Staff Publications

Staff Publications

  • external user (warningwarning)
  • Log in as
  • language uk
  • About

    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

    We have a manual that explains all the features 

    Records 1 - 20 / 32

    • help
    • print

      Print search results

    • export

      Export search results

    Check title to add to marked list
    Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin : Letter to the editor
    Zeeuwen, Patrick L.J.M. ; Ederveen, Thomas H.A. ; Krieken, Danique A. van der; Niehues, Hanna ; Boekhorst, Jos ; Kezic, Sanja ; Hanssen, Daniëlle A.T. ; Otero, Marisol E. ; Hanssen, Daniëlle A.T. ; Rodijk-Olthuis, Diana ; Falcone, Denise ; Bogaard, Ellen H.J. van den; Kamsteeg, Marijke ; Koning, Heleen D. de; Zeeuwen-Franssen, Manon E.J. ; Steensel, Maurice A.M. van; Kleerebezem, Michiel ; Timmerman, Harro M. ; Hijum, Sacha A.F.T. van; Schalkwijk, Joost - \ 2017
    Journal of Allergy and Clinical Immunology 139 (2017)4. - ISSN 0091-6749 - p. 1368 - 1371.
    Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro
    Schmeits, P.C.J. ; Shao, J. ; Krieken, D.A. van der; Volger, O.L. ; Loveren, H. van; Peijnenburg, A.A.C.M. ; Hendriksen, P.J.M. - \ 2015
    Journal of Applied Toxicology 35 (2015)7. - ISSN 0260-437X - p. 831 - 841.
    polycyclic aromatic-hydrocarbons - brominated flame retardants - tetrabromobisphenol-a - balb/c mice - vitamin-c - chlorpyrifos - activation - exposure - rats - kinase
    Previously, we identified 25 classifier genes that were able to assess immunotoxicity using human Jurkat T cells. The present study aimed to validate these classifiers. For that purpose, Jurkat cells were exposed for 6¿h to subcytotoxic doses of nine immunotoxicants, five non-immunotoxicants and four compounds for which human immunotoxicity has not yet been fully established. RNA was isolated and subjected to Fluidigm quantitative real time (qRT)–PCR analysis. The sensitivity, specificity and accuracy of the screening assay as based on the nine immunotoxicants and five non-immunotoxicants used in this study were 100%, 80% and 93%, respectively, which is better than the performance in our previous study. Only one compound was classified as false positive (benzo-e-pyrene). Of the four potential (non-)immunotoxicants, chlorantraniliprole and Hidrasec were classified immunotoxic and Sunset yellow and imidacloprid as non-immunotoxic. ToxPi analysis of the PCR data provided insight in the molecular pathways that were affected by the compounds. The immunotoxicants 2,3-dichloro-propanol and cypermethrin, although structurally different, affected protein metabolism and cholesterol biosynthesis and transport. In addition, four compounds, i.e.¿chlorpyrifos, aldicarb, benzo-e-pyrene and anti-CD3, affected genes in cholesterol metabolism and transport, protein metabolism and transcription regulation. qRT–PCR on eight additional genes coding for similar processes as defined in ToxPi analyzes, supported these results. In conclusion, the 25 immunotoxic classifiers performed very well in a screening with new non-immunotoxic and immunotoxic compounds. Therefore, the Jurkat screening assay has great promise to be applied within a tiered approach for animal free testing of human immunotoxicity.
    Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans
    Timmers, Silvie ; Konings, Ellen ; Bilet, Lena ; Houtkooper, Riekelt H. ; Weijer, Tineke van de; Hoeks, Joris ; Krieken, Sophie van der; Ryu, Dongryeol ; Kersten, Sander ; Moonen-Kornips, Esther ; Goossens, Gijs H. ; Hesselink, Matthijs K. ; Kunz, Iris ; Schrauwen-Hinderling, Vera B. ; Blaak, Ellen E. ; Auwerx, Johan ; Schrauwen, Patrick - \ 2011
    Wageningen University
    Homo sapiens - GSE32357 - PRJNA14724 - Homo sapiens - GSE32357
    Resveratrol is a naturally occurring compound that profoundly affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here we treated 10 healthy, obese men with placebo and 150 mg/day resveratrol in a randomized double-blind cross-over study for 30 days. Resveratrol supplementation significantly reduced sleeping- and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1alpha protein levels, increased citrate synthase activity, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels, and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces profound metabolic changes in obese subjects, mimicking the effects of calorie restriction.
    Calorie Restriction-like Effects of 30 Days of Resveratrol Supplementation on Energy Metabolism and Metabolic Profile in Obese Humans
    Timmers, S. ; Konings, E. ; Bilet, L. ; Houtkooper, R.H. ; Weijer, T. van de; Goossens, G.H. ; Hoeks, J. ; Krieken, S. van der; Ryu, D. ; Kersten, A.H. ; Moonen-Kornips, E. ; Hesselink, M.K.C. ; Kunz, I. ; Schrauwen-Hinderling, V.B. ; Blaak, E.E. ; Auwerx, J. ; Schrauwen, P. - \ 2011
    Cell Metabolism 14 (2011)5. - ISSN 1550-4131 - p. 612 - 622.
    beta-cell function - life-span - insulin sensitivity - mitochondrial-function - skeletal-muscle - saccharomyces-cerevisiae - sirt1 activation - lipid-metabolism - fat oxidation - exercise
    Resveratrol is a natural compound that affects energy metabolism and mitochondrial function and serves as a calorie restriction mimetic, at least in animal models of obesity. Here, we treated 11 healthy, obese men with placebo and 150 mg/day resveratrol (resVida) in a randomized double-blind crossover study for 30 days. Resveratrol significantly reduced sleeping and resting metabolic rate. In muscle, resveratrol activated AMPK, increased SIRT1 and PGC-1 alpha protein levels, increased citrate synthase activity without change in mitochondrial content, and improved muscle mitochondrial respiration on a fatty acid-derived substrate. Furthermore, resveratrol elevated intramyocellular lipid levels and decreased intrahepatic lipid content, circulating glucose, triglycerides, alanine-aminotransferase, and inflammation markers. Systolic blood pressure dropped and HOMA index improved after resveratrol. In the postprandial state, adipose tissue lipolysis and plasma fatty acid and glycerol decreased. In conclusion, we demonstrate that 30 days of resveratrol supplementation induces metabolic changes in obese humans, mimicking the effects of calorie restriction.
    Verbetering acclimatisatie geënt uitgangsmateriaal : inventarisatie van stress bij enten van glasgroenten met MIPS en vermindering uitval tijdens acclimatisatie door Graft Promotors
    Snel, J. ; Stevens, L.H. ; Schoor, R. van der; Davelaar, E. ; Dijkhuis, P. ; Jalink, H. ; Krieken, W.M. van der - \ 2010
    Wageningen : Plant Research International (Rapport / Plant Research International 363) - 22
    tuinbouw - glastuinbouw - glasgroenten - acclimatisatie - conditionering - enten - uitselecteren - stresstolerantie - het enten (grafting) - toegepast onderzoek - horticulture - greenhouse horticulture - greenhouse vegetables - acclimatization - conditioning - scions - culling - stress tolerance - grafting - applied research
    In dit project zullen met MIPS nieuwe procedures ontwikkeld worden voor het conditioneren en acclimatiseren van enten van groentengewassen. Met MIPS kunnen de effecten van conditionering en acclimatisering op groei, stress en stressgevoeligheid van de enten in de kas nauwkeurig en snel gemeten worden. Op deze wijze wordt een flink aantal conditionering/acclimatisering combinaties in relatief korte tijd geanalyseerd. Uiteindelijk zal uit deze combinaties een aantal geselecteerd worden voor evaluatie en validatie onder praktijkcondities.
    Lignosulfonate compositions for control of plant pathogens
    Krieken, W.M. van der; Kok, C.J. ; Stevens, L.H. ; Davelaar, E. - \ 2010
    Octrooinummer: US20100068299, gepubliceerd: 2010-03-18.
    The present invention relates to a composition comprising a soluble combination comprising lignosulfonate, a metal salt, and a phosphorus compound selected from the group consisting of phosphorus acid and spontaneously soluble salts thereof, and mixtures thereof. The present invention also relates to the use of such compositions as pesticide
    Verbetering bedrijfszekerjeid van productie van geënt uitgangsmateriaal
    Stevens, L.H. ; Krieken, W.M. van der - \ 2009
    Wageningen : Plant Research International - 26
    het enten (grafting) - uitselecteren - productie - plantenvermeerdering - tuinbouw - grafting - culling - production - propagation - horticulture
    Verslag van een onderzoek naar de mogelijkheden om het risico bij uitval bij enten te verminderen door voorbehandling van de onderstam met een duurzaam product (Certigraft) dat eerder bij komkommer en tomaat onder praktijkcondities tot significant minder uitval leidde.
    Compositions for the control of plant pathogens and for use as plant fertilizer
    Krieken, W.M. van der; Kok, C.J. ; Davelaar, E. ; Stevens, L.H. - \ 2009
    Octrooinummer: WO2009082206, gepubliceerd: 2009-07-02.
    The present invention relates to a composition comprising a metal compound, a lignosulfonate and phosphorous acid and/or a salt and/or a hydrate and/or an ester thereof and its use as fungicide, bactericide or fertilizer and its use in preventing the formation of a metal phosphite precipitate in an aqueous composition. The composition is preferably an aqueous composition comprising 0.1 wt.% to 40 wt.% of dry matter, calculated on the total weight of the aqueous composition. The present invention also relatesto a process for preparing the aqueous composition.
    Compositions comprising lignosulfonates for improving crop yields and quality
    Stevens, L.H. ; Kok, C.J. ; Krieken, W.M. van der - \ 2009
    Octrooinummer: WO2004066730, gepubliceerd: 2009-12-17.
    The invention relates to a composition for protecting an agricultural crop against external threats, such as weeds, pathogens, abiotic and biotic stresses and/or for improving the quality of the products produced by the crop, which composition comprises one or more poly-phenols and one or more other active ingredients. The other active ingredients may be small particles of organic material, in particular of fibrous organic material, compounds that induce stress tolerance, compounds that stimulate wound repair and growth, natural crop protection compounds, or cellulose containing materials.
    Treatment of banana and potato plants with a new antifungal composition
    Stark, J. ; Rijn, F.T.J. van; Krieken, W.M. van der; Stevens, L.H. - \ 2009
    Octrooinummer: WO2009077613, gepubliceerd: 2009-06-25.
    The present invention relates to the treatment of banana and potato plants with a composition containing natamycin and at least one phosphite containing compound.
    A new antifungal composition
    Stark, J. ; Rijn, F.T.J. van; Krieken, W.M. van der; Stevens, L.H. - \ 2008
    Octrooinummer: WO2008009657, gepubliceerd: 2008-01-24.
    The present invention relates to a process for the treatment of an agricultural product which comprises the addition of a composition which comprises phosphite and natamycin to the agricultural product wherein the composition comprises preferably less than 0.1 g lignosulphonate, more preferably less than 0.1 g polyphenol, per gram natamycin and is still more preferably free of lignosulphonate and most preferably free of polyphenol.
    Selectie Low Risk Profile componenten voor nieuwe middelen tegen aardappelziekte
    Stevens, L.H. ; Krieken, W.M. van der; Schepers, H.T.A.M. ; Spits, H.G. - \ 2007
    aardappelen - phytophthora infestans - doseringseffecten - fungiciden - plagenbestrijding - bestrijdingsprogramma's - milieubeheersing - alternatieve methoden - ecotoxicologie - potatoes - phytophthora infestans - dosage effects - fungicides - pest control - control programmes - environmental control - alternative methods - ecotoxicology
    Met als doel een beduidende vermindering van de milieubelasting, werkt WUR aan de ontwikkeling van fungiciden gebaseerd op combinaties van stoffen met een gunstig ecotoxicologisch profiel (low risk profile, LRP). De alternatieve middelen moeten qua prijs en effectiviteit kunnen concurreren met gangbare middelen
    Duurzame bestrijding van valse meeldauw in ui
    Stoopen, G.M. ; Stevens, L.H. ; Davelaar, E. ; Krieken, W.M. van der; Schepers, H.T.A.M. ; Meier, R. ; Baar, J. ; Olijnsma, T.W. - \ 2006
    uien - allium - peronospora farinosa - ziektebestrijding - duurzaamheid (sustainability) - fungiciden - gewasbescherming - onions - allium - peronospora farinosa - disease control - sustainability - fungicides - plant protection
    Onderzoek naar de ontwikkeling van een duurzaam fungicide voor de bestrijding van valse meeldauw in ui
    Verhoging van de intrinsieke plantweerstand met behulp van bodembacteriën
    Stevens, L.H. ; Goossen-van de Geijn, H.M. ; Köhl, J. ; Stoopen, G.M. ; Krieken, W.M. van der - \ 2005
    bodembacteriën - verdedigingsmechanismen - ziekteresistentie - azospirillum brasilense - bacillus subtilis - plantenontwikkeling - soil bacteria - defence mechanisms - disease resistance - azospirillum brasilense - bacillus subtilis - plant development
    Diverse bodembacteriën kunnen de plantenontwikkeling bevorderen en de plant weerbaarder maken tegen suboptimale condities. Onderzocht werden hoe preparaten van azospirillum brasilense en bacillus subtilis gebruikt kunnen worden tegen abiotische en biotische stress
    Verhoging van de intrinsieke plantweerstand met behulp van bodembacteriën
    Stevens, L.H. ; Goossen-van de Geijn, H.M. ; Köhl, J. ; Stoopen, G.M. ; Krieken, W.M. van der - \ 2005
    In: Supplement Gewasbeschermingsmanifestatie 27 april 2005. - - p. 57S - 57S.
    Mogelijkheden productie uitgangsmateriaal voor biologische en duurzame teelt
    Zuilichem, J.A.A. van; Vreeburg, P.J.M. ; Jansma, J.E. ; Krieken, W.M. van der; Wolf, J.M. van der - \ 2004
    Lisse : PPO Bloembollen - 47 p.
    Use of lignosulphonate for plant protection
    Krieken, W.M. van der; Veen, B.W. ; Kok, C.J. - \ 2001
    Octrooinummer: WO0135747, gepubliceerd: 2001-05-25.
    The present invention relates to the use of lignosulphonates in the protection of plants. The lignosulphonates have a variety of applications, such as forming a top layer on the soil in which plants are growing to inhibit emergence of weeds or reduce evaporation of water from the soil. Lignosulphonates also find application in the induction of plant defense and in the control of plant pathogenic nematodes.
    Regulation and exploitation of gentically modified crops
    Kleter, G.A. ; Krieken, W.M. van der; Kok, E.J. ; Bosch, D. ; Jordi, W. ; Gilissen, L.J.W.J. - \ 2001
    Nature Biotechnology 19 (2001)12. - ISSN 1087-0156 - p. 1105 - 1110.
    Contained production of genetically modified health-beneficial crop foods: an option to be considered
    Kleter, G.A. ; Krieken, W.M. van der; Kok, E.J. ; Bosch, H.J. ; Jordi, W. ; Gilissen, L.J.W.J. - \ 2001
    Innovations in Food Technology 13 (2001). - ISSN 1465-0460 - p. 29 - 30.
    Anjer langer houdbaar met SR-AOA
    Krieken, W.M. van der - \ 1999
    Vakblad voor de Bloemisterij 29 (1999). - ISSN 0042-2223 - p. 46 - 47.
    Check title to add to marked list
    << previous | next >>

    Show 20 50 100 records per page

     
    Please log in to use this service. Login as Wageningen University & Research user or guest user in upper right hand corner of this page.