Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Plasma metabolites associated with colorectal cancer stage: Findings from an international consortium
Geijsen, Anne J.M.R. ; Roekel, Eline H. van; Duijnhoven, Fränzel J.B. van; Achaintre, David ; Bachleitner-Hofmann, Thomas ; Baierl, Andreas ; Bergmann, Michael M. ; Boehm, Jürgen ; Bours, Martijn J.L. ; Brenner, Hermann ; Breukink, Stéphanie O. ; Brezina, Stefanie ; Chang-Claude, Jenny ; Herpel, Esther ; Wilt, Johannes H.W. de; Gicquiau, Audrey ; Gigic, Biljana ; Gumpenberger, Tanja ; Hansson, Bibi M.E. ; Hoffmeister, Michael ; Holowatyj, Andreana N. ; Karner-Hanusch, Judith ; Keski-Rahkonen, Pekka ; Keulen, Eric T.P. ; Koole, Janna L. ; Leeb, Gernot ; Ose, Jennifer ; Schirmacher, Peter ; Schneider, Martin A. ; Schrotz-King, Petra ; Stift, Anton ; Ulvik, Arve ; Vogelaar, Jeroen F. ; Wesselink, Evertine ; Zutphen, Moniek van; Gsur, Andrea ; Habermann, Nina ; Kampman, Ellen ; Scalbert, Augustin ; Ueland, Per M. ; Ulrich, Alexis B. ; Ulrich, Cornelia M. ; Weijenberg, Matty P. ; Kok, Dieuwertje E. - \ 2019
International Journal of Cancer (2019). - ISSN 0020-7136
colorectal cancer - disease stage - epidemiology - metabolomics - plasma metabolites

Colorectal cancer is the second most common cause of cancer-related death globally, with marked differences in prognosis by disease stage at diagnosis. We studied circulating metabolites in relation to disease stage to improve the understanding of metabolic pathways related to colorectal cancer progression. We investigated plasma concentrations of 130 metabolites among 744 Stages I–IV colorectal cancer patients from ongoing cohort studies. Plasma samples, collected at diagnosis, were analyzed with liquid chromatography-mass spectrometry using the Biocrates AbsoluteIDQ™ p180 kit. We assessed associations between metabolite concentrations and stage using multinomial and multivariable logistic regression models. Analyses were adjusted for potential confounders as well as multiple testing using false discovery rate (FDR) correction. Patients presented with 23, 28, 39 and 10% of Stages I–IV disease, respectively. Concentrations of sphingomyelin C26:0 were lower in Stage III patients compared to Stage I patients (pFDR < 0.05). Concentrations of sphingomyelin C18:0 and phosphatidylcholine (diacyl) C32:0 were statistically significantly higher, while citrulline, histidine, phosphatidylcholine (diacyl) C34:4, phosphatidylcholine (acyl-alkyl) C40:1 and lysophosphatidylcholines (acyl) C16:0 and C17:0 concentrations were lower in Stage IV compared to Stage I patients (pFDR < 0.05). Our results suggest that metabolic pathways involving among others citrulline and histidine, implicated previously in colorectal cancer development, may also be linked to colorectal cancer progression.

Mutagenesis of odorant coreceptor Orco fully disrupts foraging but not oviposition behaviors in the hawkmoth Manduca sexta
Fandino, Richard A. ; Alexander, H. ; Bisch-Knaden, S. ; Zhang, J. ; Bucks, S. ; Nguyen, T.A.T. ; Schröder, K. ; Werckenthin, Achim ; Rybak, J. ; Stengl, Monika ; Knaden, M. ; Hansson, Bill S. ; Groβe-Wilde, Ewald - \ 2019
Proceedings of the National Academy of Sciences of the United States of America 116 (2019)31. - ISSN 0027-8424 - p. 15677 - 15685.
CRISPR-Cas9 - Insect olfaction - Insect-plant interactions - Manduca sexta - Orco

The hawkmoth Manduca sexta and one of its preferred hosts in the North American Southwest, Datura wrightii, share a model insect-plant relationship based on mutualistic and antagonistic life-history traits. D. wrightii is the innately preferred nectar source and oviposition host for M. sexta. Hence, the hawkmoth is an important pollinator while the M. sexta larvae are specialized herbivores of the plant. Olfactory detection of plant volatiles plays a crucial role in the behavior of the hawkmoth. In vivo, the odorant receptor coreceptor (Orco) is an obligatory component for the function of odorant receptors (ORs), a major receptor family involved in insect olfaction. We used CRISPR-Cas9 targeted mutagenesis to knock out (KO) the MsexOrco gene to test the consequences of a loss of OR-mediated olfaction in an insect-plant relationship. Neurophysiological characterization revealed severely reduced antennal and antennal lobe responses to representative odorants emitted by D. wrightii. In a wind-tunnel setting with a flowering plant, Orco KO hawkmoths showed disrupted flight orientation and an ablated proboscis extension response to the natural stimulus. The Orco KO gravid female displayed reduced attraction toward a nonflowering plant. However, more than half of hawkmoths were able to use characteristic odor-directed flight orientation and oviposit on the host plant. Overall, OR-mediated olfaction is essential for foraging and pollination behaviors, but plant-seeking and oviposition behaviors are sustained through additional OR-independent sensory cues.

A framework to assess the resilience of farming systems
Meuwissen, Miranda P.M. ; Feindt, Peter H. ; Spiegel, A. ; Termeer, Catrien J.A.M. ; Mathijs, Erik ; Mey, Yann de; Finger, Robert ; Balmann, Alfons ; Wauters, E. ; Urquhart, J. ; Vigani, M. ; Zawalińska, Katarzyna ; Herrera, Hugo ; Nicholas-Davies, Phillipa ; Hansson, Helena ; Paas, Wim ; Slijper, Thomas ; Coopmans, Isabeau ; Vroege, Willemijn ; Ciechomska, Anna ; Accatino, Francesco ; Kopainsky, Birgit ; Poortvliet, Marijn P. ; Candel, Jeroen J.L. ; Maye, Damian ; Severini, Simone ; Senni, Saverio ; Soriano, Bárbara ; Lagerkvist, Carl Johan ; Peneva, Mariya ; Gavrilescu, Camelia ; Reidsma, Pytrik - \ 2019
Agricultural Systems 176 (2019). - ISSN 0308-521X
Enabling environment - Farming systems - Long-term stresses - Private and public goods - Resilience capacities - Shocks

Agricultural systems in Europe face accumulating economic, ecological and societal challenges, raising concerns about their resilience to shocks and stresses. These resilience issues need to be addressed with a focus on the regional context in which farming systems operate because farms, farmers' organizations, service suppliers and supply chain actors are embedded in local environments and functions of agriculture. We define resilience of a farming system as its ability to ensure the provision of the system functions in the face of increasingly complex and accumulating economic, social, environmental and institutional shocks and stresses, through capacities of robustness, adaptability and transformability. We (i) develop a framework to assess the resilience of farming systems, and (ii) present a methodology to operationalize the framework with a view to Europe's diverse farming systems. The framework is designed to assess resilience to specific challenges (specified resilience) as well as a farming system's capacity to deal with the unknown, uncertainty and surprise (general resilience). The framework provides a heuristic to analyze system properties, challenges (shocks, long-term stresses), indicators to measure the performance of system functions, resilience capacities and resilience-enhancing attributes. Capacities and attributes refer to adaptive cycle processes of agricultural practices, farm demographics, governance and risk management. The novelty of the framework pertains to the focal scale of analysis, i.e. the farming system level, the consideration of accumulating challenges and various agricultural processes, and the consideration that farming systems provide multiple functions that can change over time. Furthermore, the distinction between three resilience capacities (robustness, adaptability, transformability) ensures that the framework goes beyond narrow definitions that limit resilience to robustness. The methodology deploys a mixed-methods approach: quantitative methods, such as statistics, econometrics and modelling, are used to identify underlying patterns, causal explanations and likely contributing factors; while qualitative methods, such as interviews, participatory approaches and stakeholder workshops, access experiential and contextual knowledge and provide more nuanced insights. More specifically, analysis along the framework explores multiple nested levels of farming systems (e.g. farm, farm household, supply chain, farming system) over a time horizon of 1–2 generations, thereby enabling reflection on potential temporal and scalar trade-offs across resilience attributes. The richness of the framework is illustrated for the arable farming system in Veenkoloniën, the Netherlands. The analysis reveals a relatively low capacity of this farming system to transform and farmers feeling distressed about transformation, while other members of their households have experienced many examples of transformation.

Are Ergothioneine Levels in Blood Associated with Chronic Peripheral Neuropathy in Colorectal Cancer Patients Who Underwent Chemotherapy?
Winkels, Renate M. ; Brakel, Lieve Van; Baar, Harm Van; Beelman, Robert B. ; Duijnhoven, Fränzel J.B. Van; Geijsen, Anne ; Halteren, Henk K. Van; Hansson, Bibi M.E. ; Richie, John P. ; Sun, Dongxiao ; Wesselink, Evertine ; Zutphen, Moniek Van; Kampman, Ellen ; Kok, Dieuwertje E. - \ 2019
Nutrition and Cancer (2019). - ISSN 0163-5581

Objective: Chronic Chemotherapy-Induced Peripheral Neuropathy (CIPN) is highly prevalent among colorectal cancer (CRC) patients. Ergothioneine (ET)–a dietary antioxidant -protected against CIPN in experimental models, but human studies are lacking. We explored whether whole blood ET levels were associated with chronic peripheral neuropathy among CRC patients who had completed chemotherapy. Methods: At diagnosis, median ET-concentration in whole blood of 159 CRC patients was 10.2 μg/ml (7.2–15.8). Patients completed questionnaires on peripheral neuropathy 6 months after completion of chemotherapy. We calculated prevalence ratios (PR) to assess associations of ET-concentrations and prevalence of peripheral neuropathy and used linear regression to assess associations with severity of peripheral neuropathy. Results: Prevalence of total and sensory peripheral neuropathy were both 81%. Higher ET-concentrations tended to be associated with lower prevalence of total and sensory peripheral neuropathy, but not statistically significant (highest versus lowest tertile of ET: PR = 0.93(0.78, 1.11) for total neuropathy, and PR = 0.84(0.70, 1.02) for sensory neuropathy). ET-concentrations were not associated with severity of neuropathy. Conclusion: Statistically significant associations were not observed, possibly because of limited sample size. Although data may putatively suggest higher levels of ET to be associated with a lower prevalence of neuropathy, analyses should be repeated in larger populations with larger variability in ET-concentrations.

Flower movement balances pollinator needs and pollen protection
Haverkamp, Alexander ; Li, Xiang ; Hansson, Bill S. ; Baldwin, Ian T. ; Knaden, Markus ; Yon, Felipe - \ 2019
Ecology 100 (2019)1. - ISSN 0012-9658
flower handling - flower orientation - Manduca - Nicotiana - pollen viability - pollination

Flower signaling and orientation are key characteristics that determine a flower's pollinator guild. However, many flowers actively move during their daily cycle, changing both their detectability and accessibility to pollinators. The flowers of the wild tobacco Nicotiana attenuata orientate their corolla upward at sunset and downward after sunrise. Here, we investigated the effect of different flower orientations on a major pollinator of N. attenuata, the hawkmoth Manduca sexta. We found that although flower orientation influenced the flight altitude of the moth in respect to the flower, it did not alter the moth's final flower choice. These behavioral observations were consistent with the finding that orientation did not systematically change the spatial distribution of floral volatiles, which are major attractants for the moths. Moreover, hawkmoths invested the same amount of time into probing flowers at different orientations, even though they were only able to feed and gather pollen from horizontally and upward-oriented flowers, but not from downward-facing flowers. The orientation of the flower was hence crucial for a successful interaction between N. attenuata and its hawkmoth pollinator. Additionally, we also investigated potential adverse effects of exposing flowers at different orientations to natural daylight levels, finding that anther temperature of upward-oriented flowers was more than 7°C higher than for downward-oriented flowers. This increase in temperature likely caused the significantly reduced germination success that was observed for pollen grains from upward-oriented flowers in comparison to those of downward and horizontally oriented flowers. These results highlight the importance of flower reorientation to balance pollen protection and a successful interaction of the plant with its insect pollinators by maintaining the association between flower volatiles and flower accessibility to the pollinator.

Data from: Flower movement balances pollinator needs and pollen protection
Haverkamp, Alexander ; Li, Xiang ; Hansson, Bill S. ; Baldwin, Ian T. ; Knaden, Markus ; Yon, Felipe - \ 2018
flower orientation - pollination - flower handling - pollen viability
Flower signaling and orientation are key characteristics, which determine a flower’s pollinator guild. However, many flowers actively move during their daily cycle, changing both their detectability and accessibility to pollinators. The flowers of the wild tobacco Nicotiana attenuata orientate their corolla upwards at sunset and downwards after sunrise. Here, we investigated the effect of different flower orientations on a major pollinator of N. attenuata, the hawkmoth Manduca sexta. We found that although flower orientation influenced the flight altitude of the moth in respect to the flower, it did not alter its overall attractiveness. These behavioral observations were consistent with the finding that orientation did not systematically change the spatial distribution of floral volatiles, which are major attractants for moths. Moreover, moths invested the same amount of time into probing flowers at different orientations, even though they were only able to feed and take up pollen from horizontally and upward oriented flowers, but not from downward facing flowers. The orientation of the flower was hence crucial for a successful interaction between N. attenuata and its hawkmoth pollinator. Additionally, we determined potential adverse effects of exposing flowers at different orientations to natural daylight levels, finding that anther temperature of upward oriented flowers was more than 7°C higher than for downward oriented flowers. This increase in temperature likely caused the significantly reduced germination success that was observed for pollen grains from upward oriented flowers in comparison to those of downward and horizontally oriented flowers. These results highlight the importance of flower reorientation to ensure pollen protection, while maintaining the association between flower signals and flower accessibility necessary for a successful interaction of the plant with its insect pollinators.
Preparation for the evaluation of the list of mandatory research surveys at sea
Sampson, David ; Alvarez, P. ; Armesto, Angeles ; Casey, J. ; Natale, A. Di; Hansson, Maria ; Karp, W.A. ; Mannini, A. ; Panayotova, Marina ; Renaud, F. ; Somarakis, Stylianos ; Spedicato, M.T. ; Stransky, C. ; Verver, S.W. ; Worsoe Clausen, L.A. ; Hoof, L.J.W. van - \ 2018
Luxembourg : Luxembourg (Publications Office of the european Union EWG-18-04) - ISBN 9789279793875 - 51 p.
Low radiographic muscle density is associated with lower overall and disease-free survival in early-stage colorectal cancer patients
Baar, Harm van; Beijer, S. ; Bours, M.J.L. ; Weijenberg, M.P. ; Zutphen, M. van; Duijnhoven, F.J.B. van; Slooter, G.D. ; Pruijt, J.F.M. ; Dronkers, J.J. ; Haringhuizen, A. ; Spillenaar Bilgen, E.J. ; Hansson, B.M.E. ; Wilt, J.H.W. de; Kampman, E. ; Winkels, R.M. - \ 2018
Journal of Cancer Research and Clinical Oncology 144 (2018)11. - ISSN 0171-5216 - p. 2139 - 2147.
Colorectal cancer - Mortality - Skeletal muscle density - Survival

Background: In cancer patients with a poor prognosis, low skeletal muscle radiographic density is associated with higher mortality. Whether this association also holds for early-stage cancer is not very clear. We aimed to study the association between skeletal muscle density and overall mortality among early-stage (stage I–III) colorectal cancer (CRC) patients. Furthermore, we investigated the association between skeletal muscle density and both CRC-specific mortality and disease-free survival in a subset of the study population. Methods: Skeletal muscle density was assessed in 1681 early-stage CRC patients, diagnosed between 2006 and 2015, using pre-operative computed tomography images. Adjusted Cox proportional hazard models were used to evaluate the association between muscle density and overall mortality, CRC-specific mortality and disease-free survival. Results: The median follow-up time was 48 months (range 0–119 months). Low muscle density was detected in 39% of CRC patients. Low muscle density was significantly associated with higher mortality (low vs. normal: adjusted HR 1.91, 95% CI 1.53–2.38). After stratification for comorbidities, the association was highest in patients with ≥ 2 comorbidities (HR 2.11, 95% CI 1.55–2.87). Furthermore, low skeletal muscle density was significantly associated with poorer disease-free survival (HR 1.68, 95% CI 1.14–2.47), but not with CRC-specific mortality (HR 1.68, 95% CI 0.89–3.17) in a subset of the study population. Conclusion: In early-stage CRC patients, low muscle density was significantly associated with higher overall mortality, and worse disease-free survival.

Dietary intake of magnesium or calcium and chemotherapy-induced peripheral neuropathy in colorectal cancer patients
Wesselink, Evertine ; Winkels, Renate M. ; Baar, Harm Van; Geijsen, Anne J.M.R. ; Zutphen, Moniek Van; Halteren, Henk K. Van; Hansson, Bibi M.E. ; Radema, Sandra A. ; Wilt, Johannes H.W. De; Kampman, Ellen ; Kok, Dieuwertje E.G. - \ 2018
Nutrients 10 (2018)4. - ISSN 2072-6643
Calcium - Chemotherapy - Colorectal cancer - Magnesium - Neuropathy - Oxaliplatin
Chemotherapy-induced peripheral neuropathy (CIPN) is a common and severe side-effect in colorectal cancer (CRC) patients. This study assessed the association between habitual dietary intake of magnesium or calcium and prevalence and severity of chronic CIPN in CRC patients receiving adjuvant chemotherapy. For this prospective cohort study, 196 CRC patients were considered. Magnesium and calcium intake was determined using a food frequency questionnaire at diagnosis, during and after chemotherapy. Chronic CIPN was assessed 12 months after diagnosis using the quality of life questionnaire CIPN20. Prevalence ratios were calculated to assess the association between magnesium or calcium intake and the prevalence of CIPN. Multivariable linear regression analysis was used to assess the association between magnesium or calcium intake and severity of CIPN. CIPN was reported by 160 (82%) patients. Magnesium intake during chemotherapy was statistically significantly associated with lower prevalence of CIPN (prevalence ratio (PR) 0.53, 95% confidence interval (CI) 0.32, 0.92). Furthermore, higher dietary intake of magnesium during (β-1.08, 95% CI -1.95, -0.22) and after chemotherapy (β-0.93, 95% CI -1.81, -0.06) was associated with less severe CIPN. No associations were found for calcium intake and the prevalence and severity of CIPN. To conclude, we observed an association between higher dietary magnesium intake and lower prevalence and severity of CIPN in CRC patients.
Response of submerged macrophyte communities to external and internal restoration measures in north temperate shallow lakes
Hilt, Sabine ; Alirangues Nuñez, Marta M. ; Bakker, Elisabeth S. ; Blindow, Irmgard ; Davidson, Thomas A. ; Gillefalk, Mikael ; Hansson, Lars Anders ; Janse, Jan H. ; Janssen, Annette B.G. ; Jeppesen, Erik ; Kabus, Timm ; Kelly, Andrea ; Köhler, Jan ; Lauridsen, Torben L. ; Mooij, Wolf M. ; Noordhuis, Ruurd ; Phillips, Geoff ; Rücker, Jacqueline ; Schuster, Hans Heinrich ; Søndergaard, Martin ; Teurlincx, Sven ; Weyer, Klaus van de; Donk, Ellen van; Waterstraat, Arno ; Willby, Nigel ; Sayer, Carl D. - \ 2018
Frontiers in Plant Science 9 (2018). - ISSN 1664-462X
Aquaticplants - Biomanipulation - Eutrophication - Lakerestoration - Nutrient loadreduction - PCLake - Plant traits - Regime shift
Submerged macrophytes play a key role in north temperate shallow lakes by stabilizing clear-water conditions. Eutrophication has resulted in macrophyte loss and shifts to turbid conditions in many lakes. Considerable efforts have been devoted to shallow lake restoration in many countries, but long-term success depends on a stable recovery of submerged macrophytes. However, recovery patterns vary widely and remain to be fully understood. We hypothesize that reduced external nutrient loading leads to an intermediate recovery state with clear spring and turbid summer conditions similar to the pattern described for eutrophication. In contrast, lake internal restoration measures can result in transient clear-water conditions both in spring and summer and reversals to turbid conditions. Furthermore, we hypothesize that these contrasting restoration measures result in different macrophyte species composition, with added implications for seasonal dynamics due to differences in plant traits. To test these hypotheses, we analyzed data on water quality and submerged macrophytes from 49 north temperate shallow lakes that were in a turbid state and subjected to restoration measures. To study the dynamics of macrophytes during nutrient load reduction, we adapted the ecosystem model PCLake. Our survey and model simulations revealed the existence of an intermediate recovery state upon reduced external nutrient loading, characterized by spring clear-water phases and turbid summers, whereas internal lake restoration measures often resulted in clear-water conditions in spring and summer with returns to turbid conditions after some years. External and internal lake restoration measures resulted in different macrophyte communities. The intermediate recovery state following reduced nutrient loading is characterized by a few macrophyte species (mainly pondweeds) that can resist wave action allowing survival in shallowareas, germinate early in spring, have energy-rich vegetative propagules facilitating rapid initial growth and that can complete their life cycle by early summer. Later in the growing season these plants are, according to our simulations, outcompeted by periphyton, leading to late-summer phytoplankton blooms. Internal lake restoration measures often coincide with a rapid but transient colonization by hornworts, waterweeds or charophytes. Stable clear-water conditions and a diverse macrophyte flora only occurred decades after external nutrient load reduction or when measures were combined.
Report on resilience framework for EU agriculture : Sustainable and resilient EU farming systems (SureFarm) project report, work package D1.1
Meuwissen, M.P.M. ; Paas, W.H. ; Slijper, Thomas ; Coopmans, Isabeau ; Ciechomska, Anna ; Lievens, Eewoud ; Deckers, Jo ; Vroege, Willemijn ; Mathijs, E. ; Kopainsky, Birgit ; Herrera, H. ; Nitzko, Sina ; Finger, Robert ; Mey, Y. de; Poortvliet, P.M. ; Nicholas-Davies, Philippa ; Midmore, Peter ; Vigani, M. ; Maye, Damian ; Urquhart, Julie ; Balmann, Alfons ; Appel, Franziska ; Termeer, K. ; Feindt, Peter ; Candel, Jeroen ; Tichit, M. ; Accatino, Francesco ; Severini, Simone ; Senni, S. ; Wauters, Erwin ; Bardají, Isabel ; Soriano, B. ; Zawalinska, Katarzina ; Lagerkvist, Carl-Johan ; Manevska-Tasevska, Gordana ; Hansson, Helena ; Peneva, Mariya ; Gavrilescu, Camelia ; Reidsma, P. - \ 2018
Wageningen : Wageningen University & Research - 26 p.
Exploring the economic potential of reducing broiler lameness
Gocsik, Eva ; Silvera, A.M. ; Hansson, H. ; Saatkamp, H.W. ; Blokhuis, H.J. - \ 2017
British Poultry Science 58 (2017)4. - ISSN 0007-1668 - p. 337 - 347.
Animal welfare - broilerproduction - economicperformance - farmers’perception - lameness

1. The present study was designed first to explore the potential economic benefits of adopting management practices to reduce lameness in broiler farms, and second to explore farmers’ possible perceptions of this potential in the Swedish context. The likely financial effects were addressed using a normative economic model, whereas a questionnaire-based survey was used to obtain in-depth knowledge about the perceptions of a group of broiler farmers in Sweden. 2. The three alternative practices (out of 6 tested) which realised the greatest improvements in gross margin and net return to management compared to the conventional practice were feeding whole wheat, sequential feeding and meal feeding. 3. The model showed that the negative effect of feeding whole wheat on feed conversion rate was outweighed by the effect of a low feed price and the associated decrease in feed costs. The price of wheat played a major role in the improvement of economic performance, whereas the reduction of lameness itself made a relatively minor contribution. 4. Apparently, the surveyed farmers do not recognise the potential of the positive effects of changing feed or feeding practices on both broiler welfare and farm economics although their implementation can be of great importance in the broiler sector where profit margins are very tight.​

An increase in physical activity after colorectal cancer surgery is associated with improved recovery of physical functioning : A prospective cohort study
Zutphen, Moniek van; Winkels, Renate M. ; Duijnhoven, Fränzel J.B. van; Harten-Gerritsen, Suzanne A. van; Gils-Kok, Dieuwertje van; Duijvendijk, Peter van; Halteren, Henk K. van; Hansson, Bibi M.E. ; Kruyt, Flip M. ; Spillenaar Bilgen, Ernst J. ; Wilt, Johannes H.W. de; Dronkers, Jaap J. ; Kampman, Ellen - \ 2017
BMC Cancer 17 (2017)1. - ISSN 1471-2407
Colorectal cancer - Colorectal surgery - Epidemiology - Physical activity - Recovery of function - Rehabilitation
Background: The influence of physical activity on patient-reported recovery of physical functioning after colorectal cancer (CRC) surgery is unknown. Therefore, we studied recovery of physical functioning after hospital discharge by (a) a relative increase in physical activity level and (b) absolute activity levels before and after surgery. Methods: We included 327 incident CRC patients (stages I-III) from a prospective observational study. Patients completed questionnaires that assessed physical functioning and moderate-to-vigorous physical activity shortly after diagnosis and 6 months later. Cox regression models were used to calculate prevalence ratios (PRs) of no recovery of physical functioning. All PRs were adjusted for age, sex, physical functioning before surgery, stage of disease, ostomy and body mass index. Results: At 6 months post-diagnosis 54% of CRC patients had not recovered to pre-operative physical functioning. Patients who increased their activity by at least 60 min/week were 43% more likely to recover physical function (adjusted PR 0.57 95%CI 0.39-0.82), compared with those with stable activity levels. Higher post-surgery levels of physical activity were also positively associated with recovery (P for trend = 0.01). In contrast, activity level before surgery was not associated with recovery (P for trend = 0.24). Conclusions: At 6 month post-diagnosis, about half of CRC patients had not recovered to preoperative functioning. An increase in moderate-to-vigorous physical activity after CRC surgery was associated with enhanced recovery of physical functioning. This benefit was seen regardless of physical activity level before surgery. These associations provide evidence to further explore connections between physical activity and recovery from CRC surgery after discharge from the hospital.
Evaluating early-warning indicators of critical transitions in natural aquatic ecosystems
Gsell, A.S. ; Scharfenberger, Ulrike ; Özkundakci, Deniz ; Walters, Annika ; Hansson, Lars Anders ; Janssen, Annette B.G. ; Nõges, Peeter ; Reid, Philip C. ; Schindler, Daniel E. ; Donk, Ellen Van ; Dakos, Vasilis ; Adrian, Rita - \ 2016
Proceedings of the National Academy of Sciences of the United States of America 113 (2016)50. - ISSN 0027-8424 - p. E8089 - E8095.
Competition - Intraguild predation - Resilience indicators - Time series - Trophic cascade

Ecosystems can show sudden and persistent changes in state despite only incremental changes in drivers. Such critical transitions are difficult to predict, because the state of the system often shows little change before the transition. Early-warning indicators (EWIs) are hypothesized to signal the loss of system resilience and have been shown to precede critical transitions in theoretical models, paleo-climate time series, and in laboratory as well as whole lake experiments. The generalizability of EWIs for detecting critical transitions in empirical time series of natural aquatic ecosystems remains largely untested, however. Here we assessed four commonly used EWIs on long-term datasets of five freshwater ecosystems that have experienced sudden, persistent transitions and for which the relevant ecological mechanisms and drivers are well understood. These case studies were categorized by three mechanisms that can generate critical transitions between alternative states: competition, trophic cascade, and intraguild predation. Although EWIs could be detected in most of the case studies, agreement among the four indicators was low. In some cases, EWIs were detected considerably ahead of the transition. Nonetheless, our results show that at present, EWIs do not provide reliable and consistent signals of impending critical transitions despite using some of the best routinely monitored freshwater ecosystems. Our analysis strongly suggests that a priori knowledge of the underlying mechanisms driving ecosystem transitions is necessary to identify relevant state variables for successfully monitoring EWIs.

The interaction between cyanobacteria and zooplankton in a more eutrophic world
Ger, Kemal Ali ; Urrutia-Cordero, Pablo ; Frost, Paul C. ; Hansson, Lars Anders ; Sarnelle, Orlando ; Wilson, Alan E. ; Lurling, Miguel - \ 2016
Harmful Algae 54 (2016). - ISSN 1568-9883 - p. 128 - 144.
Co-evolution - Eutrophication - Grazing - Local-adaptation - Plankton

As blooms of cyanobacteria expand and intensify in freshwater systems globally, there is increasing interest in their ecological effects. In addition to being public health hazards, cyanobacteria have long been considered a poor quality food for key zooplankton grazers that link phytoplankton to higher trophic levels. While past laboratory studies have found negative effects of nutritional constraints and defensive traits (i.e., toxicity and colonial or filamentous morphology) on the fitness of large generalist grazers (i.e., Daphnia), cyanobacterial blooms often co-exist with high biomass of small-bodied zooplankton in nature. Indeed, recent studies highlight the remarkable diversity and flexibility in zooplankton responses to cyanobacterial prey. Reviewed here are results from a wide range of laboratory and field experiments examining the interaction of cyanobacteria and a diverse zooplankton taxa including cladocerans, copepods, and heterotrophic protists from temperate to tropical freshwater systems. This synthesis shows that longer exposure to cyanobacteria can shift zooplankton communities toward better-adapted species, select for more tolerant genotypes within a species, and induce traits within the lifetime of individual zooplankton. In turn, the function of bloom-dominated plankton ecosystems, the coupling between primary producers and grazers, the stability of blooms, and the potential to use top down biomanipulation for controlling cyanobacteria depend largely on the species, abundance, and traits of interacting cyanobacteria and zooplankton. Understanding the drivers and consequences of zooplankton traits, such as physiological detoxification and selective vs. generalist grazing behavior, are therefore of major importance for future studies. Ultimately, co-evolutionary dynamics between cyanobacteria and their grazers may emerge as a critical regulator of blooms.

The significance of land-atmosphere interactions in the Earth system-iLEAPS achievements and perspectives
Suni, T. ; Guenther, A. ; Hansson, H.C. ; Kulmala, M. ; Andreae, M.O. ; Arneth, A. ; Artaxo, P. ; Blyth, E. ; Brus, M. ; Ganzeveld, L. ; Kabat, P. ; de. Noblet-Ducoudré, N. ; Reichstein, M. ; Reissell, A. ; Rosenfeld, D. ; Seneviratne, S. - \ 2015
Anthropocene (2015). - ISSN 2213-3054 - p. 69 - 84.

The integrated land ecosystem-atmosphere processes study (iLEAPS) is an international research project focussing on the fundamental processes that link land-atmosphere exchange, climate, the water cycle, and tropospheric chemistry. The project, iLEAPS, was established 2004 within the International Geosphere-Biosphere Programme (IGBP). During its first decade, iLEAPS has proven to be a vital project, well equipped to build a community to address the challenges involved in understanding the complex Earth system: multidisciplinary, integrative approaches for both observations and modeling. The iLEAPS community has made major advances in process understanding, land-surface modeling, and observation techniques and networks. The modes of iLEAPS operation include elucidating specific iLEAPS scientific questions through networks of process studies, field campaigns, modeling, long-term integrated field studies, international interdisciplinary mega-campaigns, synthesis studies, databases, as well as conferences on specific scientific questions and synthesis meetings. Another essential component of iLEAPS is knowledge transfer and it also encourages community- and policy-related outreach activities associated with the regional integrative projects. As a result of its first decade of work, iLEAPS is now setting the agenda for its next phase (2014-2024) under the new international initiative, future Earth. Human influence has always been an important part of land-atmosphere science but in order to respond to the new challenges of global sustainability, closer ties with social science and economics groups will be necessary to produce realistic estimates of land use and anthropogenic emissions by analysing future population increase, migration patterns, food production allocation, land management practices, energy production, industrial development, and urbanization.

Understanding cyanobacteria-zooplankton interactions in a more eutrophic world
Ger, K.A. ; Hansson, L. ; Lurling, M.F.L.L.W. - \ 2014
Freshwater Biology 59 (2014)9. - ISSN 0046-5070 - p. 1783 - 1798.
mussels dreissena-polymorpha - copepods eurytemora-affinis - san-francisco estuary - pelagic food webs - top-down control - microcystis-aeruginosa - toxic cyanobacteria - trophic cascades - calanoid copepods - daphnia-pulicaria
1.We review and update recent observations of cyanobacteria–zooplankton interactions, identify theoretical and methodological limitations and evaluate approaches necessary for understanding the effects of increasing cyanobacterial blooms on plankton dynamics. 2.The emphasis on oversimplified studies using large-bodied Daphnia species, not previously exposed to cyanobacteria, has limited our understanding of how the plankton responds to proliferating blooms. This overlooks the great diversity in zooplankton traits, and the adaptability of planktonic grazers, that enables them to deal with toxic prey. 3.Under increasing temperature and nutrient loading, the zooplankton will be subjected to increasingly intense selection pressure to tolerate cyanobacteria. Short zooplankton generation times suggest that increased blooms may select for the rapid evolution of behavioural and physiological traits that improve tolerance. 4.As eutrophication intensifies, should we expect physiologically tolerant zooplankton that may be able to control blooms, or be concerned with the effects of selective grazers in stabilising blooms? 5.We conclude that the increasing frequency, duration and intensity of blooms will select for better adapted zooplankton that coexist with, rather than control, cyanobacteria. Future evaluations of cyanobacteria–zooplankton interactions should consider that increasing exposure to blooms induces phenotypic and genotypic traits improving zooplankton tolerance. Equally important will be studies of the ecophysiology of zooplankton species that coexist with prolonged blooms, rather than those of a few large-bodied generalist cladocerans. 6.Since cyanobacteria produce more than one toxic or inhibitory metabolite, the unsystematic designation of toxicity based on single well-identified compounds (e.g. microcystin) should be revised. 7.Overall, the coevolutionary interaction between cyanobacterial defences and zooplankton grazer responses emerges as a critical but understudied regulator of bloom dynamics.
Synergistic and species-specific effects of climate change and water colour on cyanobacterial toxicity and bloom formation
Ekvall, M.K. ; Faassen, E.J. ; Gustafsson, J.A. ; Lurling, M. ; Hansson, L. - \ 2013
Freshwater Biology 58 (2013)11. - ISSN 0046-5070 - p. 2414 - 2422.
dissolved organic-carbon - harmful cyanobacteria - subg. dolichospermum - drinking-water - genus anabaena - lakes - daphnia - toxins - biomanipulation - microcystins
Cyanobacterial blooms are a worldwide phenomenon in both marine and freshwater ecosystems and are predicted to occur more frequently due to global climate change. However, our future water resources may also simultaneously suffer from other environmental threats such as elevated amounts of humic content and consequent increased water colour, a phenomenon called 'brownification'. In order to investigate the effects of temperature and water colour in combination, we performed a mesocosm experiment combining a 3 °C increase in temperature and a doubling in water colour. With this, we created a projected future scenario for our water resources, and we specifically focused on how these changes would affect cyanobacterial bloom formation and toxicity. We showed that despite total cyanobacterial biomass remaining unaffected, the abundance of one individual cyanobacterial species, Microcystis botrys, increased in response to the combination of elevated temperature and increased water colour. Furthermore, population fluctuations in M. botrys explained the majority of the variations in microcystin concentrations, suggesting that this species was responsible for the more than 300% higher microcystin concentrations in the future scenario treatment compared to the ambient scenario. Hence, it was not a change in cyanobacterial biomass, but rather a species-specific response that had the most profound impact on bloom toxicity. We argue that understanding such species-specific responses to multiple stressors is crucial for proper management decisions because toxic blooms can significantly affect both biodiversity and ecosystem functioning, as well as ecosystem services such as drinking water supply and recreation. © 2013 John Wiley & Sons Ltd.
Infodisruption : Pollutants interfering with the natural chemical information conveyance in aquatic systems
Lurling, Miguel - \ 2012
In: Chemical Ecology in Aquatic Systems / Bronmark, Christer, Hansson, Lars-Anders, Oxford University Press - ISBN 9780199583096
Anthropogenic activities - Aquatic systems - Chemical environment - Food web functioning - Infochemicals - Infodisruption - Information network - Metabolic products

Infodisruption is a widespread phenomenon in aquatic systems, which can be caused by all kind of anthropogenic activities that change the chemical environment in which the organisms live. The chemicals that transfer information between organisms may be considered metabolic products that leak to the environment and incidentally convey information. These compounds are referred to as infochemicals, which are chemicals that convey information between two organisms, evoking in the receiving organism a behavioural or physiological response that is adaptively favourable to one or both organisms. This chapter discusses how infochemicals influence the temporal and spatial distribution of organisms, creating a tight connection between the information network and food web functioning.

Info-disruption: pollutants interfering with the natural chemical information conveyance in aquatic systems
Lurling, M.F.L.L.W. - \ 2012
In: Chemical Ecology in Aquatic Systems / Bronmark, C., Hansson, L.A., Oxford University Press - ISBN 9780199583102 - p. 250 - 271.
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