Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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Natural variation in toxicity of wheat: potential for selection of nontoxic varieties for celiac disease patients
Spaenij-Dekking, L. ; Kooy-Winkelaar, Y. ; Veelen, P. van; Drijfhout, J.W. ; Jonker, H.H. ; Soest, L.J.M. van; Smulders, M.J.M. ; Bosch, H.J. ; Gilissen, L.J.W.J. ; Koning, F. de - \ 2005
Gastroenterology 129 (2005)3. - ISSN 0016-5085 - p. 797 - 806.
t-cell recognition - tissue transglutaminase - prolyl endopeptidase - gliadin peptides - interferon-gamma - cereal toxicity - alpha-gliadin - in-vivo - gluten - epitopes
Background & Aims: Celiac disease (CD) is an intestinal disorder caused by T-cell responses to peptides derived from the gluten proteins present in wheat. Such peptides have been found both in the gliadin and glutenin proteins in gluten. The only cure for CD is a lifelong gluten-free diet. It is unknown, however, if all wheat varieties are equally harmful for patients. We investigated whether wheat varieties exist with a natural low number of T-cell¿stimulatory epitopes. Methods: Gluten proteins present in public databases were analyzed for the presence of T-cell¿stimulatory sequences. In addition, wheat accessions from diploid (AA, SS/BB, and DD genomes), tetraploid (AABB), and hexaploid (AABBDD) Triticum species were tested for the presence of T-cell¿stimulatory epitopes in gliadins and glutenins by both T-cell and monoclonal antibody¿based assays. Results: The database analysis readily identified gluten proteins that lack 1 or more of the known T-cell¿stimulatory sequences. Moreover, both the T-cell¿ and antibody-based assays showed that a large variation exists in the amount of T-cell¿stimulatory peptides present in the wheat accessions. Conclusions: Sufficient genetic variation is present to endeavor the selection of wheat accessions that contain low amounts of T-cell¿stimulatory sequences. Such materials may be used to select and breed wheat varieties suitable for consumption by CD patients, contributing to a well-balanced diet and an increase in their quality of life. Such varieties also may be useful for disease prevention in individuals at risk.
The effect of PEGT/PBT scaffold architecture on oxygen gradients in tissue engineered cartilaginous constructs
Malda, J. ; Woodfield, T.B.F. ; Vloodt, F. van der; Kooy, F.K. ; Martens, D.E. ; Tramper, J. ; Blitterswijk, C.A. van; Riesle, J. - \ 2004
Biomaterials 25 (2004)26. - ISSN 0142-9612 - p. 5773 - 5780.
solid-state fermentation - articular-cartilage - polyactive(r) - hypoxia - system - model - cells - bone - biocompatibility - chondrocytes
Repair of articular cartilage defects using tissue engineered constructs composed of a scaffold and cultured autologous cells holds promise for future treatments. However, nutrient limitation (e.g. oxygen) has been suggested as a cause of the onset of chondrogenesis solely within the peripheral boundaries of larger constructs. In the present study, oxygen gradients were evaluated by microelectrode measurements in two porous polyethylene glycol terephthalate/polybutylene terephthalate (PEGT/PBT) scaffold architectures, a compression-molded and particle-leached sponge (CM) and a 3D-deposited fiber (3DF) scaffold. During the first 14 days in vitro, gradients intensified, after which a gradual decrease of the gradients was observed in vitro. In vivo, however, gradients changed instantly and became less pronounced. Although similar gradients were observed regardless of scaffold type, significantly more cells were present in the center of 3DF constructs after 2 weeks of in vivo culture. Our results stress the importance of a rationally designed scaffold for tissue-engineering applications. Organized structures, such as the 3DF PEGT/PBT polymer scaffolds, offer possibilities for regulation of nutrient supply and, therefore, hold promise for clinical approaches for cartilage repair. (C) 2004 Elsevier Ltd. All rights reserved.
Oxygen gradients in tissue-engineered PEGT/PBT cartilaginous constructs: measurement and modeling
Malda, J. ; Rouwkema, J. ; Martens, D.E. ; Paul le Comte, E. ; Kooy, F.K. ; Tramper, J. ; Blitterswijk, C.A. van; Riesle, J. - \ 2004
Biotechnology and Bioengineering 86 (2004)1. - ISSN 0006-3592 - p. 9 - 18.
articular-cartilage - in-vitro - synovial fluids - tension - chondrocytes - metabolism - microelectrode - diffusion - pressure - computer
The supply of oxygen within three-dimensional tissue-engineered (TE) cartilage polymer constructs is mainly by diffusion. Oxygen consumption by cells results in gradients in the oxygen concentration. The aims of this study were, firstly, to identify the gradients within TE: cartilage polymer constructs and, secondly, to predict the profiles during in vitro culture. A glass microelectrode system was adapted and used to penetrate cartilage and TE cartilaginous constructs, yielding reproducible measurements with high spatial resolution. Cartilage polymer constructs were cultured for up to 41 days in vitro. Oxygen concentrations, as low as 2 - 5%, were measured within the center of these constructs. At the beginning of in vitro culture, the oxygen gradients were steeper in TE constructs in comparison to native tissue. Nevertheless, during the course of culture, oxygen concentrations approached the values measured in native tissue. A mathematical model was developed which yields oxygen profiles within cartilage explants and TE constructs. Model input parameters were assessed, including the diffusion coefficient of cartilage (2.2 x 10(-9)) + (0.4 x 10(-9) m(2) s(-1)), 70% of the diffusion coefficient of water and the diffusion coefficient of constructs (3.8 x 10(-10) m(2) s(-1)). The model confirmed that chondrocytes in polymer constructs cultured for 27 days have low oxygen requirements (0.8 x 10(-19) mol m(-3) s(-1)), even lower than chondrocytes in native cartilage. The ability to measure and predict local oxygen tensions offers new opportunities to obtain more insight in the relation between oxygen tension and chondrogenesis. (C) 2004 Wiley Periodicals, Inc.
Vraag het de bomen; creativiteit in bosbeheer
Dijs, F. ; Ansembourg, F. d'; Claessens, B. ; Fennema, A. ; Groot Bruinderink, G.W.T.A. ; Heybroek, H. ; Hommel, P.W.F.M. ; Hussendörfer, E. ; Klein, J. de; Koopmans, G. ; Kooy, F. van der; Olsthoorn, A.F.M. ; Ouden, J. den; Schanz, H. ; Spek, T. ; Swart, B. ; Waal, R.W. de; Wijk, M.N. van - \ 2003
Utrecht : Matrijs - ISBN 9053452346 - 120
bosbedrijfsvoering - bosbeleid - landgoederen - particuliere bosbouw - particulier eigendom - houtteelt - nederland - dauerwald - forest management - forest policy - estates - private forestry - private ownership - silviculture - netherlands
De geschiedenis van het bosbeheer van landgoed Middachten, ten tijde van Graaf zu Ortenburg (1927-2001)
Effects of endotoxin-contaminated FSH-preparations in heifers.
Kooy, E. van der; Kindahl, H. ; Gustafsson, H. - \ 1995
Acta Veterinaria Scandinavica 35 (1995). - ISSN 0044-605X - p. 449 - 451.
Changes in body composition and in fat distribution in response to weight loss and weight gain.
Kooy, K. van der; Leenen, R. ; Deurenberg, P. ; Seidell, J.C. ; Hautvast, J.G.A.J. - \ 1994
In: Obesity in Europe 93 / Ditschuneit, H., London : John Libbey - p. 301 - 308.
Visceral fat and weight loss in obese subjects.
Leenen, R. ; Kooy, K. van der; Seidell, J.C. ; Deurenberg, P. ; Hautvast, J.G.A.J. - \ 1994
In: Obesity in Europe 93 / Ditschuneit, H., London : John Libbey - p. 309 - 317.
Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy.
Leenen, R. ; Kooy, K. van der; Seidell, J.C. ; Deurenberg, P. ; Koppeschaar, H.P.F. - \ 1994
Journal of Clinical Endocrinology and Metabolism 78 (1994). - ISSN 0021-972X - p. 1515 - 1520.
Molmuis ondergraaft vegetatie-ontwikkeling.
Kooy, J. van der; Maanen, B. van - \ 1994
Zoogdier 5 (1994)2. - ISSN 0925-1006 - p. 3 - 7.
dieren - begrazing - herbivoren - muizen - muridae - plantensuccessie - ratten - verstoring - limburg - animals - grazing - herbivores - mice - plant succession - rats - disturbance
Veranderingen in serumlipiden bij vermageren. Vergelijking van effecten van verlaging (verzadigde) vetconsumptie en energiebeperking.
Leenen, R. ; Kooy, K. van der; Meyboom, S. ; Seidell, J.C. ; Deurenberg, P. ; Weststrate, J.A. - \ 1993
Voeding 54 (1993). - ISSN 0042-7926 - p. 20 - 20.
Abdominal diameters as indicators of visceral fat: comparison between magnetic resonance imaging and anthropometry
Kooy, K. van der; Leenen, R. ; Seidell, J.C. ; Deurenberg, P. ; Visser, M. - \ 1993
The British journal of nutrition 70 (1993)1. - ISSN 0007-1145 - p. 47 - 58.
Waist-hip ratio is a poor predictor of changes in visceral fat.
Kooy, K. van der; Leenen, R. ; Seidell, J.C. ; Deurenberg, P. ; Droop, A. ; Bakker, C.J.G. - \ 1993
American Journal of Clinical Nutrition 57 (1993). - ISSN 0002-9165 - p. 327 - 333.
Visceral fat loss measured by magnetic resonance imaging in relation to changes in serum lipids of obese men and women.
Leenen, R. ; Kooy, K. van der; Droop, A. ; Seidell, J.C. ; Deurenberg, P. ; Weststrate, J.A. ; Hautvast, J.G.A.J. - \ 1993
Arteriosclerosis and Thrombosis 13 (1993). - ISSN 1049-8834 - p. 487 - 494.
Visceral fat accumulation in relation to sex hormones in obese men and women undergoing weight loss therapy.
Leenen, R. ; Kooy, K. van der; Seidell, J.C. ; Deurenberg, P. ; Koppeschaar, H.P.F. - \ 1993
International Journal of Obesity 17 (1993)suppl. 2. - ISSN 0307-0565 - p. 57 - 57.
Techniques for the measurement of visceral fat a practical guide.
Kooy, K. van der; Seidell, J.C. - \ 1993
International Journal of Obesity 17 (1993). - ISSN 0307-0565 - p. 187 - 196.
Resting metabolic rate and body composition in obese subjects losing and regaining weight.
Kooy, K. van der; Leenen, R. ; Deurenberg, P. ; Seidell, J.C. ; Meyboom, S. ; Schouten, F.J.M. - \ 1993
International Journal of Obesity 17 (1993)suppl. 2. - ISSN 0307-0565 - p. 28 - 28.
Relative effects of weight loss and dietary fat modification on serum lipid levels in the dietary treatment of obesity.
Leenen, R. ; Kooy, K. van der; Meyboom, S. ; Seidell, J.C. ; Deurenberg, P. ; Weststrate, J.A. - \ 1993
International Journal of Obesity 17 (1993)suppl. 2. - ISSN 0307-0565 - p. 49 - 49.
Relative effects of weight loss and dietary fat modification on serum lipid levels in dietary treatment of obesity.
Leenen, R. ; Kooy, K. van der; Meyboom, S. ; Seidell, J.C. ; Deurenberg, P. ; Weststrate, J.A. - \ 1993
Journal of Lipid Research 34 (1993). - ISSN 0022-2275 - p. 2183 - 2191.
Effect of weight cycle on visceral fat deposition.
Kooy, K. van der; Leenen, R. ; Seidell, J.C. ; Deurenberg, P. ; Hautvast, J.G.A.J. - \ 1993
International Journal of Obesity 17 (1993)suppl. 2. - ISSN 0307-0565 - p. 60 - 60.
Effect of a weight cycle on visceral fat accumulation.
Kooy, K. van der; Leenen, R. ; Seidell, J.C. ; Deurenberg, P. ; Hautvast, J.G.A.J. - \ 1993
American Journal of Clinical Nutrition 58 (1993). - ISSN 0002-9165 - p. 853 - 857.
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