Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    The damage-associated molecular pattern HMGB1 is released early after clinical hepatic ischemia/reperfusion
    Golen, Rowan F. van; Reiniers, Megan J. ; Marsman, Gerben ; Alles, Lindy K. ; Rooyen, Derrick M. van; Petri, Björn ; Mark, Vincent A. Van der; Beek, Adriaan A. van; Meijer, Ben ; Maas, Martinus A. ; Zeerleder, Sacha ; Verheij, Joanne ; Farrell, Geoffrey C. ; Luken, Brenda M. ; Teoh, Narci C. ; Gulik, Thomas M. van; Murphy, Michael P. ; Heger, Michal - \ 2019
    Biochimica et Biophysica Acta. Molecular Basis of Disease 1865 (2019)6. - ISSN 0925-4439 - p. 1192 - 1200.
    Antioxidants - Damage-associated molecular patterns - Intravital microscopy - Liver resection - Mitochondrial DNA - Sterile inflammation

    Objective and background: Activation of sterile inflammation after hepatic ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with mitochondrial oxidative stress and cell death during early reperfusion. The link between mitochondrial oxidative stress, damage-associate molecular pattern (DAMP) release, and sterile immune signaling is incompletely understood and lacks clinical validation. The aim of the study was to validate this relation in a clinical liver I/R cohort and to limit DAMP release using a mitochondria-targeted antioxidant in I/R-subjected mice. Methods: Plasma levels of the DAMPs high-mobility group box 1 (HMGB1), mitochondrial DNA, and nucleosomes were measured in 39 patients enrolled in an observational study who underwent a major liver resection with (N = 29) or without (N = 13) intraoperative liver ischemia. Circulating cytokine and neutrophil activation markers were also determined. In mice, the mitochondria-targeted antioxidant MitoQ was intravenously infused in an attempt to limit DAMP release, reduce sterile inflammation, and suppress I/R injury. Results: In patients, HMGB1 was elevated following liver resection with I/R compared to liver resection without I/R. HMGB1 levels correlated positively with ischemia duration and peak post-operative transaminase (ALT) levels. There were no differences in mitochondrial DNA, nucleosome, or cytokine levels between the two groups. In mice, MitoQ neutralized hepatic oxidative stress and decreased HMGB1 release by ±50%. MitoQ suppressed transaminase release, hepatocellular necrosis, and cytokine production. Reconstituting disulfide HMGB1 during reperfusion reversed these protective effects. Conclusion: HMGB1 seems the most pertinent DAMP in clinical hepatic I/R injury. Neutralizing mitochondrial oxidative stress may limit DAMP release after hepatic I/R and reduce liver damage.

    Hypothermic perfusion with retrograde outflow during right hepatectomy is safe and feasible
    Reiniers, Megan J. ; Olthof, Pim B. ; Golen, Rowan F. van; Heger, Michal ; Beek, Adriaan A. van; Meijer, Ben ; Leen, René ; Kuilenburg, André B.P. van; Mearadji, Banafsche ; Bennink, Roelof J. ; Verheij, Joanne ; Gulik, Thomas M. van - \ 2017
    Surgery 162 (2017)1. - ISSN 0039-6060 - p. 48 - 58.

    Background: In situ hypothermic perfusion during liver resection performed under vascular inflow occlusion decreases hepatic ischemia-reperfusion injury, but technical limitations have restricted its widespread use. In situ hypothermic perfusion with retrograde outflow circumvents these impediments and thus could extend the applicability of in situ hypothermic perfusion. The safety and feasibility of in situ hypothermic perfusion with retrograde outflow were analyzed in selected patients undergoing right (extended) hepatectomy and compared to intermittent vascular inflow occlusion, the gold standard method, in this randomized pilot study. Methods: Patients were first screened for parenchymal liver disease (exclusion criteria: steatosis ≥30%, cirrhosis, or cholestasis). Study participants were randomized intraoperatively to undergo in situ hypothermic perfusion with retrograde outflow (n = 9) or intermittent vascular inflow occlusion (n = 9). The target liver core temperature during in situ hypothermic perfusion with retrograde outflow was 28°C. The primary end point was ischemia-reperfusion injury (expressed by peak postoperative transaminase levels). Secondary outcomes included functional liver regeneration (assessed by hepatobiliary scintigraphy) and clinical outcomes. Results: Peak transaminase levels, total bilirubin, and the international normalized ratio were similar between both groups, although a trend toward more rapid normalization of bilirubin levels was noted for the in situ hypothermic perfusion with retrograde outflow group. Functional liver regeneration as evaluated by hepatobiliary scintigraphy was improved on postoperative day 3 following in situ hypothermic perfusion with retrograde outflow but not after intermittent vascular inflow occlusion. Furthermore, in situ hypothermic perfusion with retrograde outflow (requiring continuous ischemia) was comparable to intermittent vascular inflow occlusion for all clinical outcomes, including postoperative complications and hospital stay. Conclusion: The use of in situ hypothermic perfusion with retrograde outflow appears to be safe and feasible in selected patients with healthy liver parenchyma and may benefit early functional liver regeneration. Future applications of in situ hypothermic perfusion with retrograde outflow include patients with damaged liver parenchyma who would require major hepatic resection with a prolonged vascular inflow occlusion duration.

    Warm ischemia time-dependent variation in liver damage, inflammation, and function in hepatic ischemia/reperfusion injury
    Olthof, Pim B. ; Golen, Rowan F. van; Meijer, Ben ; Beek, Adriaan A. van; Bennink, Roelof J. ; Verheij, Joanne ; Gulik, Thomas M. van; Heger, Michal - \ 2017
    Biochimica et Biophysica Acta. Molecular Basis of Disease 1863 (2017)2. - ISSN 0925-4439 - p. 375 - 385.

    Background Hepatic ischemia/reperfusion (I/R) injury is characterized by hepatocellular damage, sterile inflammation, and compromised postoperative liver function. Generally used mouse I/R models are too severe and poorly reflect the clinical injury profile. The aim was to establish a mouse I/R model with better translatability using hepatocellular injury, liver function, and innate immune parameters as endpoints. Methods Mice (C57Bl/6J) were subjected to sham surgery, 30 min, or 60 min of partial hepatic ischemia. Liver function was measured after 24 h using intravital microscopy and spectroscopy. Innate immune activity was assessed at 6 and 24 h of reperfusion using mRNA and cytokine arrays. Liver inflammation and function were profiled in two patient cohorts subjected to I/R during liver resection to validate the preclinical results. Results In mice, plasma ALT levels and the degree of hepatic necrosis were strongly correlated. Liver function was bound by a narrow damage threshold and was severely impaired following 60 min of ischemia. Severe ischemia (60 min) evoked a neutrophil-dominant immune response, whereas mild ischemia (30 min) triggered a monocyte-driven response. Clinical liver I/R did not compromise liver function and displayed a cytokine profile similar to the mild I/R injury model. Conclusions Mouse models using ≤ 30 min of ischemia best reflect the clinical liver I/R injury profile in terms of liver function dynamics and type of immune response. General significance This short duration of ischemia therefore has most translational value and should be used to increase the prospects of developing effective interventions for hepatic I/R.

    Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture
    Shah, Mihir V. ; Mastrigt, Oscar van; Heijnen, Joseph J. ; Gulik, Walter M. van - \ 2016
    Yeast 33 (2016)4. - ISSN 0749-503X - p. 145 - 161.
    Fumaric acid - Futile cycling - Metabolism - Permeability coefficient - saccharomyces cerevisiae - Transport mechanism

    Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH

    Inhibition of NF-kB in tumor cells exacerbates immune celll activation following photodynamic therapy
    Broekgaarden, M. ; Kos, M. ; Jurg, F.A. ; Beek, A.A. van; Gulik, M. van; Heger, M. - \ 2015
    International Journal of Molecular Sciences 16 (2015)8. - ISSN 1661-6596 - p. 19960 - 19977.
    Although photodynamic therapy (PDT) yields very good outcomes in numerous types of superficial solid cancers, some tumors respond suboptimally to PDT. Novel treatment strategies are therefore needed to enhance the efficacy in these therapy-resistant tumors. One of these strategies is to combine PDT with inhibitors of PDT-induced survival pathways. In this respect, the transcription factor nuclear factor ¿B (NF-¿B) has been identified as a potential pharmacological target, albeit inhibition of NF-¿B may concurrently dampen the subsequent anti-tumor immune response required for complete tumor eradication and abscopal effects. In contrast to these postulations, this study demonstrated that siRNA knockdown of NF-¿B in murine breast carcinoma (EMT-6) cells increased survival signaling in these cells and exacerbated the inflammatory response in murine RAW 264.7 macrophages. These results suggest a pro-death and immunosuppressive role of NF-¿B in PDT-treated cells that concurs with a hyperstimulated immune response in innate immune cells.
    Het nieuwe Telen bij tulpenbroei
    Gulik, T. van der; PPO BBF Bloembollen, - \ 2013
    BloembollenVisie 2013 (2013)264. - ISSN 1571-5558 - p. 24 - 25.
    In juni 2008 heeft de KAVB het Convenant Schone & Zuinige Agrosectoren ondertekend, waarbij het doel is: een energiebesparing van 2,2 % per jaar. De ambitie is om in 2020 bij nieuw te starten bloembollenbedrijven klimaatneutraal en economisch rendabel te kunnen telen/broeien. In dit artikel de stand van zaken.
    State-of-the-Art bewaarsysteem tulpenbollen : Resultaten 2011
    Wildschut, J. ; Dam, M.F.N. van; Kok, M. ; Gulik, T. van der - \ 2012
    Lisse : Praktijkonderzoek Plant & Omgeving, Bollen en Bomen - 33 p.
    bloembollen - tulpen - opslag - ventilatie - temperatuur - energiebesparing - landbouwkundig onderzoek - ornamental bulbs - tulips - storage - ventilation - temperature - energy saving - agricultural research
    Resultaten van het op 5e jaar State-of-Art bewaren van tulpenbollen op 12 bedrijven waarvan de energie- en achtergrondgegevens verzameld zijn. De 12 bedrijven hadden allen dit jaar een zeer laag berekend percentage zure bollen (0.06 % tot maximaal 1,3%). Door geheel of gedeeltelijk de ventilatie op ethyleenmetingen te sturen en ook de circulatie hierop aan te passen kon hierdoor veel energie bespaard worden. Op gas is er gemiddeld 27% bespaard, variërend van -15% (op het bedrijf dat de ventilatie niet stuurt op basis van de ethyleenmeting) tot 80%. Bij volledige sturing van de ventilatie op basis van een ethyleengrens van 100 ppb had de gemiddelde besparing 79% kunnen zijn. Op elektra is door terugtoeren gemiddeld 53% bespaard, variërend van -17% (op het bedrijf dat continue op voltoeren circuleert) tot 95%. Bij terugtoeren evenredig met verminderde ventilatie a.g.v. de lage ethyleenproductie, maar met een minimum frequentie-instelling van 15 Hz, had gemiddeld 84% bespaard kunnen worden. Op elektra is dus meer bespaard dan op gas. Op het totale energieverbruik (gas voor het opwarmen van buitenlucht voor ventilatie + elektra voor circulatieventilatoren) is bij de bewaring gemiddeld 44% bespaard, variërend van -17% tot 76%.
    Ontsmetten met Easy Ice Clean ("Coldblast") "Proof of principle"
    Ludeking, D.J.W. ; Hamelink, R. ; Gulik, M.W. van; Diepenhorst, T. - \ 2012
    Bleiswijk : Wageningen UR Glastuinbouw (Rapporten GTB 1156) - 22
    glastuinbouw - hygiëne - decontaminatie - hogedruktechnologie - koudeshock - ontsmettingsmiddelen - nederland - greenhouse horticulture - hygiene - decontamination - high pressure technology - cold shock - disinfectants - netherlands
    In dit onderzoek is er gekeken naar de potentie en het proof of principle van de Cold Jet techniek van Easy Ice Clean in de tuinbouw. Met dit onderzoek is getracht te beantwoorden of de Cold Jet techniek potentie heeft als alternatieve ontsmettingstechniek voor chemische middelen. De techniek die in dit onderzoek een rol speelde is een techniek die gebruik maakt van droogijs (bevroren CO2). Droogijspellets worden onder grote druk op een te reinigen oppervlak gestraald. Als gevolg van de koude shock en de kracht van de straal kunnen oppervlakken worden gereinigd en misschien wel worden ontsmet. Deze techniek kan een milieuvriendelijke oplossing zijn voor het reinigen van oppervlakken zoals tafels, vloeren, materialen en kassen bij uiteenlopende glastuinbouwteelten. Op basis van het uitgevoerde experiment kan worden geconcludeerd dat de droogijsstraal techniek een onvoldoende ontsmettend effect heeft om een alternatief te zijn voor chemische ontsmettingsmiddelen. De techniek heeft potentie in de glastuinbouw bij het schoonmaken van ernstig vervuilde oppervlakken en complexe apparatuur en installaties. Ook installaties en apparatuur die gevoelig zijn voor water (corrosie) kunnen met deze methode wel grondig worden schoon gemaakt. Ook kan de techniek in combinatie met andere aanvullende technieken wel leiden tot een schoon én ontsmet oppervlak.
    State-of-the-Art bewaarsysteem tulpenbollen : Resultaten 2010
    Wildschut, J. ; Putten, K. van der; Dam, M.F.N. van; Sapounas, A. ; Gulik, T. van der; Diepen, G. van - \ 2011
    Lisse : PPO Bloembollen en Bomen - 43 p.
    bloembollen - tulpen - opslag - ventilatie - temperatuur - energiebesparing - duurzame energie - landbouwkundig onderzoek - ornamental bulbs - tulips - storage - ventilation - temperature - energy saving - sustainable energy - agricultural research
    Het project State-of-the-Art bewaren van tulpenbollen is in 2007 opgestart om te demonstreren wat er met behoud of verbetering van productkwaliteit, met de huidige stand der techniek aan energiebesparing mogelijk is. En om met aanvullend onderzoek op de deelnemende bloembollenbedrijven in de toekomst nog meer te kunnen besparen. Voor het 4de jaar op rij is er door de nu 10 deelnemers fors bespaard op energie: gemiddeld 30% op gas en 44% op elektra. Op het bedrijf dat het meest op gas bespaarde was dat zelfs 72% en op het bedrijf dat het meest op elektra bespaarde was dat 80%. Het doel van het project is tweeledig: Spoor 1) demonstreren wat er met behoud of verbetering van de productkwaliteit met de huidige stand der techniek aan energiebesparing in de bewaring bij tulp mogelijk is. Spoor 2) aanvullend onderzoek & ontwikkeling om hierbij in de toekomst nog meer energie te kunnen besparen.
    State-of-the-Art bewaarsysteem tulpenbollen - Resultaten 2009
    Wildschut, J. ; Gude, H. ; Dam, M. van; Sapounas, A. ; Kok, M. ; Gulik, T. van der - \ 2010
    Lisse : PPO Bloembollen, Boomkwekerij en Fruit (PPO-rapport ) - 47 p.
    Energiebesparingen in het project Energiek geregeld : drogen met kaslucht en andere maatregelen
    Wildschut, J. ; Kok, M. ; Gulik, T. van der - \ 2010
    Lisse : PPO Bloembollen en Bomen
    State-fo-the-Art bewaren van tulpenbollen, resultaten 2009
    Wildschut, J. ; Sapounas, A. ; Kok, M. ; Gulik, T. van der - \ 2010
    BloembollenVisie 2010 (2010)209. - ISSN 1571-5558 - p. 24 - 25.
    duurzaamheid (sustainability) - bloembollen - tulpen - opslagkwaliteit - energiebehoud - besparingen - sustainability - ornamental bulbs - tulips - storage quality - energy conservation - savings
    Het project State-of-the Art bewaren van tulpenbollen' is in 2007 met vier bloembollenbedrijven van start gegaan. Hoofddoel van het project was vooral het demonstreren van energiebesparingsmogelijkheden. Uiteraart met behoud van de kwaliteit van het product, of beter nog, met verbetering van de kwaliteit. Doel twee was te onderzoeken hoe er in de toekomst nog meer energie kan worden bespaard. Dat blijkt aardig wat te kunnen zijn.
    State-of-the-Art bewaarsysteem tulpenbollen
    Wildschut, J. ; Gude, H. ; Sapounas, A. ; Kok, M. ; Gulik, T. van der - \ 2010
    Lisse : PPO Bloembollen, Boomkwekerij en Fruit (PPO-rapport ) - 47 p.
    State/of/the/Art 2009 : Verbetering luchtverdeling één-laagssysteem
    Wildschut, J. ; Gulik, T. van der; Wit, G. de - \ 2010
    beluchting - landbouwtechniek - systeemontwikkeling - systeeminnovatie - aeration - agricultural engineering - system development - system innovation
    Poster over de verbetering van de luchtverdeling, een één-laagssysteem.
    State-of-the-Art bewaarsysteem tulpenbollen - Resultaten 2008
    Wildschut, J. ; Gude, H. ; Kok, M. ; Gulik, T. van der; Bisschops, B. - \ 2009
    Lisse : PPO Bloembollen, Boomkwekerij en Fruit (PPO-rapport ) - 36 p.
    State-of-the-Art 2009 : Verbetering luchtverdeling één-laagssysteem
    Wildschut, J. ; Gulik, T. van der; Wit, G. de - \ 2009
    State-of-the-Art 2008 : Resultaten Energiebesparing
    Wildschut, J. ; Gude, H. ; Kok, M. ; Gulik, T. van der - \ 2008
    Hakselen strodek op klei alleen effectief tegen graanopslag
    Zuilichem, J.A.A. van; Gulik, T.I.N. van der - \ 2005
    Landbouwmechanisatie 56 (2005)10. - ISSN 0023-7795 - p. 15 - 15.
    bloembollen - tulpen - tulipa - alternatieve landbouw - biologische landbouw - onkruidbestrijding - mulchen - stromulches - hakselen - strooisel - ornamental bulbs - tulips - tulipa - alternative farming - organic farming - weed control - chopping - litter (plant) - mulching - straw mulches
    Het hakselen van een dik strodek op tulpen in het najaar blijkt op zavel- en kleigrond alleen effectief te zijn tegen graanopslag. Er werd geen effect gevonden van het hakselen op het aantal onkruiden dat door het strodek kwam, zo is uit onderzoek van PPO en DLV bij een biologische teler gebleken
    Onderzoek in de pijplijn: onkruidbeheersing op zware grond en vreemde bladvlekkenziekte in bol- en knolgewassen
    Gulik, T. van der; Zuilichem, J.A.A. van - \ 2005
    BloembollenVisie (2005)70. - ISSN 1571-5558 - p. 22 - 22.
    tulpen - cultuurmethoden - biologische landbouw - strooisel - afdekken - onkruidbestrijding - bodemtypen (naar textuur) - bloembollen - bladvlekkenziekte - afwijkingen, planten - schimmelziekten - landbouwkundig onderzoek - tulips - cultural methods - organic farming - litter (plant) - casing - weed control - soil types (textural) - ornamental bulbs - leaf spotting - plant disorders - fungal diseases - agricultural research
    Aandacht voor toepassing van strodek tegen onkruidgroei in de biologische teelt van tulp en onderzoek naar gewasmonsters van bollen en knollen met vreemde bladaantastingen
    Effects of soil fumigation and flooding on suppression of Pythium root rot in ornamental bulb culture
    Os, G.J. van; Wijnker, J.P.M. ; Gulik, W.J.M. van - \ 1999
    European Journal of Plant Pathology 105 (1999). - ISSN 0929-1873 - p. 791 - 800.
    Disease development of Pythium root rot in bulbous Iris and Crocus
    Os, G.J. van; Gulik, W.J.M. van; Boer, W.J. de - \ 1998
    Annals of Applied Biology 132 (1998). - ISSN 0003-4746 - p. 227 - 238.
    Effects of flooding, soil fumigation, and composted organic household waste on pythium root rot in bulbous iris
    Os, G.J. Van; Gulik, W.J.M. Van; Wijnker, J.P.M. - \ 1997
    In: Acta Horticulturae - p. 587 - 589.
    Pythium in krokus
    Os, G.J. van; Wijnker, J.P.M. ; Gulik, W.J.M. van - \ 1997
    Lisse : Laboratorium voor Bloembollenonderzoek (Rapport bloembollenonderzoek nr. 109) - 39
    plantenziekteverwekkende schimmels - pythium - bloembollen - nederland - plant pathogenic fungi - pythium - ornamental bulbs - netherlands
    Pythium - aantasting : het gevolg van een verstoord biologisch evenwicht : eindverslag van het project "Bestrijding van Pythium spp. in de bloembollenteelt"
    Os, G.J. van; Gulik, W.J.M. van; Koster, A.T.J. - \ 1995
    Lisse : LBO (Urgentieprogramma bollenziekte- en veredelingsonderzoek ) - 25
    cultuurmethoden - bloembollen - plantenziekteverwekkende schimmels - gewasbescherming - pythium - cultural methods - ornamental bulbs - plant pathogenic fungi - plant protection - pythium
    Themes, scenes, and taste in the history of Japanese garden art
    Kuitert, W. - \ 1988
    Agricultural University. Promotor(en): M.J. Vroom; W.R. van Gulik; M. Nakamura. - Uithoorn : Gieben - ISBN 9789050630214 - 348
    ontwerp - landgoederen - tuinen - geschiedenis - japan - landschap - landschapsarchitectuur - parken - particulier eigendom - taxatie - landschapsbouw - design - estates - gardens - history - japan - landscape - landscape architecture - parks - private ownership - valuation - landscaping

    The present study deals - in its three parts - with three fragments of the garden history of Japan. It reveals how the meaning a garden had to the people of its time was significantly different in all of these periods.

    Part one, titled "Themes", deals with the later Heian period, from the tenth until the late twelfth century. The foundations of a native, Japanese tradition of garden art were laid. The first chapters introduce the palace gardens of the courtly aristocracy in the capital Heian. None of these gardens exist and they are only known from records and illustrative paintings. These paintings are not only informative about the appearance of the gardens, but also show us how the gardens were used by the courtiers. For example, a spacious yard in front of the main palace hall was used for festive ceremonies, a large pond that laid in front of this yard was used for boating parties. One of the palaces, the Tosanjoden Palace, is discussed at length.
    Some late eleventh and twelfth century gardens are still found at temples that lay remote from the capital Heian. These gardens must be viewed as an extension of the traditions that originated in the palace gardens. This is illustrated in a chapter on the remains of a garden at the twelfth century temple of Motsu-ji.
    The practice and theory of garden making in the Heian period was still in an early stage. Yet a manual on gardens was written, the eleventh century Sakuteiki. The manual departs from the typical lay out of the pond gardens of the period, without further discussion.
    Part one of the present work shows how this lay out evolved as a result of modest changes in the natural topography of the typical palace site in the capital Heian. In this respect one cannot speak of a conscious design policy. Furthermore, the typical, topographically determined lay out was theoretically backed up with a philosophy on the divination of sites. It is concluded that the manual does not advocate a search for harmony with nature, or rejects man-made artificialities, as is often believed.
    The manual Sakuteiki was a secret garden book and was written by one of the Heian noblemen who showed an active interest in garden art. There were only a few interested noblemen and they all belonged to the Fujiwara clan. The manual's secrecy can be explained with its Fujiwara authorship; all clan-knowledge was secret. Although some of the Fujiwara noblemen were seriously interested in garden art, it is not likely that they had any idea of the techniques of garden making. The manual Sakuteiki does not cover this subject. Construction and maintenance of the gardens was done by nameless bondsmen that belonged to the manorial landholdings of the courtly aristocracy.
    The manual Sakuteiki, as well as contemporary novels such as the Tale of Genji, give us a clear insight into the way nature was perceived by the men and women at the court. Mental images of nature relied on archetypes that were derived from classical literature. Most outspoken in this respect were themes of the lyrical poetry that was widely read and written at the Heian court. Practically all of the lyrical poetry was concerned with images of nature, so that it gave an emotional content to plants, trees and other things of nature, present in the garden. The poetic aesthetics of plant material were apparently so well known, that the Sakuteiki hardly discusses planting design in the garden, except for some implicit remarks in its introduction. The conclusion is drawn that the illusion of landscape in the courtly garden of the Heian period relied for a great deal on the evocation and recognition of the imagery of lyrical themes. But these thematic images were not designed as a formal composition; what mattered were the essential elements of the lyrical theme. Composition of form was important for the design of decorative arrangements of rocks in the garden. The manual Sakuteiki employs in this respect the term 'landscape scenery as it is found in nature'. The phrase and the appearance of the Heian rock arrangements suggest a link with landscape painting.

    Part two, titled "Scenes", deals with the mediaeval period. In Chapter I the period is roughly defined as the fourteenth and fifteenth century. The focus is shifted from the Heian courtly nobility to the rising aristocracy of Zen Buddhist priests and powerful military men. It is shown that the small mediaeval gardens found in front of halls where the new aristocracy held their fashionable gatherings were laid out to be perceived as an outward form, a landscape scene.
    The early fourteenth century garden art in Japan witnessed a strong influence of Chinese ideas on landscape art from the Song period (960 - 1279). This is illustrated with a chapter on the extant pond garden at the Zen Buddhist temple Tenryu-ji. This garden is designed as a scene to be viewed from the main hall, a Chinese idea that was never found in Heian period gardens. Tenryu-ji's pond is too small to stage boating parties. A large rock arrangement, suggestive of a waterfall, lies at the pond edge that faces the main hall of the temple. The composition of rocks for
    this waterfall evokes a depth of perspective, for which it effectively employs the compositional theories of Chinese landscape painting. As a concept it is so revolutionary for its time that it is unthinkable that it was designed by a Japanese. Even the native landscape painters of that time did not understand the Chinese composition schemes of landscape painting and were only hesitatingly experimenting with these. In the discussion about the life of the Zen priest Muso Kokushi, who founded the Tenryu-ji, the popular view that he designed or built its garden, as well as some others, is rejected. It is concluded that gardens, such as at Tenryu-ji were conceived by Chinese immigrants. Many of these Chinese were cultured men that had fled from China after the fall of the Song dynasty. They were welcomed at the early mediaeval Zen monasteries that were directly sponsored by the central military government. Monasteries and military government formed a rapidly rising institute of political power. These monasteries were in fact prestigious academies of Chinese learning, part of which formed the literary criticism on landscape art. Japanese garden making in the Zen temples stood under strong Chinese influence, and thus the appraisal of gardens was done using Chinese phraseology.
    The situation was quite different in the late mediaeval period starting around the mid-fifteenth century. In the course of time a particular kind of cultural gathering had developed at which the elite of the military men and Zen priests showed each other the Chinese exotics which they possessed. These were imported works of art: ceramics; paintings; etcetera. Chinese literature was frequently discussed, or verses were written. Adapting to the requirements of the new salon, a type of architecture was developed, the architecture of the 'reading room', that allowed for a most profitable display of the Chinese imports. The emergence of a large alcove at the head end of the reading room most evidently indicates the changing of the function of the salon architecture. Manuals appeared on the subject of the correct arrangement of the Chinese objects in the alcove. The wall, of one side of the reading room, consisted of sliding screens that could be pushed aside in order to give a full view of the garden that was always situated in front of it. This garden could not be entered, it was only meant to be viewed and was therefore conceived as a landscape scene.
    The cramped lay out of the walled-in residences of the elite only allowed for a garden of a limited size. Illustrative for this is the small family temple, in fact the private residence-cum-working place of a wealthy Zen priest. There is an explosive growth in the number of these small temples, parallel to the waning of the central military power and the large Zen monasteries they sponsored. Within the compound of the typical family temple a reading room could be found, with a decorative garden out in
    front of it. Many of these small gardens at family temples have survived. They feature scenic rock compositions, sparse plantation but hardly ever water in a designed form, because of the limited space. The typical appearance of a scenic composition in a small enclosed space has recently aroused great interest and the characteristics of 'the' style in which they were supposedly layed out have been defined. This twentieth century stylistic definition, referred to as the karesansui , or dry landscape style, has even engendered the face-lifting of some old family temple gardens. Some of these gardens are examined as for their compositional ideas and for their historicity.
    The research into the history of the famous stone garden at Ryoan-ji is of particular interest because this garden proves to be of a much later date than is generally believed. A discussion on a recently excavated small scenic garden, at the residence of a warlord in the provinces, illustrates that the mediaeval achievement of a scenic concept of garden design should not be thought of as to be limited to the dry landscape style, as this little garden employs a pond.
    As an effect of the increasing dynamics of Japan's mediaeval economy a class of landless outcasts came into existence. They were only permitted to do dirty work: handling the dead; building roads; working with earth or garden materials. Many of them became proficient in garden making and they caught the attention of the literate. As a group of professional gardeners they were faced with the design problem of the small scenic garden outside the reading room. It is presumed that, referring to the gardens of previous times, they found the waterfalls composed of rocks most spectacular and recognized these as a landscape composition. A connection between the outcast garden makers with the late mediaeval landscape painters - now fully making use of the Chinese composition theory of landscape scenes - can be surmised. Some of the landscape painters were also of low birth.
    The waterfall composition became a popular theme in the small gardens of late mediaeval date. The gardens continued to be appraised with Chinese literary phrases, sometimes explicitly lauding the technique of evoking a depth of perspective.
    The developments in Japan's mediaeval garden history are thus interpreted in the present work as the development of a scenic garden concept. The scenic garden relied in its landscape illusion on the suggestion of a shape, a scene, rather than on themes with an implied lyrical connotation as in the Heian period.
    The last chapter, chapter 8, of part two, further clarifies my interpretation of the mediaeval small garden as being scenic, and criticizes the popular interpretation of this type of garden that sees it as an expression of 'the spirit of Zen'. The most important argument is the total lack of any historic evidence that mediaeval garden makers wanted to express the spirit of Zen with their creations. A short analysis of the origins of the 'Zen interpretation', as it presently prevails, is given. The interpretation originated in the intellectual climate of Japan's 1930's, under threatening nationalism and the advent of World War II. After the War it became popular abroad.

    Part three, titled "Taste", deals with the early modern period, roughly, the first half of the seventeenth century. It is called 'modern', because practice and theory of garden art became established in a way that differs not very much from our own twentieth century.
    The economic progress of the late mediaeval period led to the formation of several merchant towns. The old capital Heian, now called by its modern name Kyoto, was one of these. In the urban fashionable societies of such towns, a romantic appreciation of nature became a generally understood emotion in the course of the sixteenth century. This was largely due to the activities of traveling poets who came into a profound contact with natural landscapes outside the town. In the towns the poets joined the salons of the rich merchants where their poetry was read, recited, and composed in sociable sessions. Such gatherings were held in little outbuildings at the back of the town houses. Conveniences, like a hearth or a privy were luxuries like the good food and rice wine that was served. All of this not only greatly helped to heighten the atmosphere of the meetings, but also made that the hardships of nature could be appreciated as something romantic, because it was now separated from the comforts of daily life.
    Towards the end of the sixteenth century military men in the provinces rose to power. They inevitably came into contact with the commercial centres in the towns and with their leading circles. At political meetings, of military men and urban leaders, rules of conduct were of utmost importance. It took form in the elaborate etiquette of tea drinking. The tea meetings took place in the outbuildings at the back of the house, a structure now exclusively furnished for the etiquette of tea. To this small building belonged a tea garden that indicated through its stepping stones the correct way of proceeding towards the tea house. The tea garden was therefore a garden that was designed out of a single abstract concept, namely to give material form to the procedures of the etiquette; it was no longer set up as a scene or a series of themes as in earlier history. The tea experts that conceived the tea garden also introduced the free use in the garden of any kind of material they could think of. To design a garden departing from an abstract concept, as well as to make free use of any kind of material were two basic achievements in the establishment of the early modern garden art.
    The single, limited concept of the tea garden was surpassed in the garden world of the seventeenth century urban elite in Kyoto. Tea experts, artists, rich merchants, and intellectuals gathered around the emperor, who was completely stripped of any political power by the provincial military men who managed to centralize their rule over all of Japan. The elite around the Imperial Court was politically powerless, but - to keep it befriended - financially supported by the central military government. Among them a typical escapist attitude became fashionable. It brought forth an imaginative attitude towards the scenery of natural landscape as well as that of the garden. It must be taken, together with the popular rise of nature romanticism in the cities, as an important driving force behind the modernization of garden art. This modernization is illustrated by some of the imperial gardens of that time, that in their peculiar design show us the modern imaginative attitude. Romantic appreciation of landscape scenery is expressed in the gardens that take actual views of natural landscapes up as a part of the overall composition.
    The production of gardens became modern when all the stages in the process of making became the task of different or separated groups of people. It is demonstrated that Kobori Enshu, generally considered to have been a kind of garden artist, was actually a high government official who stood in hierarchy above an office that directed the building and designing of gardens. His role is illustrated with the history of the making of the well-documented, and extant, garden at Konchi-in. The intellectual and direct symbolism of this garden is also illustrative for the intellectual approach to garden design of the gardens of the early modern elite in Kyoto. The elite around the emperor developed an abstract concept of 'taste' that drew heavily on classical literary ideas and on values of the earlier urban salons. They restricted themselves to a fictitious kind of simplicity in beauty, which through its limitations automatically stressed the need for intellectualism and invention. Thus they came to value a liberal, intellectual kind of creativity, which is illustrated with the analysis of compositions of the gardens at Koho-an, where Kobori Enshu intended to live after his retirement.

    Jaaroverzicht 1979
    Werdmuller, G.A. ; Labrijn, J.F. ; Oortwijn, H. ; Ruig, W.G. de - \ 1980
    Wageningen : RIKILT (Verslag / RIKILT 80.19) - 8
    kazen - stremsel - melk - kwaliteitscontroles - voedselinspectie - cheeses - rennet - milk - quality controls - food inspection
    Een overzicht te krijgen in de eventuele niveauverschillen en spreidingen bij de bepalingen in kaas door de Kaascontrolestations en het Rijkszuivelstation. Aan alle Kaascontrolestations zijn in 1979 de volgende monsters ter onderzoek gestuurd: 13 monsters volvette kaas voor vocht- en vetbepaling; 11 monsters 40+ kaas voor vocht- en vetbepaling; 12 monsters kaas voor nitraatbepaling volgens twee methoden; 12 monsters 20+ kaas voor vocht- en vetbepaling; 12 monsters stremseloplossing voor stremkrachtbepaling; 28 monsters kaas voor zoutbepaling; 12 monsters kaas voor pH- bepaling; 12 monsters melk voor fosfatasebepaling. Naar de Kaascontrolestations in Leusden en Leeuwarden zijn bovendien nog gestuurd: 12 monsters dieetkaas voor natrium- , kalium-, chloride- en ammoniumbepaling; 12 monsters smeltkaas voor fosfor- en citroenzuurbepaling. Alle analyses zijn verricht volgens de Methoden van Bemonstering en Onderzoek behorende bij de Kaascontrolebeschikking 1970. Dit houd niet in dat alle laboratoria een onderzoek volgens dezelfde methode doen. De Kaascontrolestations bepalen bijvoorbeeld het vetgehalte volgens NEN 3059-57 (Gerber-Van Gulik) , het Rijkszuivelstation volgens NEN 3170-60 (Schmid-Bondzynski-Ratzlaff). De analyseresultaten zijn samengevat in de tabellen 1 t/m 21. Het vet-in-dedrogestofgehalte is berekend uit het vocht- en vetgehalte. Van elk laboratorium is per monster het verschil tussen de gevonden waarde ( gemiddelde van duplo's) en de over alle laboratoria gemiddelde waarde berekend. Deze verschillen zijn samengevat in de tabellen 1a t/m 20a en vermeld in de grafieken 1 t /m 20. De gepoolde standaardafwijking van deze verschillen, dat wil zeggen de spreiding van de laboratoria om hun gemiddelde, is berekend. Met een --- resp. === is tweemaal resp. driemaal de standaardafwijking in de grafieken aangegeven. Ongeveer 95% van de verschillen moeten binnen de - - - en ongeveer 99,7% binnen de === lijnen liggen. Resultaten buiten de === lijnen kunnen in het algemeen als onbetrouwbaar beschouwd worden. Op de gemiddelde verschillen is de toets van Student-Newman en Keuls toegepast. Men plaatst de laboratoria in oplopende volgorde van niveau en onderstreept de laboratoria waartussen geen niveauverschillen zijn aan te tonen. Er is getoetst met een onbetrouwbaarheid van 1%. In paragraaf 22 worden de vetbepalingsmethoden en in paragraaf 23 de vochtbepalingsmethode met elkaar vergeleken.
    Een statistisch onderzoek naar den invloed van het weer op de opbrengst en het gehalte van suikerbieten in Nederland
    Frankena, H.J. - \ 1932
    Wageningen University. Promotor(en): D. van Gulik. - Groningen : Noordhoff - 173
    oogsttoename - oogstverliezen - opbrengsten - beta vulgaris - suikerbieten - meteorologische factoren - wind - statistische analyse - statistische gegevens - nederland - yield increases - yield losses - yields - beta vulgaris - sugarbeet - meteorological factors - wind - statistical analysis - statistical data - netherlands
    Correlation coefficients were calculated to examine the relation over the period 1899-1926 between beet yield and sugar content, and rainfall, sunshine and temperature. For every decade and combinations of two or more decades of the period March-October, the correlation coefficient was calculated. The interrelations between the three elements were also considered. The main purpose was to find critical periods as a basis for forecasting yield.
    There were two critical periods for yield. The sowing period (20 April-20 May) had to be dry. The correlation coefficient with the rainfall was -0.66 ± 0. 11. The month of July had to be warm and bright. (Correlation coefficient for temperature + 0.60 ± 0,12 and for hours of sunshine + 0.66 ± 0.11.)

    Sugar content was stimulated by a bright dry autumn. Correlation coefficients were for hours of sunshine +0.61±0.12 and for rainfall -0.72 ± 0.09.

    The main cropping districts Zeeland and Groningen differed strikingly in the correlation coefficient for temperature in August: for Zeeland (south of the Netherlands) +0.27 ± 0.17 and for Groningen (north of the Netherlands) +0.62 ± 0.12.

    The main regression equation for beet yield was X = M + 761x 2 - 75x 3 . M average yield (kg/ha), x 2 = departure from average temperature (°C) during the last 20 days of July and x 3 = departure from average rainfall (mm) during the period 20 April to 20 May.
    Het absorptiespectrum van chlorophyl tusschen de golflengten 3,55 en 0,25 micron
    Gulik, D. van - \ 1930
    Wageningen : Veenman (Mededelingen van de Landbouwhogeschool te Wageningen dl. 34, verh. 2) - 9
    Stralingsmetingen te Wageningen
    Gulik, D. van - \ 1929
    Wageningen : Veenman (Mededelingen van de Landbouwhoogeschool te Wageningen dl. 33, verh. 5) - 15
    Het registreeren der bestraling van het aardoppervlak
    Gulik, D. van - \ 1927
    Wageningen : Veenman (Mededelingen van de Landbouwhogeschool te Wageningen dl. 31, verh. 8)
    Over nachtvorst
    Gulik, D. van - \ 1924
    Wageningen : Veenman (Mededeelingen van de Landbouwhoogeschool en van de daaraan verbonden instituten dl. 27, verh. 6) - 16
    Gulik, D. van - \ 1922
    Wageningen : Veenman (Mededeelingen van de Landbouwhoogeschool en van de daaraan verbonden instituten dl. 24, verh. 1) - 12
    De energiestraling der zon en hare beteekenis voor den mensch
    Gulik, D. van - \ 1920
    Wageningen : Veenman - 14
    zonne-energie - fotosynthese - landbouwproductie - solar energy - photosynthesis - agricultural production
    Het studiejaar 1919-1920
    Gulik, D. van - \ 1920
    Wageningen : Veenman - 13
    onderwijs - landbouw - geschiedenis - universiteiten - education - agriculture - history - universities
    De wichelroede
    Gulik, D. van - \ 1917
    Wageningen : Veenman (Mededeelingen van de Rijks Hoogere Land-, Tuin- en Boschbouwschool en van de daaraan verbonden instituten dl. 12, [verh. 4])
    exploratie - geologie - geofysica - exploration - geology - geophysics
    Over de verspreiding van weerberichten door middel van draadlooze telegrafie
    Gulik, D. van - \ 1913
    Wageningen : Veenman (Mededeelingen van de Rijks Hoogere Land-, Tuin- en Boschbouwschool en van de daaraan verbonden instituten dl. 6, [verh. 5])
    Iets over het gebruik van glas in broeikassen
    Gulik, D. van - \ 1910
    Wageningen : Veenman (Mededeelingen van de Rijks Hoogere Land-, Tuin- en Boschbouwschool en van de daaraan verbonden instituten dl. 3, [verh. 4])
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