Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort
    Pertiwi, Kamalita ; Wanders, Anne J. ; Harbers, Marjolein C. ; Küpers, Leanne K. ; Soedamah-Muthu, Sabita S. ; Goede, Janette de; Zock, Peter L. ; Geleijnse, Johanna M. - \ 2020
    Diabetes Care 43 (2020)2. - ISSN 0149-5992 - p. 358 - 365.

    OBJECTIVE: To study plasma and dietary linoleic acid (LA) in relation to type 2 diabetes risk in post-myocardial infarction (MI) patients. RESEARCH DESIGN AND METHODS: We included 3,257 patients aged 60-80 years (80% male) with a median time since MI of 3.5 years from the Alpha Omega Cohort and who were initially free of type 2 diabetes. At baseline (2002-2006), plasma LA was measured in cholesteryl esters, and dietary LA was estimated with a 203-item food-frequency questionnaire. Incident type 2 diabetes was ascertained through self-reported physician diagnosis and medication use. Hazard ratios (with 95% CIs) were calculated by Cox regressions, in which dietary LA isocalorically replaced the sum of saturated (SFA) and trans fatty acids (TFA). RESULTS: Mean ± SD circulating and dietary LA was 50.1 ± 4.9% and 5.9 ± 2.1% energy, respectively. Plasma and dietary LA were weakly correlated (Spearman r = 0.13, P < 0.001). During a median follow-up of 41 months, 171 patients developed type 2 diabetes. Plasma LA was inversely associated with type 2 diabetes risk (quintile [Q]5 vs. Q1: 0.44 [0.26, 0.75]; per 5%: 0.73 [0.62, 0.86]). Substitution of dietary LA for SFA+TFA showed no association with type 2 diabetes risk (Q5 vs. Q1: 0.78 [0.36, 1.72]; per 5% energy: 1.18 [0.59, 2.35]). Adjustment for markers of de novo lipogenesis attenuated plasma LA associations. CONCLUSIONS: In our cohort of post-MI patients, plasma LA was inversely related to type 2 diabetes risk, whereas dietary LA was not related. Further research is needed to assess whether plasma LA indicates metabolic state rather than dietary LA in these patients.

    Adherence to the Dutch dietary guidelines and 15-year incidence of heart failure in the EPIC-NL cohort
    Harbers, Marjolein C. ; Kroon, Marleen A. de; Boer, Jolanda M.A. ; Asselbergs, Folkert W. ; Geleijnse, Johanna M. ; Verschuren, Monique W. ; Schouw, Yvonne T. van der; Sluijs, Ivonne - \ 2020
    European Journal of Nutrition (2020). - ISSN 1436-6207
    Dietary patterns - Dutch dietary guidelines - Dutch Healthy Diet 2015 Index - Heart failure

    Purpose: A healthy diet may contribute to the primary prevention of heart failure (HF), but evidence is still inconclusive. We aimed to study the association between adherence to the Dutch dietary guidelines and incidence of HF. Methods: We studied 37,468 participants aged 20–70 years and free of HF at baseline from the EPIC-NL cohort. At baseline (1993–1997), data were collected on demographics, lifestyle, and presence of chronic diseases. Dietary intake was assessed using a 178-item validated food frequency questionnaire. Dietary intake data were used to calculate scores on the Dutch Healthy Diet 2015 Index (DHD15-index) measuring adherence to the Dutch dietary guidelines. The DHD15-index is based on the average daily intake of 14 food groups resulting in a total score ranging between 0 and 140, with higher scores indicating better adherence. HF morbidity and mortality during follow-up were ascertained through linkage with national registries. Cox proportional hazards analysis was used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs) for the association between DHD15 adherence and HF risk, adjusting for sociodemographic and lifestyle characteristics. Results: The average score on the DHD15-index was 71 (SD = 15). During a median follow-up of 15.2 years (IQR 14.1–16.5), 674 HF events occurred. After adjustment for demographic and lifestyle characteristics, higher scores on the DHD15-index were associated with lower risk of HF (HRQ4vsQ1 0.73; 95% CI 0.58–0.93; Ptrend 0.001). Conclusion: In a large Dutch population of middle-aged adults, higher adherence to the Dutch dietary guidelines was associated with lower risk of HF.

    Students’ Experiences with Different Learning Pathways to Higher Professional Bachelor Programmes
    Biemans, H.J.A. ; Mariën, H. ; Fleur, E. ; Beliaeva, T. ; Harbers, J. - \ 2020
    International Journal for Research in Vocational Education and Training 7 (2020)1. - ISSN 2197-8638 - p. 1 - 20.
    Context: In the Dutch educational system, different learning pathways to higher professional bachelor (or HBO) programmes have been created: the regular VET route, the general secondary education route, and continuing learning pathways (such as the Green Lyceum or GL) that combine characteristics of these two traditional routes and that are specifically de-signed for students who combine a relatively high cognitive level with an affinity for practical, vocation-oriented assignments.Approach: The present study aimed to compare the experiences of students coming from these three different learning pathways to HBO. 62 former GL students, 127 former middle-management VET (or MBO) students, and 81 former regular general secondary education (or HAVO) students completed an online questionnaire on their experiences in their first HBO study year and their scores on the various scales were compared.Findings: Students from the three groups were equally satisfied with their current HBO programme. The same pattern was found for perceived study success in their HBO pro-*Corresponding author: harm.biemans@wur.nl2Students’experiences with different learning pathwaysgramme. Former GL students, however, mentioned that they had been better prepared in terms of development of study skills needed in HBO. Compared with the MBO route to HBO, former GL students felt better prepared in terms of the theoretical subjects addressed in their previous educational programme. In this regard, their level of theoretical preparation was comparable to that of former HAVO students. When the vocation-oriented aspects of education were concerned, however, the GL appeared to be comparable with the MBO route to HBO (in the HAVO curriculum, vocation-oriented preparation for HBO is absent). Moreover, former HAVO students scored lower than former GL and former MBO students with respect to the extent to which they felt that they had received support in choosing a particular HBO programme in their previous educational programme. Conclusion: The GL seems to combine the advantages of MBO and HAVO programmes for this particular group of students: theoretical preparation for HBO at HAVO level com-bined with practical preparation at MBO level, systematic career orientation and guidance, and development of study skills required in HBO. In other words, such continuing learning pathways can be a curriculum design solution for specific student groups to promote their transition to HBO
    Toekomstperspectief van de leerling centraal : Onderzoeksverslag
    Harbers, J. ; Berg, N.S. van den; Biemans, H.J.A. ; Fekkes, M. ; Hakkaart, Q. ; Hanekamp, R. ; Jager, A. ; Jong, C. de; Jong, F. de; Meijden, A. van der; Nawijn, A. ; Schalkwijk, B. ; Speksnijder, J. - \ 2019
    Den Haag : NRO
    Ervaringen van studenten met verschillende routes naar het hoger beroepsonderwijs
    Biemans, H.J.A. ; Harbers, J. ; Mariën, H. ; Fleur, E. ; Beliaeva, T. - \ 2019
    Promoting Students’ Transitions to Successive VET Levels through Continuing Learning Pathways
    Biemans, H.J.A. ; Mariën, H. ; Fleur, Erik ; Beliaeva, Tanya ; Harbers, Jan - \ 2019
    Vocations and Learning: Studies in Vocational and Professional Education 12 (2019)2. - ISSN 1874-785X - p. 179 - 195.
    Continuing learning pathways have been proposed as curriculum design solutions to reduce student drop-out rates and to promote their transitions to successive levels of the educational system. The present study aimed to compare the effects of a specific continuing learning pathway in Dutch VET (the Green Lyceum or GL, which combines a lower secondary pre-vocational school-based (VMBO) programme and a middle-management VET (MBO) programme in an integrated learning trajectory offered by agricultural (or ‘green’) VET institutes) with a more traditional route (a regular middle-management VET programme) in terms of students’ learning performance at MBO level and their transitions to a higher professional bachelor programme (HBO). GL students more often obtained a MBO diploma at EQF level 4 in the nominal study time period than comparable students in terms of cognitive level in regular MBO. Moreover, former GL students more often proceeded with an HBO programme than comparable students coming from regular MBO. Finally, students coming from the GL less often opted for HBO programmes in the agricultural domain than comparable students coming from regular ‘green’ MBO and more often decided to start with programmes corresponding with other sectors. To conclude, the combination of design characteristics of these continuing learning pathways seems to promote students’ transitions within the VET system and, thus, can inspire the design and implementation of comparable learning routes to solve transition problems.
    Making sense of sensors in transition cow care
    Hulsen, Jan ; Vreeburg, N. ; Eerdenburg, F.J.C.M. van; Hooijer, G. ; Hut, P. ; Harbers, Arnold ; Stassen, E.N. - \ 2018
    Hoard's Dairyman (2018). - ISSN 0018-2885 - p. 265 - 265.
    Using sensors to monitor behaviour at the dairy farm
    Eerdenburg, F.J.C.M. van; Hut, P. ; Hooijer, G. ; Harbers, Arnold ; Stassen, E.N. ; Hulsen, Jan - \ 2017
    In: Proceedings of the ISAE Benelux conference 2017 International Society for Applied Ethology (ISAE) - p. 20 - 20.
    Using sensors to monitor behaviour at the dairy farm
    Eerdenburg, Frank J.C.M. ; Hut, P. ; Hooijer, G. ; Harbers, A. ; Stassen, E.N. ; Hulsen, J. - \ 2017
    In: Proceedings of the 7th International Conference on the Assessment of Animal Welfare at Farm and Group Level. - Wageningen : Wageningen Academic Publishers - ISBN 9789086863143 - p. 228 - 228.
    Sensors can measure various types of behaviour automatically in a dairy herd. They can,therefore, be used to monitor a herd and the computer can detect deviations of normalbehaviour and give an attention to the farmer. In order to do so, normal baseline values areneeded. Since these may vary due to parity and housing conditions, the aim of this study wasto investigate the effects of parity and freestall bedding (cow matrass vs deep litter) on dailylying time, locomotion, standing and eating time from 42d a.p. – 28d p.p. Sixteen Dutch dairyfarms (3,158 cows) were used in this study and the number of steps per day, time of standingand lying (in sec/2 h period)and time eating (in sec/2 h) were collected by means of Nedapsmart tags (Groenlo, the Netherlands). Furthermore, in the first two weeks post-partum bloodsamples were collected to measure BHB levels. T-tests and timeseries were used for comparison.The results of locomotion revealed that primiparous cows made 833 (SD 132; P<0.001) moresteps on daily basis in comparison with multiparous cows. Animals housed on cow matrassesmade on daily basis on average 621 (SD 30; P<0.001) more steps vs animals in stalls with deeplitter bedding. Primiparous cows spent daily on average 64 minutes (SD 4.8; P<0.001) less timelying down and animals on farms with cow matrasses lie on daily basis around 30 (SD 17.3;P<0.001) minutes less when compared with animals housed on farms with deep litter bedding.The number of lying bouts increased from 6 to 9 per day 1 day before calving and decreased to7 per day after calving. The time lying per day decreased before calving. And the average lyingtime increases again in the first week post-partum. Cows that had a subclinical ketosis postpartumwere eating half an hour less during the dry period. Already 42 days before calving thisdifference could be observed. It became clear that with sensors differences in behaviour duringthe dry period can be detected that could lead to managerial interventions to reduce the riskfor diseases post-partum. This study is ongoing and more data will be obtained.
    Het Groene Lyceum, een doorlopende leerlijn nader onderzocht
    Harbers, J. ; Biemans, H.J.A. - \ 2016
    Van Twaalf tot Achttien 26 (2016)2. - ISSN 1380-4731 - p. 36 - 37.
    De kerk; De veranderde rol van kerkgebouwen in het publieke domein
    Donk, W.B.H.J. van de; Janssen, J. - \ 2013
    In: Bestemming gewijzigd; Moderniteit en stedelijke transformaties / Dijstelbloem, H., Hagendijk, R., Harbers, H., Terreehorst, P., Amsterdam : Universiteit van Amsterdam - p. 40 - 59.
    Identification of Nucleotide Variation in Genomes Using Next-Generation Sequencing
    Megens, H.J.W.C. ; Groenen, M.A.M. - \ 2012
    In: Tag-Based Next Generation Sequencing / Harbers, M., Kahl, G., Weinheim, Germany : Wiley-VCH - ISBN 9783527328192 - p. 257 - 276.
    Discovery of genome-wide variation has taken a huge leap forward with the introduction of next-generation sequencing (NGS) technology. Variant discovery requires sampling of a number of haplotypes. This can be either the two haplotypes of a diploid organism or multiple haplotypes in a population. Variant discovery can be done by sequencing pooled DNA and NGS makes it cost-effective to sample many haplotypes. In this chapter, we discuss various sequencing strategies for variation discovery, focusing mainly on single nucleotide polymorphisms, and to a lesser extent on short insertion/deletions (Indels). We discuss different options, such as specific library construction and the amount of sequencing required to meet a certain objective. While the benefits of NGS to their own research may be obvious to many researchers, the main obstacle for applying NGS is often practical - how to manipulate and analyze the amount of data from a typical NGS run. The methods therefore focus on practical considerations dealing with large NGS datasets, such as sequence processing and filtering, mapping to a reference genome, and variant calling. In addition, we focus on data standards and tools to manipulate and analyze data from such standardized datasets. By providing examples and links to easy-to-implement scripts and software, we hope to lower the threshold for biologists to further explore the wealth of information that can be obtained by these new molecular resources
    Registratie robotbezoek en voeding [Koe & Wij]
    Harbers, J. ; Groeneveld, L. ; Nistelrooy, J. van - \ 2007
    melkveehouderij - melkkoeien - voedering - opname (intake) - weiden - begrazing - robots - melkproductie - dairy farming - dairy cows - feeding - intake - pastures - grazing - robots - milk production
    Melkveehouders Johan Harbers, Leen Groeneveld en Jan van Nistelrooy uit de AMS groep hebben het voortouw genomen bij de analyse van de voedingsregistraties. Hoewel de drie heren, maar ook de rest van de groep het moeilijk vonden om harde conclusies te verbinden aan de analyseresultaten, is er toch een aantal trends waargenomen
    Efficacy of different doses of iodized peanut oil on iodine status of lactating women and their infants in a rural mountainous area in Guatemala
    Eussen, S.J. ; Harbers, M. ; Mutsert, R. de; West, C.E. ; Heide, D. van der; Bulux, J. ; Romero-Abal, M.E. ; Solomons, N.W. - \ 2001
    In: Annals of Nutrition & Metabolism : 17th International Congress of Nutrition, August 27-31, 2001, Vienna, Austria - p. 40 - 40.
    The supplementation of iodized oil to lactating rural Guatemalan women improves their child's iodine status
    Bulux, J. ; Eussen, S. ; Harbers, R. ; Mutsert, R. de; Romero-Abal, M.E. ; West, C.E. ; Solomons, N.W. - \ 2001
    In: Annals of Nutrition & Metabolism : 17th International Congress of Nutrition, August 27-31, 2001, Vienna, Austria. - [S.l.] : [s.n.], 2001
    Effects of Information Technology on Dairy Farms in The Netherlands: An Empirical Analysis of Milk Production Records
    Asseldonk, M.A.P.M. van; Huirne, R.B.M. ; Dijkhuizen, A.A. ; Tomaszewski, M.A. ; Harbers, A.G.F. - \ 1998
    Journal of Dairy Science 81 (1998)10. - ISSN 0022-0302 - p. 2752 - 2759.
    This study empirically quantified the effects of the adoption of an automated concentrate feeder, on-line measurement of milk production, and activity measurement on milk production and reproduction. The data comprised annual results of Dutch farms operating in a milk quota system from 1987 to 1996; data included both adopters and nonadopters as well as farm results before and after adoption. The use of an automated concentrate feeder improved the annual carrier production of milk, milk protein, and milk fat (102, 4.95, and 5.52 kg per cow, respectively). In contrast, on-line measurement of milk production did not significantly affect milk production records. Calving interval was shortened by 5.7 d after the adoption of an activity measurement system but was not affected by the adoption of an automated concentrate feeder or by the measurement of on-line milk production.
    L.M.R.V.-verslag van de N.P.K.-oefening kerncentrale Borssele op 3 december 1996
    Harbers, J.A.C. ; Vries, P.H.U. de - \ 1997
    Wageningen : DLO-Rijks-Kwaliteitsinstituut voor Land- en Tuinbouwprodukten (Rapport / RIKILT-DLO 97.15)
    kernenergiecentrales - voedselkwaliteit - radioactiviteit - radionucliden - verval - nederland - nuclear power stations - food quality - radioactivity - radionuclides - decay - netherlands
    In het kader van het Nationaal Plan Kernongevallenbestrijding is door het Crisismanagementteam van het Ministerie van VROM op 3 december 1996 een landelijke oefening georganiseerd. Het RIKILT-Steuncentrum en het Landelijk Meetnet Radioactiviteit in Voedsel hebben aan deze oefening deelgenomen. De resultaten in dit verslag laten zien dat de oefening zeer goed verlopen is. De deelnemers hebben een uitstekende inzet en operationele prestatle geleverd.
    LMRV verslag van de NPK oefening Kerncentrale Borssele op 3 december 1996
    Harbers, J.A.C. - \ 1997
    Unknown Publisher (RIKILT-DLO rapport 97.15)
    Bodemkaart van Nederland 1:50.000 : toelichting bij kaartblad 44 Oost Oosterhout
    Harbers, P. ; Steur, G.L. ; Heijink, W. ; Bakker, H. de; Boersma, O.H. ; Hamming, C. - \ 1990
    Wageningen : Staring Centrum - 164
    bodemkarteringen - kaarten - nederland - noord-brabant - soil surveys - maps - netherlands - noord-brabant
    Bodemkaart van Nederland 1:50.000 : toelichting bij de herziene uitgave van blad 45 West 's-Hertogenbosch
    Bles, B.J. ; Harbers, P. ; Visschers, R. ; Steur, G.G.L. ; Heijink, W. - \ 1984
    Wageningen : STIBOKA - 7
    bodemkarteringen - kaarten - nederland - noord-brabant - soil surveys - maps - netherlands - noord-brabant
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