Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

Records 1 - 8 / 8

  • help
  • print

    Print search results

  • export

    Export search results

  • alert
    We will mail you new results for this query: q=Heijligenberg
Check title to add to marked list
Changes in Micronutrient Intake and Status, Diet Quality and Glucose Tolerance from Preconception to the Second Trimester of Pregnancy
Looman, M. ; Geelen, M.M.E.E. ; Samlal, Rahul A.K. ; Heijligenberg, Rik ; Klein Gunnewiek, Jacqueline T.M. ; Balvers, Michiel ; Wijnberger, Lia D.E. ; Brouwer-Brolsma, Elske ; Feskens, E.J.M. - \ 2019
Nutrients 11 (2019)2. - ISSN 2072-6643
Data on changes in dietary intake and related blood parameters throughout pregnancy are scarce; moreover, few studies have examined their association with glucose homeostasis. Therefore, we monitored intake of folate, vitamin B6, vitamin B12, vitamin D and iron, their status markers, and diet quality from preconception to the second trimester of pregnancy, and we examined whether these dietary factors were associated with glucose homeostasis during pregnancy. We included 105 women aged 18–40 years with a desire to get pregnancy or who were already <24 weeks pregnant. Women at increased gestational diabetes (GDM) risk were oversampled. Measurements were scheduled at preconception (n = 67), and 12 (n =53) and 24 weeks of pregnancy (n =66), including a fasting venipuncture, 75-grams oral glucose tolerance test, and completion of a validated food frequency questionnaire. Changes in micronutrient intake and status, and associations between dietary factors and glucose homeostasis, were examined using adjusted repeated measures mixed models. Micronutrient intake of folate, vitamin B6 and vitamin D and related status markers significantly changed throughout pregnancy, which was predominantly due to changes in the intake of supplements. Micronutrient intake or status levels were not associated with glucose homeostasis, except for iron intake (FE µg/day) with fasting glucose (β = −0.069 mmol/L, p = 0.013) and HbA1c (β = −0.4843 mmol, p = 0.002). Diet quality was inversely associated with fasting glucose (β = −0.006 mmol/L for each DHD15-index point, p = 0.017). It was shown that micronutrient intakes and their status markers significantly changed during pregnancy. Only iron intake and diet quality were inversely associated with glucose homeostasis.
Supplement use and dietary sources of folate, vitamin D, and n-3 fatty acids during preconception : The GLIMP2 study
Looman, Moniek ; Berg, Claudia van den; Geelen, Anouk ; Samlal, Rahul A.K. ; Heijligenberg, Rik ; Klein Gunnewiek, Jacqueline M.T. ; Balvers, Michiel G.J. ; Leendertz-Eggen, Caroline L. ; Wijnberger, Lia D.E. ; Feskens, Edith J.M. ; Brouwer-Brolsma, Elske M. - \ 2018
Nutrients 10 (2018)8. - ISSN 2072-6643
Diet - Folate - N-3 fatty acids - Preconception - Supplements - Vitamin D

An adequate nutritional status during the preconception period is important, particularly for folate, vitamin D, and n-3 fatty acids (i.e., EPA+DHA). We aimed to determine supplement intake and the main dietary sources of folate, vitamin D, and EPA+DHA using the data of 66 Dutch women aged 18–40 years who wished to become pregnant. Additionally, associations of these intakes with their blood levels were examined. Dietary intake was assessed with a validated food frequency questionnaire, and supplement use with a structured questionnaire. 25-hydroxyvitamin D levels were determined in serum and folate and phospholipid EPA+DHA levels in plasma. Partial Spearman’s correlations, restricted cubic splines and trend analyses over tertiles of nutrient intakes were performed to examine intake-status associations. A large proportion of women did not meet the Dutch recommended intakes of folate (50%), vitamin D (67%), and EPA+DHA (52%). Vegetables were the main contributor to dietary folate intake (25%), oils and fats to dietary vitamin D intake (39%), and fish to dietary EPA+DHA intake (69%). Fourteen percent of the women had an inadequate folate status and 23% an inadequate vitamin D status. Supplemental folate intake, supplemental and dietary vitamin D intake and dietary EPA+DHA intake were significantly associated with their blood levels. In conclusion, even in our highly educated population, a large proportion did not achieve recommended folate, vitamin D and n-3 fatty acid intakes. Promotion of folate and vitamin D supplement use and fish consumption is needed to improve intakes and blood levels of these nutrients in women who wish to become pregnant.

A saturated fatty acid rich diet can induce an 'obese-like' gene expression profile in adipose tissue
Dijk, Susan van; Feskens, Edith ; Bos, M.B. ; Hoelen, Dianne W. ; Heijligenberg, Rik ; Grootte Bromhaar, Mechteld ; Groot, Lisette de; Vries, Jeanne de; Muller, Michael ; Afman, Lydia - \ 2010
GSE14954 - Homo sapiens - PRJNA111821
We investigated the effect of a saturated (SFA) and a monounsaturated (MUFA) rich diet on insulin sensitivity and adipose tissue gene expression profiles of subjects at risk for metabolic syndrome. A controlled-feeding trial was performed with 20 moderately overweight subjects. Subjects received a SFA-rich or a MUFA-rich diet for 8 weeks. Subcutaneous adipose tissue samples were obtained and insulin sensitivity was measured. Whole genome micro-array analysis was performed on the adipose tissue samples. Consumption of a SFA-rich diet resulted in a pro-inflammatory 'obese-like' gene expression profile while consumption of a MUFA-rich diet caused a more anti-inflammatory profile. This suggests that replacement of dietary SFA by MUFA could prevent adipose tissue inflammation and may reduce the risk for inflammation related diseases such as the metabolic syndrome.
Effect of a high monounsaturated fatty acids diet and a Mediterranean diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity
Bos, M.B. ; Vries, J.H.M. de; Feskens, E.J.M. ; Dijk, S.J. van; Hoelen, D. ; Siebelink, E. ; Heijligenberg, R. ; Groot, C.P.G.M. de - \ 2010
Nutrition, Metabolism & Cardiovascular Diseases 20 (2010)8. - ISSN 0939-4753 - p. 591 - 598.
glucose-tolerance - controlled-trials - randomized-trial - heart-disease - risk-factors - healthy-men - cholesterol - metaanalysis - resistance - determinants
Background and aims - Diets high in monounsaturated fatty acids (MUFA) such as a Mediterranean diet may reduce the risk of cardiovascular diseases by improving insulin sensitivity and serum lipids. Besides being high in MUFA, a Mediterranean diet also contains abundant plant foods, moderate wine and low amounts of meat and dairy products, which may also play a role. We compared the effects of a high MUFA-diet with a diet high in saturated fatty acids (SFA) and the additional effect of a Mediterranean diet on insulin sensitivity and serum lipids. Methods and results - A randomized parallel controlled-feeding trial was performed, in 60 non-diabetics (40–65 y) with mild abdominal obesity. After a two week run-in diet high in SFA (19 energy-%), subjects were allocated to a high MUFA-diet (20 energy-%), a Mediterranean diet (MUFA 21 energy-%), or the high SFA-diet, for eight weeks. The high MUFA and the Mediterranean diet did not affect fasting insulin concentrations. The high MUFA-diet reduced total cholesterol (-0.41 mmol/L, 95% CI -0.74, -0.09) and LDL-cholesterol (-0.38 mmol/L, 95% CI -0.65, -0.11) compared with the high SFA-diet, but not triglyceride concentrations. The Mediterranean diet increased HDL-cholesterol concentrations (+0.09 mmol/L, 95% CI 0.0, 0.18) and reduced the ratio of total cholesterol/HDL-cholesterol (-0.39, 95% CI -0.62, -0.16) compared with the high MUFA-diet. Conclusion - Replacing a high SFA-diet with a high MUFA or a Mediterranean diet did not affect insulin sensitivity, but improved serum lipids. The Mediterranean diet was most effective, it reduced total and LDL-cholesterol, and also increased HDL-cholesterol and reduced total cholesterol/HDL-cholesterol ratio.
A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome
Dijk, S.J. van; Feskens, E.J.M. ; Bos, M.B. ; Hoelen, D.W. ; Heijligenberg, R. ; Bromhaar, M.G. ; Groot, C.P.G.M. de; Vries, J.H.M. de; Müller, M.R. ; Afman, L.A. - \ 2009
American Journal of Clinical Nutrition 90 (2009)6. - ISSN 0002-9165 - p. 1656 - 1664.
inflammation-related genes - activated receptor-alpha - blood mononuclear-cells - nonobese pima-indians - insulin-resistance - healthy-men - glucose-metabolism - weight-loss - plasma - accumulation
Background: Changes in dietary fat composition could lower the risk of developing metabolic syndrome. Adipose tissue is an interesting tissue in this respect because of its role in lipid metabolism and inflammation. Objective: Our objective was to investigate the effect of a saturated fatty acid (SFA)– and a monounsaturated fatty acid (MUFA)–rich diet on insulin sensitivity, serum lipids, and gene expression profiles of adipose tissue in subjects at risk of metabolic syndrome. Design: A parallel controlled-feeding trial was conducted in 20 abdominally overweight subjects. Subjects received an SFA diet or an MUFA diet for 8 wk. Plasma and subcutaneous adipose tissue samples were obtained, and insulin sensitivity was measured by using a hyperinsulinemic-euglycemic clamp. Adipose tissue samples underwent whole-genome microarray and histologic analysis. Plasma and adipose tissue fatty acid composition and concentrations of serum cholesterol and plasma cytokine were determined. Results: Consumption of the SFA diet resulted in increased expression of genes involved in inflammation processes in adipose tissue, without changes in morphology or insulin sensitivity. The MUFA diet led to a more antiinflammatory gene expression profile, which was accompanied by a decrease in serum LDL-cholesterol concentrations and an increase in plasma and adipose tissue oleic acid content. Conclusions: Consumption of an SFA diet resulted in a proinflammatory "obesity-linked" gene expression profile, whereas consumption of an MUFA diet caused a more antiinflammatory profile. This suggests that replacement of dietary SFA with MUFA could prevent adipose tissue inflammation and may reduce the risk of inflammation-related diseases such as metabolic syndrome. This trial was registered at clinicaltrials.gov as NCT00405197.
Effect of a high olive oil and a Mediterranean type of diet on serum lipids and insulin sensitivity in adults with mild abdominal obesity
Bos, M.B. ; Vries, J.H.M. de; Feskens, E.J.M. ; Dijk, S.J. van; Hoelen, D. ; Siebelink, E. ; Heijligenberg, R. ; Groot, C.P.G.M. de - \ 2008
Effect of a high olive oil and a Mediterranean type of diet on serum lipids and insulin sensitivity
Bos, M.B. ; Vries, J.H.M. de; Feskens, E.J.M. ; Dijk, S.J. van; Hoelen, D. ; Siebelink, E. ; Heijligenberg, R. ; Groot, C.P.G.M. de - \ 2008
Mediterrenean diet and the prevention of type 2 diabetes; Impact of monounsaturated fatty acids on insulin sensitivity and underlying mechanisms
Dijk, S.J. van; Afman, L.A. ; Hoelen, D. ; Grootte Bromhaar, M.M. ; Vries, J.H.M. de; Heijligenberg, R. ; Müller, M.R. ; Feskens, E.J.M. - \ 2008
Chemistry and Physics of Lipids 154 (2008)S-1. - ISSN 0009-3084 - p. S45 - S45.
Check title to add to marked list

Show 20 50 100 records per page

 
Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.