Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    Coupling DAD and MS data in untargeted metabolomics
    Wehrens, H.R.M.J. ; Engel, J. ; Treuren, R. van; Vos, R. de; Haug, Kenneth ; Rocca-Serra, Philippe - \ 2019
    Risk to human health related to the presence of perfluorooctane sulfonic acid and perfluorooctanoic acid in food
    Knutsen, Helle Katrine ; Alexander, Jan ; Barregård, Lars ; Bignami, Margherita ; Brüschweiler, Beat ; Ceccatelli, Sandra ; Cottrill, Bruce ; Dinovi, Michael ; Edler, Lutz ; Grasl‐Kraupp, Bettina ; Hogstrand, Christer ; Hoogenboom, Laurentius ; Nebbia, Carlo Stefano ; Oswald, Isabelle P. ; Petersen, Annette ; Rose, Martin ; Roudot, Alain-Claude ; Vleminckx, Christiane ; Vollmer, Günter ; Wallace, Heather ; Bodin, Laurent ; Cravedi, Jean-Pierre ; Halldorsson, Thorhallur Ingi ; Haug, Line Småstuen ; Johansson, Niklas ; Loveren, Henk van; Gergelova, Petra ; Mackay, Karen ; Levorato, Sara ; Manen, Mathijs van; Schwerdtle, Tanja - \ 2018
    EFSA Journal 16 (2018)12. - ISSN 1831-4732
    The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in food. Regarding PFOS and PFOA occurrence, the final data set available for dietary exposure assessment contained a total of 20,019 analytical results (PFOS n = 10,191 and PFOA n = 9,828). There were large differences between upper and lower bound exposure due to analytical methods with insufficient sensitivity. The CONTAM Panel considered the lower bound estimates to be closer to true exposure levels. Important contributors to the lower bound mean chronic exposure were ‘Fish and other seafood’, ‘Meat and meat products’ and ‘Eggs and egg products’, for PFOS, and ‘Milk and dairy products’, ‘Drinking water’ and ‘Fish and other seafood’ for PFOA. PFOS and PFOA are readily absorbed in the gastrointestinal tract, excreted in urine and faeces, and do not undergo metabolism. Estimated human half‐lives for PFOS and PFOA are about 5 years and 2–4 years, respectively. The derivation of a health‐based guidance value was based on human epidemiological studies. For PFOS, the increase in serum total cholesterol in adults, and the decrease in antibody response at vaccination in children were identified as the critical effects. For PFOA, the increase in serum total cholesterol was the critical effect. Also reduced birth weight (for both compounds) and increased prevalence of high serum levels of the liver enzyme alanine aminotransferase (ALT) (for PFOA) were considered. After benchmark modelling of serum levels of PFOS and PFOA, and estimating the corresponding daily intakes, the CONTAM Panel established a tolerable weekly intake (TWI) of 13 ng/kg body weight (bw) per week for PFOS and 6 ng/kg bw per week for PFOA. For both compounds, exposure of a considerable proportion of the population exceeds the proposed TWIs.
    Automated assembly of species metabolomes through data submission into a public repository
    Salek, Reza ; Conesa, Pablo ; Cochrane, Keeva ; Haug, Kenneth ; Williams, M. ; Kale, Namrata ; Moreno, P. ; Jayaseelan, Kalai Vanii ; Macias, Jose Ramon ; Nainala, Venkata Chandrasekhar ; Hall, R.D. ; Reed, Laura ; Viant, Mark ; Donovan, C. ; Steinbeck, Christoph - \ 2017
    GigaScience 6 (2017)8. - ISSN 2047-217X - 4 p.
    Following similar global efforts to exchange genomic and other biomedical data, global databases in metabolomics have now been established. MetaboLights, the first general purpose, publically available, cross-species, cross-application database in metabolomics, has become the fastest growing data repository at the European Bioinformatics Institute in terms of data volume. Here we present the automated assembly of species metabolomes in MetaboLights, a crucial reference for chemical biology, which is growing through user submissions.
    The role of red processed meat in colorectal cancer development a perspective
    Oostindjer, M. ; Alexander, J. ; Amdam, G.V. ; Andersen, G. ; Bryan, N.S. ; Chen, D. ; Corpet, D.E. ; Smet, S. de; Dragsted, L.O. ; Haug, A. ; Karlsson, A.H. ; Kleter, G.A. ; Kok, E.J. ; Kulseng, B. ; Milkowski, A.L. ; Martin, R.J. ; Pajari, A.M. ; Paulsen, J.E. ; Pickova, J. ; Rudi, K. ; Sodring, M. ; Weed, D.L. ; Egelandsdal, B. - \ 2014
    Meat Science 97 (2014)4. - ISSN 0309-1740 - p. 583 - 596.
    mucin-depleted foci - aberrant crypt foci - endothelium-dependent vasodilation - familial adenomatous polyposis - colonic epithelial-cells - n-3 fatty-acids - dna-damage - intestinal tumorigenesis - microtubule stability - potential mechanisms
    This paper is based on a workshop held in Oslo, Norway in November 2013, in which experts discussed how to reach consensus on the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake of red and processed meat to reduce cancer risk, in particular colorectal cancer (CRC). Epidemiological and mechanistic data on associations between red and processed meat intake and CRC are inconsistent and underlying mechanisms are unclear. There is a need for further studies on differences between white and red meat, between processed and whole red meat and between different types of processed meats, as potential health risks may not be the same for all products. Better biomarkers of meat intake and of cancer occurrence and updated food composition databases are required for future studies. Modifying meat composition via animal feeding and breeding, improving meat processing by alternative methods such as adding phytochemicals and improving our diets in general are strategies that need to be followed up.
    Uniting Tricholoma sulphureum and T. bufonium
    Comandini, O. ; Haug, I. ; Rinaldi, A.C. ; Kuyper, T.W. - \ 2004
    Mycological Research 108 (2004)10. - ISSN 0953-7562 - p. 1162 - 1171.
    ectomycorrhizal associations - monotropoideae ericaceae - abies-alba - specificity - mycorrhizae - identification
    The taxonomic status and relationship of Tricholoma sulphureum and the similar T. bufonium were investigated using different sets of characters. These included morphological data on fruit bodies, ecological and chorological data, and analysis of the sequence data obtained for the ITS of basidiomes of different ecological and geographic origin. Moreover, the ectomycorrhizas formed by T. bufonium on Abies alba and Quercus sp. were characterised, and anatomical features compared with those of T. sulphureum mycorrhizas on coniferous and broad-leaved host trees. Our results revealed extensive ITS variation in members of the T. sulphureum group, but this variation was not correlated with morphology, ecology, or geographical distribution. We conclude that T. bufonium cannot be maintained as an autonomous taxon and should be treated as an infraspecific variant of T. sulphureum.
    Lumping Tricholoma sulphureum and T.bufonium?
    Comandini, O. ; Haug, I. ; Rinaldi, A.C. ; Kuyper, T.W. - \ 2002
    In: Book of Abstracts, International Mycological Congress 7 : International Mycological Congress, Oslo, 2002. - [S.l.] : [s.n.], 2002 - p. 196 - 196.
    Constructing knowledge from multivariate spatiotemporal data: integrating geographical visualization with knowledge discovery in database methods
    MacEachren, A.M. ; Wachowicz, M. ; Edsall, R. ; Haug, D. ; Masters, R. - \ 1999
    International Journal of Geographical Information Science 13 (1999)4. - ISSN 1365-8816 - p. 311 - 334.
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