Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

    Records 1 - 20 / 182

    • help
    • print

      Print search results

    • export

      Export search results

    Check title to add to marked list
    Disparities in cancer-related healthcare among people with intellectual disabilities:A population-based cohort study with health insurance claims data
    Cuypers, Maarten ; Tobi, Hilde ; Huijsmans, Cornelis A.A. ; Gerwen, Lieke van; Hove, Michiel ten; Weel, Chris van; Kiemeney, Lambertus A.L.M. ; Naaldenberg, Jenneken ; Leusink, Geraline L. - \ 2020
    Cancer Medicine (2020). - ISSN 2045-7634
    early detection of cancer - healthcare disparities - hospital - intellectual disability - neoplasms - oncology service

    Background: Concerns have been raised about the accessibility and quality of cancer-related care for people with intellectual disabilities (ID). However, there is limited insight into cancer incidence and the utilization of cancer care at the ID population level to inform targeted cancer control strategies. Therefore, we aimed to examine differences in the utilization of cancer-related care between people with and without ID, identified through diagnostic codes on health insurance claims. Methods: In a population-based cohort study, Dutch individuals of all ages who received residential care through the Chronic Care Act due to an ID (n = 65 183) and an age and sex-matched sample of persons without ID (1:2 ratio), who were cancer-free at enrollment in 2013 were followed through 2015. Incidence rates (IRs) of newly started cancer care and IR ratios (IRRs) with 95% CIs were used to compare groups. Separate analyses were performed per cancer type. Results: Individuals with ID received less cancer-related care than individuals without (IRR = 0.64, 95% CI 0.62-0.66). Differences increased with age and were larger for females than for males. Utilization of care for cancers within the national screening program (female breast, cervical, and colon cancer) was lower for people with ID compared to people without ID. Conclusion: Cancer may be underdiagnosed and/or undertreated in people with ID, or cancer is truly less prevalent in this population. In particular, the differences detected between males and females with ID, and the potential underutilization of national screening programs, require urgent follow-up investigations.

    Evidence on effects of plant pests on IPPC strategic objectives and monitoring and evaluation mechanisms by the SPS community : Report based on literature review and interviews with SPS organisations
    Kusters, Cecile ; Hove, Hermine ten - \ 2020
    Wageningen : Wageningen Centre for Development Innovation (Report WCDI 20-108) - ISBN 9789463954051 - 44
    This report is commissioned by the International Plant Protection Commission (IPPC) and is the result of a literature review on the effects of plant pests on the IP strategic objectives, as well as interviews and document review on the monitoring and evaluation (M&E) mechanisms of the SPS community. The review shows that there is evidence that the prevention of pests contributes to IPPC’s strategic objectives: enhancing global food security and sustainable agriculture productivity; protecting the environment; and facilitating safe trade, development, and economic growth. However, the context is very important and requires context specific interventions. In particular low-income countries struggle to reduce plant pests and need support in this to help them to also contribute to these overarching objectives. The review also shows that the different SPS organisations have different mechanisms in place for monitoring and evaluation, and these are generally not embedded in a formal monitoring and evaluation system. There is need for more attention to monitoring and evaluation in support of adaptive management of the SPS organisations, that work in often complex environments.
    Conference Report: Monitoring and Evaluation for Inclusive and Sustainable Food Systems 3-4 April 2019, the Netherlands
    Kusters, Cecile ; Hove, Hermine ten; Bosch, Diane ; Herens, Marion ; Wigboldus, Seerp - \ 2019
    Wageningen : Wageningen Centre for Development Innovation (Report / WCDI 19-066) - 43
    Exploring the views of learners and parents on the effects of school feeding : Action research in the TIDE School Milk Programme, South West Uganda
    Hove, Hermine ten; Roefs, Marlene ; Herens, Marion ; Kizito, Frederick ; Katungye, Vincent ; Mugabi, Faith ; Wasswa, Cosma ; Mugizi, Dan - \ 2019
    Wageningen : Wageningen Centre for Development Innovation (Wageningen Centre for Development Innovation report 19-078) - 35
    This report presents the results of the second phase of the action research on the SNV TIDE School Milk Programme (SMP). The study explores the views of learners and their parents on three aspects ofschool feeding that were identified in the first phase. These areas are 1) Relation between school and home feeding, 2) (Rise of) inequality among learners and 3) Sharing food in school. Focus group interviews were held with parents and learners in three schools, split into groups based on the level of participation in the programme.
    Review of the draft CDC Food & Agriculture Impact Framework : Report for the Food and Agriculture Division of the CDC Group
    Kusters, C.S.L. ; Blomne Sopov, M. ; Wattel, C.J. ; Hove, Hermine ten - \ 2019
    Wageningen : Wageningen Centre for Development Innovation (WCDI-19-071 ) - 81 p.
    A SOSEKI-based coordinate system interprets global polarity cues in Arabidopsis
    Yoshida, Saiko ; Schuren, Alja van der; Dop, Maritza van; Galen, Luc van; Saiga, Shunsuke ; Adibi, Milad ; Möller, Barbara ; Hove, Colette A. ten; Marhavy, Peter ; Smith, Richard ; Friml, Jiri ; Weijers, Dolf - \ 2019
    Nature Plants 5 (2019)2. - ISSN 2055-026X - p. 160 - 166.

    Multicellular development requires coordinated cell polarization relative to body axes, and translation to oriented cell division 1–3 . In plants, it is unknown how cell polarities are connected to organismal axes and translated to division. Here, we identify Arabidopsis SOSEKI proteins that integrate apical–basal and radial organismal axes to localize to polar cell edges. Localization does not depend on tissue context, requires cell wall integrity and is defined by a transferrable, protein-specific motif. A Domain of Unknown Function in SOSEKI proteins resembles the DIX oligomerization domain in the animal Dishevelled polarity regulator. The DIX-like domain self-interacts and is required for edge localization and for influencing division orientation, together with a second domain that defines the polar membrane domain. Our work shows that SOSEKI proteins locally interpret global polarity cues and can influence cell division orientation. Furthermore, this work reveals that, despite fundamental differences, cell polarity mechanisms in plants and animals converge on a similar protein domain.

    Creating effective case studies : a practical guide to making inclusive agribusiness experiences accessible and inspiring
    Guijt, Joost ; Reuver, Roger ; Hove, Hermine ten; Brouwer, Jan ; Sopov, Monika ; Salverda, Irene - \ 2018
    Wageningen : Wageningen Centre for Development Studies - 30
    Shining light on gold nanoparticles
    Schijven, L.M.I. ; Wang, J. ; Hove, J.B. ten; Velders, A.H. - \ 2018
    Manipulating and monitoring nanoparticles in micellar thin film superstructures
    Hove, Jan Bart ten; Leeuwen, Fijs W.B. van; Velders, Aldrik H. - \ 2018
    Nature Communications 9 (2018)1. - ISSN 2041-1723

    Understanding the dynamics of discrete self-assembled structures under influence of external triggers is of interest to harvest the potential of nano- and mesoscale materials. In particular, controlling the hierarchical organization of (macro)molecular and nanoparticle building blocks in monolayer superstructures is of paramount importance for tuning properties and characteristics. Here we show how the electron beam in cryo-transmission electron microscopy can be exploited to induce and follow local migration of building blocks and global migration of micellar aggregates inside micrometer-sized superstructures. We employ stroboscopic exposure to heat up and convert the vitrified superstructure into a liquid-like thin film under cryogenic conditions, resulting in controlled evaporation of water that finally leads to rupture of the micelle-containing superstructure. Micelle-embedded nanoparticles prove a powerful tool to study the complex hierarchically built-up superstructures, and to visualize both global movement of individual dendrimicelles and local migration of nanoparticles inside the micellar core during the exposure series.

    Size-controlled and water-soluble gold nanoparticles using UV-induced ligand exchange and phase transfer
    Hove, Jan Bart ten; Schijven, Laura M.I. ; Wang, Junyou ; Velders, Aldrik H. - \ 2018
    Chemical Communications 54 (2018)95. - ISSN 1359-7345 - p. 13355 - 13358.

    Oleylamine-capped gold nanoparticles (AuNPs) with sizes ranging from 5 to 13 nm and narrow size distributions (<10%) are synthesized by using a seeded growth approach. Water-solubility is achieved by using a UV-induced ligand exchange approach, resulting in transfer from the organic to an aqueous phase.

    Cyclodextrin-based complex coacervate core micelles with tuneable supramolecular host–guest, metal-to-ligand and charge interactions
    Facciotti, Camilla ; Saggiomo, Vittorio ; Bunschoten, Anton ; Fokkink, Remco ; Hove, Jan Bart Ten ; Wang, Junyou ; Velders, Aldrik H. - \ 2018
    Soft Matter 14 (2018)47. - ISSN 1744-683X - p. 9542 - 9549.
    Micelles have been recognized as versatile platforms for different biomedical applications, from bioimaging to drug delivery. Complex coacervate core micelles present great advantages compared to traditional micelles, however controlling the number of charges per core-unit and the stability is still a challenge. We here present cyclodextrin-based complex coacervate core micelles where the charge per core-unit can be straightforwardly tuned by cyclodextrin host–guest interactions. By varying the ratio between two adamantane guest molecules, 1-adamantanecarboxylic acid and 1,3-adamantanediacetic acid, the charge of the monomeric core-units can be finely tuned from 6− to 9−. By adding an adamantane bislinker, monomeric core-units can be combined together in dimeric and polymeric structures, increasing the micelles’ stability. The orthogonal supramolecular host–guest and coordination-chemistry allows for well-controlled cyclodextrin-based complex coacervate core micelles that offer a versatile platform for designing future, e.g., responsive systems.
    Clever and cool : generating design guidelines for climate-responsive urban green infrastructure
    Klemm, Wiebke - \ 2018
    Wageningen University. Promotor(en): A. van den Brink, co-promotor(en): S. Lenzholzer; L.W.A. van Hove. - Wageningen : Wageningen University - ISBN 9789463433051 - 289

    Urban heat problems due to global climate change and urbanization may pose a serious risk to thermal comfort related public health in cities. Urban green infrastructure (UGI), such as parks, gardens and street trees, has the ability to alleviate urban heat and improve residents’ thermal comfort during warm summer days. Research in the field of urban micrometeorology delivers insights into the impacts of UGI on objective thermal conditions. Yet, this knowledge lacks insights into impacts of UGI on people’s subjective thermo-spatial perception and does not match the demand of spatially explicit information by urban designers. Consequently, urban designers lack guidance in the design of climate-responsive UGI in outdoor urban spaces.

    The development of a spatially explicit evidence of subjective and objective impacts of UGI on thermal comfort, and based on that evidence the subsequent development of useful design guidelines for climate-responsive UGI, were the objectives of this thesis. The research approach consisted of two phases: The ‘Research for Design’ approach, a combination of qualitative (surveys, observations) and quantitative (micrometeorological measurements) research methods, delivered scientific evidence needed to inform climate-responsive urban design. A set of multiscale case studies was conducted during warm summer periods in the moderate climate of the Netherlands. In a subsequent participatory ‘Research through Designing’ approach the novel scientific evidence was translated into preliminary design guidelines, and applied in practical design settings with landscape architects. Observations, plan analysis and questionnaires provided insights into the usefulness of the guidelines for end-users and directed the refinement into revised design guidelines for climate-responsive UGI.

    ‘Clever and cool’ urban green can be achieved by implementing the design guidelines for climate-responsive UGI. Findings of the first phase demonstrate that UGI enhances residents’ subjective thermal perception and improves thermal conditions in urban environments. This phase provides spatially-explicit evidence of UGI relevant for design. It furthermore shows the importance of residents’ physical adaptation in the context of thermal perception. The second phase delivered evidence-based, generally applicable design guidelines for climate-responsive UGI that are accompanied by visual representations. Additionally operational principles to support site-specific implementation of the guidelines at the respective scales. The practical design settings furthermore showed that urban designers need a basic understanding of microclimate processes and skills to conduct microclimate analysis to appropriately implement the guidelines. Concluding, this thesis argues for climate-responsive UGI that is ‘clever and cool’: UGI that is designed resource efficiently, is based on site-specific microclimate analysis, and considers spatial conditions as well as the behavioural demands of urban dwellers. Through combining perspectives and knowledge of microclimate science and design practice this thesis provides evidence-based solutions that are considered useful by end-users. As such the design guidelines for climate-responsive UGI, as presented in this thesis, can enhance urban design practice for more thermally comfortable and liveable cities now and in the future.

    Income intervention quick scan: agro-corridors : Farmer Income Lab Intervention Quick Scan
    Hove, Hermine ten - \ 2018
    Wageningen : Wageningen Centre for Development Innovation (Report / WCDI 18-024) - 18
    This quick scan, commissioned by the Farmer Income Lab, is part of a wider research effort looking at, “What are the most effective actions that lead buyers can take to enable smallholder farmers in global supply chains to meaningfully increase their incomes?”. The quick scan provides an overview of the publicly available evidence on the impact of agro-corridors have had on raising farmer income. Such subsidies have had little positive effect on farmer income, are not notably beneficial for women nor is this effect long-term. They have been applied at large scale. This quick scan is part of a series of 16, contributing to a synthesis report “What Works to Raise Farmer’s Income: a Landscape Review"
    Income intervention quick scan: savings-led group models : Farmer Income Lab Intervention Quick Scan
    Hove, Hermine ten - \ 2018
    Wageningen : Wageningen Centre for Development Innovation (Report / WCDI 18-037) - 18
    This quick scan, commissioned by the Farmer Income Lab, is part of a wider research effort looking at, “What are the most effective actions that lead buyers can take to enable smallholder farmers in global supply chains to meaningfully increase their incomes?”. The quick scan provides an overview of the publicly available evidence on the impact of savings-led group models have had on raising farmer income. Such subsidies have had little positive effect on farmer income, are not notably beneficial for women nor is this effect long-term. They have been applied at large scale. This quick scan is part of a series of 16, contributing to a synthesis report “What Works to Raise Farmer’s Income: a Landscape Review”.
    Nanoparticles reveal Extreme Size-Sorting and Morphologies in Complex Coacervate Superstructures
    Hove, Jan Bart ten; Oosterom, Matthias N. van; Leeuwen, Fijs W.B. van; Velders, Aldrik H. - \ 2018
    Scientific Reports 8 (2018)1. - ISSN 2045-2322

    We here provide detailed insight in self-assembled complex coacervate systems exploiting gold nanoparticles for cryoTEM contrast. Nanoparticle-containing dendrimicelles are formed from fifth-generation dendrimer-encapsulated nanoparticles (DENs) and dendrimer-stabilized nanoparticles (DSNs). The complex coacervate structures self-organize in biconcave thin water layers into size-sorted monolayer superstructures. The embedded nanoparticles are a straightforward tool to visualize dendrimicelles and determine the aggregation number and polydispersity. The superstructure shows extreme size-sorting patterns which, contrary to related systems with higher generation dendrimers, consists not only of dendrimicelles but also much bigger complex coacervate nanoassemblies, such as vesicles.

    Conference report: Communicating Evidence for Sustainable Development : 4-5 April 2018, the Netherlands
    Kusters, Cecile ; Hove, Hermine ten; Brouwers, Jan ; Mostert, Riti Hermán - \ 2018
    Wageningen : Wageningen Centre for Development Innovation (Wageningen Centre for Development Innovation report WCDI-18-012) - 36
    This report presents the key highlights and contributions from the conference ‘Communicating Evidence for Sustainable Development’. This conference was held on 4-5 April 2018 in Wageningen, the Netherlands and was the eleventh annual ‘M&E on the Cutting Edge’ conference. This event was organised by Wageningen Centre for Development Innovation (WCDI). This conference aimed to seek clarity in the role that communication can play in generating and using evidence for sustainable development
    Onderzoekers helpen bij tellen van vissen in het Noordzeekanaal
    Leuverink, Cecile - \ 2018
    Mesoscale organization of nanoparticle assemblies: looking into superstructures and aggregates
    Hove, Jan Bart ten - \ 2018
    Wageningen University. Promotor(en): A.H. Velders, co-promotor(en): F.W.B. van Leeuwen. - Wageningen : Wageningen University - ISBN 9789463438391 - 181

    For this thesis, the goal was to investigate:

    1) the self-assembly of amine-terminated dendrimers into well-defined dendrimicelles

    2) the use of the micelle embedded nanoparticles as ‘spy’ particles

    3) the effect of a templating matrix on the self-organization of these dendrimicelles into mesoscale superstructures.

    Throughout the thesis, it is shown that well-defined, 50 nm-sized dendrimicelles can be obtained from PAMAM dendrimer generations five through nine. By combining cryoTEM and light scattering experiments, the self-assembly behavior of the dendrimicelles is studied in unique detail. The dendrimicelle-embedded nanoparticles serve a dualistic purpose; not only do they provide additional contrast in the cryoTEM micrographs, they also allow for the direct determination of the micelle aggregation numbers by simply counting the number of nanoparticles.

    Combining food-based dietary recommendations using Optifood with zinc-fortified water potentially improves nutrient adequacy among 4- to 6-year-old children in Kisumu West district, Kenya
    Kujinga, Prosper ; Borgonjen-van den Berg, Karin J. ; Superchi, Cecilia ; Hove, Hermine J. ten; Onyango, Elizabeth Opiyo ; Andang'o, Pauline ; Galetti, Valeria ; Zimmerman, Michael B. ; Moretti, Diego ; Brouwer, Inge D. - \ 2018
    Maternal and Child Nutrition 14 (2018)2. - ISSN 1740-8695
    children - diets - Optifood - water - zinc
    Children in developing countries often face multiple micronutrient deficiencies. Introduction of zinc-fortified water can increase zinc intake, but additional recommendations are required to address overall diet nutrient adequacy. We developed and tested food-based recommendations (FBRs) that included zinc-fortified water for children aged between 4 and 6 years from rural Kenya to achieve the best possible nutrient adequacy. Dietary intakes of 60 children aged 4–6 years, from Kisumu West district, Kenya, were assessed using a quantitative multipass 24-hr recall. Linear programming model parameters were derived, including a list of foods consumed, median serving sizes, and distribution of frequency of consumption. By using the Optifood linear programming tool, we developed FBRs for diets including zinc-fortified water. FBRs with nutrient levels achieving ≥70% recommended nutrient intake (RNI) of the World Health Organization/Food and Agriculture Organization of the United Nations RNI for most of the 12 considered nutrients were selected as the final recommendations for the children. With no FBRs and no zinc-fortified water, percent RNI coverage range was between 40% and 76% for zinc, improving to 66–101% after introduction of zinc-fortified water. The final set of FBRs achieved nutrient adequacy for all nutrients except for vitamin A (25% RNI) and folate (68% RNI). Introduction of zinc-fortified water combined with FBRs will likely improve the nutrient adequacy of diets consumed by children in Kenya but needs to be complemented with alternative interventions to ensure dietary adequacy.
    Linking slow dynamics and microscopic connectivity in dense suspensions of charged colloids
    Higler, Ruben ; Krausser, Johannes ; Gucht, Jasper Van Der; Zaccone, Alessio ; Sprakel, Joris - \ 2018
    Soft Matter 14 (2018)5. - ISSN 1744-683X - p. 780 - 788.
    The quest to unravel the nature of the glass transition, where the viscosity of a liquid increases by many orders of magnitude, while its static structure remains largely unaffected, remains unresolved. While various structural and dynamical precursors to vitrification have been identified, a predictive and quantitative description of how subtle changes at the microscopic scale give rise to the steep growth in macroscopic viscosity is missing. It was recently proposed that the presence of long-lived bonded structures within the liquid may provide the long-sought connection between local structure and global dynamics. Here we directly observe and quantify the connectivity dynamics in liquids of charged colloids en route to vitrification using three-dimensional confocal microscopy. We determine the dynamic structure from the real-space van Hove correlation function and from the particle trajectories, providing upper and lower bounds on connectivity dynamics. Based on these data, we extend Dyre's model for the glass transition to account for particle-level structural dynamics; this results in a microscopic expression for the slowing down of relaxations in the liquid that is in quantitative agreement with our experiments. These results indicate how vitrification may be understood as a dynamical connectivity transition with features that are strongly reminiscent of rigidity percolation scenarios.
    Check title to add to marked list
    << previous | next >>

    Show 20 50 100 records per page

     
    Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.