women and were attenuated by smoking. For postmenopausal breast cancer, increased risks were confined to women who never used hormone therapy. Overall, 8.4 % of all obesity-related cancers could be attributed to overweight at any age. These findings provide further insights into the role of overweight duration in the etiology of cancer and indicate that weight control is relevant at all ages. This knowledge is vital for the development of effective and targeted cancer prevention strategies.
Quantification of the smoking-associated cancer risk with rate advancement periods : Meta-analysis of individual participant data from cohorts of the CHANCES consortium
Ordóñez-Mena, José Manuel ; Schöttker, Ben ; Mons, Ute ; Jenab, Mazda ; Freisling, Heinz ; Bueno-de-Mesquita, Bas ; O'Doherty, Mark G. ; Scott, Angela ; Kee, Frank ; Stricker, Bruno H. ; Hofman, Albert ; Keyser, Catherine E. de; Ruiter, Rikje ; Söderberg, Stefan ; Jousilahti, Pekka ; Kuulasmaa, Kari ; Freedman, Neal D. ; Wilsgaard, Tom ; Groot, Lisette C.P.G.M. de; Kampman, Ellen ; Håkansson, Niclas ; Orsini, Nicola ; Wolk, Alicja ; Nilsson, Lena Maria ; Tjønneland, Anne ; Pajak, Andrzej ; Malyutina, Sofia ; Kubínová, Růžena ; Tamosiunas, Abdonas ; Bobak, Martin ; Katsoulis, Michail ; Orfanos, Philippos ; Boffetta, Paolo ; Trichopoulou, Antonia ; Brenner, Hermann - \ 2016
BMC Medicine 14 (2016)1. - ISSN 1741-7015
Cancer - Cohort - Incidence - Meta-analysis - Mortality - Smoking

Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality. Methods: This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs. Results: Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking. Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.

Erratum to: Bias in protein and potassium intake collected with 24-h recalls (EPIC-Soft) is rather comparable across European populations
Crispim, Sandra P. ; Geelen, Anouk ; Vries, Jeanne H.M. De; Freisling, Heinz ; Souverein, Olga W. ; Hulshof, Paul J.M. ; Ocke, Marga C. ; Boshuizen, Hendriek ; Andersen, Lene F. ; Ruprich, Jiri ; Keyzer, Willem De; Huybrechts, Inge ; Lafay, Lionel ; Magistris, Maria S. De; Ricceri, Fulvio ; Tumino, Rosario ; Krogh, Vittorio ; Bueno-De-Mesquita, H.B. ; Beulens, Joline W.J. ; Boutron-Ruault, Marie Christine ; Naska, Androniki ; Crowe, Francesca L. ; Boeing, Heiner ; McTaggart, Alison ; Kaaks, Rudolf ; Veer, Pieter van 't; Slimani, Nadia - \ 2013
European Journal of Nutrition 52 (2013)2. - ISSN 1436-6207 - p. 857 - 858.
Bias in protein and potassium intake collected with 24-h recalls (EPIC-Soft) is rather comparable across European populations
Crispim, S.P. ; Geelen, A. ; Freisling, H. ; Souverein, O.W. ; Hulshof, P.J.M. ; Ocke, M.C. ; Boshuizen, H.C. ; Andersen, L.F. ; Ruprich, J. ; Keizer, W. de; Huybrechts, I. ; Lafay, L. ; DeMagistris, M.S. ; Ricceri, F. ; Tumino, R. ; Krogh, V. ; Bueono-de-Mesquita, H.B. ; Beulens, J.W.J. ; Boutron-Ruault, M.C. ; Naska, A. ; Crowe, F.L. ; Boeing, H. ; McTaggart, A.R. ; Kaaks, R. ; Veer, P. van 't; Slimani, N. - \ 2012
European Journal of Nutrition 51 (2012)8. - ISSN 1436-6207 - p. 997 - 1010.
consumption validation efcoval - diet recall - urinary nitrogen - nutrition - cancer - calibration - telephone - countries - biomarker - centers
Purpose: We investigated whether group-level bias of a 24-h recall estimate of protein and potassium intake, as compared to biomarkers, varied across European centers and whether this was influenced by characteristics of individuals or centers. Methods: The combined data from EFCOVAL and EPIC studies included 14 centers from 9 countries (n = 1,841). Dietary data were collected using a computerized 24-h recall (EPIC-Soft). Nitrogen and potassium in 24-h urine collections were used as reference method. Multilevel linear regression analysis was performed, including individual-level (e.g., BMI) and center-level (e.g., food pattern index) variables. Results: For protein intake, no between-center variation in bias was observed in men while it was 5.7% in women. For potassium intake, the between-center variation in bias was 8.9% in men and null in women. BMI was an important factor influencing the biases across centers (p <0.01 in all analyses). In addition, mode of administration (p = 0.06 in women) and day of the week (p = 0.03 in men and p = 0.06 in women) may have influenced the bias in protein intake across centers. After inclusion of these individual variables, between-center variation in bias in protein intake disappeared for women, whereas for potassium, it increased slightly in men (to 9.5%). Center-level variables did not influence the results. Conclusion: The results suggest that group-level bias in protein and potassium (for women) collected with 24-h recalls does not vary across centers and to a certain extent varies for potassium in men. BMI and study design aspects, rather than center-level characteristics, affected the biases across centers
Rationale and methods of the European Food Consumption Validation (EFCOVAL) Project
Boer, E.J. de; Slimani, N. ; Boeing, H. ; Feinberg, M. ; Leclerq, C. ; Trolle, E. ; Amiano, P. ; Andersen, L.F. ; Freisling, H. ; Geelen, A. ; Harttig, U. ; Huybrechts, I. ; Kaic-Rak, A. ; Lafay, L. ; Lillegaard, I.T.L. ; Ruprich, J. ; Vries, J.H.M. de; Ocke, M.C. - \ 2011
European Journal of Clinical Nutrition 65 (2011). - ISSN 0954-3007 - p. S1 - S4.
epic-soft software - dietary exposure - calibration - centers
Background/Objectives: The overall objective of the European Food Consumption Validation (EFCOVAL) Project was to further develop and validate a trans-European food consumption method to be used for the evaluation of the intake of foods, nutrients and potentially hazardous chemicals within the European population. Subjects/Methods: The EFCOVAL Project was carried out by 13 institutes from 11 European countries. The main activities were centered on the three main objectives of the project organized in different sub-projects. Results: In EFCOVAL, EPIC-Soft (the software developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) was reprogrammed and adapted according to prioritized specifications, resulting in a software program working under the Windows operating system. In parallel of the EPIC-Soft development, the repeated 24-HDR method using EPIC-Soft and a food propensity questionnaire was evaluated against biomarkers in 24-h urine collections and in blood samples among adults from Belgium, the Czech Republic, (the South of) France, the Netherlands and Norway. As a result from an expert workshop on a proposed dietary assessment method for children (4–12 years), the suggested method was tested in a feasibility study in Denmark and Spain among children of 4–5, 7–8 and 12–13 years. To ensure that collected data had sufficient detail in food description for the assessment of additives and contaminants to foods the EPIC-Soft databases were adapted. Finally, the EFCOVAL Consortium developed a statistical tool (Multiple Source Method) for estimating the usual intake and distribution, which has been tested using real food consumption data and compared with three other statistical methods through a simulation study. In addition, a methodology was developed to quantify uncertainty due to portion-size estimation in usual intake distributions. Conclusion: The findings of EFCOVAL provide sufficient evidence to conclude that the repeated 24-HDR using EPIC-Soft for standardization in combination with a food propensity questionnaire and modeling of usual intake is a suitable method for pan-European surveillance of nutritional adequacy and food safety among healthy adults and maybe in children aged 7 years and older
Respondents' evaluation of the 24-h dietary recall method (EPIC-Soft) in the EFCOVAL Project
Huybrechts, I. ; Geelen, A. ; Vries, J.H.M. de; Casagrande, C. ; Nicolas, G. ; Keyzer, W. de; Lillegaard, I.T.L. ; Ruprich, J. ; Lafay, L. ; Wilson-van den Hooven, E.C. ; Niekerk, E.M. ; Margaritis, I. ; Rehurkova, I. ; Crispim, S.P. ; Freisling, H. ; Henauw, S. de; Slimani, N. - \ 2011
European Journal of Clinical Nutrition 65 (2011). - ISSN 0954-3007 - p. S29 - S37.
multiple-pass method - validation - children - accuracy - centers
Background: To improve participation rate, accuracy and respondents’ compliance, it is important to know the respondents’ viewpoint. Objective: To evaluate respondents’ preferences and perception about the EPIC-Soft (the software developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) 24-HDR interviews and to compare these preferences and perception between population groups (for example, between genders). Design: Data were collected in Belgium, Czech Republic, France, the Netherlands and Norway in 2007. Two 24-HDRs (face-to-face and telephone administered) were conducted using EPIC-Soft. An evaluation questionnaire on different study aspects was completed by the respondents. Setting: Data were collected in the European Food Consumption Validation Study. Subjects: A convenience sample of 600 apparently healthy men and women, 45–65 years old and including all educational levels, were recruited (120 subjects per country). Differences among population groups were compared by means of the ¿ 2-test. Results: A total of 585 respondents completed the evaluation questionnaire. In all, 88% experienced problems only to a low degree when answering face-to-face and telephone-administered 24-HDR using EPIC-Soft. A total of 15% would have preferred help of another person during the face-to-face interview in the study center (mainly men: P
Inventory of experiences from national/regional dietary monitoring surveys using EPIC-Soft
Huybrechts, I. ; Casagrande, C. ; Nicolas, G. ; Geelen, A. ; Crispim, S.P. ; Keyzer, W. de; Freisling, H. ; Henauw, S. de; Maeyer, M. de; Krems, C. ; Amiano, P. ; Boer, E.J. de; Ocke, M.C. ; Vries, J.H.M. de; Slimani, N. - \ 2011
European Journal of Clinical Nutrition 65 (2011). - ISSN 0954-3007 - p. S16 - S28.
recall - calibration - program - cancer
Background/Objectives: The EPIC-Soft 24-h recall (the software developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) has been used in several regional/national dietary monitoring surveys. The main objective of the study was to present and discuss design, settings, logistics, data management and quality controls of dietary monitoring surveys that used EPIC-Soft for the collection of food consumption data. Subjects/Methods: Within European Food Consumption Validation (EFCOVAL), a questionnaire including questions on current/past EPIC-Soft experiences and requirements for the future was developed and sent to all institutes that used EPIC-Soft in their food consumption survey(s) (five surveys in four different countries). Results: EPIC-Soft was used in the national food consumption survey in Belgium (greater than or equal to15–97 years), Germany (14–80 years), the Netherlands (19–30 years and 2–6 years) and Spain (regional only; 4–18 years). Participation rates in these surveys were 46% (Belgium), 42% (Germany), 42% (Dutch survey in adults), 79% (Dutch survey in children) and 77% (Basque survey). Two 24-HDRs were collected by conducting face-to-face interviews in Belgium and Spain, and through telephone interviews in Germany and the Netherlands. Except the Netherlands (19–30 years), where the study was conducted only in autumn, in all other countries the study was conducted throughout the four seasons, including all days of the week. Interviews were conducted by dietitians, except in Germany and Spain. Mean EPIC-Soft interview time was 20–34¿min. The dropout rate between the first and second interviews was low (
Potential and requirements for a standarized pan-European food consumption survey using the EPIC-Soft software
Ocke, M.C. ; Slimani, N. ; Brants, H.A.M. ; Buurma-Rethans, E. ; Casagrande, C. ; Nicolas, G. ; Dofkova, M. ; Donne, C. le; Freisling, H. ; Geelen, A. ; Huybrechts, I. ; Keyzer, W. de; Laan, J.D. van der; Lafay, L. ; Lillegaard, I.T.L. ; Niekerk, E.M. ; Vries, J.H.M. de; Wilson-van den Hooven, E.C. ; Boer, E.J. de - \ 2011
European Journal of Clinical Nutrition 65 (2011). - ISSN 0954-3007 - p. S48 - S57.
24-hour diet recall - plasma carotenoids - level correlations - nutrient intake - nutrition - cancer - recommendations - questionnaires - calibration - validation
Background/Objectives: To describe the strengths, limitations and requirements of using EPIC-Soft software (the software developed to conduct 24-h dietary recalls in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) in pan-European food consumption surveys, and to discuss potentials and barriers for a harmonized pan-European food consumption survey. Subjects/Methods: The paper is based on the experiences in the ‘European Food Consumption and Validation’ Project, which included updating six existing and preparing one new country-specific EPIC-Soft version, applying EPIC-Soft in validation and feasibility studies, and estimating the intake of nutrients and flavoring substances. The experiences were discussed in the September 2009 workshop ‘Pan-European Food Consumption Surveys—for Standardized and Comparable Transnational Data Collection’. Results: EPIC-Soft is suitable for detailed and standardized food consumption data collection in pan-European food consumption surveys. A thorough preparation of all aspects of the food consumption survey is important for the quality and efficiency during data collection and processing. The preparation and data-handling phase of working with EPIC-Soft is labor intensive and requires trained, motivated and qualified personnel. Conclusions: Given the suitability of EPIC-Soft as standardized dietary assessment tool in European dietary monitoring, the proposed strategy toward a pan-European food consumption survey is to prepare well, to allow flexibility in national extensions and to start with a limited number of countries that are interested
The standardized computerized 24-h dietary recall method EPIC-Soft adapted for pan-European dietary monitoring
Slimani, N. ; Casagrande, C. ; Nicolas, G. ; Freisling, H. ; Huybrechts, I. ; Ocke, M.C. ; Niekerk, E.M. ; Rossum, C. van; Bellemans, M. ; Maeyer, M. de; Lafay, L. ; Krems, C. ; Amiano, P. ; Trolle, E. ; Geelen, A. ; Vries, J.H.M. de; Boer, E.J. de - \ 2011
European Journal of Clinical Nutrition 65 (2011)S1. - ISSN 0954-3007 - p. S5 - S15.
nutrition - cancer - calibration - project - validation - rationale - countries - nitrogen - centers - program
Background/Objectives: The EPIC-Soft program (the software initially developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) was recommended as the best way to standardize 24-HDRs for future pan-European dietary monitoring. Within European Food Consumption Validation (EFCOVAL), EPIC-Soft was adapted and further developed on various aspects that were required to optimize its use. In this paper, we present the structure and main interview steps of the EPIC-Soft program, after implementation of a series of new specifications deemed to satisfy specific requirements of pan-European monitoring surveys and other international studies. Subjects/Methods: Updates to optimize the EPIC-Soft program were ascertained according to the following stepwise approach: (1) identification of requested specifications to be potentially implemented through an ad hoc ‘EPIC-Soft specifications questionnaire’ sent to past, current and possible future users of the software; (2) evaluation of the specifications in collaboration with two ad hoc task force groups and through a workshop; (3) development of a technical solution for each retained specification; (4) implementation of the specifications by software developers; (5) testing and amendment of bugs. Results: A number of new specifications and facilities were implemented to EPIC-Soft program. In addition, the software underwent a full reprogramming and migration to a modern Windows environment, including changes in its internal architecture and user interface. Although the overall concept and structure of the initial software were not changed substantially, these improvements ease the current and future use of EPIC-Soft and increase further its adaptation to other countries and study contexts. Conclusions: EPIC-Soft is enriched with further functions and facilities expected to fulfil specific needs of pan-European dietary monitoring and risk assessment purposes. The validity, feasibility and relevance of this software for different national and international study designs, and the logistical aspects related to its implementation are reported elsewhere.
The European Food Consumption Validation Project: conclusions and recommendations
Boer, E.J. de; Slimani, N. ; Veer, P. van 't; Boeing, H. ; Feinberg, M. ; Leclerq, C. ; Trolle, E. ; Amiano, P. ; Andersen, L.F. ; Freisling, H. ; Geelen, A. ; Harttig, U. ; Huybrechts, I. ; Kaic-Rak, A. ; Lafay, L. ; Lillegaard, I.T.L. ; Ruprich, J. ; Vries, J.H.M. de; Ocke, M.C. - \ 2011
European Journal of Clinical Nutrition 65 (2011). - ISSN 0954-3007 - p. S102 - S107.
epic-soft software - dietary exposure - calibration - databases - centers
Background/Objectives: To outline and discuss the main results and conclusions of the European Food Consumption Validation (EFCOVAL) Project. Subjects/Methods: The EFCOVAL Project was carried out within the EU Sixth Framework Program by researchers in 11 EU countries. The activities focused on (1) the further development of the EPIC-Soft software (the software developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) and the validation of the 2-day non-consecutive 24-HDR method using EPIC-Soft, (2) defining and investigating the applicability of the most appropriate dietary assessment method to younger age groups and expanding the applicability of the software for use in exposure assessment of some potentially hazardous chemicals and (3) to improve the methodology and statistical methods that estimate usual intake distributions from short-term dietary intake information and develop a methodology to quantify uncertainty in usual intake distributions. Results: The preexisting EPIC-Soft application was reprogrammed into a Windows environment and more than 60 new specifications were implemented in the software. A validation study showed that two non-consecutive EPIC-Soft 24-HDRs are suitable to estimate the usual intake distributions of protein and potassium of European adult populations. The 2-day non-consecutive 24-HDRs in combination with a food propensity questionnaire also appeared to be appropriate to rank individuals according to their fish and fruit and vegetable intake in a comparable way in five European centers. Dietary intake of (young) children can be assessed by the combination of EPIC-Soft 24-HDRs and food recording booklets. The EPIC-Soft-standardized method of describing foods is useful to estimate dietary exposure to potentially hazardous chemicals such as specific flavoring substances. With the developed Multiple Source Method, repeated non-consecutive 24-HDR data in combination with food propensity data can be used to estimate the population distribution of the usual intake by estimating the individual usual intakes.
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