Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Therapeutic immunization against glioblastoma
    Schijns, Virgil E.J.C. ; Pretto, Chrystel ; Strik, Anna M. ; Gloudemans-Rijkers, Rianne ; Deviller, Laurent ; Pierre, Denis ; Chung, Jinah ; Dandekar, Manisha ; Carrillo, Jose A. ; Kong, Xiao Tang ; Fu, Beverly D. ; Hsu, Frank P.K. ; Hofman, Florence M. ; Chen, Thomas C. ; Zidovetzki, Raphael ; Bota, Daniela A. ; Stathopoulos, Apostolos - \ 2018
    International Journal of Molecular Sciences 19 (2018)9. - ISSN 1661-6596
    Allogenic - Autologous - Brain tumor - Glioma tumor - Immunotherapy - Therapeutic vaccine
    Glioblastoma is the most common form of brain cancer in adults that produces severe damage to the brain leading to a very poor survival prognosis. The standard of care for glioblastoma is usually surgery, as well as radiotherapy followed by systemic temozolomide chemotherapy, resulting in a median survival time of about 12 to 15 months. Despite these therapeutic efforts, the tumor returns in the vast majority of patients. When relapsing, statistics suggest an imminent death dependent on the size of the tumor, the Karnofsky Performance Status, and the tumor localization. Following the standard of care, the administration of Bevacizumab, inhibiting the growth of the tumor vasculature, is an approved medicinal treatment option approved in the United States, but not in the European Union, as well as the recently approved alternating electric fields (AEFs) generator NovoTTF/Optune. However, it is clear that regardless of the current treatment regimens, glioma patients continue to have dismal prognosis and novel treatments are urgently needed. Here, we describe different approaches of recently developed therapeutic glioma brain cancer vaccines, which stimulate the patient’s immune system to recognize tumor-associated antigens (TAA) on cancer cells, aiming to instruct the immune system to eventually attack and destroy the brain tumor cells, with minimal bystander damage to normal brain cells. These distinct immunotherapies may target particular glioma TAAs which are molecularly defined, but they may also target broad patient-derived tumor antigen preparations intentionally evoking a very broad polyclonal antitumor immune stimulation.
    The development and validation of a five-factor model of Sources of Self-Efficacy in clinical nursing education
    Gloudemans, H. ; Reynaert, W. ; Schalk, R. ; Braeken, J. - \ 2013
    Journal of Nursing Education and Practice 3 (2013). - ISSN 1925-4040 - p. 80 - 87.
    Background: The aim of this study is to validate a newly developed nurses' self-efficacy sources inventory. We test the validity of a five-dimensional model of sources of self-efficacy, which we contrast with the traditional four-dimensional model based on Bandura’s theoretical concepts.

    Methods: Confirmatory factor analysis was used in the development of the newly developed self-efficacy measure. Model fit was evaluated based upon commonly recommended goodness-of-fit indices, including the χ2 of the model fit, the Root Mean Square Error of approximation (RMSEA), the Tucker-Lewis Index (TLI), the Standardized Root Mean Square Residual (SRMR), and the Bayesian Information Criterion (BIC).

    Results: All 22 items of the newly developed five-factor sources of self-efficacy have high factor loadings (range .40-.80). Structural equation modeling showed that a five-factor model is favoured over the four-factor model.
    Conclusions and implications: Results of this study show that differentiation of the vicarious experience source into a peer- and expert based source reflects better how nursing students develop self-efficacy beliefs. This has implications for clinical learning environments: a better and differentiated use of self-efficacy sources can stimulate the professional development of nursing students.
    Het recht op voedsel waar maken
    Hospes, O. - \ 2013
    In: De voedselparadox. Over grootschalige honger in een wereld die (meer dan) genoeg voedsel produceert / Habets, J., Gloudemans, H., Tilburg : Stichting WereldDelen - p. 103 - 113.
    Scanning Imaging Absorption Spectrometer for Atmospheric Chartography carbon monoxide total columns: Statistical evaluation and comparison with chemistry transport model results
    Laat, A.T.J. de; Gloudemans, A.M.S. ; Aben, I. ; Krol, M.C. ; Meirink, J.F. ; Werf, G.R. van der; Schrijver, H. - \ 2007
    Journal of Geophysical Research: Atmospheres 112 (2007). - ISSN 2169-897X - 16 p.
    interannual variability - wfm-doas - mopitt instrument - tropospheric co - forest-fires - data set - sciamachy - emissions - pollution - impact
    This paper presents a detailed statistical analysis of one year (September 2003 to August 2004) of global Scanning Imaging Absorption Spectrometer for Atmospheric Chartography (SCIAMACHY) carbon monoxide (CO) total column retrievals from the Iterative Maximum Likelihood Method (IMLM) algorithm, version 6.3. SCIAMACHY provides the first solar reflectance measurements of CO and is uniquely sensitive down to the boundary layer. SCIAMACHY measurements and chemistry transport model (CTM) results are compared and jointly evaluated. Significant improvements in agreement occur, especially close to biomass burning emission regions, when the new Global Fire Emissions Database version 2 (GFEDv2) is used with the CTM. Globally, the seasonal variation of the model is very similar to that of the SCIAMACHY measurements. For certain locations, significant differences were found, which are likely related to modeling errors due to CO emission uncertainties. Statistical analysis shows that differences between single SCIAMACHY CO total column measurements and corresponding model results are primarily explained by random instrument noise errors. This strongly suggests that the random instrument noise errors are a good diagnostic for the precision of the measurements. The analysis also indicates that noise in single SCIAMACHY CO measurements is generally greater than actual variations in total columns. It is thus required to average SCIAMACHY data over larger temporal and spatial scales to obtain valuable information. Analyses of monthly averaged SCIAMACHY measurements over 3° × 2° geographical regions indicates that they are of sufficient accuracy to reveal valuable information about spatial and temporal variations in CO columns and provide an important tool for model validation. A large spatial and temporal variation in instrument noise errors exists which shows a close correspondence with the spatial distribution of surface albedo and cloud cover. This large spatial variability is important for the use of monthly and annual mean SCIAMACHY CO total column measurements. The smallest instrument noise errors of monthly mean 3° × 2° SCIAMACHY CO total columns measurements are 0.01 × 1018 molecules/cm2 for high surface albedo areas over the Sahara. Errors in SCIAMACHY CO total column retrievals due to errors other than instrument noise, like cloud cover, calibration, retrieval uncertainties and averaging kernels are estimated to be about 0.05–0.1 × 1018 molecules/cm2 in total. The bias found between model and observations is around 0.05–0.1 1018 molecules/cm2 (or about 5%) which also includes model errors. This thus provides a best estimate of the currently achievable measurement accuracy for SCIAMACHY CO monthly mean averages.
    Quantitative analysis of SCIAMACHY carbon monoxide total column measurements
    Laat, A.T.J. de; Gloudemans, A.M.S. ; Schrijver, H. ; Broek, M.M.P. van den; Meirink, J.F. ; Aben, I. ; Krol, M.C. - \ 2006
    Geophysical Research Letters 33 (2006). - ISSN 0094-8276 - 5 p.
    co - instrument - resolution - retrieval - emissions - mopitt - trends - impact - ch4
    Global tropospheric ozone distributions, budgets, and radiative forcings from an ensemble of 26 state-of-the-art atmospheric chemistry models have been intercompared and synthesized as part of a wider study into both the air quality and climate roles of ozone. Results from three 2030 emissions scenarios, broadly representing “optimistic,” “likely,” and “pessimistic” options, are compared to a base year 2000 simulation. This base case realistically represents the current global distribution of tropospheric ozone. A further set of simulations considers the influence of climate change over the same time period by forcing the central emissions scenario with a surface warming of around 0.7K. The use of a large multimodel ensemble allows us to identify key areas of uncertainty and improves the robustness of the results. Ensemble mean changes in tropospheric ozone burden between 2000 and 2030 for the 3 scenarios range from a 5% decrease, through a 6% increase, to a 15% increase. The intermodel uncertainty (±1 standard deviation) associated with these values is about ±25%. Model outliers have no significant influence on the ensemble mean results. Combining ozone and methane changes, the three scenarios produce radiative forcings of -50, 180, and 300 mW m-2, compared to a CO2 forcing over the same time period of 800–1100 mW m-2. These values indicate the importance of air pollution emissions in short- to medium-term climate forcing and the potential for stringent/lax control measures to improve/worsen future climate forcing. The model sensitivity of ozone to imposed climate change varies between models but modulates zonal mean mixing ratios by ±5 ppbv via a variety of feedback mechanisms, in particular those involving water vapor and stratosphere-troposphere exchange. This level of climate change also reduces the methane lifetime by around 4%. The ensemble mean year 2000 tropospheric ozone budget indicates chemical production, chemical destruction, dry deposition and stratospheric input fluxes of 5100, 4650, 1000, and 550 Tg(O3) yr-1, respectively. These values are significantly different to the mean budget documented by the Intergovernmental Panel on Climate Change (IPCC) Third Assessment Report (TAR). The mean ozone burden (340 Tg(O3)) is 10% larger than the IPCC TAR estimate, while the mean ozone lifetime (22 days) is 10% shorter. Results from individual models show a correlation between ozone burden and lifetime, and each model's ozone burden and lifetime respond in similar ways across the emissions scenarios. The response to climate change is much less consistent. Models show more variability in the tropics compared to midlatitudes. Some of the most uncertain areas of the models include treatments of deep tropical convection, including lightning NO x production; isoprene emissions from vegetation and isoprene's degradation chemistry; stratosphere-troposphere exchange; biomass burning; and water vapor concentrations.
    Evidence for long-range transport of Carbon Monoxide in the Southern Hemisphere from SCIAMACHY observations
    Gloudemans, A.M.S. ; Krol, M.C. ; Meirink, J.F. ; Laat, A.T.J. de; Werf, G.R. van der; Schrijver, H. ; Broek, M.M.P. van den; Aben, I. - \ 2006
    Geophysical Research Letters 33 (2006). - ISSN 0094-8276 - 5 p.
    wfm-doas - total columns - data set - co - retrieval - ch4 - calibration - instrument - emissions - pacific
    The SCIAMACHY satellite instrument shows enhanced carbon monoxide (CO) columns in the Southern Hemisphere during the local Spring. Chemistry-transport model simulations using the new GFEDv2 biomass-burning emission database show a similar temporal and spatial CO distribution, indicating that the observed enhancements are mainly due to biomass burning (BB). Large differences between the year 2003 and 2004 are observed in both the measurements and the model for South America and Australia. This study analyzes the origin of these observed enhancements in the Southern Hemisphere. The fact that SCIAMACHY is sensitive to surface CO allows for the observation of enhanced CO columns in both emission areas and in areas that are affected by long-range transport of CO. Model results show a large contribution of South American BB CO over Australian BB regions during the 2004 BB season of up to similar to 30-35% and up to 55% further south, with smaller contributions for 2003. BB CO transported from southern Africa contributes up to similar to 40% in 2003 and similar to 30% in 2004. The results indicate that differences between SCIAMACHY CO and the model simulations over Australian BB areas are probably not only caused by uncertainties in local emissions but also in overseas emissions.
    Weidegang in Zweden verplicht, maar..
    Lankveld, C. van - \ 2002
    Praktijkkompas. Rundvee 16 (2002)5. - ISSN 1570-8586 - p. 10 - 10.
    Claudia van Lankveld en Twan Gloudemans zijn in 1998 geëmigreerd naar Zweden. Ze zijn in januari 1998 gestart met 98 koeien op de grupstal en 576.000 kg melk.
    Excretion and metabolism of desogestrel in healthy postmenopausal women
    Verhoeven, C.H.J. ; Gloudemans, R.H.M. ; Peeters, P.A.M. ; Lier, J.J. van; Verheggen, F.T.M. ; Groothuis, G.M.M. ; Rietjens, I.M.C.M. ; Vos, R.M.E. - \ 2001
    Journal of Steroid Biochemistry and Molecular Biology 78 (2001). - ISSN 0960-0760 - p. 471 - 480.
    Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal volunteers
    Verhoeven, C.H.J. ; Gloudemans, R.H.M. ; Groothuis, G.M.M. ; Rietjens, I.M.C.M. ; Vos, R.M.E. - \ 2000
    Journal of Steroid Biochemistry and Molecular Biology 73 (2000). - ISSN 0960-0760 - p. 39 - 48.
    The root epidermis-specific pea gene RH2 is homologous to a pathogenesis-related gene.
    Mylona, P. ; Moerman, M. ; Yang, W.C. ; Gloudemans, T. ; Kerckhove, J. van de; Kammen, A. van; Bisseling, T. ; Franssen, H.J. - \ 1994
    Plant Molecular Biology 26 (1994). - ISSN 0167-4412 - p. 39 - 50.
    Two-dimensional gel electrophoresis of pea root and root hair proteins revealed the existence of at least 10 proteins present at elevated levels in root hairs. One of these, named RH2, was isolated and a partial amino acid sequence was determined from two tryptic peptides. Using this sequence information oligonucleotides were designed to isolate by PCR an RH2 cDNA clone. In situ hybridization studies with this cDNA clone showed that rh2 is not only expressed in root hairs, but also in root epidermal cells lacking these tubular outgrowths. During post-embryonic development the gene is switched on after the transition of protoderm into epidermis and since rh2 is already expressed in a globular pea embryo in the protoderm at the side attached to the suspensor, we conclude that the expression of rh2 is developmentally regulated. At the amino acid level RH2 is 95% homologous to the pea PR protein I49a. These gene encoding I49a is induced in pea pods upon inoculation with the pathogen Fusarium solani [12]. We postulate that rh2 contributes to a constitutive defence barrier in the root epidermis. A similar role has been proposed for chalcone synthase (CHS) and chitinase, pathogenesis-related protein that are also constitutively present in certain epidermal tissues.
    The ENOD 12 gene product is involved in the infection process during the pea-rhizobium interaction.
    Scheres, B. ; Wiel, C. van de; Zalensky, A. ; Horvath, B. ; Spaink, H. ; Eck, H. van; Zwartkruis, F. ; Wolters, A.M. ; Gloudemans, T. ; Kammen, A. van; Bisseling, T. - \ 1990
    Cell 60 (1990). - ISSN 0092-8674 - p. 281 - 294.
    The pea cDNA clone pPsENOD12 represents a gene involved in the infection process during Pisum sativum L.-Rhizobium leguminosarum bv. viciae symbiosis. The ENOD12 protein is composed of pentapeptides containing two hydroxyprolines. The expression of the ENOD12 gene is induced in cells through which the infection thread is migrating, but also in cells that do not yet contain an infection thread. Soluble compounds from Rhizobium are involved in eliciting ENOD12 gene expression. Rhizobium common and host-specific nodulation genes are essential for the production of these compounds. Two ENOD12 genes are expressed in nodules and in stem tissue of uninoculated plants. The gene represented by the cloned ENOD12 mRNA is also expressed in flowers, but a different transcription start may be used.
    Identification and characterization of root hair specific proteins in pea.
    Franssen, H.J. ; Moerman, M. ; Gloudemans, T. ; Folkertsma, R. ; Bisseling, T. - \ 1990
    In: Abstractbook 5th Int. Symp. Molecular genetics of plant-microbe interactions. Interlaken, Switzerland - p. P195 - P195.
    Plant gene expression in early stages of Rhizobium-legume symbiosis.
    Gloudemans, T. ; Bisseling, T. - \ 1989
    Plant Science 65 (1989). - ISSN 0168-9452 - p. 1 - 14.
    Upon infection of the root of a leguminous plant with Rhizobium or Bradyrhizobium bacteria, root nodules are formed. During root nodule formation a set of genes, called nodulin genes, is specifically expressed. Based upon the stage of nodule development in which they become expressed, they are divided into early and late nodulin genes. Early nodulin genes become expressed just before or during infection and during the formation of the nodule structure. Late nodulin genes are first expressed at the onset of dinitrogen fixation, when the nodule structure is essentially ready. The role of plant and bacterial genes involved in root nodule morphogenesis from stages preceding actual infection, through infection until the start of dinitrogen fixation is reviewed.
    Genetic and physiologic characterization of a Bradyrhizobium japonicum mutant defective in early bacteroid development.
    Rossbach, S. ; Gloudemans, T. ; Bisseling, T. ; Studer, D. ; Kaluza, B. ; Ebling, S. ; Hennecke, H. - \ 1989
    Molecular Plant-Microbe Interactions 2 (1989). - ISSN 0894-0282 - p. 233 - 240.
    Cloning of a DNA region from Bradyrhizobium japonicum encoding pleiotropic functions in heme metabolism and respiration.
    Ramseier, Th.M. ; Kaluza, B. ; Studer, D. ; Gloudemans, T. ; Bisseling, T. ; Jordan, P.M. ; Jones, R.M. ; Zuber, M. ; Hennecke, H. - \ 1989
    Archives of Microbiology 151 (1989). - ISSN 0302-8933 - p. 203 - 212.
    Random and site-directed Tn5-induced mutagenesis of Bradyrhizobium japonicum yielded two mutations, one in strain 2960 and the other in strain 2606::Tn5-20, which mapped close to each other but in separate genes. The corresponding wild-type genes were cloned, and their approximate location on the cloned DNA was determined. Mutant 2960 was Fix- and formed green nodules on soybean, whereas strain 2606::Tn5-20 had ca. 4% of wild-type Fix activity and formed white nodules. Cytochrome oxidase assays (Nadi tests) showed a negative reaction with both mutants, indicating a functional deficiency of cytochrome c or its terminal oxidase or both. However, the mutants grew well under aerobic conditions on minimal media with different carbon sources. Furthermore, mutant 2960 had a reduced activity in hydrogen uptake, was unable to grow anaerobically with nitrate as the terminal electron acceptor and 2960-infected soybean nodules contained little, if any, functional leghemoglobin. Southern blot analysis showed that a B. japonicum heme biosynthesis mutant [strain LO505: O'Brian MR, Kirshbom PM, Maier RJ (1987) Proc Natl Acad Sci USA 84: 8390–8393] had its mutation close to the Tn5 insertion site of our mutant 2606::Tn5-20. This finding, combined with the observed phenotypes, suggested that the genes affected in mutants 2960 and 2606::Tn5-20 were involved in some steps of heme biosynthesis thus explaining the pleiotropic respiratory deficiencies of the mutants. Similar to strain LO505, the mutant 2606::Tn5-20 (but not 2960) was defective in the activity of protoporphyrinogen IX oxidase which catalyzes the penultimate step in the heme biosynthesis pathway. This suggests that one of the two cloned genes may code for this enzyme.
    Involvement of Rhizobium leguminosarum nodulation genes in gene expression in pea root hairs.
    Gloudemans, T. ; Bhuvaneswari, T.V. ; Moerman, M. ; Brussel, T. van; Kammen, A. van; Bisseling, T. - \ 1989
    Plant Molecular Biology 12 (1989). - ISSN 0167-4412 - p. 157 - 167.
    The mRNA population in pea root hairs was characterized by means of in vitro translation of total root hair RNA followed by 2-dimensional gel electrophoresis of the translation products. Root hairs contain several mRNAs not detectable in total RNA preparations from roots. Most of these root hair-specific mRNAs occur in elongating root hairs at higher levels than in mature root hairs. The expression of some genes in pea root hairs is typically affected by inoculation with Rhizobium leguminosarum. One gene, encoding RH-42, is specifically induced while the expression of another gene, encoding RH-44, is markedly enhanced. Using R. leguminosarum mutants it was shown that the nodC gene is required for the induction and enhancement of expression of the RH-42 and RH-44 genes, respectively, while the Rhizobium chromosomal gene pss1, involved in exopolysaccharide synthesis, is not essential. After induction of the nod genes with apigenin the bacteria excrete into the culture medium a factor that causes root hair deformation. This deformation factor stimulates the expression of the RH-44 gene but does not induce the expression of the gene encoding RH-42.
    Gene expression in the pea root hairs upon inoculation with Rhizobium.
    Gloudemans, T. ; Moerman, M. ; Bhuvaneswari, T.V. ; Kammen, A. van; Bisseling, T. - \ 1988
    In: Abstract 7th Int. Congr. Nitrogen fixation, Koln, FRG - p. 10 - 01.
    Nodulin genes involved in early stages of the legume-Rhizobium interaction.
    Bisseling, T. ; Franssen, H. ; Gloudemans, T. ; Govers, F. ; Moerman, M. ; Nap, J.P.H. ; Scheres, B. ; Wiel, C. van de; Kammen, A. van - \ 1988
    In: Abstract 7th Int. Congr. Nitrogen fixation, Koln, FRG (1988) L.12.4
    Pisum sativum early nodulin related to the Rhizobium infection process.
    Scheres, B. ; Wiel, C. van de; Gloudemans, T. ; Eck, H. van; Zwartkruis, F. ; Bisseling, T. - \ 1988
    In: Abstract 2nd ISPMB Congr., Jerusalem - p. 446 - 446.
    Nodulins and the early stages of Rhizobium-plant interactions.
    Bisseling, T. ; Franssen, H. ; Gloudemans, T. ; Govers, F. ; Kammen, A. van; Moerman, M. ; Scheres, B. ; Wiel, C. van de - \ 1988
    In: Abstract 2nd ISPMB Congr., Jerusalem - p. 38 - 38.
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