Higher Serum Vitamin D Concentrations Are Longitudinally Associated with Better Global Quality of Life and Less Fatigue in Colorectal Cancer Survivors up to 2 Years after Treatment
Koole, Janna L. ; Bours, Martijn J.L. ; Roekel, Eline H. van; Breedveld-Peters, José J.L. ; Duijnhoven, Fränzel J.B. van; Ouweland, Jody van den; Breukink, Stéphanie O. ; Janssen-Heijnen, Maryska L.G. ; Keulen, Eric T.P. ; Weijenberg, Matty P. - \ 2020
Cancer Epidemiology Biomarkers & Prevention 29 (2020)6. - ISSN 1055-9965 - p. 1135 - 1144.
BACKGROUND: Vitamin D status may be an important determinant of health-related quality of life of colorectal cancer survivors. The current study investigated longitudinal associations between serum 25-hydroxyvitamin D3 (25OHD3) concentrations and quality of life in stage I-III colorectal cancer survivors up to 2 years after treatment. METHODS: Patients with colorectal cancer (n = 261) were included upon diagnosis. Home visits (including blood sampling) were performed at diagnosis and at 6 weeks, 6 months, 1 year, and 2 years after treatment. Serum 25OHD3 concentrations were measured using LC/MS-MS and adjusted for season. Validated questionnaires were used to assess global quality of life and cognitive functioning (EORTC-QLQ-C30), fatigue (EORTC-QLQ-C30 and Checklist Individual Strength, CIS), and depression and anxiety (Hospital Anxiety and Depression Scale). Statistical analyses were performed using linear mixed models and adjusted for sex, age, time since diagnosis, therapy, comorbidities, physical activity, and body mass index. RESULTS: At diagnosis, 45% of patients were vitamin D deficient (<50 nmol/L). After treatment, 25OHD3 concentrations increased on average with 3.1 nmol/L every 6 months. In confounder-adjusted models, 20 nmol/L increments in 25OHD3 were longitudinally associated with increased global quality of life [β 2.9; 95% confidence interval (CI), 1.5-4.3] and reduced fatigue (EORTC-QLQ-C30 subscale: β -3.5; 95% CI, -5.3 to -1.8 and CIS: β -2.8; 95% CI, -4.7 to -0.9). Observed associations were present both within and between individuals over time. CONCLUSIONS: Higher concentrations of 25OHD3 were longitudinally associated with better global quality of life and less fatigue in colorectal cancer survivors. IMPACT: This study suggests that higher 25OHD3 concentrations may be beneficial for colorectal cancer survivors. Future intervention studies are needed to corroborate these findings.
Mobility and redox transformation of arsenic during treatment of artificially recharged groundwater for drinking water production
Ahmad, Arslan ; Heijnen, Leo ; Waal, Luuk de; Battaglia-Brunet, Fabienne ; Oorthuizen, Wim ; Pieterse, Brent ; Bhattacharya, Prosun ; Wal, Albert van der - \ 2020
Water Research 178 (2020). - ISSN 0043-1354
Arsenic - Co-precipitation - Drinking water - Fe(III)(oxyhydr)oxides - Rapid sand filtration
In this study we investigate opportunities for reducing arsenic (As) to low levels, below 1 μg/L in produced drinking water from artificially infiltrated groundwater. We observe that rapid sand filtration is the most important treatment step for the oxidation and removal of As at water treatment plants which use artificially recharged groundwater as source. Removal of As is mainly due to As co-precipitation with Fe(III)(oxyhydr)oxides, which shows higher efficiency in rapid sand filter beds compared to aeration and supernatant storage. This is due to an accelerated oxidation of As(III) to As(V) in the filter bed which may be caused by the manganese oxides and/or As(III) oxidizing bacteria, as both are found in the coating of rapid sand filter media grains by chemical analysis and taxonomic profiling of the bacterial communities. Arsenic removal does not take place in treatment steps such as granular activated carbon filtration, ultrafiltration or slow sand filtration, due to a lack of hydrolyzing iron in their influent and a lack of adsorption affinity between As and the filtration surfaces. Further, we found that As reduction to below 1 μg/L can be effectively achieved at water treatment plants either by treating the influent of rapid sand filters by dosing potassium permanganate in combination with ferric chloride or by treating the effluent of rapid sand filters with ferric chloride dosing only. Finally, we observe that reducing the pH is an effective measure for increasing As co-precipitation with Fe(III)(oxyhydr)oxides, but only when the oxidized arsenic, As(V), is the predominant species in water.
Portioning meat and vegetables in four different out of home settings : A win-win for guests, chefs and the planet
Reinders, Machiel J. ; Lieshout, Lilou van; Pot, Gerda K. ; Neufingerl, Nicole ; Broek, Eva van den; Battjes-Fries, Marieke ; Heijnen, Joris - \ 2020
Appetite 147 (2020). - ISSN 0195-6663
Environmental impact - Healthy diet - Meat - Plant-forward diet - Portion size - Real-life intervention study - Restaurant - Vegetables
Individuals increasingly consume their meals away from home. This article describes a series of studies that examined the effects of meals with reduced amounts of meat and increased amounts of vegetables on food consumption, waste and guest satisfaction in four real-life restaurant settings in the Netherlands: an a-la-carte restaurant, six company canteens, a self-service restaurant, and a buffet restaurant, including nearly 1500 participants in total. The four studies in these four different out of home settings consistently showed that adapting portion sizes of meat and vegetables was effective to reduce meat consumption and increase vegetable consumption, while maintaining high guest satisfaction. Guest satisfaction even increased when vegetables were presented and prepared in a more attractive and tasty way. Thus, adapting portion sizes of meat and vegetables provides a viable strategy to stimulate healthy and environmentally sustainable consumption patterns in out of home settings.
Menu-engineering in restaurants - adapting portion sizes on plates to enhance vegetable consumption : A real-life experiment
Reinders, Machiel J. ; Huitink, Marlijn ; Dijkstra, S.C. ; Maaskant, Anna J. ; Heijnen, Joris - \ 2017
International journal of behavioral nutrition and physical activity 14 (2017)1. - ISSN 1479-5868
Diet - Intake - Meat - Menu - Portion size - Restaurant - Vegetables
Background: The aim of this research was to investigate whether increased portion sizes of vegetables and decreased portion sizes of meat on main dishes increased the amount of vegetables consumed in a real-life restaurant setting without affecting customer satisfaction. The participants were unaware of the experiment. Methods: A cross-over design was used in which three restaurants were randomly assigned to a sequence of an intervention and control condition. In the intervention period, the vegetable portion sizes on the plates of main dishes were doubled (150 g of vegetables instead of 75 g) and the portion sizes of meat on the plates were reduced by an average of 12.5%. In the control period, the portion sizes of the main dishes were maintained as usual. In total, 1006 observations and questionnaires were included. Results: Vegetable consumption from plates was significantly higher during the intervention period (M = 115.5 g) than during the control period (M = 61.7 g). Similarly, total vegetable consumption (including side dishes) was significantly higher during the intervention period (M = 178.0 g) than during the control period (M = 137.0 g). Conversely, meat consumption was significantly lower during the intervention period (M = 183.1 g) than during the control period (M = 211.1 g). Satisfaction with the restaurant visit did not differ between the intervention period (M = 1.27) and control period (M = 1.35). Satisfaction with the main dish was significantly lower during the intervention period (M = 1.25) than during the control period (M = 1.38), although in both cases, the scores indicated that participants remained (very) satisfied with their main dish. Conclusions: This study showed that increasing vegetable portions in combination with decreasing meat portions (unknowingly to the consumer) increased the amount of vegetables consumed and decreased the amount of meat consumed. Furthermore, despite the changes in portion sizes, participants remained satisfied with their restaurant visit and main dish. The findings of this study suggest that modifying portion size in restaurants is an effective tool for stimulating vegetable consumption and consequently healthy and sustainable diets.
|Menu-engineering in restaurants: Using portion sizes on plates to promote healthy eating
Reinders, M.J. ; Huitink, M. ; Heijnen, J. - \ 2016
Transport and metabolism of fumaric acid in Saccharomyces cerevisiae in aerobic glucose-limited chemostat culture
Shah, Mihir V. ; Mastrigt, Oscar van; Heijnen, Joseph J. ; Gulik, Walter M. van - \ 2016
Yeast 33 (2016)4. - ISSN 0749-503X - p. 145 - 161.
Fumaric acid - Futile cycling - Metabolism - Permeability coefficient - saccharomyces cerevisiae - Transport mechanism
Currently, research is being focused on the industrial-scale production of fumaric acid and other relevant organic acids from renewable feedstocks via fermentation, preferably at low pH for better product recovery. However, at low pH a large fraction of the extracellular acid is present in the undissociated form, which is lipophilic and can diffuse into the cell. There have been no studies done on the impact of high extracellular concentrations of fumaric acid under aerobic conditions in S. cerevisiae, which is a relevant issue to study for industrial-scale production. In this work we studied the uptake and metabolism of fumaric acid in S. cerevisiae in glucose-limited chemostat cultures at a cultivation pH of 3.0 (pH
Fermentation broth components influence droplet coalescence and hinder advanced biofuel recovery during fermentation
Heeres, A.S. ; Schroën, C.G.P.H. ; Heijnen, J.J. ; Wielen, L.A.M. van der; Cuellar, M.C. - \ 2015
Biotechnology Journal 10 (2015)8. - ISSN 1860-6768 - p. 1206 - 1215.
Developments in synthetic biology enabled the microbial production of long chain hydrocarbons, which can be used as advanced biofuels in aviation or transportation. Currently, these fuels are not economically competitive due to their production costs. The current process offers room for improvement: by utilizing lignocellulosic feedstock, increasing microbial yields, and using cheap-er process technology. Gravity separation is an example of the latter, for which droplet growth by coalescence is crucial. The aim of this study was to study the effect of fermentation broth compo-nents on droplet coalescence. Droplet coalescence was measured using two setups: a microflu-idic chip and regular laboratory scale stirred vessel (2 L). Some fermentation broth components had a large impact on droplet coalescence. Especially components present in hydrolysed cellulosic biomass and mannoproteins from the yeast cell wall retard coalescence. To achieve a technically feasible gravity separation that can be integrated with the fermentation, the negative effects of these components on coalescence should be minimized. This could be achieved by redesign of the fermentation medium or adjusting the fermentation conditions, aiming to minimize the release of surface active components by the microorganisms. This way, another step can be made towards economically feasible advanced biofuel production.
Model collaboration for the improved assessment of biomass supply, demand, and impacts
Wicke, B. ; Hilst, F. van der; Daioglou, V. ; Banse, M. ; Beringer, T. ; Gerssen-Gondelach, S. ; Heijnen, S. ; Karssenberg, D. ; Laborde, D. ; Lippe, M. ; Meijl, H. van; Nassar, A. ; Powell, J.P. ; Prins, A.G. ; Rose, S.N.K. ; Smeets, E.M.W. ; Stehfest, E. ; Tyner, W.E. ; Verstegen, J.A. ; Valin, H. ; Vuuren, D.P. van; Yeh, S. ; Faaij, A.P.C. - \ 2015
Global change biology Bioenergy 7 (2015)3. - ISSN 1757-1693 - p. 422 - 437.
land-use change - global agricultural markets - greenhouse-gas emissions - eu biofuel policies - bioenergy production - united-states - energy crops - trade-offs - bio-energy - ethanol
Existing assessments of biomass supply and demand and their impacts face various types of limitations and uncertainties, partly due to the type of tools and methods applied (e.g., partial representation of sectors, lack of geographical details, and aggregated representation of technologies involved). Improved collaboration between existing modeling approaches may provide new, more comprehensive insights, especially into issues that involve multiple economic sectors, different temporal and spatial scales, or various impact categories. Model collaboration consists of aligning and harmonizing input data and scenarios, model comparison and/or model linkage. Improved collaboration between existing modeling approaches can help assess (i) the causes of differences and similarities in model output, which is important for interpreting the results for policy-making and (ii) the linkages, feedbacks, and trade-offs between different systems and impacts (e.g., economic and natural), which is key to a more comprehensive understanding of the impacts of biomass supply and demand. But, full consistency or integration in assumptions, structure, solution algorithms, dynamics and feedbacks can be difficult to achieve. And, if it is done, it frequently implies a trade-off in terms of resolution (spatial, temporal, and structural) and/or computation. Three key research areas are selected to illustrate how model collaboration can provide additional ways for tackling some of the shortcomings and uncertainties in the assessment of biomass supply and demand and their impacts. These research areas are livestock production, agricultural residues, and greenhouse gas emissions from land-use change. Describing how model collaboration might look like in these examples, we show how improved model collaboration can strengthen our ability to project biomass supply, demand, and impacts. This in turn can aid in improving the information for policy-makers and in taking better-informed decisions.
Op weg naar een hogere groente- en fruitconsumptie: barrières en succesfactoren : eerste inventarisatie en verkenning van kennis en meest kansrijke interventies rondom het verhogen groente- en fruitconsumptie
Sluis, A.A. van der; Stijnen, D.A.J.M. ; Maaskant, A.J. ; Zeinstra, G.G. ; Vingerhoeds, M.H. ; Heuts, F. ; Heijnen, J. - \ 2013
Wageningen : Wageningen UR Food & Biobased (Rapport / Wageningen UR Food & Biobased Research 1431) - ISBN 9789461737007 - 91
consumptiepatronen - consumptie - voedselvoorkeuren - voedingsvoorkeuren - consumentenvoorkeuren - fruit - groenten - maatregel op voedingsgebied - voeding - consumption patterns - consumption - food preferences - feeding preferences - consumer preferences - fruit - vegetables - nutritional intervention - nutrition
Gezond eten en drinken is naast voldoende beweging, één van de belangrijkste manieren om zelf te zorgen dat je gezond en vitaal oud wordt. Een ongezond voedingspatroon en een ongezonde levensstijl zorgen voor een enorme stijging van de kosten voor medische zorg, verlies aan arbeidsproductiviteit en verlies aan gezonde levensjaren. Groente- en fruitproducten zijn een belangrijke bron van voedingsvezels en hebben een relatief hoog gehalte aan voedingstoffen die essentieel zijn voor de gezondheid. Zo leveren groenten en fruit een belangrijk aandeel in de inname van vitamines, mineralen en bioactieve stoffen. Bijkomend voordeel is dat groenten en fruit een relatief lage energiedichtheid hebben en vooral door de vezels een goede maagvulling zijn. Dat het eten van groenten en fruit bijdraagt aan een gezonde levensstijl is inmiddels voldoende bekend. Toch blijft de verkoop en consumptie van groenten en fruit veel lager dan de aanbevolen hoeveelheid. Tot dusver hebben campagnes en interventies deze lage consumptie niet of onvoldoende kunnen tegengaan. Dit rapport beschrijft het resultaat van een onderzoek naar de mogelijkheden om de groente- en fruitconsumptie in Nederland te verhogen. Het doel van dit onderzoek is het verkennen van het eetgedrag van consumenten rondom groente- en fruit en het inventariseren van recente interventies en strategieën om de groente- en fruitconsumptie te verhogen (welke hebben wel gewerkt, welke niet).
Jatropha sustainability assessment: Data from Tanzania, Mali and Mozambique
Eijck, J.A.J. van; Rom Colthoff, J. ; Romijn, H.A. ; Heijnen, S. ; Ruijter, F.J. de; Jongschaap, R.E.E. - \ 2013
Utrecht : NL Agency - 101
Proces intensification in the future production of base chemicals from biomass
Sanders, J.P.M. ; Clark, J.H. ; Harmsen, G.J. ; Heeres, H.J. ; Heijnen, J.J. ; Kersten, S.R.A. ; Swaaij, W.P.M. ; Moulijn, J.A. - \ 2012
Chemical Engineering and Processing 51 (2012)1. - ISSN 0255-2701 - p. 117 - 136.
lactic-acid - amino-acids - saccharomyces-cerevisiae - bulk chemicals - levulinic acid - industrial - water - gasification - conversion - hydrolysis
Biomass is an attractive resource for the production of bulk chemicals. Process intensification (PI) is a valuable approach in developing economical processes with a minimal global footprint which will require new infrastructure to be designed and built. An attempt is presented to describe the future architecture of the bio-based chemical industry. The field is in its infancy and it is thus instructive to consider specific case studies of biomass based production routes. The first illustrates a route to mono propylene glycol, an established bulk chemical. The thermo-chemical production of hydrogen from waste biomass streams and the production of base chemicals from amino acids highlight the potential of using agricultural rest streams. Two case studies focus on the use of lignocellulosic biomass in the production of platform molecules (isosorbide and hydroxymethylfurfural) and the last case study on the novel combination of two (relatively) new technologies for a genuinely sustainable production: microwave processing and supercritical extraction technology. In all of these case studies PI aspects are present and major technological challenges are addressed. The end result is a list of research topics with objectives that are intended to contribute to a sustainable future chemical industry for the production of bio-based chemicals.
Chemicals & energy; building a sustainable bio-based economy for the Netherlands: 2020 & beyond
Wielen, L.A.M. van der; Arends, I. ; Heijnen, S. ; Sanders, J.P.M. ; Scott, E.L. - \ 2009
In: Partners in de polder; A vision for the life sciences in the Netherlands and the role of public-private partnership / Laane, Colja, Besteman, Koen, S.n. - ISBN 9789080735774 - p. 136 - 157.
onderzoek - samenwerking - innovaties - levenswetenschappen - publiek-private samenwerking - toekomst - Nederland - research - cooperation - innovations - life sciences - public-private cooperation - future - Netherlands
Partners in the Polder is a book in two parts. Part I is called Unity, and presents the field’s joint vision of the future of the life sciences in the Netherlands, and the past, present and future role of public-private partnerships. Part II, Diversity, looks at (the future of) the life sciences and PPPs from the perspectives of the sectors involved (food, health, chemicals & energy and agriculture) and the disciplines linking them (technology, education, valorization and social aspects).The two parts can be read separately, but together illustrate a field united in diversity. Each chapter in Part II can be read on its own.
|Meten aan het klimaat : observeren om te kunnen participeren
Veraart, J.A. ; Hurk, B. van den; Hutjes, R.W.A. ; Heijnen, M. - \ 2008
Geografie 17 (2008)9. - ISSN 0926-3837 - p. 6 - 7.
klimaatverandering - meteorologische waarnemingen - monitoring - climatic change - meteorological observations - monitoring
Het Nederlandse klimaatbeleid wordt steeds meer onderbouwd met resultaten uit klimaatmodellen. Het vergelijken van de uitkomsten van deze modellen met meetgegevens is belangrijk om de kans op systematische fouten in de klimaatprojecties te minimaliseren. Dit themanummer van Geografie (ondersteund door Klimaat voor ruimte) staat stil bij de rol van meetobservaties in Nederland bij het evalueren en verbeteren van klimaatmodellen
A prospective, community-based study on virologic assessment among elderly people with and without symptoms of acute respiratory infection
Graat, J.M. ; Schouten, E.G. ; Heijnen, M.L. ; Kok, F.J. ; Pallast, E.G. ; Greeff, S.C. de; Dorigo-Zetsma, J.W. - \ 2003
Journal of Clinical Epidemiology 56 (2003)12. - ISSN 0895-4356 - p. 1218 - 1223.
polymerase-chain-reaction - tract infections - mycoplasma-pneumoniae - chlamydia-pneumoniae - syncytial virus - influenza - etiology - illness - pcr
Background and Objective: Community-based elderly studies concerning microbiology of acute respiratory infections are scarce. Data on subclinical infections are even totally absent, although asymptomatic persons might act as a source of respiratory infections. Methods: In a 1-year community-based study, we prospectively investigated the possible virologic cause of acute respiratory infections in 107 symptomatic case episodes and 91 symptom-free control periods. Participants, persons greater than or equal to60 years, reported daily the presence of respiratory symptoms in a diary. Virologic assessment was performed by polymerase chain reaction (PCR) and serology. Results: In 58% of the case episodes a pathogen was demonstrated, the most common being rhinoviruses (32%), coronaviruses (17%), and influenzaviruses (7%). The odds ratio for demonstrating a virus in cases with symptoms vs. controls without symptoms was 30.0 (95% confidence interval 10.2-87.6). In 4% of the symptom-free control periods a virus was detected. Conclusion: This study supports the importance of rhinovirus infections in community-dwelling elderly persons, whereas asymptomatic elderly persons can also harbor pathogens as detected by PCR, and thus might be a source of infection for their environment. (C) 2003 Elsevier Inc. All rights reserved.
|CESAR rainfall experiment 2002 (C-Rex '02) - Experimental setup and first results
Uijlenhoet, R. ; Stricker, J.N.M. ; Heijnen, S. ; Russchenberg, H. ; Zwam, F. van der; Holleman, I. ; Hovius, W. ; Klein Baltink, H. ; Warmer, J. - \ 2003
In: 31ste American Meteorological Society Conference on Radar Meteorology [S.l.] : S.n. - p. 427 - 428.
|CESAR rainfall experiment 2002 (C-Rex'02) - Experimental setup and first results
Uijlenhoet, R. ; Heijnen, S. ; Holleman, I. ; Hovius, W. ; Klein Baltink, H. - \ 2003
|CESAR rainfall experiment 2002 (C-REX '02) - Experimental septup and first results
Uijlenhoet, R. ; Heijnen, S. ; Holleman, I. ; Hovius, W. ; Klein Baltink, H. ; Stricker, J.N.M. ; Warmer, J. ; Zwam, F. van der - \ 2003
Limited effect of consumption of uncooked (RS2) or retrograded (RS3) resistant starch on putative risk factors for colon cancer in healthy men.
Heijnen, M.L.A. ; Amelsvoort, J.M.M. van; Deurenberg, P. ; Beynen, A.C. - \ 1998
American Journal of Clinical Nutrition 67 (1998). - ISSN 0002-9165 - p. 322 - 331.
Effect of consumption of uncooked (RS2) and retrograded (RS3) resistant starch on apparent absorption of magnesium, calcium and phosphorus in pigs.
Heijnen, M.L.A. ; Beynen, A.C. - \ 1998
Zeitschrift fur ernahrungswissenschaft 37 (1998). - ISSN 0044-264X - p. 13 - 17.
|De gezinssociologie in Nederland: opkomst, bloei en neergang.
Hoog, C. de - \ 1998
In: Het heilig vuur: de kern van het universitaire bestaan / Willemen, K., Heijnen, G., Termeer, G., - p. 340 - 348.