Staff Publications

Staff Publications

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    'Staff publications' is the digital repository of Wageningen University & Research

    'Staff publications' contains references to publications authored by Wageningen University staff from 1976 onward.

    Publications authored by the staff of the Research Institutes are available from 1995 onwards.

    Full text documents are added when available. The database is updated daily and currently holds about 240,000 items, of which 72,000 in open access.

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    The One that I Want: Strong personal preferences render the center-stage nudge redundant
    Venema, Tina A.G. ; Kroese, Floor M. ; Vet, E. De; Ridder, Denise T.D. De - \ 2019
    Food Quality and Preference 78 (2019). - ISSN 0950-3293
    Center-stage effect - Effectiveness - Healthy diet goals - Nudge - Preference - Soft drinks

    In recent years there has been increased attention for nudging as a tool to alter consumer decisions. While nudges should in theory preserve freedom of choice by respecting consumers’ preferences, empirical scrutiny of this claim is sparse. This research investigates the effectiveness of a center-stage nudge to encourage the consumption of a small portion size of soda. Specifically, in all studies we measure the extent to which strong preferences that are incongruent with the aim of the nudge (i.e. thirst and liking) and nudge congruent preferences (i.e. intentions to reduce soda consumption (study 1); Healthy diet goals (observed in study 2; manipulated in study 3) could be expressed when a choice is nudged. In three studies (n = 119; n = 184; n = 202) it was found that strong preferences are not trumped by the nudge and in fact overrule the effectiveness of a center-stage nudge. These findings contribute to the debate about the ethical considerations that are voiced concerning nudge interventions, and urge choice architects to consider consumers’ prior preferences as an important boundary condition of effective nudge interventions.

    Brucella pinnipedialis in grey seals (Halichoerus grypus) and harbor seals (Phoca vitulina) in the Netherlands
    Kroese, Michiel V. ; Beckers, Lisa ; Bisselink, Yvette J.W.M. ; Brasseur, Sophie ; Tulden, Peter W. van; Koene, Miriam G.J. ; Roest, Hendrik I.J. ; Ruuls, Robin C. ; Backer, Jantien A. ; Ijzer, Jooske ; Giessen, Joke W.B. van der; Willemsen, Peter T.J. - \ 2018
    Journal of Wildlife Diseases 54 (2018)3. - ISSN 0090-3558 - p. 439 - 449.
    Brucella pinnipedialis - Halichoerus grypus - MALDI-TOF MS - Marine mammals - MLST - MLVA-16 - Phoca vitulina - The Netherlands

    Brucellosis is a zoonotic disease with terrestrial or marine wildlife animals as potential reservoirs for the disease in livestock and human populations. The primary aim of this study was to assess the presence of Brucella pinnipedialis in marine mammals living along the Dutch coast and to observe a possible correlation between the presence of B. pinnipedialis and accompanying pathology found in infected animals. The overall prevalence of Brucella spp. antibodies in sera from healthy wild grey seals (Halichoerus grypus; n=11) and harbor seals (Phoca vitulina; n=40), collected between 2007 and 2013 ranged from 25% to 43%. Additionally, tissue samples of harbor seals collected along the Dutch shores between 2009 and 2012, were tested for the presence of Brucella spp. In total, 77% (30/ 39) seals were found to be positive for Brucella by IS711 real-time PCR in one or more tissue samples, including pulmonary nematodes. Viable Brucella was cultured from 40% (12/30) real-time PCR-positive seals, and was isolated from liver, lung, pulmonary lymph node, pulmonary nematode, or spleen, but not from any PCR-negative seals. Tissue samples from lung and pulmonary lymph nodes were the main source of viable Brucella bacteria. All isolates were typed as B. pinnipedialis by multiple-locus variable number of tandem repeats analysis-16 clustering and matrix-assisted laser desorption ionization-time of flight mass spectrometry, and of sequence type ST25 by multilocus sequence typing analysis. No correlation was observed between Brucella infection and pathology. This report displays the isolation and identification of B. pinnipedialis in marine mammals in the Dutch part of the Atlantic Ocean.

    Wetenschapper in de klas volgens aanbod
    Kroese-Hoedeman, Hetty - \ 2017

    Hoe houdt een gekko zich vast aan de muur? Hoe haal je elektriciteit uit planten? Wat kunnen drones in de landbouw? Wetenschappers van Wageningen University komen het graag in de klas vertellen en doen zeker ook onderzoekjes met de kinderen.

    Consumers’ choice-blindness to ingredient information
    Cheung, T.T.L. ; Junghans, A.F. ; Dijksterhuis, G.B. ; Kroese, F. ; Johansson, P. ; Hall, L. ; Ridder, D.T.D. De - \ 2016
    Appetite 106 (2016). - ISSN 0195-6663 - p. 2 - 12.
    Attention - Choice-blindness paradigm - Clean label - Food choice - Ingredient information

    Food manufacturers and policy makers have been tailoring food product ingredient information to consumers’ self-reported preference for natural products and concerns over food additives. Yet, the influence of this ingredient information on consumers remains inconclusive. The current study aimed at examining the first step in such influence, which is consumers’ attention to ingredient information on food product packaging. Employing the choice-blindness paradigm, the current study assessed whether participants would detect a covertly made change to the naturalness of ingredient list throughout a product evaluation procedure. Results revealed that only few consumers detected the change on the ingredient lists. Detection was improved when consumers were instructed to judge the naturalness of the product as compared to evaluating the product in general. These findings challenge consumers’ self-reported use of ingredient lists as a source of information throughout product evaluations. While most consumers do not attend to ingredient information, this tendency can be slightly improved by prompting their consideration of naturalness. Future research should investigate the reasons for consumers’ inattention to ingredient information and develop more effective strategies for conveying information to consumers.

    Prediction of carcinogenic potential of chemicals using repeated-dose (13-week) toxicity data
    Woutersen, Ruud A. ; Soffers, Ans E.M.F. ; Kroese, E.D. ; Krul, Cyrille A.M. ; Laan, Jan Willem van der; Benthem, Jan van; Luijten, Mirjam - \ 2016
    Regulatory Toxicology and Pharmacology 81 (2016). - ISSN 0273-2300 - p. 242 - 249.
    Carcinogenicity - Non-genotoxic carcinogens - Predictivity - Preneoplastic lesions - Rat - Risk assessment - Sub-chronic toxicity - Tumours

    Sub-chronic toxicity studies of 163 non-genotoxic chemicals were evaluated in order to predict the tumour outcome of 24-month rat carcinogenicity studies obtained from the EFSA and ToxRef databases. Hundred eleven of the 148 chemicals that did not induce putative preneoplastic lesions in the sub-chronic study also did not induce tumours in the carcinogenicity study (True Negatives). Cellular hypertrophy appeared to be an unreliable predictor of carcinogenicity. The negative predictivity, the measure of the compounds evaluated that did not show any putative preneoplastic lesion in de sub-chronic studies and were negative in the carcinogenicity studies, was 75%, whereas the sensitivity, a measure of the sub-chronic study to predict a positive carcinogenicity outcome was only 5%. The specificity, the accuracy of the sub-chronic study to correctly identify non-carcinogens was 90%. When the chemicals which induced tumours generally considered not relevant for humans (33 out of 37 False Negatives) are classified as True Negatives, the negative predictivity amounts to 97%. Overall, the results of this retrospective study support the concept that chemicals showing no histopathological risk factors for neoplasia in a sub-chronic study in rats may be considered non-carcinogenic and do not require further testing in a carcinogenicity study.

    Supersize my brain: a cross-sectional voxel-based morphometry study on the association between self-reported dietary restraint and regional grey matter volumes
    Laan, Laura N. van der; Charbonnier, L. ; Griffioen-Roose, S. ; Kroese, F.M. ; Rijn, I. van; Smeets, P.A.M. - \ 2016
    Biological Psychology 117 (2016). - ISSN 0301-0511 - p. 108 - 116.
    Restrained eaters do not eat less than their unrestrained counterparts. Proposed underlying mechanisms are that restrained eaters are more reward sensitive and that they have worse inhibitory control. Although fMRI studies assessed these mechanisms, it is unknown how brain anatomy relates to dietary restraint. Voxel-based morphometry was performed on anatomical scans from 155 normal-weight females to investigate how regional grey matter volume correlates with restraint. A positive correlation was found in several areas, including the parahippocampal gyrus, hippocampus, striatum and the amygdala (bilaterally, p < 0.05, corrected). A negative correlation was found in several areas, including the inferior frontal gyrus, superior frontal gyrus, supplementary motor area, middle cingulate cortex and precentral gyrus (p < 0.05, corrected). That higher restraint relates to higher grey matter volume in reward-related areas and lower grey matter volume in regions involved in inhibition, provides a neuroanatomical underpinning of theories relating restraint to increased reward sensitivity and reduced inhibitory capacity.
    Nudging: een opinieverkenning onder gezondheidsprofessionals
    Vet, E.W.M.L. de; Kroese, Floor ; Schillemans, Thomas ; Ridder, Denise de - \ 2015
    Tijdschrift voor Gezondheidswetenschappen 93 (2015)8. - ISSN 1388-7491 - p. 298 - 299.
    Het zingt steeds meer rond onder beleidsmakers en gezondheidsprofessionals: Nudging, een strategie voor gedragsbeïnvloeding waarbij gebruik wordt gemaakt van de impulsieve, automatische processen die mensen gebruiken om keuzes te maken. Een ‘nudge’ kan mensen een duwtje geven in de richting van verstandige, gezonde keuzes. Hoewel deze aanpak veelbelovend lijkt, stuit nudging ook op weerstand. In dit stuk bespreken we een inventarisatie van de meningen van gezondheidsprofessionals over nudging: hoe effectief, legitiem en haalbaar vinden zij nudges voor het bevorderen van gezond gedrag? Als in algemene termen over nudging wordt gesproken is men overwegend positief; specifieke voorbeelden van nudges blijken echter meer discussie op te leveren.
    Aquatag zet door met waterbesparing
    Dalfsen, P. van; Baltissen, A.H.M.C. ; Stenfert Kroese, W. - \ 2015
    De Boomkwekerij 28 (2015)24. - ISSN 0923-2443 - p. 28 - 29.
    Save water and fertilisers with the Aqua Tag, a low-cost, contact-less soil moisture sensor
    Balendonck, J. ; Stenfert Kroese, W. ; Hilhorst, M. ; Tuzel, H. - \ 2014
    Assuring safety without animal testing concept (ASAT). Integration of human disease data with in vitro data to improve toxicology testing
    Stierum, R. ; Aarts, J.M.M.J.G. ; Boorsma, J. ; Bosgra, S. ; Caiment, F. ; Ezendam, J. ; Greuping, R. ; Hendriksen, P. ; Soeteman-Hernandez, L.G. ; Jennen, D. ; Kleinjans, J. ; Kroese, D. ; Kuper, F. ; Loveren, H. van; Monshouwer, M. ; Russel, F. ; Someren, E. van; Tsamou, M. ; Groothuis, G. - \ 2014
    Toxicology Letters 229 (2014)suppl.10. - ISSN 0378-4274 - p. S4 - S21.
    According to the Assuring Safety Without Animal Testing (ASAT) principle, risk assessment may ultimately become possible without the use of animals (Fentem et al., (2004). Altern. Lab. Anim. 32, 617–623). The ASAT concept takes human disease mechanisms as starting point and tries to define if activation of these mechanisms by chemical exposure in in vitro models can be used for toxicological risk assessment. The goal of the present research was to study if integration of public data, from human diseases and in vitro toxicology, is possible at the data level. Two human diseases, associated with chemical exposure, were included: human hepatocellular carcinoma and allergic contact dermatitis (ACD). Data were retrieved from expert knowledge and different online sources (e.g. GEO, ArrayExpress) and a Knowledge Base for storage and modelling of the data was established. Using the Knowledge Base for ACD, it was possible to discern sensitizing from non-sensitizing compounds, as defined by enrichment of clinically defined disease gene sets in in vitro genomics datasets. In addition, the strongest sensitizers most profoundly activated these gene sets. During the presentation, the Knowledge Base will be shown. In addition, the ongoing incorporation of (reverse) kinetic modelling to judge the relevance of in vitro concentrations, in relation to realistic in vivo exposure scenarios, will be illustrated. Finally, the expansion towards the development of data models for other disease areas (cholestasis) will be discussed.
    Een goedkope vochtsensor voor de boomkwekerij
    Dalfsen, P. van; Baltissen, A.H.M.C. ; Stenfert Kroese, W. - \ 2014
    De Boomkwekerij 2014 (2014)2. - ISSN 0923-2443 - p. 31 - 31.
    boomkwekerijen - houtachtige planten - boomteelt - irrigatiesystemen - sensors - instrumenten (meters) - proeven - vochtigheid - forest nurseries - woody plants - arboriculture - irrigation systems - sensors - instruments - trials - humidity
    SensorTagSolutions ontwikkelde een goedkoop meetsysteem, AquaTag, zodat meer kraanvakken kunnen worden voorzien van sensoren. Drie boomkwekers in regio Boskoop testen het systeem met hulp van PPO.
    Toxicogenomics ans Systems Toxicology Databases and Resources: Chemical Effects in Biological Systems (CEBS) and Data Integration by Applying Models in Design and Safety (DIAMONDS)
    Fostel, J. ; Someren, E. van; Pronk, T. ; Pennings, J. ; Schmeits, P. ; Shao, J. ; Kroese, D. ; Stierum, R. - \ 2014
    In: Toxicogenomics-Based cellular models, Alternatives to Animal Testing for Safety Assessment / Kleinjans, J., Maastricht : Academic Press Elsevier - ISBN 9780123978622 - p. 275 - 290.
    Save Water and Fertilisers with the AquaTag, a low-cost, contact-less Soil Moisture Sensor
    Balendonck, J. ; Stenfert Kroese, W. ; Hilhorst, M. ; Hakki Tüzel, I. - \ 2013
    Düsük Maliyetli ve Kablosuz Toprak Nem Sensörü AquaTag ile Su ve Gübre Tasarrufu
    Balendonck, J. ; Stenfert Kroese, W. ; Hilhorst, M. ; Hakki Tüzel, I. - \ 2013
    Detection of Coxiella burnetii in goat semen by PCR
    Heijne, M. ; Kroese, M.V. ; Rotterdam, B. van; Koene, M.G.J. ; Roest, H.I.J. - \ 2013
    Exploring the development of a decision support system (DSS) to prioritize engineered nanoparticles for risk assessment
    Marvin, H.J.P. ; Bouwmeester, H. ; Bakker, M. ; Kroese, E.D. ; Meent, D. van de; Bourgeois, F. ; Lokers, R.M. ; Ham, H. van der; Verhelst, L. - \ 2013
    Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology 15 (2013). - ISSN 1388-0764
    metal-oxide nanoparticles - biological-systems - protein corona - nanomaterials - identification - food - cytotoxicity - management - framework - tool
    Engineered nanoparticles (ENPs) have gained huge commercial interest because of their unique and size-related physicochemical properties. The diversity and complexity of ENPs is increasing with the introduction of next generation nanoparticles. The current approaches are not able to assess the safety of all types and applications of ENPs. Therefore, we are developing a decision support system (DSS) that helps to identify those ENPs and applications that should get priority in the risk assessment. This DSS smartly uses existing knowledge in publicly available databases. With the aid of vocabularies, knowledge rules and logic reasoning new knowledge will be derived. In this paper, the procedure for a DSS is described. Since this system is open by design, others can re-use and extend the DSS content, and newly developed DSS tools can be easily accommodated, which will make the DSS more effective over the years. Data of newly emerging studies will be used for the validation of the DSS. The results will benefit regulating authorities and scientists focussing on the development of inherently safe ENPs.
    A Wireless Passive Soil Water Content Sensor Tag
    Balendonck, J. ; Hilhorst, M. ; Stenfert Kroese, W. ; Meijer, G. - \ 2013
    In: Conference Proceedings of the 10th International Conference on Electromagnetic Wave Interaction with Water and Moist Substances - ISEMA 2013, 25-27 September 2013, Weimar, Germany. - Weimar : MFPA - p. 282 - 289.
    Allured or alarmed: Counteractive control responses to food temptations in the brain
    Smeets, P.A.M. ; Kroese, F.M. ; Evers, C. ; Ridder, D.T.D. de - \ 2013
    Behavioural Brain Research 248 (2013). - ISSN 0166-4328 - p. 41 - 45.
    self-regulatory-success - menstrual-cycle phase - primary visual-cortex - attentional control - inhibitory control - goal activation - fmri - metaanalysis - reliability - validity
    Typically, it is believed that palatable, high caloric foods signal reward and trigger indulgent responses. However, Counteractive Control Theory suggests that, to the extent that people are concerned about their weight, a confrontation with palatable foods should also trigger ‘alarm bell responses’ which promote successful self-control. Our study is the first to investigate such counteractive control processes in the brain employing functional magnetic resonance imaging (fMRI) in a sample of successful self-regulators. Indeed, besides the traditional finding that foods elicit heightened attention as witnessed by greater activation of primary visual cortex, we found that viewing palatable foods elicited brain activation in areas associated with self-regulation. Crucially, brain activation in self-regulation areas was related to diet importance. Thus, our results are the first to show that food cues not only evoke hedonic brain responses; in successful self-regulators they also trigger alarm bell responses, which may reflect the neural processes underlying successful self-control.
    Data quality assessment for in silico methods: A survey of approaches and needs
    Nendza, M. ; Aldenberg, T. ; Benfenati, E. ; Benigni, R. ; Cronin, M. ; Escher, S. ; Fernandez, A. ; Gabbert, S.G.M. ; Giralt, F. ; Hewitt, M. ; Hrovat, M. ; Jeram, S. ; Kroese, D. ; Madden, J. ; Mangelsdorf, I. ; Rallo, R. ; Roncaglioni, A. ; Rorije, E. ; Segner, H. ; Simon-Hettich, B. ; Vemeire, T. - \ 2010
    In: In Silico Toxicology: Principles and applications / Cronin, M., Madden, J., Cambridge, UK : Royal Society of Chemistry (Issues of toxicology 7) - ISBN 9781849730044 - p. 59 - 117.
    The nsp1 alpha and nsp1 beta papain-like autoproteinases are essential for porcine reproductive and respiratory syndrome virus RNA synthesis
    Kroese, M.V. ; Zevenhoven-Dobbe, J.C. ; Ruijter, J.N.A.B.D. ; Peeters, B.P.H. ; Meulenberg, J.J.M. ; Cornelissen, A.H.M. ; Snijder, E.J. - \ 2008
    Journal of General Virology 89 (2008). - ISSN 0022-1317 - p. 494 - 499.
    equine arteritis virus - double-membrane vesicles - replicase orf1a protein - genome - nidovirales - proteases - complex - region - virion
    The two N-terminal cleavage products, nsp1 alpha and nsp1 beta, of the replicase polyproteins of porcine reproductive and respiratory syndrome virus (PRRSV) each contain a papain-like autoproteinase domain, which have been named PCP alpha and PCP beta, respectively. To assess their role in the PRRSV life cycle, substitutions and deletions of the presumed catalytic cysteine and histidine residues of PCPa and PCP beta were introduced into a PRRSV infectious cDNA clone. Mutations that inactivated PCPa activity completely blocked subgenomic mRNA synthesis, but did not affect genome replication. In contrast, mutants in which PCPP activity was blocked proved to be non-viable and no sign of viral RNA synthesis could be detected, indicating that the correct processing of the nsp1 beta/nsp2 cleavage site is essential for PRRSV genome replication. In conclusion, the data presented here show that a productive PRRSV life cycle depends on the correct processing of both the nsp1 alpha/nsp1 beta and nsp1 beta/nsp2 junctions.
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